Initiation of minute virus of mice DNA replication is regulated at the level of origin unwinding by atypical protein kinase C phosphorylation of NS1

Journal of Virology

Volumn 75, Issue 13, 2001, Pages 5730-5739

  Nuesch J P F ^a   Christensen, J ^a   Rommelaere, J ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; HELICASE; PROTEIN KINASE C; PROTEIN NS1; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS PROTEIN;

ARTICLE; CONTROLLED STUDY; DEPHOSPHORYLATION; DNA MODIFICATION; DNA REPLICATION; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ESTERIFICATION; GENE MUTATION; NONHUMAN; PARVOVIRUS; PRIORITY JOURNAL; PROTEIN ANALYSIS; TRANSLATION INITIATION; VIRUS REPLICATION;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ANIMALS; DNA; DNA REPLICATION; MICE; MINUTE VIRUS OF MICE; PHOSPHORYLATION; PROTEIN KINASE C; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 0034968465     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.13.5730-5739.2001     Document Type: Article

References (45)

1. The cytotoxicity of the parvovirus minute virus of mice nonstructural protein NS1 is related to changes in the synthesis and phosphorylation of cell proteins
2. Structural and functional homology of parvovirus and papovavirus polypeptides
3. Specific initiation of replication at the right-end telomere of the closed species of minute virus of mice replicative-form DNA
4. Cyclin A activates the DNA polymerase delta-dependent elongation machinery in vitro: A parvovirus DNA replication model
5. Rep-mediated nicking of the adeno-associated virus origin requires two biochemical activities, DNA helicase activity and transesterification
6. Mechanism of Rep-mediated adeno-associated virus origin nicking
7. Programmed killing of human cells by means of an inducible clone of paroviral genes encoding non-structural proteins
8. Minute virus of mice transcriptional activator protein NS1 binds directly to the transactivation region of the viral P38 promoter in a strictly ATP-dependent manner
9. A novel cellular site-specific DNA-binding protein cooperates with the viral NS1 polypeptide to initiate parvovirus DNA replication
10. Parvovirus initiation factor PIF: A novel human DNA-binding factor which coordinately recognizes two ACGT motifs
11. Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites
12. Regulation of MVM NS1 by protein kinase C: Impact of mutagenesis at consensus phosphorylation sites on replicative functions and cytopathic effects
13. Phosphorylation of the viral nonstructural protein NS1 during MVMp infection of A9 cells
14. Transformation of human fibroblasts by ionizing radiation, a chemical carcinogen, or simian virus 40 correlates with an increase in susceptibility to the autonomous parvoviruses H-1 and minute virus of mice
15. 2-3
16. Two widely spaced initiator binding sites create an HMG1-dependent parvovirus rolling-hairpin replication origin
17. In vitro excision and replication of 5′telomeres of minute virus of mice DNA from clones palindromic concatemer junctions
18. Asymmetric resolution of a parvovirus palindrome in vitro
19. The autonomously replicating parvoviruses of vertebrates
20. The NS-1 polypeptide of minute virus of mice is covalently attached to the 5′ termini of duplex replicative-form DNA and progeny single strands
21. A genome-linked copy of the NS-1 polypeptide is located on the outside of infectious parvovirus particles
22. An asymmetric nucleotide in the parvoviral 3′hairpin directs segregation of a single active origin of DNA replication
23. DNA replication in the autonomous parvoviruses
24. High-mobility group 1/2 proteins are essential for initiating rolling-circle-type DNA replication at a parvovirus hairpin origin
25. H-1 parvovirus-associated replication bodies: A distinct virus-induced nuclear structure
26. DNA unwinding functions of minute virus of mice NS1 protein are modulated specifically by the lambda isoform of protein kinase C
27. Use of a hybrid vaccinia virus-T7 RNA polymerase system for expression of target genes
28. Development-dependent replication of minute virus of mice in differentiated mouse testicular cell lines
29. Computer-assisted dissection of rolling circle DNA replication
30. The construction and characterization of vaccinia virus recombinants expressing foreign genes
31. Protein kinase C
32. The small nonstructural protein (NS2) of the parvovirus minute virus of mice is required for efficient DNA replication and infectious virus production in a cell-type-specific manner
33. Biochemical activities of minute virus of mice nonstructural protein NS1 are modulated in vitro by the phosphorylation state of the polypeptide
34. Expression of functional parvoviral NS1 from recombinant vaccinia virus: Effects of mutations in the nucleotide-binding motif
35. Sequence motifs in the replicator protein of parvovirus MVM essential for nicking and covalent attachment to the viral origin: Identification of the linking tyrosine
36. Replicative functions of minute virus of mice NS1 protein are regulated in vitro by phosphorylation through protein kinase C
37. Nuclear targeting of the parvoviral replicator molecule NS1: Evidence for self-association prior to nuclear transport
38. Viruses and cell cycle
39. Inhibition of parvovirus minute virus of mice replication by a peptide involved in the oligomerization of nonstructural protein NS1
40. Characterization of the transactivation-responsive element of the parvovirus H-1 P38 promoter
41. Accumulation of MVM gene products is differentially regulated by transcription initiation, RNA processing and protein stability
42. Transactivation of a cellular promoter by the NS1 protein of the parvovirus minute virus of mice through a putative hormone-responsive element
43. Roles of phosphorylation in DNA replication