Endothelin, sex and hypertension

Clinical Science

Volumn 114, Issue 1-2, 2008, Pages 85-97

  Tostes, Rita C ^a,b   Fortes, Zuleica B ^a   Callera, Glaucia E ^c   Montezano, Augusto C ^c   Touyz, Rhian M ^c   Webb, R Clinton ^b   Carvalho, Maria Helena C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

17 oestradiol; Arterial hypertension; End organ damage; Endothelin; Endothelin receptor; Sex; Testosterone

Indexed keywords

DARUSENTAN; ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; SEX HORMONE; SITAXSENTAN; TAK 044; ANTIHYPERTENSIVE AGENT;

BLOOD PRESSURE REGULATION; CARDIOVASCULAR SYSTEM; DISEASE COURSE; ENZYME ACTIVATION; HUMAN; HYPERTENSION; KIDNEY FAILURE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; REVIEW; SEX DIFFERENCE; URINARY TRACT; VASOCONSTRICTION; CARDIOVASCULAR FUNCTION; DRUG ANTAGONISM; FEMALE; KIDNEY; MALE; PHYSIOLOGY; SEXUAL DEVELOPMENT; SIGNAL TRANSDUCTION;

ANTIHYPERTENSIVE AGENTS; CARDIOVASCULAR PHYSIOLOGY; ENDOTHELINS; FEMALE; HUMANS; HYPERTENSION; KIDNEY; MALE; RECEPTORS, ENDOTHELIN; SEX CHARACTERISTICS; SIGNAL TRANSDUCTION;

EID: 38349010551     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20070169     Document Type: Review

References (123)

1. Hickey, K. A., Rubanyi, G., Paul, R. J. and Highsmith, R. F. (1985) Characterization of a coronary vasoconstrictor produced by cultured endothelial cells. Am. J. Physiol. 248, C550-C556
2. Yanagisawa, M., Kurihara, H., Kimura, S. et al. (1988) A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332, 411-415
3. Inoue, A., Yanagisawa, M., Kimura, S. et al. (1989) The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc. Natl. Acad. Sci. U.S.A. 86, 2863-2867
4. Arai, H., Hori, S., Aramori, I., Ohkubo, H. and Nakanishi, S. (1990) Cloning and expression of a cDNA encoding an endothelin receptor. Nature 348, 730-732
5. Sakurai, T., Yanagisawa, M., Takuwa, Y. et al. (1990) Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor. Nature 348, 732-735
6. Takahashi, M., Matsushita, Y., Iijima, Y. and Tanzawa, K. (1993) Purification and characterization of endothelin-converting enzyme from rat lung. J. Biol. Chem. 268, 21394-21398
7. Xu, D., Emoto, N., Giaid, A. et al. (1994) ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell 78, 473-485
8. Emoto, N. and Yanagisawa, M. (1995) Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum. J. Biol. Chem. 270, 15262-15268
9. Kishi, F., Minami, K., Okishima, N. et al. (1998) Novel 31-amino acid length endothelins cause constriction of vascular smooth muscle. Biochem. Biophys. Res. Commun. 248, 387-390
10. Fecteau, M. H., Honore, J. C., Plante, M., Labonte, J., Rae, G. A. and D'Orleans-Juste, P. (2005) Endothelin-1 (1-31) is an intermediate in the production of endothelin-1 after big endothelin-1 administration in vivo. Hypertension 46, 87-92
11. Takasaki, C., Tamiya, N., Bdolah, A., Wollberg, Z. and Kochva, E. (1988) Sarafotoxins S6, several isotoxins from Atractaspis engaddensis (burrowing asp) venom that affect the heart. Toxicon 26, 543-548
12. Kurnik, D., Haviv, Y. and Kochva, E. (1999) A snake bite by the burrowing asp, Atractaspis engaddensis. Toxicon 37, 223-227
13. Borgheresi, R. A., Leroy, J. M., Yogi, A., DosSantos, R. A., Breno, M. C. and Tostes, R. C. (2006) Pharmacologic and molecular characterization of the vascular ETA receptor in the venomous snake Bothrops jararaca. Exp. Biol. Med. 231, 729-735
14. Russell, F. D., Skepper, J. N. and Davenport, A. P. (1998) Human endothelial cell storage granules: a novel intracellular site for isoforms of the endothelin converting enzyme. Circ. Res. 83, 314-321
15. Davenport, A. P. and Maguire, J. J. (2006) Endothelin. Handb. Exp. Pharmacol. 176, 295-329
16. Tostes, R. C. and Muscara, M. N. (2005) Endothelin receptor antagonists: another potential alternative for cardiovascular diseases. Curr. Drug Targets Cardiovasc. Haematol. Disord. 5, 287-301
17. Brunner, F., Bras-Silva, C., Cerdeira, A. S. and Leite-Moreira, A. F. (2006) Cardiovascular endothelins: essential regulators of cardiovascular homeostasis. Pharmacol. Ther. 111, 508-531
18. Granger, J. P., Abram, S., Stec, D., Chandler, D. and LaMarca, B. (2006) Endothelin, the kidney, and hypertension. Curr. Hypertens. Rep. 8, 298-303
19. Turner, A. J. and Tanzawa, K. (1997) Mammalian membrane metallopeptidases: NEP, ECE, KELL, and PEX. FASEB J. 11, 355-364
20. Turner, A. J., Barnes, K., Schweizer, A. and Valdenaire, O. (1998) Isoforms of endothelin-converting enzyme: why and where? Trends Pharmacol. Sci. 19, 483-486
21. Russel, F. D. and Molenaar, P. (2000) The human heart endothelin system: ET-1 synthesis, storage, release and effect. Trends Pharmacol. Sci. 21, 353-359
22. Modesti, P. A., Vanni, S., Paniccia, R. et al. (1999) Endothelin receptors in adult human and swine isolated ventricular cardiomyocytes. Biochem. Pharmacol. 58, 369-374
23. Penna, C., Rastaldo, R., Mancardi, D. et al. (2006) Effect of endothelins on the cardiovascular system. J. Cardiovasc. Med. 7, 645-652
24. Kohan, D. E. (2006) The renal medullary endothelin system in control of sodium and water excretion and systemic blood pressure. Curr. Opin. Nephrol. Hypertens. 15, 34-40
25. Vassileva, I., Mountain, C. and Pollock, D. M. (2003) Functional role of ETB receptors in the renal medulla. Hypertension 41, 1359-1363
26. Bagnall, A. J., Kelland, N. F., Gulliver-Sloan, F. et al. (2006) Deletion of endothelial cell endothelin B receptors does not affect blood pressure or sensitivity to salt. Hypertension 48, 286-293
27. D'Orleans-Juste, P., Labonte, J., Bkaily, G., Choufani, S., Plante, M. and Honore, J. (2002) Function of the endothelin(B) receptor in cardiovascular physiology and pathophysiology. Pharmacol. Ther. 95, 221-238
28. Johnström, P., Fryer, T. D., Richards, H. K. et al. (2005) Positron emission tomography using 18F-labelled endothelin-1 reveals prevention of binding to cardiac receptors owing to tissue-specific clearance by ETB receptors in vivo. Br. J. Pharmacol. 144, 115-122
29. Masaki, T., Vane, J. R. and Vanhoutte, P. M. (1994) International Union of Pharmacology nomenclature of endothelin receptors. Pharmacol. Rev. 46, 137-142
30. Davenport, A. P. (2002) International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature. Pharmacol. Rev. 54, 219-226
31. Schiffrin, E. L. and Touyz, R. M. (1998) Vascular biology of endothelin. J. Cardiovasc. Pharmacol. 32 (Suppl. 3), S2-S13
32. Schiffrin, E. L. (2005) Vascular endothelin in hypertension, Vasc. Pharmacol. 43, 19-29
33. Wu-Wong, J. R. (1998) Sticky conundrums in the endothelin system: unique binding characteristics of receptor agonists and antagonists, In: Endothelin Receptors and Signaling Mechanisms (Pollock, D.M. and Highsmith, R.F., eds), pp. 23-40, Springer-Verlag, Berlin
34. Loffler, B. M. (2000) Endothelin-converting enzyme inhibitors: current status and perspectives. J. Cardiovasc. Pharmacol. 35 (Suppl. 2), S79-S82
35. Muller, D. N., Fiebeler, A., Park, J. K., Dechend, R. and Luft, F. C. (2003) Angiotensin II and endothelin induce inflammation and thereby promote hypertension-induced end-organ damage. Clin. Nephrol. 60 (Suppl. 1), S2-S12
36. Hernandez-Perera, O., Perez-Sala, D., Navarro-Antolin, J. et al. (1998) Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells. J. Clin. Invest. 101, 2711-2719
37. Montezano, A. C., Amiri, F., Tostes, R. C., Touyz, R. M. and Schiffrin, E. L. (2007) Inhibitory effects of PPAR-γ on endothelin-1-induced inflammatory pathways in vascular smooth muscle cells from normotensive and hypertensive rats, J. Am. Soc. Hypertens. 1, 150-160
38. Davenport, A. P., Ashby, M. J., Easton, P., Ella, S., Bedford, J. and Dickerson, C. (1990) A sensitive radioimmunoassay measuring endothelin-like immunoreactivity in human plasma: comparison of levels in patients with essential hypertension and normotensive control subjects. Clin. Sci. 78, 261-264
39. Schiffrin, E. L. and Thibault, G. (1991) Plasma endothelin in human essential hypertension. Am. J. Hypertens. 4, 303-308
40. Touyz, R. M. and Schiffrin, E. L. (2003) Role of endothelin in human hypertension. Can. J. Physiol. Pharmacol. 81, 533-541
41. Haynes, W. G., Hand, M., Johnstone, H., Padfield, P. and Webb, D. J. (1994) Direct and sympathetically mediated venoconstriction in essential hypertension: enhanced response to endothelin-1. J. Clin. Invest. 94, 1359-1364
42. Kiowski, W., Luscher, T. F., Linder, L. and Buhler, F. R. (1991) Endothelin-1-induced vasoconstriction in humans. Reversal by calcium channel blockade but not by nitrovasodilators or endothelium-derived relaxing factor. Circulation 83, 469-475
43. Cardillo, C., Kilcoyne, C. M., Waclawiw, M., Cannon, III, R. O. and Panza, J. A. (1999) Role of endothelin in the increased vascular tone of patients with essential hypertension. Hypertension 33, 753-758
44. Schiffrin, E. L., Deng, L. Y. and Larochelle, P. (1992) Blunted effects of endothelin upon subcutaneous resistance arteries of mild essential hypertensive patients. J. Hypertens. 10, 437-444
45. Ferro, C. J., Haynes, W. G., Hand, M. F. and Webb, D. J. (2002) Forearm vasoconstriction to endothelin-1 is impaired, but constriction to sarafotoxin 6c and vasodilatation to BQ-123 unaltered, in patients with essential hypertension. Clin. Sci. 103 (Suppl. 48), 53S-58S
46. Moreau, P. and Schiffrin, E. L. (2003) Role of endothelins in animal models of hypertension: focus on cardiovascular protection. Can. J. Physiol. Pharmacol. 81, 511-521
47. Tostes, R. C., Touyz, R. M., He, G., Chen, X. and Schiffrin, E. L. (2002) Contribution of ET-1 to renal AP-1 activation and macrophage infiltration in aldosterone-induced hypertension. Clin. Sci. 103 (Suppl. 48), 25S-30S
48. Muller, D. N., Mervaala, E. M. A., Schmidt, F. et al. (2000) Effect of bosentan on NF-κB, inflammation, and tissue factor in angiotensin II-induced end-organ damage. Hypertension 36, 282-293
49. Ammarguellat, F. Z., Gannon, P. O., Amiri, F. and Schiffrin, E. L. (2002) Fibrosis, matrix metalloproteinases, and inflammation in the heart of DOCA-salt hypertensive rats: role of ETA receptors. Hypertension 39, 679-684
50. Tostes, R. C., Touyz, R. M., He, G., Ammarguellat, F. and Schiffrin, E. L. (2002) ETA receptor blockade decreases expression of growth factors and collagen and improves MMP-2 activity in kidneys from stroke-prone spontaneously hypertensive rats. J. Cardiovasc. Pharmacol. 39, 892-900
51. Callera, G. E., Montezano, A. C., Touyz, R. M. et al. (2004) ETA receptor blockade decreases adhesion molecules expression and cardiac injury in Doca-salt hypertension. Hypertension 43, 872-879
52. Pollock, D. M. and Pollock, J. S. (2005) Endothelin and oxidative stress in the vascular system. Curr. Vasc. Pharmacol. 3, 365-367
53. Li, L., Fink, G. D., Watts, S. W. et al. (2003) Endothelin-1 increases vascular superoxide via endothelin(A)-NADPH oxidase pathway in low-renin hypertension. Circulation 107, 1053-1058
54. Loomis, E. D., Sullivan, J. C., Osmond, D. A., Pollock, D. M. and Pollock, J. S. (2005) Endothelin mediates superoxide production and vasoconstriction through activation of NADPH oxidase and uncoupled nitric-oxide synthase in the rat aorta. J. Pharmacol. Exp. Ther. 315, 1058-1064
55. Callera, G. E., Touyz, R. M., Teixeira, S. A. et al. (2003) ETA receptor blockade decreases vascular superoxide generation in DOCA-salt hypertension. Hypertension 42, 811-817
56. Callera, G. E., Tostes, R. C., Yogi, A., Montezano, A. C. and Touyz, R. M. (2006) Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms. Clin. Sci. 110, 243-253
57. Amiri, F., Virdis, A., Neves, M. F. et al. (2004) Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction. Circulation 110, 2233-2240
58. Campia, U., Cardillo, C. and Panza, J. A. (2004) Ethnic differences in the vasoconstrictor activity of endogenous endothelin-1 in hypertensive patients. Circulation 109, 3191-3195
59. Cardillo, C., Campia, U., Iantorno, M. and Panza, J. A. (2004) Enhanced vascular activity of endogenous endothelin-1 in obese hypertensive patients. Hypertension 43, 36-40
60. Hajjar, I., Kotchen, J. M. and Kotchen, T. A. (2006) Hypertension: trends in prevalence, incidence, and control. Annu. Rev. Public Health 27, 465-490
61. Mosca, L., Manson, J. E., Sutherland, S. E., Langer, R. D., Manolio, T. and Barratt-Connor, E. (1997) Cardiovascular disease in women. A statement of healthcare professionals from the American Heart Association. Circulation 96, 2468-2482
62. Messerli, F. H., Guillermo, E., Garavaglia, E. et al. (1987) Disparate cardiovascular findings in men and women with essential hypertension. Ann. Int. Med. 107, 158-161
63. Safar, M. E. and Smulyan, H. (2004) Hypertension in women. Am. J. Hypertens. 17, 82-87
64. Cambotti, L. J., Cole, F. E., Gerall, A. A., Frolich, E. D. and Macphee, A. A. (1984) Neonatal gonadal hormones and blood pressure in the spontaneously hypertensive rat. Am. J. Physiol. 247, E258-E264
65. Crofton, J. and Share, L. (1997) Gonadal hormones modulate deoxycorticosterone-salt hypertension in male and female rats. Hypertension 29, 494-499
66. Silbiger, S. R. and Neugarten, J. (1995) The impact of gender on the progression of chronic renal disease. Am. J. Kidney Dis. 25, 515-533
67. Stringer, K. D., Komers, R., Osman, S. A., Oyama, T. T., Lindsley, J. N. and Anderson, S. (2005) Gender hormones and the progression of experimental polycystic kidney disease. Kidney Int. 68, 1729-1739
68. Pechere-Bertschia, A. and Burnier, M. (2007) Gonadal steroids, salt-sensitivity and renal function. Curr. Opin. Nephrol. Hypertens. 16, 16-21
69. Fortepiani, L. A., Yanes, L., Zhang, H., Racusen, L. C. and Reckelhoff, J. F. (2003) Role of androgens in mediating renal injury in aging SHR. Hypertension 42, 952-955
70. Reckelhoff, J. F. and Fortepiani, L. A. (2004) Novel mechanisms responsible for postmenopausal hypertension. Hypertension 43, 918-923
71. Dubey, R. K. and Jackson, E. K. (2001) Estrogen-induced cardiorenal protection: potential cellular, biochemical, and molecular mechanisms. Am. J. Physiol. Renal Physiol. 280, F365-F388
72. Khalil, R. A. (2005) Sex hormones as potential modulators of vascular function in hypertension. Hypertension 46, 249-254
73. Tostes, R. C., Nigro, D., Fortes, Z. B. and Carvalho, M. H. C. (2003) Effects of estrogen on the vascular system. Braz. J. Med. Biol. Res. 36, 1143-1158
74. Mankhey, R. W., Bhatti, F. and Marie, C. (2005) 17β-Estradiol replacement improves renal function and pathology associated with diabetic nephropathy. Am. J. Physiol. Renal Physiol. 288, F399-F405
75. Polderman, K. H., Stehouwer, C. D., van Kamp, G. J., Dekker, G. A., Verheugt, F. W. and Gooren, L. J. (1993) Influence of sex hormones on plasma endothelin levels. Ann. Intern. Med. 118, 429-132
76. Miyauchi, T., Yanagisawa, M., Iida, K. et al. (1992) Age-and sex-related variation of plasma endothelin-1 concentration in normal and hypertensive subjects. Am. Heart J. 123, 1092-1093
77. Polderman, K. H., Stehouwer, C. D., van Kamp, G. J., Schalkwijk, C. G. and Gooren, L. J. (2000) Modulation of plasma endothelin levels by the menstrual cycle. Metab. Clin. Exp. 49, 648-650
78. Carbonne, B., Mignot, T. M., Tsatsaris, V. and Ferre, F. (1998) Changes in plasma and amniotic fluid endothelin levels during pregnancy: facts or artefacts? Eur. J. Obstet. Gynecol. Reprod. Biol. 76, 15-19
79. Lygnos, M. C., Pappa, K. I., Papadaki, H. A. et al. (2006) Changes in maternal plasma levels of VEGF, bFGF, TGF-β1, ET-1 and sKL during uncomplicated pregnancy, hypertensive pregnancy and gestational diabetes. In Vivo 20, 157-163
80. Maeda, S., Tanabe, T., Miyauchi, T. et al. (2003) Aerobic exercise training reduces plasma endothelin-1 concentration in older women. J. Appl. Physiol. 95, 336-341
81. Best, P. J., Berger, P. B., Miller, V. M. and Lerman, A. (1998) The effect of estrogen replacement therapy on plasma nitric oxide and endothelin-1 levels in postmenopausal women. Ann. Intern. Med. 128, 285-288
82. Saitta, A., Morabito, N., Frisina, N. et al. (2001) Cardiovascular effects of raloxifene hydrochloride. Cardiovasc. Drug Rev. 19, 57-74
83. Van Kesteren, P. J. M., Kooistra, T., Lansink, M. et al. (1998) The effects of sex steroids on plasma levels of marker proteins of endothelial cell functioning. Thromb. Haemostasis 79, 1029-1033
84. Diamanti-Kandarakis, E., Spina, G., Kouli, C. and Migdalis, I. (2001) Increased endothelin-1 levels in women with polycystic ovary syndrome and the beneficial effect of metformin therapy. J. Clin. Endocrinol. Metab. 86, 4666-4673
85. Diamanti-Kandarakis, E., Alexandraki, K., Piperi, C. et al. (2006) Inflammatory and endothelial markers in women with polycystic ovary syndrome. Eur. J. Clin. Invest. 36, 691-697
86. Kumanov, P., Tomova, A. and Kirilov, G. (2007) Testosterone replacement therapy in male hypogonadism is not associated with increase of endothelin-1 levels. Int. J. Androl 30, 41-47
87. David, F. L., Carvalho, M. H., Cobra, A. L. et al. (2001) Ovarian hormones modulate endothelin-1 vascular reactivity and mRNA expression in DOCA-salt hypertensive rats. Hypertension 38, 692-696
88. David, F. L., Montezano, A. C. I., Rebouças, N. A. et al. (2002) Gender differences in vascular expression of endothelin and ETA/ETB receptors, but not in calcium handling mechanisms, in deoxycorticosterone acetate-salt hypertension. Braz. J. Med. Biol. Res. 35, 1061-1068
89. Stringer, K. D., Komers, R., Osman, S. A., Oyama, T. T., Lindsley, J. N. and Anderson, S. (2005) Gender hormones and the progression of experimental polycystic kidney disease. Kidney Int. 68, 1729-1739
90. Ba, Z. F., Shimizu, T., Szalay, L., Bland, K. I. and Chaudry, I. H. (2005) Gender differences in small intestinal perfusion following trauma hemorrhage: the role of endothelin-1. Am. J. Physiol. Gastrointest. Liver Physiol. 288, G860-G865
91. Bilsel, A. S., Moini, H., Tetik, E., Aksungar, F., Kaynak, B. and Ozer, A. (2000) 17β-Estradiol modulates endothelin-1 expression and release in human endothelial cells. Cardiovasc. Res. 46, 579-584
92. Akishita, M., Kozaki, K., Eto, M. et al. (1998) Estrogen attenuates endothelin-1 production by bovine endothelial cells via estrogen receptor. Biochem. Biophys. Res. Commun. 251, 17-21
93. Wang, X., Barber, D. A., Lewis, D. A. et al. (1997) Gender and transcriptional regulation of NO synthase and ET-1 in porcine aortic endothelial cells. Am. J. Physiol. 273, H1962-H1967
94. Juan, S.-H., Chen, J.-J., Chen, C.-H. et al. (2004) 17β-Estradiol inhibits cyclic strain-induced endothelin-1 gene expression within vascular endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 287, H1254-H1261
95. Dubey, R. K., Jackson, E. K., Keller, P. J., Imthurn, B. and Rosselli, M. (2001) Estradiol metabolites inhibit endothelin synthesis by an estrogen receptor-independent mechanism. Hypertension 37, 640-644
96. Hong, H.-J., Liu, J.-C., Chan, P. et al. (2004) 17β-Estradiol downregulates angiotensin-II-induced endothelin-1 gene expression in rat aortic smooth muscle cells. J. Biomed. Sci. 11, 27-36
97. Chao, H.-H., Chen, J.-J., Chen, C.-H. et al. (2005) Inhibition of angiotensin II induced endothelin-1 gene expression by 17-β-oestradiol in rat cardiac fibroblast. Heart 91, 664-669
98. Akishita, M., Ouchi, Y., Miyoshi, H. et al. (1996) Estrogen inhibits endothelin-1 production and c-fos gene expression in rat aorta. Atherosclerosis 125, 27-38
99. Tan, Z., Wang, T.-H., Yang, D., Fu, X.-D. and Pan, J.-Y. (2003) Mechanisms of 17β-estradiol on the production of ET-1 in ovariectomized rats. Life Sci. 73, 2665-2674
100. Rodrigo, M. C., Martin, D. S. and Eyster, K. M. (2003) Vascular ECE-1 mRNA expression decreases in response to estrogens. Life Sci. 73, 2973-2983
101. Heigl, A., Lachat, M., Lattmann, T., Luscher, T. and Barton, M. (2002) Acute effects of 17β-oestradiol on functional activity of endothelin-converting enzymes in human arteries and veins. Clin. Sci. 103 (Suppl. 48), 438S-441S
102. Ergul, A., Shoemaker, K., Puett, D. and Tackett, R. L. (1998) Gender differences in the expression of endothelin receptors in human saphenous vein in vitro. J. Pharmacol. Exp. Ther. 285, 511-517
103. Kellogg, Jr., D. L., Liu, Y. and Pérgola, P. E. (2001) Selected contribution: Gender differences in the endothelin-B receptor contribution to basal cutaneous vascular tone in humans. J. Appl. Physiol. 91, 2407-2411
104. Tostes, R. C. A., David, F. L., Carvalho, M. H. C., Nigro, D., Scivoletto, R. and Fortes, Z. B. (2000) Gender differences in vascular reactivity to endothelin-1 in deoxycorticosterone acetate-salt hypertensive rats. J. Cardiovasc. Pharmacol. 35 (Suppl. 6), S99-S101
105. Tostes, R. C. A., David, F. L., Fortes, Z. B., Nigro, D., Scivoletto, R. and Carvalho, M. H. C. (2000) Deoxycorticosterone acetate-salt hypertensive rats display gender-related differences in ETB receptor-mediated vascular responses. Br. J. Pharmacol. 130, 1092-1098
106. Fortes, Z. B., Nigro, D., Scivoletto, R. and Carvalho, M. H. (1991) Influence of sex on the reactivity to endothelin-1 and noradrenaline in spontaneously hypertensive rats. Clin. Exp. Hypertens. 13, 807-816
107. Laughlin, M. H., Schrage, W. G., McAllister, R. M., Garverick, H. A. and Jones, A. W. (2001) Interaction of gender and exercise training: vasomotor reactivity of porcine skeletal muscle arteries. J. Appl. Physiol. 90, 216-227
108. Jones, A. W., Rubin, L. J. and Magliola, L. (1999) Endothelin-1 sensitivity of porcine coronary arteries is reduced by exercise training and is gender dependent. J. Appl. Physiol. 87, 1172-1177
109. Tatchum-Talom, R., Martel, C., Labrie, C., Labrie, F. and Marette, A. (2000) Gender differences in hemodynamic responses to endothelin-1. J. Cardiovasc. Pharmacol. 36 (Suppl. 1), S102-S104
110. Lamping, K. G. and Nuno, D. W. (1996) Effects of 17β-estradiol on coronary microvascular responses to endothelin-1. Am. J. Physiol. 271, H1117-H1124
111. Sudhir, K., Ko, E., Zellner, C. et al. (1997) Physiological concentrations of estradiol attenuate endothelin-1-induced coronary vasoconstriction in vivo. Circulation 96, 3626-3632
112. Teoh, H., Quan, A., Leung, S. W. S. and Man, R. Y. K. (2000) Differential effects of 17β-estradiol and testosterone on the contractile responses of porcine coronary arteries. Br. J. Pharmacol. 129, 1301-1308
113. Antoniucci, D., Miller, V. M., Sieck, G. C. and Fitzpatrick, L. A. (2001) Gender-related differences in proliferative responses of vascular smooth muscle cells to endothelin-1. Endothelium 8, 137-145
114. Yager, J. Y., Wright, S., Armstrong, E. A., Jahraus, C. M. and Saucier, D. M. (2005) A new model for determining the influence of age and sex on functional recovery following hypoxic-ischemic brain damage. Dev. Neurosci. 27, 112-120
115. Montezano, A. C., Callera, G. E., Mota, A. L. et al. (2005) Endothelin-1 contributes to the sexual differences in renal damage in DOCA-salt rats. Peptides 26, 1454-1462
116. Yanes, L. L., Romero, D. G., Cucchiarelli, V. E. et al. (2005) Role of endothelin in mediating postmenopausal hypertension in a rat model. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288, R229-R233
117. Muller, V., Losonczy, G., Heemann, U. et al. (2002) Sexual dimorphism in renal ischemia-reperfusion injury in rats: possible role of endothelin. Kidney Int. 62, 1364-1371
118. Barber, D. A., Michener, S. R., Ziesmer, S. C. and Miller, V. M. (1996) Chronic increases in blood flow upregulate endothelin-B receptors in arterial smooth muscle. Am. J. Physiol. 270, H65-H71
119. Nuedling, S., Van Eickels, M., Alléra, A. et al. (2003) 17β-Estradiol regulates the expression of endothelin receptor type B in the heart. Br. J. Pharmacol. 140, 195-201
120. Kawanishi, H., Hasegawa, Y., Nakano, D. et al. (2007) Involvement of the endothelin ETB receptor in gender differences in deoxycorticosterone acetate-salt-induced hypertension. Clin. Exp. Pharmacol. Physiol. 34, 280-285
121. Taylor, T. A., Gariepy, C. E., Pollock, D. M. and Pollock, J. S. (2003) Gender differences in ET and NOS systems in ETB receptor-deficient rats: effect of a high salt diet. Hypertension 41, 657-662
122. Sharkey, L. C., Holycross, B. J., McCune, S. A. and Radin, M. J. (2001) Obese female SHHF/Mcc-fa(cp) rats resist antihypertensive effects of renin-angiotensin system inhibition. Clin. Exp. Hypertens. 23, 227-239
123. Hallberg, P., Karlsson, J., Lind, L. et al. (2004) Gender-specific association between preproendothelin-1 genotype and reduction of systolic blood pressure during antihypertensive treatment-results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA). Clin. Cardiol. 27, 287-229