Parvovirus interference with intracellular signalling: Mechanism of PKCη activation in MVM-infected A9 fibroblasts

Cellular Microbiology

Volumn 10, Issue 3, 2008, Pages 755-769

  Lachmann, Sylvie ^a,b,c   Bär, Severine ^a,b   Rommelaere, Jean ^a,b   Nüesch, Jürg P F ^a,b  

^a Program 'Infection and Cancer'   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INOSITOL PHOSPHATE; NONSTRUCTURAL PROTEIN NS 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN; PROTEIN KINASE C; PROTEIN KINASE C LAMBDA; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FIBROBLAST; FLUORESCENCE MICROSCOPY; IN VIVO STUDY; MOUSE; NONHUMAN; PARVOVIRUS; PARVOVIRUS INFECTION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; CELL NUCLEUS; CYTOPLASM; FIBROBLASTS; ISOENZYMES; MICE; MICROSCOPY, FLUORESCENCE; MINUTE VIRUS OF MICE; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES;

MINUTE VIRUS OF MICE; PARVOVIRUS;

EID: 38849111120     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2007.01082.x     Document Type: Article

References (45)

1. Balendran, A., Biondi, R.M., Cheung, P.C., Casamayor, A., Deak, M., and Alessi, D.R. (2000) A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta) and PKC-related kinase 2 by PDK1. J Biol Chem 275: 20806-20813.
2. Bashir, T., Rommelaere, J., and Cziepluch, C. (2001) In vivo accumulation of cyclin A and cellular replication factors in autonomous parvovirus minute virus of mice-associated replication bodies. J Virol 75: 4394-4398.
3. Behn-Krappa, A., and Newton, A.C. (1999) The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation. Curr Biol 9: 728-737.
4. Biondi, R.M., Cheung, P.C., Casamayor, A., Deak, M., Currie, R.A., and Alessi, D.R. (2000) Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA. EMBO J 19: 979-988.
5. Bodendorf, U., Cziepluch, C., Jauniaux, J.C., Rommelaere, J., and Salome, N. (1999) Nuclear export factor CRM1 interacts with nonstructural proteins NS2 from parvovirus minute virus of mice. J Virol 73: 7769-7779.
6. Brockhaus, K., Plaza, S., Pintel, D.J., Rommelaere, J., and Salome, N. (1996) Nonstructural proteins NS2 of minute virus of mice associate in vivo with 14-3-3 protein family members. J Virol 70: 7527-7534.
7. Caillet-Fauquet, P., Perros, M., Brandenburger, A., Spegelaere, P., and Rommelaere, J. (1990) Programmed killing of human cells by means of an inducible clone of parvoviral genes encoding non-structural proteins. EMBO J 9: 2989-2995.
8. Casamayor, A., Morrice, N.A., and Alessi, D.R. (1999) Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: Identification of five sites of phosphorylation in vivo. Biochem J 342 (Part 2): 287-292.
9. Cenni, V., Doppler, H., Sonnenburg, E.D., Maraldi, N., Newton, A.C., and Toker, A. (2002) Regulation of novel protein kinase C epsilon by phosphorylation. Biochem J 363: 537-545.
10. Christensen, J., and Tattersall, P. (2002) Parvovirus initiator protein NS1 and RPA coordinate replication fork progression in a reconstituted DNA replication system. J Virol 76: 6518-6531.
11. Corbau, R., Duverger, V., Rommelaere, J., and Nuesch, J.P. (2000) Regulation of MVM NS1 by protein kinase C: Impact of mutagenesis at consensus phosphorylation sites on replicative functions and cytopathic effects. Virology 278: 151-167.
12. Cotmore, S.F., and Tattersall, P. (1987) The autonomously replicating parvoviruses of vertebrates. Adv Virus Res 33: 91-174.
13. Daeffler, L., Horlein, R., Rommelaere, J., and Nuesch, J.P. (2003) Modulation of minute virus of mice cytotoxic activities through site-directed mutagenesis within the NS coding region. J Virol 77: 12466-12478.
14. Dettwiler, S., Rommelaere, J., and Nuesch, J.P. (1999) DNA unwinding functions of minute virus of mice NS1 protein are modulated specifically by the lambda isoform of protein kinase C. J Virol 73: 7410-7420.
15. Di Piazza, M., Mader, C., Geletneky, K., Herrero, Y.C.M., Weber, E., Schlehofer, J., et al. (2007) Cytosolic activation of cathepsins mediates parvovirus H-1-induced killing of cisplatin and TRAIL-resistant glioma cells. J Virol 81: 4186-4198.
16. Flynn, P., Wongdagger, M., Zavar, M., Dean, N.M., and Stokoe, D. (2000) Inhibition of PDK-1 activity causes a reduction in cell proliferation and survival. Curr Biol 10: 1439-1442.
17. Frodin, M., Jensen, C.J., Merienne, K., and Gammeltoft, S. (2000) A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1. EMBO J 19: 2924-2934.
18. Frodin, M., Antal, T.L., Dummler, B.A., Jensen, C.J., Deak, M., Gammeltoft, S., and Biondi, R.M. (2002) A phosphoserine/ threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation. EMBO J 21: 5396-5407.
19. Gao, T., Toker, A., and Newton, A.C. (2001) The carboxyl terminus of protein kinase c provides a switch to regulate its interaction with the phosphoinositide-dependent kinase, PDK-1. J Biol Chem 276: 19588-19596.
20. Kang, B.S., French, O.G., Sando, J.J., and Hahn, C.S. (2000) Activation-dependent degradation of protein kinase C eta. Oncogene 19: 4263-4272.
21. King, J.A., Dubielzig, R., Grimm, D., and Kleinschmidt, J.A. (2001) DNA helicase-mediated packaging of adeno-associated virus type 2 genomes into preformed capsids. EMBO J 20: 3282-3291.
22. Krady, J.K., and Ward, D.C. (1995) Transcriptional activation by the parvoviral nonstructural protein NS-1 is mediated via a direct interaction with Sp1. Mol Cell Biol 15: 524-533.
23. Lachmann, S., Rommeleare, J., and Nuesch, J.P. (2003) Novel PKCeta is required to activate replicative functions of the major nonstructural protein NS1 of minute virus of mice. J Virol 77: 8048-8060.
24. Le Good, J.A., Ziegler, W.H., Parekh, D.B., Alessi, D.R., Cohen, P., and Parker, P.J. (1998) Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 281: 2042-2045.
25. Lorson, C., Pearson, J., Burger, L., and Pintel, D.J. (1998) An Sp1-binding site and TATA element are sufficient to support full transactivation by proximally bound NS1 protein of minute virus of mice. Virology 240: 326-337.
26. Miyagi, T., Tatsumi, T., Takehara, T., Kanto, T., Kuzushita, N., Sugimoto, Y., et al. (2003) Impaired expression of proteasome subunits and human leukocyte antigens class I in human colon cancer cells. J Gastroenterol Hepatol 18: 32-40.
27. Morrow, T.A., Muljo, S.A., Zhang, J., Hardwick, J.M., and Schlissel, M.S. (1999) Pro-B-cell-specific transcription and proapoptotic function of protein kinase Ceta. Mol Cell Biol 19: 5608-5618.
28. Moss, B., Elroy-Stein, O., Mizukami, T., Alexander, W.A., and Fuerst, T.R. (1990) Product review. New mammalian expression vectors. Nature 348: 91-92.
29. Mousset, S., Ouadrhiri, Y., Caillet-Fauquet, P., and Rommelaere, J. (1994) The cytotoxicity of the autonomous parvovirus minute virus of mice nonstructural proteins in FR3T3 rat cells depends on oncogene expression. J Virol 68: 6446-6453.
30. Newton, A.C. (1997) Regulation of protein kinase C. Curr Opin Cell Biol 9: 161-167.
31. Newton, A.C. (2003) Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem J 370: 361-371.
32. Nüesch, J. (2006) Regulation of non-structural protein functions by differential synthesis, modification and trafficking. In Parvoviruses. Bloom, M.E., Cotmore, S.F., Linden, R.M., Parrish, C.R., Kerr, J.R. (eds). London: Hodder Arnold, pp. 275-286.
33. Nuesch, J.P., and Rommelaere, J. (2006) NS1 interaction with CKII alpha: novel protein complex mediating parvovirus-induced cytotoxicity. J Virol 80: 4729-4739.
34. Nuesch, J.P., and Rommelaere, J. (2007) A viral adaptor protein modulating casein kinase II activity induces cytopathic effects in permissive cells. Proc Natl Acad Sci USA 104: 12482-12487.
35. Nuesch, J.P., Cotmore, S.F., and Tattersall, P. (1992) Expression of functional parvoviral NS1 from recombinant vaccinia virus: Effects of mutations in the nucleotide-binding motif. Virology 191: 406-416.
36. Nuesch, J.P., Corbau, R., Tattersall, P., and Rommelaere, J. (1998) Biochemical activities of minute virus of mice nonstructural protein NS1 are modulated in vitro by the phosphorylation state of the polypeptide. J Virol 72: 8002-8012.
37. Nuesch, J.P., Christensen, J., and Rommelaere, J. (2001) Initiation of minute virus of mice DNA replication is regulated at the level of origin unwinding by atypical protein kinase C phosphorylation of NS1. J Virol 75: 5730-5739.
38. Nuesch, J.P., Lachmann, S., Corbau, R., and Rommelaere, J. (2003) Regulation of minute virus of mice NS1 replicative functions by atypical PKClambda in vivo. J Virol 77: 433-442.
39. Nuesch, J.P., Lachmann, S., and Rommelaere, J. (2005) Selective alterations of the host cell architecture upon infection with parvovirus minute virus of mice. Virology 331: 159-174.
40. Parekh, D., Ziegler, W., Yonezawa, K., Hara, K., and Parker, P.J. (1999) Mammalian TOR controls one of two kinase pathways acting upon nPKCdelta and nPKCepsilon. J Biol Chem 274: 34758-34764.
41. Perander, M., Bjorkoy, G., and Johansen, T. (2001) Nuclear import and export signals enable rapid nucleocytoplasmic shuttling of the atypical protein kinase C lambda. J Biol Chem 276: 13015-13024.
42. Sonnemann, J., Gekeler, V., Ahlbrecht, K., Brischwein, K., Liu, C., Bader, P., et al. (2004) Down-regulation of protein kinase Ceta by antisense oligonucleotides sensitises A549 lung cancer cells to vincristine and paclitaxel. Cancer Lett 209: 177-185.
43. Sonnenburg, E.D., Gao, T., and Newton, A.C. (2001) The phosphoinositide-dependent kinase, PDK-1, phosphorylates conventional protein kinase C isozymes by a mechanism that is independent of phosphoinositide 3-kinase. J Biol Chem 276: 45289-45297.
44. Wick, M.J., Wick, K.R., Chen, H., He, H., Dong, L.Q., Quon, M.J., and Liu, F. (2002) Substitution of the autophosphorylation site Thr516 with a negatively charged residue confers constitutive activity to mouse 3-phosphoinositide-dependent protein kinase-1 in cells. J Biol Chem 277: 16632-16638.
45. Ziegler, W.H., Parekh, D.B., Le Good, J.A., Whelan, R.D., Kelly, J.J., Frech, M., et al. (1999) Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex. Curr Biol 9: 522-529.