NS1 Interaction with CKIIa: Novel protein complex mediating parvovirus-induced cytotoxicity

Journal of Virology

Volumn 80, Issue 10, 2006, Pages 4729-4739

  Nüesch, Jürg P F ^a   Rommelaere, Jean ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN KINASE II; CASEIN KINASE II ALPHA; MUTANT PROTEIN; NONSTRUCTURAL PROTEIN 1; UNCLASSIFIED DRUG; VIRUS PROTEIN; CAPSID PROTEIN; NS1 PROTEIN, PARVOVIRUS;

AFFINITY CHROMATOGRAPHY; ANIMAL CELL; ARTICLE; CELL STRAIN; CELL STRAIN A9; CELL STRUCTURE; CYTOLYSIS; CYTOPATHOGENIC EFFECT; CYTOTOXICITY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; FIBROBLAST; INTERMEDIATE FILAMENT; MICROFILAMENT; MICROTUBULE; NONHUMAN; NUCLEAR LAMINA; PARVOVIRUS; PEPTIDE ANALYSIS; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; VIRUS CAPSID; WESTERN BLOTTING; AMINO ACID SEQUENCE; ANIMAL; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HELA CELL; HUMAN; IMMUNOLOGY; INTRACELLULAR FLUID; METABOLISM; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; VIROLOGY;

ANIMALIA; MINUTE VIRUS OF MICE; MIRIDAE; PARVOVIRUS;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CAPSID PROTEINS; CASEIN KINASE II; CYTOPATHOGENIC EFFECT, VIRAL; CYTOTOXICITY, IMMUNOLOGIC; FLUORESCENT ANTIBODY TECHNIQUE; HELA CELLS; HUMANS; INTRACELLULAR FLUID; MICE; MINUTE VIRUS OF MICE; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; SIGNAL TRANSDUCTION; VIRAL NONSTRUCTURAL PROTEINS;

EID: 33646439683     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.80.10.4729-4739.2006     Document Type: Article

References (39)

1. Anouja, F., R. Wattiez, S. Moussel, and P. Caillet-Fauquet. 1997. The cytotoxicity of the parvovirus minute virus of mice nonstructural protein NS1 is related to changes in the synthesis and phosphorylation of cell proteins. J. Virol. 71:4671-4678.
2. Bashir, T., J. Rommelaere, and C. Cziepluch. 2001. In vivo accumulation of cyclin A and cellular replication factors in autonomous parvovirus minute virus of mice-associated replication bodies. J. Virol. 75:4394-4398.
3. Caillet-Fauquet, P., M. Perros, A. Brandenburger, P. Spegelaere, and J. Rommelaere. 1990. Programmed killing of human cells by means of an inducible clone of parvoviral genes encoding non-structural proteins. EMBO J. 9:2989-2995.
4. Christensen, J., S. F. Cotmore, and P. Tattersall. 1997. Parvovirus initiation factor PIF: a novel human DNA-binding factor which coordinately recognizes two ACGT motifs. J. Virol. 71:5733-5741.
5. Christensen, J., and P. Tattersall. 2002. Parvovirus initiator protein NS1 and RPA coordinate replication fork progression in a reconstituted DNA replication system. J. Virol. 76:6518-6531.
6. Corbau, R., V. Duverger, J. Rommelaere, and J. P. Nüesch. 2000. Regulation of MVM NS1 by protein kinase C: impact of mutagenesis at consensus phosphorylation sites on replicative functions and cytopathic effects. Virology 278:151-167.
7. Corbau, R., N. Salomé, J. Rommelaere, and J. P. Nüesch. 1999. Phosphorylation of the viral nonstructural protein NS1 during MVMp infection of A9 cells. Virology 259:402-415.
8. Cotmore, S. F., and P. Tattersall. 1987. The autonomously replicating parvoviruses of vertebrates. Adv. Virus Res. 33:91-174.
9. Cotmore, S. F., and P. Tattersall. 1988. The NS-1 polypeptide of minute virus of mice is covalently attached to the 5′ termini of duplex replicative-form DNA and progeny single strands. J. Virol. 62:851-860.
10. Cziepluch, C., E. Kordes, R. Poirey, A. Grewenig, J. Rommelaere, and J.-C. Jauniaux. 1998. Identification of a novel cellular TPR-containing protein, SGT, that interacts with the nonstructural protein NS1 of parvovirus H-1. J. Virol. 72:4149-4156.
11. Cziepluch, C, S. Lampel, A. Grewenig, C. Grund, P. Lichter, and J. Rommelaere. 2000. H-1 parvovirus-associated replication bodies: a distinct virus-induced nuclear structure. J. Virol. 74:4807-4815.
12. Daeffler, L., R. Hörlein, J. Rommelaere, and J. P. F. Nüesch. 2003. Modulation of minute virus of mice cytotoxic activities through site-directed mutagenesis within the NS coding region. J. Virol. 77:12466-12478.
13. Dettwiler, S., J. Rommelaere, and J. P. F. Nüesch. 1999. DNA unwinding functions of minute virus of mice NSl protein are modulated specifically by the lambda isoform of protein kinase C. J. Virol. 73:7410-7420.
14. Eichwald, V., L. Daeffler, M. Klein, J. Rommelaere, and N. Salome. 2002. The NS2 proteins of parvovirus minute virus of mice are required for efficient nuclear egress of progeny virions in mouse cells. J. Virol. 76:10307-10319.
15. Krady, J. K., and D. C. Ward. 1995. Transcriptional activation by the parvoviral nonstructural protein NS-1 is mediated via a direct interaction with Sp1. Mol. Cell. Biol. 15:524-533.
16. Lachmann, S., J. Rommeleare, and J. P. F. Nüesch. 2003. Novel PKCη is required to activate replicative functions of the major nonstructural protein NS1 of minute virus of mice. J. Virol. 77:8048-8060.
17. Legendre, D., and J. Rommelaere. 1992. Terminal regions of the NS-1 protein of the parvovirus minute virus of mice are involved in cytotoxicity and promoter trans inhibition. J. Virol. 66:5705-5713.
18. Li, X., and S. L. Rhode III. 1990. Mutation of lysine 405 to serine in the parvovirus H-1 NS1 abolishes its functions for viral DNA replication, late promoter trans activation, and cytotoxicity. J. Virol. 64:4654-4660.
19. Liu, J., Z. H. Ran, S. D. Xiao, and J. Rommelaere. 2005. Changes in gene expression profiles induced by parvovirus H-1 in human gastric cancer cells. Chin. J. Dig Dis. 6:72-81.
20. Lorson, C., J. Pearson, L. Burger, and D. J. Pintel. 1998. An Sp1-binding site and TATA element are sufficient to support full transactivation by proximally bound NS1 protein of minute virus of mice. Virology 240:326-337.
21. Maroto, B., J. C. Ramirez, and J. M. Almendral. 2000. Phosphorylation status of the parvovirus minute virus of mice particle: mapping and biological relevance of the major phosphorylation sites. J. Virol. 74:10892-10902.
22. Maroto, B., N. Valle, R. Saffrich, and J. M. Almendral. 2004. Nuclear export of the nonenveloped parvovirus virion is directed by an unordered protein signal exposed on the capsid surface. J. Virol. 78:10685-10694.
23. Moss, B., O. Elroy-Stein, T. Mizukami, W. A. Alexander, and T. R. Fuerst. 1990. Product review. New mammalian expression vectors. Nature 348:91-92.
24. Mousset, S., Y. Ouadrhiri, P. Caillet-Fauquet, and J. Rommelaere. 1994. The cytotoxicity of the autonomous parvovirus minute virus of mice non-structural proteins in FR3T3 rat cells depends on oncogene expression. J. Virol. 68:6445-6453.
25. Nüesch, J. 2005. Regulation of non-structural protein functions by differential synthesis, modification and trafficking, p. 275-289. In M. E. Bloom, S. F. Cotmore, R. M. Linden, C. R. Parrish, and J. R. Kerr (ed.), Parvoviruses. Hodder Arnold, London, United Kingdom.
26. Nüesch, J. P. F., J. Christensen, and J. Rommelaere. 2001. Initiation of minute virus of mice DNA replication is regulated at the level of origin unwinding by atypical protein kinase C phosphorylation of NSl. J. Virol. 75:5730-5739.
27. N̈esch, J. P. F., R. Corbau, P. Tattersall, and J. Rommelaere. 1998. Biochemical activities of minute virus of mice nonstructural protein NS1 are modulated in vitro by the phosphorylation state of the polypeptide. J. Virol. 72:8002-8012.
28. Nüesch, J. P. F., S. F. Cotmore, and P. Tattersall. 1992. Expression of functional parvoviral NSl from recombinant vaccinia virus: effects of mutations in the nucleotide-binding motif. Virology 191:406-416.
29. Nüesch, J. P. F., S. F. Cotmore, and P. Tattersall. 1995. Sequence motifs in the replicator protein of parvovirus MVM essential for nicking and covalent attachment to the viral origin: identification of the linking tyrosine. Virology 209:122-135.
30. Nüesch, J. P. F., S. Dettwiler, R. Corbau, and J. Rommelaere. 1998. Replicative functions of minute virus of mice NSl protein are regulated in vitro by phosphorylation through protein kinase C. J. Virol. 72:9966-9977.
31. Nüesch, J. P. F., S. Lachmann, R. Corbau, and J. Rommelaere. 2003. Regulation of minute virus of mice NS1 replicative functions by atypical PKCλ in vivo. J. Virol. 77:433-442.
32. Nüesch, J. P. F., S. Lachmann, and J. Rommelaere. 2005. Selective alterations of the host cell architecture upon infection with parvovirus minute virus of mice. Virology 331:159-174.
33. Nüesch, J. P. F., and P. Tallersall. 1993. Nuclear targeting of the parvoviral replicator molecule NS1: evidence for self-association prior to nuclear transport. Virology 196:637-651.
34. Op De Beeck, A., F. Anouja, S. Mousset, J. Rommelaere, and P. Caillet-Fauquel. 1995. The nonstructural proteins of the autonomous parvovirus minute virus of mice interfere with the cell cycle, inducing accumulation in G2. Cell Growth Differ. 6:781-787.
35. Op De Beeck, A., and P. Caillet-Fauquel. 1997. The NS1 protein of the autonomous parvovirus minute virus of mice blocks cellular DNA replication: a consequence of lesions to the chromatin? J. Virol. 71:5323-5329.
36. cip1. J. Virol. 75:11071-11078.
37. Pyerin, W., K. Ackermann, and P. Lorenz. 1996. Casein kinases, p. 117-147. In F. Marks (ed.), Protein phosphorylation. VCH Verlagsgesellschaft GmbH, Weinheim, Germany.
38. Suzuki, A., T. Yamanaka, T. Hirose, N. Manabe, K. Mizuno, M. Shimizu, K. Akimoto, Y. Izumi, T. Ohnishi, and S. Ohno. 2001. Atypical protein kinase C is involved in the evolutionarily conserved PAR protein complex and plays a critical role in establishing epithelia-specific junctional structures. J. Cell Biol. 152:1183-1196.
39. Tattersall, P., and J. Bratton. 1983. Reciprocal productive and restrictive virus-cell interactions of immunosuppressive and prototype strains of minute virus of mice. J. Virol. 46:944-955.