Design, synthesis and antimalarial activity of a glyoxylylhydrazone library

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 17, 2004, Pages 4439-4443

  Ryckebusch, A ^a   Fruchart, J S ^a   Cattiaux, L ^a   Rousselot Paillet, P ^a   Leroux, V ^a   Melnyk, O ^a   Grellier, P ^b   Mouray, E ^b   Sergheraert, C ^a   Melnyk, P ^a  

^a INSTITUT PASTEUR DE LILLE   (France)

^b Diversite Chim' Mus Natl d'H   (France)

Author keywords

Antimalarial; Glyoxylyl; Library; Parallel synthesis

Indexed keywords

CHLOROQUINE; HEMATIN; HYDRAZONE DERIVATIVE;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; NONHUMAN; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; GLYOXYLATES; HYDRAZONES; PLASMODIUM FALCIPARUM;

PLASMODIUM FALCIPARUM;

EID: 3843090722     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.06.056     Document Type: Article

References (26)

1. World Health Organisation Factsheet No 94, 1998
2. N.J. White J. Antimicrob. Chemother. 30 1992 571 585
3. T.G. Geary, J.B. Jensen, and H. Ginsburg Biochem. Pharmacol. 35 1986 3805 3812
4. A. Yayon, Z.I. Cabantchik, and H. Ginsburg EMBO J. 3 1984 2695 2700
5. S.R. Hawley, P.G. Bray, P.M. O'Neill, B.K. Park, and S.A. Ward Mol. Biochem. Parasitol. 80 1996 15 25
6. P.A. Stocks, K.J. Raynes, P.G. Bray, B.K. Park, P.M. O'Neill, and S.A. Ward J. Med. Chem. 45 2002 4975 4983
7. T.P. King, S.W. Zhao, and T. Lam Biochemistry 25 1986 5774 5779
8. B. Walker, N. McCarthy, A. Healy, T. Ye, and M.A. McKervey Biochem. J. 293 1993 321 323
9. T.D. Ocain, and D.H. Rich J. Med. Chem. 35 1992 451 456
10. D. Qasmi, E. Rosny, L. René, B. Badet, L. Vergely, N. Boggetto, and M. Reboud-Ravaux Bioorg. Med. Chem. 5 1997 707 714
11. C.R. Caffrey, M. Schanz, J. Nkemgu-Njinkeng, M. Brush, E. Hansell, F.E. Cohen, T.M. Flaherty, J.H. McKerrow, and D. Steverding Int. J. Antimicrob. Agents 19 2002 227 231
12. A. Ryckebusch, R. Déprez-Poulain, M.-A. Debreu-Fontaine, R. Vandaele, E. Mouray, P. Grellier, and C. Sergheraert Bioorg. Med. Chem. Lett. 12 2002 2595 2598
13. A. Ryckebusch, R. Deprez-Poulain, L. Maes, M.-A. Debreu-Fontaine, E. Mouray, P. Grellier, and C. Sergheraert J. Med. Chem. 46 2003 542 557
14. J.L. Vennerstrom, W.Y. Ellis, A.L. Ager, S.L. Andersen, L. Gerena, and W.K. Milhous J. Med. Chem. 35 1992 2129 2134
15. O. Melnyk, J.-S. Fruchart, C. Grandjean, and H. Gras-Masse J. Org. Chem. 66 2001 4153 4160
16. M.S. Newman, W.C. Sagar, and C.C. Cochrane J. Org. Chem. 1958 23
17. S. Koenig, S. Lohberger, and I. Ugi Synthesis 12 1993 1233 1234
18. W. Trager, and J.B. Jensen Science 193 1976 673 677
19. R.E. Desjardins, C.J. Canfield, J.D. Haynes, and J.D. Chulay Antimicrob. Agents Chemother. 16 1979 710 718
20. S. Girault, P. Grellier, A. Berecibar, L. Maes, E. Mouray, P. Lemière, M.-A. Debreu, E. Davioud-Charvet, and C. Sergheraert J. Med. Chem. 43 2000 2646 2654
21. C.D. Fitch, G. Cai, Y.-F. Chen, and J.D. Shoemaker Biochim. Biophys. Acta 1454 1999 31 37
22. F. Ayad, L. Tilley, and L.W. Deady Bioorg. Med. Chem. Lett. 11 2001 2075 2077
23. T.J. Egan, R. Hunter, C.H. Kaschula, H.M. Marques, A. Misplon, and J. Walden J. Med. Chem. 43 2000 283 291
24. C.H. Kaschula, T.J. Egan, R. Hunter, N. Basilico, S. Parapini, D. Taramelli, R. Pasini, and D. Monti J. Med. Chem. 45 2002 3531 3539
25. a DB software from Avanced Chemistry Development Inc., Toronto, Canada
26. S. Hawley, P.C. Bray, P.M. O'Neill, B.K. Park, and S.A. Ward Biochem. Pharmacol. 52 1996 723 733