메뉴 건너뛰기




Volumn 22, Issue 1, 2006, Pages 8-12

Flag in the crossroads: Flagellin modulates innate and adaptive immunity

Author keywords

Adaptive immunity; Crohn's disease; Epithelial cells; Flagellin; Innate immunity; Salmonella; Toll like receptor 5

Indexed keywords

FLAGELLIN; TOLL LIKE RECEPTOR 5; BIOLOGICAL MARKER; CELL SURFACE RECEPTOR;

EID: 33644830557     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mog.0000194791.59337.28     Document Type: Review
Times cited : (57)

References (25)
  • 1
    • 0023546355 scopus 로고
    • Effects of polymorphonuclear leukocyte transmigration on barrier function of cultured intestinal epithelial monolayers
    • Nash S, Stafford J, Madara JL. Effects of polymorphonuclear leukocyte transmigration on barrier function of cultured intestinal epithelial monolayers. J Clin Invest 1987; 80:1104-1113.
    • (1987) J Clin Invest , vol.80 , pp. 1104-1113
    • Nash, S.1    Stafford, J.2    Madara, J.L.3
  • 2
    • 0025906828 scopus 로고
    • In vitro model of intestinal crypt abcess: A novel neutrophil-derived secretagogue activity
    • Nash S, Parkos CA, Nusrat A, et al. In vitro model of intestinal crypt abcess: a novel neutrophil-derived secretagogue activity. J Clin Invest 1991; 87:1474-1477.
    • (1991) J Clin Invest , vol.87 , pp. 1474-1477
    • Nash, S.1    Parkos, C.A.2    Nusrat, A.3
  • 3
    • 0027428365 scopus 로고
    • Salmonella typhimurium attachment to human intestinal epithelial monolayers: Transcellular signalling to subepithelial neutrophils
    • McCormick BA, Colgan SP, Archer CD, et al. Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signalling to subepithelial neutrophils. J Cell Biol 1993; 123:895-907.
    • (1993) J Cell Biol , vol.123 , pp. 895-907
    • McCormick, B.A.1    Colgan, S.P.2    Archer, C.D.3
  • 4
    • 0142053206 scopus 로고    scopus 로고
    • The immunological and genetic basis of inflammatory bowel disease
    • Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 2003; 3:521-533.
    • (2003) Nat Rev Immunol , vol.3 , pp. 521-533
    • Bouma, G.1    Strober, W.2
  • 5
    • 0035170239 scopus 로고    scopus 로고
    • Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response
    • Gewirtz AT, Simon PO Jr, Schmitt CK, et al. Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response. J Clin Invest 2001; 107:99-109.
    • (2001) J Clin Invest , vol.107 , pp. 99-109
    • Gewirtz, A.T.1    Simon Jr., P.O.2    Schmitt, C.K.3
  • 6
    • 0036784636 scopus 로고    scopus 로고
    • Bacterial flagellin is an effective adjuvant for CD4(+) T cells in vivo
    • McSorley SJ, Ehst BD, Yu Y, Gewirtz AT. Bacterial flagellin is an effective adjuvant for CD4(+) T cells in vivo. J Immunol 2002; 169:3914-3919.
    • (2002) J Immunol , vol.169 , pp. 3914-3919
    • McSorley, S.J.1    Ehst, B.D.2    Yu, Y.3    Gewirtz, A.T.4
  • 7
    • 0037238970 scopus 로고    scopus 로고
    • Intestinal epithelial toll-like receptors: To protect. And serve?
    • Gewirtz AT. Intestinal epithelial toll-like receptors: to protect. And serve? Curr Pharm Des 2003; 9:1-5.
    • (2003) Curr Pharm Des , vol.9 , pp. 1-5
    • Gewirtz, A.T.1
  • 8
    • 0141920614 scopus 로고    scopus 로고
    • Flagellin is the major proinflammatory determinant of enteropathogenic Salmonella
    • Zeng H, Carlson AQ, Guo Y, et al. Flagellin is the major proinflammatory determinant of enteropathogenic Salmonella. J Immunol 2003; 171:3668-3674.
    • (2003) J Immunol , vol.171 , pp. 3668-3674
    • Zeng, H.1    Carlson, A.Q.2    Guo, Y.3
  • 9
    • 0038607406 scopus 로고    scopus 로고
    • Identification of a sequence in human toll-like receptor 5 required for the binding of Gram-negative flagellin
    • Mizel SB, West AP, Hantgan RR. Identification of a sequence in human toll-like receptor 5 required for the binding of Gram-negative flagellin. J Biol Chem 2003; 278:23624-23629.
    • (2003) J Biol Chem , vol.278 , pp. 23624-23629
    • Mizel, S.B.1    West, A.P.2    Hantgan, R.R.3
  • 10
    • 0035881675 scopus 로고    scopus 로고
    • Cutting edge: Bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression
    • Gewirtz AT, Navas TA, Lyons S, et al. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J Immunol 2001; 167:1882-1885.
    • (2001) J Immunol , vol.167 , pp. 1882-1885
    • Gewirtz, A.T.1    Navas, T.A.2    Lyons, S.3
  • 11
    • 12344285378 scopus 로고    scopus 로고
    • Salmonella typhimurium transcytoses flagellin via an SPI2-mediated vesicular transport pathway
    • Lyons S, Wang L, Casanova JE, et al. Salmonella typhimurium transcytoses flagellin via an SPI2-mediated vesicular transport pathway. J Cell Sci 2004; 117:5771-5780. This study determined the mechanism and key bacterial determinant that permit a pathogen to activate basolateral TLR5, thus resulting in epithelial proinflammatory gene expression.
    • (2004) J Cell Sci , vol.117 , pp. 5771-5780
    • Lyons, S.1    Wang, L.2    Casanova, J.E.3
  • 12
    • 0036744155 scopus 로고    scopus 로고
    • Adherent-invasive Escherichia coli: A putative new E. coli pathotype associated with Crohn's disease
    • Darfeuille-Michaud A. Adherent-invasive Escherichia coli: a putative new E. coli pathotype associated with Crohn's disease. Int J Med Microbiol 2002; 292:185-193.
    • (2002) Int J Med Microbiol , vol.292 , pp. 185-193
    • Darfeuille-Michaud, A.1
  • 14
    • 0026630075 scopus 로고
    • The intestinal permeability barrier. A hypothesis as to its regulation and involvement in Crohn's disease
    • Hollander D. The intestinal permeability barrier. A hypothesis as to its regulation and involvement in Crohn's disease. Scand J Gastroenterol 1992; 27:721-726.
    • (1992) Scand J Gastroenterol , vol.27 , pp. 721-726
    • Hollander, D.1
  • 15
    • 2342646956 scopus 로고    scopus 로고
    • Bacterial flagellin is a dominant antigen in Crohn disease
    • Lodes MJ, Cong Y, Elson CO, et al. Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest 2004; 113:1296-1306. This study used unbiased technique to define Crohn's disease antigens and revealed a dominant role for flagellin. This work further showed that immunoreactivity to flagellin was sufficient to lead to colitis in susceptible mice and correlated with disease in humans.
    • (2004) J Clin Invest , vol.113 , pp. 1296-1306
    • Lodes, M.J.1    Cong, Y.2    Elson, C.O.3
  • 17
    • 0042238051 scopus 로고    scopus 로고
    • Complete atomic model of the bacterial flagellar filament by electron cryomicroscopy
    • Yonekura K, Maki-Yonekura S, Namba K. Complete atomic model of the bacterial flagellar filament by electron cryomicroscopy. Nature 2003; 424:643-650.
    • (2003) Nature , vol.424 , pp. 643-650
    • Yonekura, K.1    Maki-Yonekura, S.2    Namba, K.3
  • 18
    • 0031134803 scopus 로고    scopus 로고
    • Identification of a natural T cell epitope presented by Salmonella-infected macrophages and recognized by T cells from orally immunized mice
    • Cookson BT, Bevan MJ. Identification of a natural T cell epitope presented by Salmonella-infected macrophages and recognized by T cells from orally immunized mice. J Immunol 1997; 158:4310-4319.
    • (1997) J Immunol , vol.158 , pp. 4310-4319
    • Cookson, B.T.1    Bevan, M.J.2
  • 19
    • 0034650406 scopus 로고    scopus 로고
    • Characterization of CD4+ T cell responses during natural infection with Salmonella typhimurium
    • McSorley SJ, Cookson BT, Jenkins MK. Characterization of CD4+ T cell responses during natural infection with Salmonella typhimurium. J Immunol 2000; 164:986-993.
    • (2000) J Immunol , vol.164 , pp. 986-993
    • McSorley, S.J.1    Cookson, B.T.2    Jenkins, M.K.3
  • 20
    • 33646471158 scopus 로고    scopus 로고
    • Non-hematopoietic cells link innate and adaptive immune responses to bacterial flagellin via early cytokine production
    • Sanders CJ, Moore DA, Williams IR, Gewirtz AT. Non-hematopoietic cells link innate and adaptive immune responses to bacterial flagellin via early cytokine production. FASEB J 2005; 19:A939.
    • (2005) FASEB J , vol.19
    • Sanders, C.J.1    Moore, D.A.2    Williams, I.R.3    Gewirtz, A.T.4
  • 21
    • 33746404575 scopus 로고    scopus 로고
    • Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease
    • Gewirtz AT, Kumar MV, Brant SR, et al. Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease. Gastroenterology 2005; 128:55A.
    • (2005) Gastroenterology , vol.128
    • Gewirtz, A.T.1    Kumar, M.V.2    Brant, S.R.3
  • 22
    • 0038222345 scopus 로고    scopus 로고
    • The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells
    • Means TK, Hayashi F, Smith KD, et al. The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. J Immunol 2003; 170:5165-5175.
    • (2003) J Immunol , vol.170 , pp. 5165-5175
    • Means, T.K.1    Hayashi, F.2    Smith, K.D.3
  • 23
    • 13744256812 scopus 로고    scopus 로고
    • Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity
    • Smythies LE, Sellers M, Clements RH, et al. Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. J Clin Invest 2005; 115:66-75. Important work showing immune cells in the gut have a very different phenotype than those isolated from blood.
    • (2005) J Clin Invest , vol.115 , pp. 66-75
    • Smythies, L.E.1    Sellers, M.2    Clements, R.H.3
  • 24
    • 10744226016 scopus 로고    scopus 로고
    • A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease
    • Hawn TR, Verbon A, Lettinga KD, et al. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med 2003; 198:1563-1572.
    • (2003) J Exp Med , vol.198 , pp. 1563-1572
    • Hawn, T.R.1    Verbon, A.2    Lettinga, K.D.3
  • 25
    • 0023866220 scopus 로고
    • Oral immunization with live, avirulent fla+ strains of Salmonella protects mice against subsequent oral challenge with Salmonella typhimurium
    • Hackett J, Attridge S, Rowley D. Oral immunization with live, avirulent fla+ strains of Salmonella protects mice against subsequent oral challenge with Salmonella typhimurium. J Infect Dis 1988; 157:78-84.
    • (1988) J Infect Dis , vol.157 , pp. 78-84
    • Hackett, J.1    Attridge, S.2    Rowley, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.