Distinctive interactions at multiple site 2 subsites by allele-specific rat and mouse Ly49 determine functional binding and class I MHC specificity

Journal of Immunology

Volumn 179, Issue 10, 2007, Pages 6856-6866

  Lavender, Kerry J ^a   Chau, Heidi H ^a   Kane, Kevin P ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

LYSINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; SOLVENT; H2 ANTIGEN; LECTIN; LY 49 ANTIGEN; LY ANTIGEN; LY-49 ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONFORMATION; CONTROLLED STUDY; ENZYME POLYMORPHISM; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; RAT; ALLELE; AMINO ACID SUBSTITUTION; ANIMAL; GENETIC POLYMORPHISM; GENETICS; IMMUNOLOGY; MISSENSE MUTATION; PROTEIN BINDING; SITE DIRECTED MUTAGENESIS; TUMOR CELL LINE;

ALLELES; AMINO ACID SUBSTITUTION; ANIMALS; ANTIGENS, LY; BINDING SITES; CELL LINE, TUMOR; H-2 ANTIGENS; LECTINS, C-TYPE; MICE; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; POLYMORPHISM, GENETIC; PROTEIN BINDING; RATS;

EID: 38449114695     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.10.6856     Document Type: Article

References (54)

1. Stewart, C., E. Vivier, and M. Colonna. 2006. Strategies of natural killer cell recognition and signaling. Curr. Top. Microbiol. Immunol. 298: 1-21.
2. Lodoen, M., and L. Lanier. 2006. Natural killer cells as an initial defense against pathogens. Curr. Opin. Immunol. 18: 391-398.
3. Ortaldo, J., and H. Young. 2005. Mouse Ly49 NK receptors: balancing activation and inhibition. Mol. Immunol. 42: 445-450.
4. Rolstad, B., C. Naper, G. Løvik, J. Vaage, J. Ryan, E. Bäckman-Petersson, R. Kirsch, and G. Butcher. 2001. Rat natural killer cell receptor systems and recognition of MHC class I molecules. Immunol. Rev. 181: 149-157.
5. Kane, K., K. Lavender, and B. Ma. 2004. Ly-49 receptors and their functions. Crit. Rev. Immunol. 24: 321-348.
6. Kane, K., E. Silver, and B. Hazes. 2001. Specificity and function of activating Ly-49 receptors. Immunol. Rev. 181: 104-114.
7. Nylenna, O., C. Naper, J. Vaage, P. Woon, D. Gauguier, E. Dissen, J. Ryan, and S. Fossum. 2005. The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex. Eur. J. Immunol. 35: 261-272.
8. Kveberg, L., K. Dai, E. Dissen, J. Ryan, B. Rolstad, J. Vaage, and C. Naper. 2006. Strain-dependent expression of four structurally related rat Ly49 receptors; correlation with NK gene complex haplotype and NK alloreactivity. Immunogenetics 58: 905-916.
9. Proteau, M., E. Rousselle, and A. Makrigiannis. 2004. Mapping of the BALB/c Ly49 cluster defines a minimal natural killer cell receptor gene repertoire. Genomics 84: 669-677.
10. Wilhelm, B., L. Gagnier, and D. Mager. 2002. Sequence analysis of the ly49 cluster in C57BL/6 mice: a rapidly evolving multigene family in the immune system. Genomics 80: 646-661.
11. Mehta, I., J. Wang, J. Roland, D. Margulies, and W. Yokoyama. 2001. Ly49A allelic variation and MHC class I specificity. Immunogenetics 53: 572-583.
12. Silver, E., K. Lavender, D. Gong, B. Hazes, and K. Kane. 2002. Allelic variation in the ectodomain of the inhibitory Ly-49G2 receptor alters its specificity for allogeneic and xenogeneic ligands. J. Immunol. 169: 4752-4760.
13. Anderson, S., J. Ortaldo, and D. McVicar. 2001. The ever-expanding Ly49 gene family: repertoire and signaling. Immunol. Rev. 181: 79-89.
14. Arase, H., E. Mocarski, A. Campbell, A. Hill, and L. Lanier. 2002. Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science 296: 1323-1326.
15. Saleh, A., G. Davies, V. Pascal, P. Wright, D. Hodge, E. Cho, S. Lockett, M. Abshari, and S. Anderson. 2004. Identification of probabilistic transcriptional switches in the Ly49 gene cluster: a eukaryotic mechanism for selective gene activation. Immunity 21: 55-66.
16. Raulet, D., W. Held, I. Correa, J. Dorfman, M. Wu, and L. Corral. 1997. Specificity, tolerance and developmental regulation of natural killer cells defined by expression of class I-specific Ly49 receptors. Immunol. Rev. 155: 41-52.
17. Ljunggren, H., and K. Kärre. 1990. In search of the 'missing self': MHC molecules and NK cell recognition. Immunol. Today 11: 237-244.
18. Winter, C., J. Gumperz, P. Parham, E. Long, and N. Wagtmann. 1998. Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition. J. Immunol. 161: 571-577.
19. Vilches, C., and P. Parham. 2002. KIR: diverse, rapidly evolving receptors of innate and adaptive immunity. Annu. Rev. Immunol. 20: 217-251.
20. Mandelboim, O., H. Reyburn, M. Valés-Gómez, L. Pazmany, M. Colonna, G. Borsellino, and J. Strominger. 1996. Protection from lysis by natural killer cells of group 1 and 2 specificity is mediated by residue 80 in human histocompatibility leukocyte antigen C alleles and also occurs with empty major histocompatibility complex molecules. J. Exp. Med. 184: 913-922.
21. Fan, Q., E. Long, and D. Wiley. 2001. Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex. Nat. Immunol. 2: 452-460.
22. Boyington, J., S. Motyka, P. Schuck, A. Brooks, and P. Sun. 2000. Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand. Nature 405: 537-543.
23. d. J. Exp. Med. 192: 447-454.
24. Matsumoto, N., M. Mitsuki, K. Tajima, W. Yokoyama, and K. Yamamoto. 2001. The functional binding site for the C-type lectin-like natural killer cell receptor Ly49A spans three domains of its major histocompatibility complex class I ligand. J. Exp. Med. 193: 147-158.
25. d inside and outside of the peptide binding groove. J. Immunol. 166: 4422-4428.
26. Chung, D., K. Natarajan, L. Boyd, J. Tormo, R. Mariuzza, W. Yokoyama, and D. Margulies. 2000. Mapping the ligand of the NK inhibitory receptor Ly49A on living cells. J. Immunol. 165: 6922-6932.
27. 2-microglobulin. J. Biol. Chem. 277: 1433-1442.
28. 2-microglobulin subunit. J. Immunol. 166: 7327-7334.
29. 2-microglobulin required for Ly49A recognition of its MHC class I ligand. Int. Immunol. 16: 197-204.
30. Tormo, J., K. Natarajan, D. Margulies, and R. Mariuzza. 1999. Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand. Nature 402: 623-631.
31. Dam, J., R. Guan, K. Natarajan, N. Dimasi, L. Chlewicki, D. Kranz, P. Schuck, D. Margulies, and R. Mariuzza. 2003. Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2Kb. Nat. Immunol. 4: 1213-1222.
32. Lavender, K., and K. Kane. 2006. Cross-species dependence of Ly49 recognition on the supertype defining B-pocket of a class I MHC molecule. J. Immunol. 177: 8578-8586.
33. Sette, A., J. Sidney, B. Livingston, J. Dzuris, C. Crimi, C. Walker, S. Southwood, E. Collins, and A. Hughes. 2003. Class I molecules with similar peptide-binding specificities are the result of both common ancestry and convergent evolution. Immunogenetics 54: 830-841.
34. McKinney, D., A. Erickson, C. Walker, R. Thimme, F. Chisari, J. Sidney, and A. Sette. 2000. Identification of five different Patr class I molecules that bind HLA supertype peptides and definition of their peptide binding motifs. J. Immunol. 165: 4414-4422.
35. Sette, A., and J. Sidney. 1998. HLA supertypes and supermotifs: a functional perspective on HLA polymorphism. Curr. Opin. Immunol. 10: 478-482.
36. Stephens, H. 2005. HIV-1 diversity versus HLA class I polymorphism. Trends Immunol. 26: 41-47.
37. Mason, L., J. Ortaldo, H. Young, V. Kumar, M. Bennett, and S. Anderson. 1995. Cloning and functional characteristics of murine large granular lymphocyte-1: a member of the Ly-49 gene family (Ly-49G2). J. Exp. Med. 182: 293-303.
38. d. J. Immunol. 165: 1771-1781.
39. Naper, C., J. Ryan, M. Nakamura, D. Lambracht, B. Rolstad, and J. Vaage. 1998. Identification of an inhibitory MHC receptor on alloreactive rat natural killer cells. J. Immunol. 160: 219-224.
40. c). Eur. J. Immunol. 32: 2031-2036.
41. Galfrè, G., C. Milstein, and B. Wright. 1979. Rat x rat hybrid myelomas and a monoclonal anti-Fd portion of mouse IgG. Nature 277: 131-133.
42. Reynolds, C., E. J. Bere, and J. Ward. 1984. Natural killer activity in the rat. III. Characterization of transplantable large granular lymphocyte (LGL) leukemias in the F344 rat. J. Immunol. 132: 534-540.
43. c MHC molecule is a xenogeneic ligand recognized by the mouse activating Ly-49W and inhibitory Ly-49G receptors. J. Immunol. 172: 3518-3526.
44. Dam, J., J. Baber, A. Grishaev, E. Malchiodi, P. Schuck, A. Bax, and R. Mariuzza. 2006. Variable dimerization of the Ly49A natural killer cell receptor results in differential engagement of its MHC class I ligand. J. Mol. Biol. 362: 102-113.
45. Paquet, M., and D. Williams. 2002. Mutant MHC class I molecules define interactions between components of the peptide-loading complex. Int. Immunol. 14: 347-358.
46. Brennan, J., G. Mahon, D. Mager, W. Jefferies, and F. Takei. 1996. Recognition of class I major histocompatibility complex molecules by Ly-49: specificities and domain interactions. J. Exp. Med. 183: 1553-1559.
47. Lian, R., Y. Li, S. Kubota, D. Mager, and F. Takei. 1999. Recognition of class I MHC by NK receptor Ly-49C: identification of critical residues. J. Immunol. 162: 7271-7276.
48. Sundbäck, J., A. Achour, J. Michaëlsson, H. Lindström, and K. Kärre. 2002. NK cell inhibitory receptor Ly-49C residues involved in MHC class I binding. J. Immunol. 168: 793-800.
49. + NK cells after amino acid substitutions in the antigen binding cleft. Eur. J. Immunol. 28: 2872-2881.
50. 2-microglobulin and presentation of a viral peptide. J. Immunol. 155: 3481-3493.
51. 2- microglobulin. J. Immunol. 169: 3105-3111.
52. 5 loop residues. J. Immunol. 171: 5337-5344.
53. Biassoni, R., A. Pessino, A. Malaspina, C. Cantoni, C. Bottino, S. Sivori, L. Moretta, and A. Moretta. 1997. Role of amino acid position 70 in the binding affinity of p50.1 and p58.1 receptors for HLA-Cw4 molecules. Eur. J. Immunol. 27: 3095-3099.
54. Winter, C., and E. Long. 1997. A single amino acid in the p58 killer cell inhibitory receptor controls the ability of natural killer cells to discriminate between the two groups of HLA-C allotypes. J. Immunol. 158: 4026-4028.