Protection from lysis by natural killer cells of group 1 and 2 specificity is mediated by residue 80 in human histocompatibility leukocyte antigen C alleles and also occurs with empty major histocompatibility complex molecules

Journal of Experimental Medicine

Volumn 184, Issue 3, 1996, Pages 913-922

  Mandelboim, Ofer ^a   Reyburn, Hugh T ^a   Valés Gómez, Mar ^a   Pazmany, Laszlo ^a   Colonna, Marco ^a   Borsellino, Giovanna ^a   Strominger, Jack L ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA B ANTIGEN; HLA C ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN;

ALLELE; ALLOTYPE; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; CYTOLYSIS; HLA SYSTEM; HUMAN; HUMAN CELL; IMMUNOGENETICS; MAJOR HISTOCOMPATIBILITY COMPLEX; NATURAL KILLER CELL; PRIORITY JOURNAL;

EID: 0029833746     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.184.3.913     Document Type: Article

References (27)

1. Ljunggren, H.G., and K. Karre. 1990. In search of the "missing self": MHC molecules and NK cell recognition. Immunol. Today. 11:237-242.
2. Colonna, M., and J. Samaridis. 1995. Cloning of immunoglobulin-superfamily members associated with HLA-C allele and HLA-B recognition by human natural killer cells. Science (Wash. DC). 268:405-408.
3. Wagtmann, N., R. Biassoni, C. Cantoni, S. Verdiani, M.S. Maltini, M. Vitale, C. Bottino, L. Moretta, A. Moretta, and E.O. Long. 1995. Molecular clones of the p58 natural killer cell receptor reveal Ig related molecules with diversity in both the extra-and intracellular domains. Immunity. 2:439-458.
4. D'Andrea, A., C. Chang, K. Franz-Bacon, T. McClanahan, J.H. Philips, and L.L. Lanier. 1995. Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes. J. Immunol. 155:2306-2313.
5. Moretta, L., E. Ciccone, M.C. Mingari, R. Biassoni, and A. Moretta. 1994. Human NK cells: origin, clonality, specificity and receptors. Adv. Immunol. 55:341-390.
6. Trinchieri, G. 1994. Recognition of major histocompatibility complex class 1 antigens by natural killer cells. J. Exp. Med. 180:417-420.
7. Colonna, M., T. Spies, J.L. Strominger, E. Ciccone, A, Moretta, L. Moretta, D. Pende, and O. Viale. 1992. Alloantigen recognition by two human natural killer cells clones is associated with HLA-C or a closely linked gene. Proc. Natl. Acad. Sci. USA. 89:7983-7985.
8. Cristianse, F.T., C.S. Witt, E. Ciccone, D. Townsend, D. Pende, O. Viale, L.J. Abraham, P.L. Dawkins, and L. Moretta. 1993. Human natural killer (NK) alloreactivity and its association with the major histocompatibility complex: ancestral haplotypes encode particular NK-defined haplotypes. J. Exp. Med. 178:1033-1039.
9. Colonna, M., E.G. Brooks, M. Falco, G.B. Ferrara, and J.L. Strominger. 1993. Generation of allospecific natural killer cells by stimulation across a polymorphism of HLA-C. Science (Wash. DC). 260:1121-1124.
10. Colonna, M., G. Borsellino, M. Falco, G.B. Ferrara, and J.L Strominger. 1993. HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells. Proc. Natl. Acad. USA. 90:12000-12004.
11. Cella, M., A. Longo, G.B. Ferrara, J.L. Strominger, and M. Colonna. 1994. NK3-specific natural killer cells are selectively inhibited by Bw4-positive HLA alleles with isoleucine 80. J. Exp. Med. 180:1235-1241.
12. Correa, I., and D.H. Raulet. 1995. Binding of diverse peptides to MHC class I molecules inhibits target cell lysis by activated natural killer cells. Immunity. 2:61-71.
13. Ljunggren, H.G., N.J. Stan, C. Ohlen, J.J. Neefjes, J. Bastin, T.N.M. Schumacher, A. Townsend, K. Karre, and H.L. Ploegh. 1990. Empty MHC molecules come out in the cold. Nature (Lond.). 346:476-480.
14. Malnati, M.S., M. Peruzzi, K.C. Parker, W.E. Biddison, E. Ciccone, A. Moretta, and E.O. Long. 1995. Peptide specificity in the recognition of MHC class I by natural killer cell clones. Science (Wash. DC). 267:1016-1018.
15. Biassoni, R., M. Falco, A. Canbiaggi, P. Costa, S. Verdiani, D. Pende, R. Conte, C. Di Donato, P. Parham, and L. Moretta. 1995. Amino acid substitutions can influence the natural killer (NK)-mediated recognition of HLA-C molecules. Role of serine-77 and lysine-80 in the target cells protection from lysis mediated by "group 1" or "group 2" NK clones. J. Exp. Med. 182:605-609.
16. Shimizu, Y., and R. DeMars. 1989. Production of human cells expressing individual transferred HLA-A, -B,-C genes using an HLA-A,-B,-C null human cell line. J. Immunol. 142: 3320-3328.
17. Melero, I., A. Salmeron, M.A. Balboa, J. Aramburu, and M. Lopez-Botet. 1994. Tyrosine kinase-dependent activation of human NK cells function upon stimulation through a 58-kDa surface antigen selectively expressed on discrete subset of NK cells and T lymphocytes. J. Immunol. 152:1662-1673.
18. Moretta, A., M. Vitale, C. Bottino, A.M. Orengo, L. Moreli. R. Augugliaro, M. Barbaresi, E. Ciccone, and L. Moretta. 1993. P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-P58 antibodies reconstitute lysis of MHC class-1 protected cells in NK clones displaying different specificities. J. Exp. Med. 178:597-604.
19. Robertson, J.R., T.J. Mauley, C. Donahue, H. Levine, and J. Ritz. 1993. Costimulatory signals are required for optimal proliferation of human natural killer cells. J. Immunol. 150: 1705-1714.
20. Gumperz, J.E., V. Litwin, J.H. Phillips, L.L. Lanier, and P. Parham. 1995. The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor. J. Exp. Med. 181:1133-1144.
21. Moretta, A., S. Sivori, M. Vitale, D. Pende, L. Morelli, R. Augugliaro, C. Bottino, and L. Moretta. 1995. Exsistance of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells. J. Exp. Med. 182:875-884.
22. Saper, M.A., P.J. Bjorkman, and D.C. Wiley. 1991. Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 Å resolution. J. Mol. Biol. 219:277-319.
23. Gumperz, J.E., and P. Parham. 1995. The enigma of the natural killer cells. Nature (Lond.). 378:245-248.
24. Kim, J., R.G. Urban, J.L. Strominger, and D.C. Wiley. 1994. Toxic shock syndrome toxin-1 complexed with a class II major histocompatibility molecule HLA-DR1. Science (Wash. DC). 266:1870-1874.
25. Baas, E.J., H.-M. van Santen, M.J. Kleijmeer, H.J. Geuze, P.J. Peters, and H.L. Ploegh. 1992 Peptide-induced stabilization and intracellular localization of empty HLA class I complexes. J. Exp. Med. 176:147-156.
26. Henderson, R.A., H. Michel, K. Sakaguchi, J. Shabanowitz, E. Appella, D.F. Hunt, and V.H. Engelhard. HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation. Science (Wash. DC). 255:1264-1266.
27. Wei, M.L., and P. Cresswell. 1992. HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides. Nature (Lond.). 356:443-446.