α-Lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria

Free Radical Biology and Medicine

Volumn 26, Issue 11-12, 1999, Pages 1495-1500

  Borcea, Valentin ^a   Nourooz Zadeh, Jaffar ^b   Wolff, Simon P ^b   Klevesath, Martina ^a   Hofmann, Marion ^a   Urich, Heinz ^c   Wahl, Peter ^a   Ziegler, Reinhard ^a   Tritschler, Hans ^c   Halliwell, Barry ^d   Nawroth, Peter P ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c ASTA MEDICA AG   (Germany)

^d UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Lipoic acid; Diabetes mellitus; Free radicals; Lipid peroxidation; Oxidative stress

Indexed keywords

ALPHA TOCOPHEROL; CHOLESTEROL; FREE RADICAL; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; LIPID HYDROPEROXIDE; THIOCTIC ACID;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; DIABETES MELLITUS; DISEASE MARKER; FEMALE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN DETERMINATION; HUMAN; LIPID BLOOD LEVEL; LIPID PEROXIDATION; MAJOR CLINICAL STUDY; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEINURIA;

ALBUMINURIA; ANTIOXIDANTS; BLOOD GLUCOSE; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; LIPID PEROXIDES; MALE; MIDDLE AGED; OXIDATIVE STRESS; REGRESSION ANALYSIS; THIOCTIC ACID;

EID: 0033010474     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(99)00011-8     Document Type: Article

References (29)

1. Baynes J.W. Role of oxidative stress in development of complications in diabetes. Diabetes. 40:1991;405-412.
2. Giugliano D., Ceriello A., Paolisso G. Oxidative stress and diabetic vascular complications. Diabetes Care. 19:1996;257-267.
3. van Dam P.S., van Asbeck B.S., Erkelens D.W., Marx J.J.M., Gispen W.H., Bravenboer B. The role of oxidative stress in neuropathy and other diabetic complications. Diabetes. 11:1995;181-192.
4. Parthiban A., Vijayalingam S., Shanmugasundaram K.R., Mohan R. Oxidative stress and the development of diabetic complications - antioxidants and lipid peroxidation in erythrocytes and cell membrane. Cell Biology International. 19:1995;987-993.
5. Williamson J.R., Chang K., Frangos M., Hasan K.S., Ido Y., Kawamura T., Nyengaard J.R., van den Enden M., Kilo C., Tilton R.G. Hyperglycemic pseudohypoxia and diabetic complications. Diabetes. 42:1993;801-813.
6. Nourooz-Zadeh J., Rahimi A., Tajaddini-Sarmadi J., Tritschler H., Rösen P., Halliwell B., Betteridge D.J. Relationship between plasma measures of oxidative stress and metabolic control in non-insulin-dependent diabetes mellitus. Diabetologia. 40:1997;647-654.
7. Jennings P.E., Jones A.F., Florkowski C.M., Lunec J., Barnett A.H. Increased diene conjugates in diabetic subjects with microangiopathy. Diab. Med. 4:1987;452-456.
8. Velazques E., Winocour P.H., Kesteven P., Alberti K.G.M.M., Laker M.F. Relation of lipid peroxides to macrovascular disease in type 2 diabetes. Diab. Med. 10:1991;331-335.
9. MacRury S.M., Gordon D., Wilson R., Bradley H., Gemmel C.G., Paterson J.R., Rumley A.G., MacCuish A.C. A comparison of different methods of assessing free radical activity in type 2 diabetes and peripheral vascular disease. Diab Med. 8:1993;752-758.
10. Griesmacher A., Kinderhauser M., Andert S., Schreiner W., Toma C., Knoebl P., Pietschmann P., Prager R. Enhanced serum levels of TBARS in diabetes mellitus. Am. J. Med. 98:1995;469-475.
11. Sundaram R.K., Bhaskar A., Vijayalingam S., Viswanattham M., Mohan R., Shanmugasundaram K.R. Antioxidant status and lipid peroxidation in type II diabetes with and without complications. Clin. Sci. 90:1996;255-260.
12. Nourooz-Zadeh J.; Tajaddini-Sarmadi J; McCarthy S.; Betteridge D. J.; Wolff S. P. Elevated levels of authentic plasma hydroperoxides in NIDDM. Diabetes 44: 1054-1058; 1995.
13. 2α levels are elevated in individuals with NIDDM. FEBS. 368:1995;225-229.
14. Dandona P., Thusu K., Cook S., Snyder B., Makowski J., Armstrong D., Nicotera T. Oxidative damage to DNA in diabetes mellitus. The Lancet. 347:1996;444-445.
15. Leinonen J., Lehtimaki T., Toyokuni S., Okada K., Tanaka T., Hiai H., Ochi H., Laippala P., Rantalaiho V., Wirta O., Pasternack A., Alho H. New biomarker evidence of oxidative DNA damage in patients with NIDDM. FEBS Letters. 417:1997;150-152.
16. Packer L., Suzuki Y.J. Vitamin E and alpha-lipoate role in antioxidant recycling and activation of the NF-kB transcription factor . Molec. Aspects Med. 14:1993;229-239.
17. Chevion S., Hofmann M., Ziegler R., Chevion M., Nawroth P.P. The antioxidant properties of thioctic acid characterization by cyclic voltammetry . Biochem. Mol. Biol. Int. 41:1997;317-327.
18. Packer L., Witt E.H., Tritschler H.J. alpha-Lipoic acid as a biological antioxidant. Free Radic. Biol. Med. 19:(2):1995;227-250.
19. Scott B.C., Aruoma O.I., Evans P.J., O'Neill C., van der Vliet A., Cross C.E., Tritschler H., Halliwell B. Lipoic and dihydrolipoic acids as antioxidants. A critical evaluation. Free Radic. Res. 20:1994;119-133.
20. Roy S., Sen C.K., Tritschler H.J., Packer L. Modulation of cellular reducing equivalent homeostasis by alpha-lipoic acid. Mechanisms and implications for diabetes and ischemic injury. Biochem. Pharmacol. 53:(3):1997;393-399.
21. Suzuki Y.J., Tsuchiya M., Packer L. Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species. Free Radic. Res. Commun. 15:1991;225-236.
22. Suzuki Y.J., Tsuchiya M., Packer L. Antioxidant activities of dihidrolipoic acid and its structural homologues. Free Radic. Res. Comm. 18:1993;115-122.
23. Kagan V.E., Shvedova A., Serbinova E., Khan S., Swanson C., Powell R., Packer L. Dihydrolipoic acid - a universal antioxidant in the membrane and the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochem. Pharmacol. 44:1992;1637-1649.
24. Sumathi R., Jayanathi S., Varalakshmi P. DL α-lipoic acid as a free radical scavenger in glyoxylate-induced lipid peroxidation. Med. Sci. Res. 21:1993;135-137.
25. Suzuki Y.J., Tsuchiya M., Packer L. Lipoate prevents glucose-induced protein modifications. Free Radic. Res. Commun. 17:(3):1992;211-217.
26. Bierhaus A., Chevion S., Chevion M., Hofmann M., Quehenberger P., Illmer T., Luther T., Berentshtein E., Tritschler H., Muller M., Wahl P., Ziegler R., Nawroth P.P. Advanced glycation end product-induced activation of NF-κB is suppressed by α-lipoic acid in cultured endothelial cells. Diabetes. 46:1997;1481-1490.
27. Hofmann A. M.; Schiekofer S.; Kanitz M.; Klevesath M. S.; Joswig M.; Lee V.; Morcos M.; Tritschler H.; Ziegler R.; Wahl P.; Bierhaus A.; Nawroth P. P. Insufficient glycemic control increases NF-κB binding activity in peripheral blood mononuclear cells isolated from patients with diabetes mellitus. In press Diabetes Care; 1998.
28. Nourooz-Zadeh J., Tajaddini-Sarmadi J., Wolff S.P. Measurement of plasma hydroperoxide concentrations by the ferrous oxidation-xylenol orange assay in conjunction with triphenylphosphine. Analytical Biochemistry. 220:1994;403-409.
29. Brenna S., Prencipe L., Montalbetti N., Perlangeli V., Palpon R. Assessing the automatic DIAMAT liquid chromatograph for glycated hemoglobins. Clin. Chem. 32:1986;896.