Endothelin A receptor blockade decreases expression of growth factors and collagen and improves matrix metalloproteinase-2 activity in kidneys from stroke-prone spontaneously hypertensive rats

Journal of Cardiovascular Pharmacology

Volumn 39, Issue 6, 2002, Pages 892-900

  Tostes, Rita C A ^a   Touyz, Rhian M ^a   He, Gang ^a   Ammarguellat, Fatima ^a   Schiffrin, Ernesto L ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Collagen; Collagenase; Endothelin; Growth factor; Hypertension; Stroke prone spontaneously hypertensive rats

Indexed keywords

5 DIMETHYLAMINO N (3,4 DIMETHYL 5 ISOXAZOLYL) 1 NAPHTHALENESULFONAMIDE; BASIC FIBROBLAST GROWTH FACTOR; COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR; GELATINASE A; GROWTH FACTOR; MESSENGER RNA; PREPROENDOTHELIN 1; PROCOLLAGEN; SODIUM CHLORIDE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; ESSENTIAL HYPERTENSION; EXTRACELLULAR MATRIX; IMMUNOBLOTTING; KIDNEY DYSFUNCTION; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BLOCKING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALT INTAKE; SPONTANEOUSLY HYPERTENSIVE RAT; ZYMOGRAPHY;

ANIMALS; ANTIHYPERTENSIVE AGENTS; CEREBROVASCULAR ACCIDENT; COLLAGEN; GROWTH SUBSTANCES; HYPERTENSION; KIDNEY; MALE; MATRIX METALLOPROTEINASE 2; RATS; RATS, INBRED SHR; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN;

EID: 0036108555     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200206000-00015     Document Type: Article

References (40)

1. Role of endothelin-1 in hypertension
2. Effect of a non-selective endothelin antagonist on vascular remodeling in DOCA-salt hypertensive rats: Evidence for a role of endothelin in vascular hypertrophy
3. Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensive but not in spontaneously hypertensive rats
4. Increased expression of ET-1 gene in blood vessels of DOCA-salt hypertensive rats
5. DOCA plus salt induces overexpression of vascular ET-1 and severe vascular hypertrophy in SHR
6. Endothelin antagonists in salt-dependent hypertension associated with renal insufficiency
7. A, receptor antagonist
8. Vascular and cardiac overexpression of ET-1 gene in one-kidney one-clip Goldblatt hypertensive rats but only in the late phase of two-kidney one clip Goldblatt hypertension
9. Vascular endothelin-1 gene expression and effect of an endothelin A receptor antagonist on structure and function of small arteries from stroke-prone spontaneously hypertensive rats
10. Effects of a selective endothelin A-receptor antagonist, BQ-123, in salt-loaded stroke-prone spontaneously hypertensive rats
11. Antihypertensive effects of BQ-123, a selective endothelin ETA receptor antagonist, in spontaneously hypertensive rats treated with DOCA-salt
12. Renal and vascular effects of chronic endothelin receptor antagonism in malignant hypertensive rats
13. Endothelin A receptor blockade alleviates hypertension and renal lesions associated with chronic nitric oxide synthase inhibition
14. Endothelin: Potential role in hypertension and vascular hypertrophy
15. Vascular biology of endothelin
16. Early-onset but not late-onset endothelin-A- receptor blockade can modulate hypertension, cerebral edema, and proteinuria in stroke-prone hypertensive rats
17. Nephroprotection of an ET(A)-receptor blocker (LU 135252) in salt-loaded uninephrectomized stroke-prone spontaneously hypertensive rats
18. Prolonged endothelin blockade reduces hypertension and cardiac hypertrophy in SHR-SP
19. Endothelin A receptor blockade improves renal function and doubles the life span of stroke-prone spontaneously hypertensive rats
20. Endothelin antagonism in end organ damage of SHR
21. Salt induces myocardial and renal fibrosis in normotensive and hypertensive rats
22. Mechanism of progression of renal disease
23. Mechanism of progression of renal disease: Growth factors and related mechanisms
24. Recent developments in the cell biology of fibroblast growth factors
25. Effects of transforming growth factor-beta1 on renal extracellular matrix components and their regulating proteins
26. Collagen I and III and mechanical properties of conduit arteries in rats with genetic hypertension
27. Matrix metalloproteinases and their inhibitors in connective tissue remodeling
28. Cloning and functional expression of a vascular smooth muscle endothelin-1 receptor
29. Cloning and expression of a cDNA encoding an endothelin receptor
30. Changes in transforming growth factor-beta procollagen types I and III mRNA in the rat heart after irradiation
31. Effect of a specific endothelin A receptor antagonist on murine lupus nephritis
32. Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cystis but not hypertension
33. Inhibition by lacidipine of salt-dependent cardiac hypertrophy and endothelin gene expression in stroke prone spontaneously hypertensive rats
34. Antihypertensive effects of a mixed endothelin-A and -B receptor antagonist, J-104132, were augmented in the presence of an AT1receptor antagonist, MK-954
35. Effect of endothelin receptor antagonism and of the novel non-peptide antagonist Ro 46-2005 on endothelin levels in rat plasma
36. Effect of chronic ETA-selective endothelin receptor antagonism on blood pressure in experimental and genetic hypertension in rats
37. Renin angiotensin system in stroke-prone spontaneously hypertensive rats
38. Angiotensin II type I receptor antagonist inhibits the gene expression of transforming growth factor β1 and extracellular matrix in cardiac and vascular tissues of hypertensive rats
39. Enalapril prevents stroke and kidney dysfunction in salt-loaded stroke-prone spontaneously hypertensive rats
40. Role of matrix metalloproteinases in the progression of renal lesions