Expression of Toll/IL-1R domain-containing adaptor protein (TIRAP) is detrimental to primary clearance of Salmonella and is not required for the generation of protective immunity

Immunology Letters

Volumn 116, Issue 1, 2008, Pages 64-71

  Jerke, Stu ^a   Srinivasan, Aparna ^a   McSorley, Stephen J ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Bacterial infection; CD4 T cells; Toll like receptors

Indexed keywords

ADAPTOR PROTEIN; GAMMA INTERFERON; PROTEIN TIRAP; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C57BL 6 MOUSE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; IMMUNITY; IN VITRO STUDY; INFLAMMATION; INNATE IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SALMONELLA; SALMONELLOSIS; SPLEEN CELL;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; COLONY COUNT, MICROBIAL; EPITOPES; HOST-PATHOGEN INTERACTIONS; IMMUNITY, ACTIVE; IMMUNOLOGIC MEMORY; INTERFERON TYPE II; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PATTERN RECOGNITION, PHYSIOLOGICAL; RECEPTORS, INTERLEUKIN-1; SALMONELLA INFECTIONS; SALMONELLA TYPHIMURIUM; SIGNAL TRANSDUCTION; SPLEEN; T-LYMPHOCYTES;

EID: 38749120226     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2007.11.007     Document Type: Article

References (32)

1. Santos R.L., Zhang S., Tsolis R.M., Kingsley R.A., Adams L.G., and Baumler A.J. Animal models of salmonella infections: enteritis versus typhoid fever. Microbes Infect 3 (2001) 1335-1344
2. Wick M.J. Living in the danger zone: innate immunity to Salmonella. Curr Opin Microbiol 7 (2004) 51-57
3. Srinivasan A., and McSorley S.J. Activation of Salmonella-specific immune responses in the intestinal mucosa. Arch Immunol Ther Exp (Warsz) 54 (2006) 25-31
4. Akira S., Uematsu S., and Takeuchi O. Pathogen recognition and innate immunity. Cell 124 (2006) 783-801
5. Poltorak A., He X., Smirnova I., Liu M.Y., Huffel C.V., Du X., et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282 (1998) 2085-2088
6. Hoshino K., Takeuchi O., Kawai T., Sanjo H., Ogawa T., Takeda Y., et al. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162 (1999) 3749-3752
7. Hayashi F., Smith K.D., Ozinsky A., Hawn T.R., Yi E.C., Goodlett D.R., et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410 (2001) 1099-1103
8. Gewirtz A.T., Nava T.A., Lyons S., Godowski P.J., and Madera J.L. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J Immunol 167 (2001) 1882-1885
9. Weiss D.S., Raupach B., Takeda K., Akira S., and Zychlinsky A. Toll-like receptors are temporally involved in host defense. J Immunol 172 (2004) 4463-4469
10. West A.P., Koblansky A.A., and Ghosh S. Recognition and signaling by Toll-like receptors. Annu Rev Cell Dev Biol 22 (2006) 409-437
11. Adachi O., Kawai T., Takeda K., Matsumoto M., Tsutsui H., Sakagami M., et al. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9 (1998) 143-150
12. Kawai T., Adachi O., Ogawa T., Takeda K., and Akira S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11 (1999) 115-122
13. Horng T., Barton G.M., and Medzhitov R. TIRAP: an adapter molecule in the Toll signaling pathway. Nat Immunol 2 (2001) 835-841
14. Yamamoto M., Sato S., Hemmi H., Sanjo H., Uematsu S., Kaisho T., et al. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature 420 (2002) 324-329
15. Horng T., Barton G.M., Flavell R.A., and Medzhitov R. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature 420 (2002) 329-333
16. Laroux F.S., Romero X., Wetzler L., Engel P., and Terhorst C. Cutting edge: MyD88 controls phagocyte NADPH oxidase function and killing of gram-negative bacteria. J Immunol 175 (2005) 5596-5600
17. Sebastiani G., Leveque G., Lariviere L., Laroche L., Skamene E., Gros P., et al. Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice. Genomics 64 (2000) 230-240
18. Angers I., Sancho-Shimizu V., Descoteaux A., Gewirtz A.T., and Malo D. Tlr5 is not primarily associated with susceptibility to Salmonella Typhimurium infection in MOLF/Ei mice. Mamm Genome 17 (2006) 385-397
19. Uematsu S., Jang M.H., Chevrier N., Guo Z., Kumagai Y., Yamamoto M., et al. Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells. Nat Immunol 7 (2006) 868-874
20. Feuillet V., Medjane S., Mondor I., Demaria O., Pagni P.P., Galan J.E., et al. Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria. Proc Natl Acad Sci USA 103 (2006) 12487-12492
21. Jeyaseelan S., Young S.K., Yamamoto M., Arndt P.G., Akira S., Kolls J.K., et al. Toll/IL-1R domain-containing adaptor protein (TIRAP) is a critical mediator of antibacterial defense in the lung against Klebsiella pneumoniae but not Pseudomonas aeruginosa. J Immunol 177 (2006) 538-547
22. McSorley S.J., Asch S., Costalonga M., Rieinhardt R.L., and Jenkins M.K. Tracking Salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection. Immunity 16 (2002) 365-377
23. Srinivasan A., Foley J., Ravindran R., and McSorley S.J. Low-dose salmonella infection evades activation of flagellin-specific CD4 T cells. J Immunol 173 (2004) 4091-4099
24. Hess J., Ladel C., Miko D., and Kaufmann S.H. Salmonella typhimurium aroA-infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location. J Immunol 156 (1996) 3321-3326
25. Ravindran R., Foley J., Stoklasek T., Glimcher L.H., and McSorley S.J. Expression of T-bet by CD4 T cells is essential for resistance to Salmonella infection. J Immunol 175 (2005) 4603-4610
26. Srinivasan A., Foley J., and McSorley S.J. Massive number of antigen-specific CD4 T cells during vaccination with live attenuated Salmonella causes interclonal competition. J Immunol 172 (2004) 6884-6893
27. McSorley S.J., and Jenkins M.K. Antibody is required for protection against virulent but not attenuated Salmonella enterica serovar typhimurium. Infect Immun 68 (2000) 3344-3348
28. Plant J., and Glynn A.A. Natural resistance to Salmonella infection, delayed hypersensitivity and Ir genes in different strains of mice. Nature 248 (1974) 345-347
29. Jeyaseelan S., Manzer R., Young S.K., Yamamoto M., Akira S., Mason R.J., et al. Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli. J Immunol 175 (2005) 7484-7495
30. Zeng H., Carlson A.Q., Guo Y., Yu Y., Collier-Hyams L.S., Madara J.L., et al. Flagellin is the major proinflammatory determinant of enteropathogenic Salmonella. J Immunol 171 (2003) 3668-3674
31. Gelman A.E., Larosa D.F., Zhang J., Walsh P.T., Choi Y., Sunyer J.O., et al. The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4(+) T cells and enables CpG oligodeoxynucleotide-mediated costimulation. Immunity 25 (2006) 783-793
32. Hoiseth S.K., and Stocker B.A.D. Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines. Nature 291 (1981) 238-239