Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14α-demethylase (CYP51)

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 1, 2008, Pages 209-221

  Korošec, Tina ^a   Ačimovič, Jure ^a,b   Seliškar, Matej ^b   Kocjan, Darko ^a   Tacer, Klementina Fon ^b   Rozman, Damjana ^b   Urleb, Uroš ^a  

^a Lek dd   (Slovenia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Cholesterol biosynthesis inhibitors; Cholesterol intermediates profile; Human lanosterol 14 demethylase (CYP51) inhibitors; Pyridylethanolamines

Indexed keywords

2 [(3,4 DICHLOROPHENETHYL)(PROPYL)AMINO] 1 (PYRIDIN 3 YL)ETHANOL; ALCOHOL DERIVATIVE; AMINE; ATORVASTATIN; FLUCONAZOLE; HEME; KETOCONAZOLE; LANOSTEROL; PYRIDINE DERIVATIVE; PYRROLE DERIVATIVE; STEROL; STEROL 14ALPHA DEMETHYLASE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEPG2; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

ANTICHOLESTEREMIC AGENTS; BINDING SITES; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CHOLESTEROL; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HUMANS; OXIDOREDUCTASES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 38049161752     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.10.001     Document Type: Article

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