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Volumn 3, Issue 6, 2007, Pages 823-832

Current concepts in targeted therapies for the pathophysiology of diabetic microvascular complications

Author keywords

Advanced glycation end products; Aldose reductase inhibitor; Antioxidants; Diabetes; Protein kinase C inhibitor; Vascular epithelium growth factor inhibitor

Indexed keywords

ALAGEBRIUM; ALDOSE REDUCTASE INHIBITOR; AMINOGUANIDINE; BENFOTIAMINE; BENZOPORPHYRIN DERIVATIVE; BEVACIZUMAB; EPALRESTAT; FIDARESTAT; INSULIN; IRBESARTAN; METFORMIN; MIDOSTAURIN; NIFEDIPINE; PEGAPTANIB; PERINDOPRIL; PLACEBO; PONALRESTAT; PYRIDOXAMINE; PYRIDOXINE; RANIBIZUMAB; RANIRESTAT; RUBOXISTAURIN; SIMVASTATIN; SORBINIL; SULFONYLUREA DERIVATIVE; THIOCTIC ACID; TOLRESTAT; UNINDEXED DRUG; ZENARESTAT; ZOPOLRESTAT;

EID: 38149099908     PISSN: 11766344     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (50)

References (113)
  • 1
    • 29244469623 scopus 로고    scopus 로고
    • One year course of oral sulodexide in the management of diabetic nephropathy
    • Achour A, Kacem M, et al. 2005. One year course of oral sulodexide in the management of diabetic nephropathy. J Nephrol, 18:568-74.
    • (2005) J Nephrol , vol.18 , pp. 568-574
    • Achour, A.1    Kacem, M.2
  • 2
    • 29644444716 scopus 로고    scopus 로고
    • Changes in retinal neovascularization after pegaptanib (Macugen) therapy in diabetic individuals
    • Adamis AP, Altaweel M, et al. 2006. Changes in retinal neovascularization after pegaptanib (Macugen) therapy in diabetic individuals. Ophthalmology, 113:23-8.
    • (2006) Ophthalmology , vol.113 , pp. 23-28
    • Adamis, A.P.1    Altaweel, M.2
  • 3
    • 0027942607 scopus 로고
    • Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
    • Aiello LP, et al. 1994. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med, 331:1480-7.
    • (1994) N Engl J Med , vol.331 , pp. 1480-1487
    • Aiello, L.P.1
  • 4
    • 33644842187 scopus 로고    scopus 로고
    • Inhibition of PKC beta by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients
    • Aiello LP, Clermont A, et al. 2006. Inhibition of PKC beta by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients. Invest Ophthalmol Vis Sci, 47:86-92.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 86-92
    • Aiello, L.P.1    Clermont, A.2
  • 5
    • 33751520614 scopus 로고    scopus 로고
    • Effect of raboxistaurin on visual loss in patients with diabetic retinopathy
    • Aiello LP, Davis MD, et al. 2006. Effect of raboxistaurin on visual loss in patients with diabetic retinopathy. Ophthalmology, 113:2221-30.
    • (2006) Ophthalmology , vol.113 , pp. 2221-2230
    • Aiello, L.P.1    Davis, M.D.2
  • 6
    • 13644249915 scopus 로고    scopus 로고
    • American Diabetes Association, online, Accessed 25 February 2007. URL
    • American Diabetes Association. 2007. All about diabetes [online]. Accessed 25 February 2007. URL: http://www.diabetes.org/ about-diabetes.jsp
    • (2007) All about diabetes
  • 7
    • 33748982649 scopus 로고    scopus 로고
    • Intravitreal bevacizumab (Avastin) in the treatment of proliferative diabetic retinopathy
    • Avery RL, Pearlman J, et al. 2006. Intravitreal bevacizumab (Avastin) in the treatment of proliferative diabetic retinopathy. Ophthalmology, 113:e1-15.
    • (2006) Ophthalmology , vol.113
    • Avery, R.L.1    Pearlman, J.2
  • 8
    • 0032939905 scopus 로고    scopus 로고
    • Metformin reduces systemic methylglyoxal levels in type 2 diabetes
    • Beisswenger PJ, Howell SK, et al. 1999. Metformin reduces systemic methylglyoxal levels in type 2 diabetes. Diabetes, 48:198-202.
    • (1999) Diabetes , vol.48 , pp. 198-202
    • Beisswenger, P.J.1    Howell, S.K.2
  • 9
    • 10744223527 scopus 로고    scopus 로고
    • Randomized trial of an inhibitor of formation of advanced glycation end products in diabetic nephropathy
    • Bolton WK, Cattran DC, et al. 2004. Randomized trial of an inhibitor of formation of advanced glycation end products in diabetic nephropathy. Am J Nephrol, 24:32-40.
    • (2004) Am J Nephrol , vol.24 , pp. 32-40
    • Bolton, W.K.1    Cattran, D.C.2
  • 10
    • 0033010474 scopus 로고    scopus 로고
    • Alpha-Lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria
    • Borcea V, Nourooz-Zadeh J, et al. 1999. Alpha-Lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria. Free Radic Biol Med, 26:1495-500.
    • (1999) Free Radic Biol Med , vol.26 , pp. 1495-1500
    • Borcea, V.1    Nourooz-Zadeh, J.2
  • 11
    • 4644271552 scopus 로고    scopus 로고
    • Aldose reductase inhibition by AS-3201 in sural nerve from patients with diabetic sensorimotor polyneuropathy
    • Bril V, Buchanan RA. 2004. Aldose reductase inhibition by AS-3201 in sural nerve from patients with diabetic sensorimotor polyneuropathy. Diabetes Care, 27:2369-75.
    • (2004) Diabetes Care , vol.27 , pp. 2369-2375
    • Bril, V.1    Buchanan, R.A.2
  • 12
    • 33644876711 scopus 로고    scopus 로고
    • Long-term effects of ranirestat (AS-3201) on peripheral nerve function in patients with diabetic sensorimotor polyneuropathy
    • Bril V, Buchanan RA. 2006. Long-term effects of ranirestat (AS-3201) on peripheral nerve function in patients with diabetic sensorimotor polyneuropathy. Diabetes Care, 29:68-72.
    • (2006) Diabetes Care , vol.29 , pp. 68-72
    • Bril, V.1    Buchanan, R.A.2
  • 13
    • 2342466268 scopus 로고    scopus 로고
    • Natural progression of diabetic peripheral neuropathy in the Zenarestat study population
    • Brown MJ, Bird SJ, et al. 2004. Natural progression of diabetic peripheral neuropathy in the Zenarestat study population. Diabetes Care, 27:1153-9.
    • (2004) Diabetes Care , vol.27 , pp. 1153-1159
    • Brown, M.J.1    Bird, S.J.2
  • 14
    • 33749451356 scopus 로고    scopus 로고
    • Ranibizumab versus verteporfin for neovascular age-related macular degeneration
    • Brown DM, Kaiser P. 2006. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med, 355:1432-44.
    • (2006) N Engl J Med , vol.355 , pp. 1432-1444
    • Brown, D.M.1    Kaiser, P.2
  • 15
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M. 2001. Biochemistry and molecular cell biology of diabetic complications. Nature, 414:813-20.
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 16
    • 20044376702 scopus 로고    scopus 로고
    • Brownlee M. 2065. The pathobiology of diabetic complications: a unifying mechanism. Diabetes, 54:1615-25.
    • Brownlee M. 2065. The pathobiology of diabetic complications: a unifying mechanism. Diabetes, 54:1615-25.
  • 17
    • 1542742166 scopus 로고    scopus 로고
    • Reduction of diabetic macular edema by oral administration of the kinase inhibitor PKC412
    • C99-PKC412-003 Study Group
    • Campochiaro PA, C99-PKC412-003 Study Group. 2004. Reduction of diabetic macular edema by oral administration of the kinase inhibitor PKC412. Invest Ophthalmol Vis Sci, 45:922-31.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 922-931
    • Campochiaro, P.A.1
  • 18
    • 13144252260 scopus 로고    scopus 로고
    • Tobacco smoke is a source of toxic reactive glycation products
    • Cerami C, Founds H, et al. 1997. Tobacco smoke is a source of toxic reactive glycation products. Proc Natl Acad Sci U S A, 94:13915-20.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 13915-13920
    • Cerami, C.1    Founds, H.2
  • 19
    • 0042093769 scopus 로고    scopus 로고
    • New insights on oxidative stress and diabetic complications may lead to a "causal" antioxidant therapy
    • Ceriello A. 2003. New insights on oxidative stress and diabetic complications may lead to a "causal" antioxidant therapy. Diabetes Care, 26:1589-96.
    • (2003) Diabetes Care , vol.26 , pp. 1589-1596
    • Ceriello, A.1
  • 20
    • 33748957021 scopus 로고    scopus 로고
    • A pilot study of multiple intravitreal injections of ranibizumab in patients with center-involving clinically significant diabetic macular edema
    • Chun DW, Heier JS, et al. 2006. A pilot study of multiple intravitreal injections of ranibizumab in patients with center-involving clinically significant diabetic macular edema. Ophthalmology, 113:1706-12.
    • (2006) Ophthalmology , vol.113 , pp. 1706-1712
    • Chun, D.W.1    Heier, J.S.2
  • 21
    • 33644819294 scopus 로고    scopus 로고
    • The effect of monochromatic infrared energy on sensation in patients with diabetic peripheral neuropathy: A double-blind, placebo-controlled study
    • Clifft JK, Kasser RJ, et al. 2005. The effect of monochromatic infrared energy on sensation in patients with diabetic peripheral neuropathy: a double-blind, placebo-controlled study. Diabetes Care, 28:2896-900.
    • (2005) Diabetes Care , vol.28 , pp. 2896-2900
    • Clifft, J.K.1    Kasser, R.J.2
  • 22
    • 0025313272 scopus 로고
    • Increase in diacylglycerol mass in isolated glomeruli by glucose from de novo synthesis of glycerolipids
    • Craven PA, Davidson CM, et al. 1990. Increase in diacylglycerol mass in isolated glomeruli by glucose from de novo synthesis of glycerolipids. Diabetes, 39:667-74.
    • (1990) Diabetes , vol.39 , pp. 667-674
    • Craven, P.A.1    Davidson, C.M.2
  • 23
    • 0030902095 scopus 로고    scopus 로고
    • Nitric oxide inhibition of transforming growth factor-beta and collagen synthesis in mesangial cells
    • Craven PA, Studer RK, et al. 1997. Nitric oxide inhibition of transforming growth factor-beta and collagen synthesis in mesangial cells. Diabetes, 46:671-81.
    • (1997) Diabetes , vol.46 , pp. 671-681
    • Craven, P.A.1    Studer, R.K.2
  • 24
    • 0037880855 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor therapy for neovascular age-related macular degeneration: Promises and pitfalls
    • Csaky K. 2003. Anti-vascular endothelial growth factor therapy for neovascular age-related macular degeneration: promises and pitfalls. Ophthalmology, 110:879-81.
    • (2003) Ophthalmology , vol.110 , pp. 879-881
    • Csaky, K.1
  • 25
    • 33751171940 scopus 로고    scopus 로고
    • Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes
    • Cuccurullo C, Lezzi A, et al. 2006. Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler Thromb Vasc Biol, 26:2716-23.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 2716-2723
    • Cuccurullo, C.1    Lezzi, A.2
  • 26
    • 25844513658 scopus 로고    scopus 로고
    • A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema
    • Cunningham ET Jr, et al. 2005. A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema. Ophthalmology, 112:1747-57.
    • (2005) Ophthalmology , vol.112 , pp. 1747-1757
    • Cunningham Jr, E.T.1
  • 27
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • The Diabetes Control and Complications Trial Research Group
    • The Diabetes Control and Complications Trial Research Group. 1993. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med, 329:977-86.
    • (1993) N Engl J Med , vol.329 , pp. 977-986
  • 28
    • 0034710891 scopus 로고    scopus 로고
    • Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation
    • Du XL, Edelstein D, et al. 2000. Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation. Proc Natl Acad Sci USA, 97:12222-6.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 12222-12226
    • XL, D.1    Edelstein, D.2
  • 29
    • 0029004025 scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
    • Dvorak HF, Brown LF, et al. 1995. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol, 146:1029-39.
    • (1995) Am J Pathol , vol.146 , pp. 1029-1039
    • Dvorak, H.F.1    Brown, L.F.2
  • 30
    • 0028235625 scopus 로고
    • Retinal circulatory abnormalities in type 1 diabetes
    • Feke GT, Buzney SM, et al. 1994. Retinal circulatory abnormalities in type 1 diabetes. Invest Ophthalmol Vis Sci, 35:2968-75.
    • (1994) Invest Ophthalmol Vis Sci , vol.35 , pp. 2968-2975
    • Feke, G.T.1    Buzney, S.M.2
  • 31
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • Ferrara N. 2004, Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev, 25:581-611.
    • (2004) Endocr Rev , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 32
    • 0031039903 scopus 로고    scopus 로고
    • Worldwide pharmacovigilance systems and tolrestat withdrawal
    • Foppiano M, Lombardo G. 1997. Worldwide pharmacovigilance systems and tolrestat withdrawal. Lancet, 349:399-400.
    • (1997) Lancet , vol.349 , pp. 399-400
    • Foppiano, M.1    Lombardo, G.2
  • 33
    • 0141483457 scopus 로고    scopus 로고
    • The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes
    • Forbes JM, Thallas V, et al. 2003. The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes. FASEB J, 17:1762-4.
    • (2003) FASEB J , vol.17 , pp. 1762-1764
    • Forbes, J.M.1    Thallas, V.2
  • 34
    • 28444472740 scopus 로고    scopus 로고
    • Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy
    • Forbes JM, Thorpe SR, et al. 2005. Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy. J Am Soc Nephrol, 16:2363-72.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2363-2372
    • Forbes, J.M.1    Thorpe, S.R.2
  • 35
    • 0032857820 scopus 로고    scopus 로고
    • Design and baseline characteristics for the aminoguanidine Clinical Trial in Overt Type 2 Diabetic Nephropathy (ACTION II)
    • Freedman BI, Wuerth JP, et al. 1999. Design and baseline characteristics for the aminoguanidine Clinical Trial in Overt Type 2 Diabetic Nephropathy (ACTION II). Control Clin Trials, 20:493-510.
    • (1999) Control Clin Trials , vol.20 , pp. 493-510
    • Freedman, B.I.1    Wuerth, J.P.2
  • 36
    • 31644447232 scopus 로고    scopus 로고
    • Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor are related to diabetic macular edema
    • Funatsu H, Yamashita H, et al. 2006. Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor are related to diabetic macular edema. Ophthalmology, 113:294-301.
    • (2006) Ophthalmology , vol.113 , pp. 294-301
    • Funatsu, H.1    Yamashita, H.2
  • 37
    • 0036014944 scopus 로고    scopus 로고
    • Oral sulodexide reduces albuminuria in microalbuminuric and macroalbuminuric type 1 and type 2 diabetic patients: The Di.N.A.S. randomized trial
    • Gambaro G, Kinalska I, et al. 2002. Oral sulodexide reduces albuminuria in microalbuminuric and macroalbuminuric type 1 and type 2 diabetic patients: the Di.N.A.S. randomized trial. J Am Soc Nephrol, 13:1615-25.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1615-1625
    • Gambaro, G.1    Kinalska, I.2
  • 38
    • 33747623255 scopus 로고    scopus 로고
    • Intravitreal triamcinolone for refractory diabetic macular edema: Two-year results of a double-masked, placebo-controlled, randomized clinical trial
    • Gillies MC, Sutter FK, et al. 2006. Intravitreal triamcinolone for refractory diabetic macular edema: two-year results of a double-masked, placebo-controlled, randomized clinical trial. Ophthalmology, 113:1533-8.
    • (2006) Ophthalmology , vol.113 , pp. 1533-1538
    • Gillies, M.C.1    Sutter, F.K.2
  • 39
    • 3843063285 scopus 로고    scopus 로고
    • Advanced glycoxidation end products in commonly consumed foods
    • Goldberg T, Cai W, et al. 2004. Advanced glycoxidation end products in commonly consumed foods. J Am Diet Assoc, 104:1287-91.
    • (2004) J Am Diet Assoc , vol.104 , pp. 1287-1291
    • Goldberg, T.1    Cai, W.2
  • 40
    • 33746920337 scopus 로고    scopus 로고
    • Advanced glycation end products: Sparking the development of diabetic vascular injury
    • Goldin A, Beckman JA, et al. 2006. Advanced glycation end products: sparking the development of diabetic vascular injury. Circulation, 114:597-605.
    • (2006) Circulation , vol.114 , pp. 597-605
    • Goldin, A.1    Beckman, J.A.2
  • 41
    • 0029085097 scopus 로고
    • Effects of an aldose reductase inhibitor, epalrestat, on diabetic neuropathy. Clinical benefit and indication for the drug assessed from the results of a placebo-controlled double-blind study
    • Goto Y, Hotta N, et al. 1995. Effects of an aldose reductase inhibitor, epalrestat, on diabetic neuropathy. Clinical benefit and indication for the drug assessed from the results of a placebo-controlled double-blind study. Biomed Pharmacother, 49:269-77.
    • (1995) Biomed Pharmacother , vol.49 , pp. 269-277
    • Goto, Y.1    Hotta, N.2
  • 42
    • 11144239923 scopus 로고    scopus 로고
    • Pegaptanib for neovascular age-related macular degeneration
    • Gragoudas ES, Adamis AP, et al. 2004. Pegaptanib for neovascular age-related macular degeneration. N Engl J Med, 351:2805-16.
    • (2004) N Engl J Med , vol.351 , pp. 2805-2816
    • Gragoudas, E.S.1    Adamis, A.P.2
  • 43
    • 0033546655 scopus 로고    scopus 로고
    • Effect of aldose reductase inhibition on nerve conduction and morphometry in diabetic neuropathy. Zenarestat Study Group
    • Greene DA, Brown MB. 1999. Effect of aldose reductase inhibition on nerve conduction and morphometry in diabetic neuropathy. Zenarestat Study Group. Neurology, 53:580-91.
    • (1999) Neurology , vol.53 , pp. 580-591
    • Greene, D.A.1    Brown, M.B.2
  • 44
    • 0023899234 scopus 로고
    • Diabetic neuropathy in the upper limb and the effect of twelve months sorbinil treatment
    • Guy RJ, Gilbey SG, et al. 1988. Diabetic neuropathy in the upper limb and the effect of twelve months sorbinil treatment. Diabetologia, 4:214-20.
    • (1988) Diabetologia , vol.4 , pp. 214-220
    • Guy, R.J.1    Gilbey, S.G.2
  • 45
    • 0030581630 scopus 로고    scopus 로고
    • Rapid formation of advanced glycation end products by intermediate metabolites of glycolytic pathway and polyol pathway
    • Hamada Y, Araki N, et al. 1996. Rapid formation of advanced glycation end products by intermediate metabolites of glycolytic pathway and polyol pathway. Biochem Biophys Res Commun, 228:539-43.
    • (1996) Biochem Biophys Res Commun , vol.228 , pp. 539-543
    • Hamada, Y.1    Araki, N.2
  • 46
    • 0033803537 scopus 로고    scopus 로고
    • Epalrestat, an aldose reductase inhibitor, reduces the levels of Nepsilon-(carboxymethyl)lysine protein adducts and their precursors in erythrocytes from diabetic patients
    • Hamada Y, Nakamura J, et al. 2000. Epalrestat, an aldose reductase inhibitor, reduces the levels of Nepsilon-(carboxymethyl)lysine protein adducts and their precursors in erythrocytes from diabetic patients. Diabetes Care, 23:1539-44.
    • (2000) Diabetes Care , vol.23 , pp. 1539-1544
    • Hamada, Y.1    Nakamura, J.2
  • 47
    • 33845745774 scopus 로고    scopus 로고
    • Intravitreal bevacizumab (Avastin) therapy for persistent diffuse diabetic macular edema
    • Haritoglou C, Kook D, et al. 2006. Intravitreal bevacizumab (Avastin) therapy for persistent diffuse diabetic macular edema. Retina, 26:999-1005.
    • (2006) Retina , vol.26 , pp. 999-1005
    • Haritoglou, C.1    Kook, D.2
  • 48
    • 14544300095 scopus 로고    scopus 로고
    • Benfotiamine in the treatment of diabetic polyneuropathy - a three-week randomized, controlled pilot study (BEDIP study)
    • Haupt E, Ledermann H, et al, 2005. Benfotiamine in the treatment of diabetic polyneuropathy - a three-week randomized, controlled pilot study (BEDIP study). Int J Clin Pharmacol Ther, 43:71-7.
    • (2005) Int J Clin Pharmacol Ther , vol.43 , pp. 71-77
    • Haupt, E.1    Ledermann, H.2
  • 49
    • 33646501496 scopus 로고    scopus 로고
    • Local VEGF activity but not VEGF expression is tightly regulated during diabetic nephropathy in man
    • Hohenstein B, Hausknecht B, et al. 2006. Local VEGF activity but not VEGF expression is tightly regulated during diabetic nephropathy in man. Kidney Int, 69:1654-61.
    • (2006) Kidney Int , vol.69 , pp. 1654-1661
    • Hohenstein, B.1    Hausknecht, B.2
  • 50
    • 0030152978 scopus 로고    scopus 로고
    • Clinical investigation of epalrestat, an aldose reductase inhibitor, on diabetic neuropathy in Japan: Multicenter study. Diabetic Neuropathy Study Group in Japan
    • Hotta N, Sakamoto N, et al. 1996. Clinical investigation of epalrestat, an aldose reductase inhibitor, on diabetic neuropathy in Japan: multicenter study. Diabetic Neuropathy Study Group in Japan. J Diabetes Complications, 10:168-72.
    • (1996) J Diabetes Complications , vol.10 , pp. 168-172
    • Hotta, N.1    Sakamoto, N.2
  • 51
    • 0035486938 scopus 로고
    • 200 1. Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: A 52-week multicenter placebo-controlled double-blind parallel group study
    • Hotta N, Toyota T, et al. 200 1. Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study. Diabetes Care, 24:1776-82.
    • (1776) Diabetes Care , vol.24
    • Hotta, N.1    Toyota, T.2
  • 52
    • 33746456027 scopus 로고    scopus 로고
    • Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: The 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial
    • Hotta N, Akanuma Y, et al. 2006. Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial. Diabetes Care, 29:1538-44.
    • (2006) Diabetes Care , vol.29 , pp. 1538-1544
    • Hotta, N.1    Akanuma, Y.2
  • 53
    • 33746427544 scopus 로고    scopus 로고
    • Diabetes and advanced glycoxidation end products
    • Huebschmann AG, Regensteiner JG, et al. 2006. Diabetes and advanced glycoxidation end products. Diabetes Care, 29:1420-32.
    • (2006) Diabetes Care , vol.29 , pp. 1420-1432
    • Huebschmann, A.G.1    Regensteiner, J.G.2
  • 54
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, et al. 2004. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med, 350:2335-42.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2
  • 55
    • 0032929503 scopus 로고    scopus 로고
    • Long-term effect of epalrestat on cardiac autonomic neuropathy in subjects with non-insulin dependent diabetes mellitus
    • Ikeda T, Iwata K, et al. 1999. Long-term effect of epalrestat on cardiac autonomic neuropathy in subjects with non-insulin dependent diabetes mellitus. Diabetes Res Clin Pract, 43:193-8.
    • (1999) Diabetes Res Clin Pract , vol.43 , pp. 193-198
    • Ikeda, T.1    Iwata, K.2
  • 56
    • 0026489335 scopus 로고
    • Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: Differential reversibility to glycemic control by islet cell transplantation
    • Inoguchi T, Battan R, et al. 1992. Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci USA, 89:11059-63.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11059-11063
    • Inoguchi, T.1    Battan, R.2
  • 57
    • 0034869770 scopus 로고    scopus 로고
    • 200 1. Long-term effect of epalrestat, an aldose reductase inhibitor, on the development of incipient diabetic nephropathy in Type 2 diabetic patients
    • Iso K, Tada H, et al. 200 1. Long-term effect of epalrestat, an aldose reductase inhibitor, on the development of incipient diabetic nephropathy in Type 2 diabetic patients. Diabetes Complications, 15:241-4.
    • Diabetes Complications , vol.15 , pp. 241-244
    • Iso, K.1    Tada, H.2
  • 58
    • 0022633522 scopus 로고
    • Clinical studies with an aldose reductase inhibitor in the autonomic and somatic neuropathies of diabetes
    • Jaspan JB, Towle VL, et al. 1986. Clinical studies with an aldose reductase inhibitor in the autonomic and somatic neuropathies of diabetes. Metabolism, 35:83-92.
    • (1986) Metabolism , vol.35 , pp. 83-92
    • Jaspan, J.B.1    Towle, V.L.2
  • 59
    • 33749631288 scopus 로고    scopus 로고
    • Intravitreal bevacizumab (Avastin) for persistent new vessels in diabetic retmopathy (IBEPE study)
    • Jorge R, Costa RA, et al. 2006. Intravitreal bevacizumab (Avastin) for persistent new vessels in diabetic retmopathy (IBEPE study). Retina, 26:1006-13.
    • (2006) Retina , vol.26 , pp. 1006-1013
    • Jorge, R.1    Costa, R.A.2
  • 60
    • 0035949502 scopus 로고    scopus 로고
    • Improved arterial compliance by a novel advanced glycation end-product crosslink breaker
    • Kass DA, Shapiro EP, et al. 2001. Improved arterial compliance by a novel advanced glycation end-product crosslink breaker. Circulation, 104:1464-70.
    • (2001) Circulation , vol.104 , pp. 1464-1470
    • Kass, D.A.1    Shapiro, E.P.2
  • 61
    • 32844466467 scopus 로고    scopus 로고
    • Decreased endogenous secretory advanced glycation end product receptor in type 1 diabetic patients: Its possible association with diabetic vascular complications
    • Katakami N, Matsuhisa M, et al. 2005. Decreased endogenous secretory advanced glycation end product receptor in type 1 diabetic patients: its possible association with diabetic vascular complications. Diabetes Care, 28:2716-21.
    • (2005) Diabetes Care , vol.28 , pp. 2716-2721
    • Katakami, N.1    Matsuhisa, M.2
  • 62
    • 20144388230 scopus 로고    scopus 로고
    • Effect of an aldose reductase inhibitor on esophageal dysfunction in diabetic patients
    • Kinekawa F, Kubo F, et al. 2005. Effect of an aldose reductase inhibitor on esophageal dysfunction in diabetic patients. Hepatogastroenterology, 52:471-4.
    • (2005) Hepatogastroenterology , vol.52 , pp. 471-474
    • Kinekawa, F.1    Kubo, F.2
  • 63
    • 0031860340 scopus 로고    scopus 로고
    • Protein kinase C activation and the development of diabetic complications
    • Koya D, King GL. 1998. Protein kinase C activation and the development of diabetic complications. Diabetes, 47:859-66.
    • (1998) Diabetes , vol.47 , pp. 859-866
    • Koya, D.1    King, G.L.2
  • 64
    • 0032958288 scopus 로고    scopus 로고
    • Contributions of polyol pathway to oxidative stress in diabetic cataract
    • Lee AY, Chung SS. 1999. Contributions of polyol pathway to oxidative stress in diabetic cataract. FASEB J, 1:23-30.
    • (1999) FASEB J , vol.1 , pp. 23-30
    • Lee, A.Y.1    Chung, S.S.2
  • 65
    • 1042280192 scopus 로고    scopus 로고
    • Restoration of sensation, reduced pain, and improved balance in subjects with diabetic peripheral neuropathy: A double-blind, randomized, placebo-controlled study with monochromatic near-infrared treatment
    • Leonard DR, Farooqi MH, et al. 2004. Restoration of sensation, reduced pain, and improved balance in subjects with diabetic peripheral neuropathy: a double-blind, randomized, placebo-controlled study with monochromatic near-infrared treatment. Diabetes Care, 27:168-72.
    • (2004) Diabetes Care , vol.27 , pp. 168-172
    • Leonard, D.R.1    Farooqi, M.H.2
  • 66
    • 16244371321 scopus 로고    scopus 로고
    • The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failure
    • Little WC, Zile MR, et al. 2005. The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failure. J Card Fail, 11:191-5.
    • (2005) J Card Fail , vol.11 , pp. 191-195
    • Little, W.C.1    Zile, M.R.2
  • 67
    • 33750889377 scopus 로고    scopus 로고
    • Vitamin E and risk of type 2 diabetes in the women's health study randomized controlled trial
    • Liu S, Lee IM, et al. 2006. Vitamin E and risk of type 2 diabetes in the women's health study randomized controlled trial. Diabetes, 55:2856-62.
    • (2006) Diabetes , vol.55 , pp. 2856-2862
    • Liu, S.1    Lee, I.M.2
  • 68
    • 0036834582 scopus 로고    scopus 로고
    • Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: Results of the HOPE study and MICRO-HOPE substudy
    • Lonn E, Yusuf S, Hoogwerf B, et al. 2002. Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy. Diabetes Care, 25:1919-27.
    • (2002) Diabetes Care , vol.25 , pp. 1919-1927
    • Lonn, E.1    Yusuf, S.2    Hoogwerf, B.3
  • 69
    • 0023637272 scopus 로고
    • Six-month treatment with sorbinil in asymptomatic diabetic neuropathy. Failure to improve abnormal nerve function
    • Martyn CN, Reid W, et al. 1987. Six-month treatment with sorbinil in asymptomatic diabetic neuropathy. Failure to improve abnormal nerve function. Diabetes, 36:987-90.
    • (1987) Diabetes , vol.36 , pp. 987-990
    • Martyn, C.N.1    Reid, W.2
  • 70
    • 33748985366 scopus 로고    scopus 로고
    • Intravitreal injection of bevacizumab (Avastin) as adjunctive treatment of proliferative diabetic retinopathy
    • Mason 3rd JO, Nixon PA, et al. 2006. Intravitreal injection of bevacizumab (Avastin) as adjunctive treatment of proliferative diabetic retinopathy. Am J Ophthalmol, 142:685-8.
    • (2006) Am J Ophthalmol , vol.142 , pp. 685-688
    • Mason 3rd, J.O.1    Nixon, P.A.2
  • 71
    • 0032104245 scopus 로고    scopus 로고
    • The extended protein kinase C superfamily
    • Mellor H, Parker PJ. 1998. The extended protein kinase C superfamily. Biochem J, 1:281-92.
    • (1998) Biochem J , vol.1 , pp. 281-292
    • Mellor, H.1    Parker, P.J.2
  • 72
    • 0035037526 scopus 로고    scopus 로고
    • Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: An exploratory study
    • Morcos M, Borcea V, et al. 2001. Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study. Diabetes Res Clin Pract, 52:175-81
    • (2001) Diabetes Res Clin Pract , vol.52 , pp. 175-181
    • Morcos, M.1    Borcea, V.2
  • 73
    • 23744467295 scopus 로고    scopus 로고
    • Glycation products as markers and predictors of the progression of diabetic complications
    • Monnier VM, Sell DR, et al. 2005. Glycation products as markers and predictors of the progression of diabetic complications. Ann N Y Acad Sci, 1043:567-81.
    • (2005) Ann N Y Acad Sci , vol.1043 , pp. 567-581
    • Monnier, V.M.1    Sell, D.R.2
  • 74
    • 0037532456 scopus 로고    scopus 로고
    • Effects of eparlestat on plasma levels of advanced glycation end products in patients with type 2 diabetes
    • Nakamura N, Yamazaki K, et al. 2003. Effects of eparlestat on plasma levels of advanced glycation end products in patients with type 2 diabetes. In Vivo, 17:177-80.
    • (2003) In Vivo , vol.17 , pp. 177-180
    • Nakamura, N.1    Yamazaki, K.2
  • 75
    • 0035378314 scopus 로고    scopus 로고
    • Aldose reductase inhibition ameliorates pupillary light reflex and F-wave latency in patients with mild diabetic neuropathy
    • Nakayama M, Nakamura J, et al, 2001. Aldose reductase inhibition ameliorates pupillary light reflex and F-wave latency in patients with mild diabetic neuropathy. Diabetes Care, 24:1093-8.
    • (2001) Diabetes Care , vol.24 , pp. 1093-1098
    • Nakayama, M.1    Nakamura, J.2
  • 76
    • 0034643340 scopus 로고    scopus 로고
    • Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
    • Nishikawa T, Edelstein D, et al. 2000. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature, 404:787-90.
    • (2000) Nature , vol.404 , pp. 787-790
    • Nishikawa, T.1    Edelstein, D.2
  • 77
    • 0042975081 scopus 로고    scopus 로고
    • Effects of epalrestat, an aldose reductase inhibitor, on diabetic neuropathy and gastroparesis
    • Okamoto H, Nomura M, et al. 2003. Effects of epalrestat, an aldose reductase inhibitor, on diabetic neuropathy and gastroparesis. Intern Med, 42:655-64.
    • (2003) Intern Med , vol.42 , pp. 655-664
    • Okamoto, H.1    Nomura, M.2
  • 78
    • 33745392312 scopus 로고    scopus 로고
    • Regression of iris neovascularization after intravitreal injection of bevacizumab in patients with proliferative diabetic retinopathy
    • Oshima Y, Sakaguchi H, et al. 2006. Regression of iris neovascularization after intravitreal injection of bevacizumab in patients with proliferative diabetic retinopathy. Am J Ophthalmol, 142:155-8.
    • (2006) Am J Ophthalmol , vol.142 , pp. 155-158
    • Oshima, Y.1    Sakaguchi, H.2
  • 79
    • 33845523712 scopus 로고    scopus 로고
    • Irbesartan treatment reduces biomarkers of inflammatory activity in patients with type 2 diabetes and microalbuminuria: An IRMA 2 substudy
    • Persson F, Rossing P, et al. 2006. Irbesartan treatment reduces biomarkers of inflammatory activity in patients with type 2 diabetes and microalbuminuria: an IRMA 2 substudy. Diabetes, 55:3550-5.
    • (2006) Diabetes , vol.55 , pp. 3550-3555
    • Persson, F.1    Rossing, P.2
  • 80
    • 24144472565 scopus 로고    scopus 로고
    • The burden of mortality attributable to diabetes: Realistic estimates for the year 2000
    • Roglic G, Unwin N, et al. 2005. The burden of mortality attributable to diabetes: realistic estimates for the year 2000. Diabetes Care, 9:2130-5.
    • (2005) Diabetes Care , vol.9 , pp. 2130-2135
    • Roglic, G.1    Unwin, N.2
  • 81
    • 33745386921 scopus 로고    scopus 로고
    • Intravitreal avastin: The low cost alternative to lucentis?
    • Rosenfeld PJ. 2006. Intravitreal avastin: the low cost alternative to lucentis?. Am J Ophthalmol, 142:141-3.
    • (2006) Am J Ophthalmol , vol.142 , pp. 141-143
    • Rosenfeld, P.J.1
  • 82
    • 33749445317 scopus 로고    scopus 로고
    • Ranibizumab for Neovascular Age-Related Macular Degeneration
    • Rosenfeld PJ, Brown D, et al. 2006. Ranibizumab for Neovascular Age-Related Macular Degeneration. N Engl J Med, 355:1419-31.
    • (2006) N Engl J Med , vol.355 , pp. 1419-1431
    • Rosenfeld, P.J.1    Brown, D.2
  • 83
    • 14944340746 scopus 로고    scopus 로고
    • Oxidative stress and antioxidant treatment in diabetes
    • Scott JA, King GL. 2004. Oxidative stress and antioxidant treatment in diabetes. Ann N Y Acad Sci, 1031:204-13.
    • (2004) Ann N Y Acad Sci , vol.1031 , pp. 204-213
    • Scott, J.A.1    King, G.L.2
  • 84
    • 0037184495 scopus 로고    scopus 로고
    • Molecular understanding of hyperglycemia's adverse effects for diabetic complications
    • Sheetz MJ, King GL. 2002. Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA, 288:2579-88.
    • (2002) JAMA , vol.288 , pp. 2579-2588
    • Sheetz, M.J.1    King, G.L.2
  • 85
    • 0027298573 scopus 로고
    • Characterization of vascular permeability factor/vascular endothelial growth factor receptors on mononuclear phagocytes
    • Shen H, Clauss M, et al. 1993. Characterization of vascular permeability factor/vascular endothelial growth factor receptors on mononuclear phagocytes. Blood, 81:2767-73.
    • (1993) Blood , vol.81 , pp. 2767-2773
    • Shen, H.1    Clauss, M.2
  • 86
    • 0027454103 scopus 로고
    • Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation
    • Shiba T, Inoguchi T, et al. 1993. Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation. Am J Physiol, 265:E783-93.
    • (1993) Am J Physiol , vol.265
    • Shiba, T.1    Inoguchi, T.2
  • 87
    • 12844260091 scopus 로고    scopus 로고
    • Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: Results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study
    • Sola S, Mir MQ, et al. 2005. Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study. Circulation, 111:343-8.
    • (2005) Circulation , vol.111 , pp. 343-348
    • Sola, S.1    Mir, M.Q.2
  • 88
    • 0030957881 scopus 로고    scopus 로고
    • Glycosaminoglycans delay the progression of nephropathy in NIDDM
    • Solini A, Vergnani L, et al. 1997. Glycosaminoglycans delay the progression of nephropathy in NIDDM. Diabetes Care, 20:819-23.
    • (1997) Diabetes Care , vol.20 , pp. 819-823
    • Solini, A.1    Vergnani, L.2
  • 89
    • 0025073693 scopus 로고
    • Randomized trial of sorbinil, an aldose reductase inhibitor, in diabetic retinopathy
    • Sorbinil Retinopathy Trial Research Group
    • Sorbinil Retinopathy Trial Research Group. 1990. Randomized trial of sorbinil, an aldose reductase inhibitor, in diabetic retinopathy. Arch Ophthalmol, 108:1234-44.
    • (1990) Arch Ophthalmol , vol.108 , pp. 1234-1244
  • 90
    • 0027280301 scopus 로고
    • The sorbinil retinopathy trial: Neuropathy results
    • Sorbinil Retinopathy Trial Research Group
    • Sorbinil Retinopathy Trial Research Group. 1993. The sorbinil retinopathy trial: neuropathy results. Neurology, 43:1141-9.
    • (1993) Neurology , vol.43 , pp. 1141-1149
  • 91
    • 33646464279 scopus 로고    scopus 로고
    • Intravitreal bevacizumab (Avastin) treatment of proliferative diabetic retinopathy complicated by vitreous hemorrhage
    • Spaide RF, Fisher YL. 2006. Intravitreal bevacizumab (Avastin) treatment of proliferative diabetic retinopathy complicated by vitreous hemorrhage. Retina, 26:275-8.
    • (2006) Retina , vol.26 , pp. 275-278
    • Spaide, R.F.1    Fisher, Y.L.2
  • 92
    • 33749426139 scopus 로고    scopus 로고
    • The price of sight - ranibizumab, bevacizumab, and the treatment of macular degeneration
    • Steinbrook R. 2006. The price of sight - ranibizumab, bevacizumab, and the treatment of macular degeneration. N Engl J Med, 355:1409-12.
    • (2006) N Engl J Med , vol.355 , pp. 1409-1412
    • Steinbrook, R.1
  • 93
    • 33845295849 scopus 로고    scopus 로고
    • Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes
    • Stirban A, Negrean M, et al. 2006. Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes. Diabetes Care, 29:2064-71.
    • (2006) Diabetes Care , vol.29 , pp. 2064-2071
    • Stirban, A.1    Negrean, M.2
  • 94
    • 0029792216 scopus 로고    scopus 로고
    • A benfotiamine-vitainin B combination in treatment of diabetic polyneuropathy
    • Stracke H, Lindemann A, et al. 1996. A benfotiamine-vitainin B combination in treatment of diabetic polyneuropathy. Exp Clin Endocrinol Diabetes, 104:311-16.
    • (1996) Exp Clin Endocrinol Diabetes , vol.104 , pp. 311-316
    • Stracke, H.1    Lindemann, A.2
  • 95
    • 32944465911 scopus 로고    scopus 로고
    • Effect of ruboxistaurin on blood-retinal barrier permeability in relation to severity of leakage in diabetic macular edema
    • Strom C, Sander B, et al. 2005. Effect of ruboxistaurin on blood-retinal barrier permeability in relation to severity of leakage in diabetic macular edema. Invest Ophthalmol Vis Sci, 46:3855-8.
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 3855-3858
    • Strom, C.1    Sander, B.2
  • 96
    • 0026985138 scopus 로고
    • Peripheral and autonomic nerve function in 259 diabetic patients with peripheral neuropathy treated with ponalrestat (an aldose reductase inhibitor) or placebo for 18 months. United Kingdom/Scandinavian Ponalrestat Trial
    • Sundkvist G, Armstrong FM, et al. 1992. Peripheral and autonomic nerve function in 259 diabetic patients with peripheral neuropathy treated with ponalrestat (an aldose reductase inhibitor) or placebo for 18 months. United Kingdom/Scandinavian Ponalrestat Trial. J Diabetes Complications, 6:123-30.
    • (1992) J Diabetes Complications , vol.6 , pp. 123-130
    • Sundkvist, G.1    Armstrong, F.M.2
  • 97
    • 7444245438 scopus 로고    scopus 로고
    • Intravitreal triamcinolone for diabetic macular edema that persists after laser treatment: Three-month efficacy and safety results of a prospective, randomized, double-masked, placebo-controlled clinical trial
    • Sutter FK, Simpson JM, et al. 2004. Intravitreal triamcinolone for diabetic macular edema that persists after laser treatment: three-month efficacy and safety results of a prospective, randomized, double-masked, placebo-controlled clinical trial. Ophthalmology, 111:2044-9.
    • (2004) Ophthalmology , vol.111 , pp. 2044-2049
    • Sutter, F.K.1    Simpson, J.M.2
  • 98
    • 21344435254 scopus 로고    scopus 로고
    • The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy: Initial results of the Protein Kinase C beta Inhibitor Diabetic Retinopathy Study (PKC-DRS) multicenter randomized clinical trial
    • The PKC-DRS Study Group
    • The PKC-DRS Study Group. 2005. The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy: initial results of the Protein Kinase C beta Inhibitor Diabetic Retinopathy Study (PKC-DRS) multicenter randomized clinical trial. Diabetes, 54:2199-97.
    • (2005) Diabetes , vol.54 , pp. 2199-2197
  • 99
    • 0142074864 scopus 로고    scopus 로고
    • Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts
    • Thornalley PJ. 2003. Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts. Arch Biochem Biophys, 419:31-40.
    • (2003) Arch Biochem Biophys , vol.419 , pp. 31-40
    • Thornalley, P.J.1
  • 100
    • 28644442122 scopus 로고    scopus 로고
    • The effect of ruboxistaurin on nephropathy in type 2 diabetes
    • Tuttle M Bakris GL, et al. 2005. The effect of ruboxistaurin on nephropathy in type 2 diabetes. Diabetes Care, 28:2686-90.
    • (2005) Diabetes Care , vol.28 , pp. 2686-2690
    • Tuttle, M.1    Bakris, G.L.2
  • 101
    • 0029155825 scopus 로고
    • Effect of 24 weeks of treatment with epalrestat, an a1dose reductase inhibitor, on peripheral neuropathy in patients with non-insulin-dependent diabetes mellitus
    • Uchida K, Kigoshi T, Nakano S, et al. 1995. Effect of 24 weeks of treatment with epalrestat, an a1dose reductase inhibitor, on peripheral neuropathy in patients with non-insulin-dependent diabetes mellitus. Clin Ther, 17:460-6.
    • (1995) Clin Ther , vol.17 , pp. 460-466
    • Uchida, K.1    Kigoshi, T.2    Nakano, S.3
  • 102
    • 0032511583 scopus 로고    scopus 로고
    • Intensive btood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (UKPDS) Group. 1998. Intensive btood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet, 352:837-53.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 103
    • 23744440311 scopus 로고    scopus 로고
    • Diet-derived advanced glycation end products are major contributors to the body's AGE pool and induce inflammation in healthy subjects
    • Uribarri J, Cai W, et al. 2005. Diet-derived advanced glycation end products are major contributors to the body's AGE pool and induce inflammation in healthy subjects. Ann N Y Acad Sci, 1043:461-6.
    • (2005) Ann N Y Acad Sci , vol.1043 , pp. 461-466
    • Uribarri, J.1    Cai, W.2
  • 104
    • 15044349368 scopus 로고    scopus 로고
    • Inhibitors of ocular neovascularization: Promises and potential problems
    • van Wijngaarden P, Coster DJ, et al. 2005. Inhibitors of ocular neovascularization: promises and potential problems. JAMA, 293:1509-13.
    • (2005) JAMA , vol.293 , pp. 1509-1513
    • van Wijngaarden, P.1    Coster, D.J.2
  • 105
    • 25844459952 scopus 로고    scopus 로고
    • Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C beta-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, double-blind clinical trial
    • Vinik AI, Bril V, et al. 2005. Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C beta-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, double-blind clinical trial. Clin Ther, 27:1164-80.
    • (2005) Clin Ther , vol.27 , pp. 1164-1180
    • Vinik, A.I.1    Bril, V.2
  • 106
    • 23744514571 scopus 로고    scopus 로고
    • Pyridoxamine: The many virtues of a maillard reaction inhibitor
    • Voziyan PA, Hudson BG. 2005. Pyridoxamine: the many virtues of a maillard reaction inhibitor. Ann N Y Acad Sci, 1043:807-16.
    • (2005) Ann N Y Acad Sci , vol.1043 , pp. 807-816
    • Voziyan, P.A.1    Hudson, B.G.2
  • 107
    • 12144263911 scopus 로고    scopus 로고
    • A phase 2 clinical trial of pyridoxamine (pyridorin) in type 2 and type 2 diabetic patients with overt nephropathy (PYR-206) [abstract]
    • Williams M, Bolton W, Degenhardt T, et al. 2003. A phase 2 clinical trial of pyridoxamine (pyridorin) in type 2 and type 2 diabetic patients with overt nephropathy (PYR-206) [abstract]. J Am Soc Nephro, 14:7A.
    • (2003) J Am Soc Nephro , vol.14
    • Williams, M.1    Bolton, W.2    Degenhardt, T.3
  • 108
    • 33846062302 scopus 로고    scopus 로고
    • New potential agents in treating diabetic kidney disease: The fourth act
    • Williams ME. 2006. New potential agents in treating diabetic kidney disease: the fourth act. Drugs, 66:2287-98.
    • (2006) Drugs , vol.66 , pp. 2287-2298
    • Williams, M.E.1
  • 109
    • 0033042515 scopus 로고    scopus 로고
    • Effectiveness of different benfotiamine dosage regimens in the treatment of painful diabetic neuropathy
    • Winkler G, Pal B, et al. 1999. Effectiveness of different benfotiamine dosage regimens in the treatment of painful diabetic neuropathy. Arzneimittelforschung, 49:220-4.
    • (1999) Arzneimittelforschung , vol.49 , pp. 220-224
    • Winkler, G.1    Pal, B.2
  • 110
    • 0031766768 scopus 로고    scopus 로고
    • Benfotiamine in treatment of alcoholic polyneuropathy: An 8-week randomized controlled study (BAP I Study)
    • Woelk H, Lehrl S, et al. 1998. Benfotiamine in treatment of alcoholic polyneuropathy: an 8-week randomized controlled study (BAP I Study). Alcohol Alcohol, 33:631-8.
    • (1998) Alcohol Alcohol , vol.33 , pp. 631-638
    • Woelk, H.1    Lehrl, S.2
  • 111
    • 34548774883 scopus 로고    scopus 로고
    • The World Health Organization, online, Accessed 25 February 2007. URL
    • The World Health Organization 2007. Diabetes Programme: facts and figures [online]. Accessed 25 February 2007. URL: http://www.who.int/ diabetes/facts/en
    • (2007) Diabetes Programme: Facts and figures
  • 112
    • 1242337352 scopus 로고    scopus 로고
    • Treatment of symptomatic diabetic polyneuropathy with the antioxidant a-lipoic acid: A meta-analysis
    • Ziegler D, Nowak H, et al. 2004. Treatment of symptomatic diabetic polyneuropathy with the antioxidant a-lipoic acid: a meta-analysis. Diabetic Med, 21:114-21.
    • (2004) Diabetic Med , vol.21 , pp. 114-121
    • Ziegler, D.1    Nowak, H.2
  • 113
    • 33845499323 scopus 로고    scopus 로고
    • Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy. The SYDNEY 2 Trial
    • Ziegler D, Ametov A, et al. 2006. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy. The SYDNEY 2 Trial. Diabetes Care, 29:2365-70.
    • (2006) Diabetes Care , vol.29 , pp. 2365-2370
    • Ziegler, D.1    Ametov, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.