HLA supertypes and supermotifs: A functional perspective on HLA polymorphism

Current Opinion in Immunology

Volumn 10, Issue 4, 1998, Pages 478-482

  Sette, Alessandro ^a   Sidney, John ^a  

^a Epimmune   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CROSS REACTING ANTIGEN; HLA A3 ANTIGEN; HLA ANTIGEN; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; PEPTIDE;

CANCER IMMUNOLOGY; GENETIC POLYMORPHISM; HUMAN; INFECTION; NONHUMAN; SHORT SURVEY; T LYMPHOCYTE;

EID: 0032146234     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(98)80124-6     Document Type: Article

References (48)

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18. of outstanding interest Bertoni R, Sidney J, Fowler P, Chesnut RW, Chisari FV, Sette A. Human histocompatibility leukocyte antigen-binding supermotifs predict broadly cross-reactive cytotoxic T lymphocyte responses in patients with acute hepatitis. J Clin Invest. 100:1997;503-513 This describes the first validation of HLA supertypes in a chronic viral disease setting.
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25. of special interest Threlkeld SC, Wentworth PA, Kalams SA, Wilkes BM, Ruhl DJ, Keogh E, Sidney J, Southwood S, Walker BD, Sette A. Degenerate and promiscuous recognition by CTL of peptides presented by the MHC class I A3-like superfamily: implications for vaccine development. J Immunol. 159:1997;1648-1657 This is the first report, to the best of our knowledge, to describe promiscuous recognition in the context of HLA-class I.
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30. of outstanding interest Doolan DL, Hoffman SL, Southwood S, Wentworth PA, Sidney J, Chesnut RW, Keogh E, Appella E, Nutman TB, Lal AA, et al. Degenerate cytotoxic T cell epitopes from P. falciparum restricted by multiple HLA-A and HLA-B supertype alleles. Immunity. 7:1997;97-112 This provides validation of HLA supertypes in the setting of malaria. The data presented demonstrate correlation of immune status and recognition of supertype peptides.
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32. of special interest Kawashima I, Hudson SJ, Tsai V, Southwood S, Takesako K, Appella E, Sette A, Celis E. The multi-epitope approach for immunotherapy for cancer: identification of several CTL epitopes from various tumor-associated antigens expressed on solid epithelial tumors. Hum Immunol. 59:1998;1-14 These are further studies validating HLA supertypes in tumor immunology.
33. of special interest Wang R-F, Johnston SL, Southwood S, Sette A, Rosenberg SA. Recognition of an antigenic peptide derived from tyrosinase-related protein-2 by CTL in the context of HLA-A31 and -A33. J Immunol. 160:1998;890-897 These are further studies validating HLA supertypes in tumor immunology.
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40. of special interest Bertoni R, Sette A, Sidney J, Guidotti LG, Shapiro M, Purcell R, Chisari FV. Human class I supertypes and cytotoxic T lymphocyte repertoires extend to chimpanzees. J Immunol. 1988; This study suggests that HLA supertypes may extend to nonhuman primates.
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