Elevated expression of lanosterol 14α-demethylase (CYP51) and the synthesis of oocyte meiosis-activating sterois in postmeiotic germ cells of male rats

Endocrinology

Volumn 139, Issue 5, 1998, Pages 2314-2321

  Strömstedt, Maria ^a,e   Waterman, Michael R ^a   Haugen, Trine B ^b   Taskén, Kjetil ^b   Parvinen, Martti ^c   Rozman, Damjana ^d  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF OSLO   (Norway)

^c UNIVERSITY OF TURKU   (Finland)

^d UNIVERSITY OF LJUBLJANA   (Slovenia)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE KINASE; CYTOCHROME P450; DIHYDROLANOSTEROL; LACTATE DEHYDROGENASE; LANOSTEROL; MESSENGER RNA; SQUALENE SYNTHASE; STEROL; STEROL 14ALPHA DEMETHYLASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL SYNTHESIS; GERM CELL; LEYDIG CELL; MALE; MEIOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; POLYADENYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEMINIFEROUS TUBULE; SERTOLI CELL; SPERMATID; SPERMATOGENESIS;

EID: 0031763463     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.5.5984     Document Type: Article

References (51)

1. Trzaskos JM, Bowen WD, Shafiee A, Fischer RT, Gaylor JL 1984 Cytochrome P-450-dependent oxidation of lanosterol in cholesterol biosynthesis. J Biol Chem 259:13402-13412
2. Taton M, Salmon F, Pascal S, Rahier A 1994 Plant sterol biosynthesis: recent advances in the understanding of oxidative demethylations at C4 and C14. Plant Physiol Biochem 32:751-760
3. Aoyama Y, Yoshida Y 1978 Interaction of lanosterol to cytochrome P-450 purified from yeast microsomes: evidence for contribution of cytochrome P-450 to lanosterol metabolism. Biochem Biophys Res Commun 82:33-38
4. Schroepfer GJJ 1982 Sterol biosynthesis. Annu Rev Biochem 51:555-558
5. Kalb VF, Woods CW, Turi TG, Dey CR, Sutter TR, Loper JC 1987 Primary structure of the P450 lanosterol demethylase gene from Saccharomyces cerevisiae. DNA 6:529-537
6. Chen C, Kalb VF, Turi TG, Loper JC 1988 Primary structure of the cytochrome P450 lanosterol 14α-demethylase gene from Candida tropicalis. DNA 7:617-626
7. Lai MH, Kirsch DR 1989 Nucleotide sequence of cytochrome P450LIA1 (lanosterol 14α-demethylase) from Candida albicans. Nucleic Acids Res 17:804
8. Burgener-Kairuz P, Zuber JP, Jaunin P, Buchman TG, Bille J, Rossier M 1994 Rapid detection and identification of Candida albicans and Torulopsis (Candida) glabrata in clinical specimens by species-specific nested PCR amplification of a cytochrome P-450 lanosterol-14α-demethylase (LIA1) gene fragment. J Clin Microbiol 32:1902-1907
9. van Nistelrooy JGM, van den Brink JM, van Kan JAL, van Gorcom RFM, de Waard MA 1996 Isolation and molecular characterization of the gene encoding eburicol 14α-demethylase (CYP51) from Penicillium italicum. Mol Gen Genet 250:725-733
10. Bak S, Kahn RA, Olsen C-E, Halkier BA 1997 Cloning and expression in Escherichia coli of the obtusifoliol 14α-demethylase of Sorghum bicolor (L.) Moench, a cytochrome P450 orthologous to the sterol 14α-demethylases (CYP51) from fungi and mammals. Plant J 11:191-201
11. Cabello-Hurtado, F. Z, A., Raiher A, Taton M, DeRose R, Nedelkina S, Batard Y, Durst F, Pallett K, Wreck-Reichhart D 1997 Cloning and functional expression in yeast of a cDNA coding for obtusifoliol 14α-demethylase (CYP51) in wheat. Biochem Biophys Res Commun 230:381-385
12. Aoyama Y, Funae Y, Noshiro M, Horiuchi, T Yoshida Y 1994 Occurrence of a P450 showing high homology to yeast lanosterol 14α-demethylase (P45014DM) in the rat liver. Biochem Biophys Res Commun 201:1320-1326
13. Sloane DL, So O-Y, Leung R, Scarafia LE, Saldou N, Jarnagin K, Swinney DC 1995 Cloning and functional expression of the cDNA encoding rat lanosterol 14α demethylase. Gene 161:243-248
14. Strömstedt M, Rozman D, Waterman MR 1996 The ubiquitously expressed human CYP51 encodes lanosterol 14α-demethylase, a cytochrome P450 whose expression is regulated by oxysterols. Arch Biochem Biophys 329:73-81
15. Nelson DR, Koymans L, Kamataki T, Stegeman JJ, Feyereisen R, Waxman DJ, Waterman MR, Gotoh O, Coon MJ, Estabrook RW, Gunsalus IC, Nebert DW 1996 P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics 6:1-42
16. Rozman D, Strömstedt M, Waterman MR 1996 The three human cytochrome P450 lanosterol 14α-demethylase (CYP51) genes reside on chromosomes 3, 7 and 13: structure of the two retrotransposed pseudogenes, association with a LINE-1 element and evolution of the human CYP51 family. Arch Biochem Biophys 333:466-474
17. Rozman D, Strömstedt M, Tsui L-C, Scherer SW, Waterman MR 1996 Structure and mapping of the human lanosterol 14α-demethylase gene (CYP51) encoding the cytochrome P450 involved in cholesterol biosynthesis; comparison of exon/intron organization with other mammalian and fungal CYP genes. Genomics 38:371-381
18. Aoyama Y, Noshiro M, Gotoh O, Imaoka S, Funae Y, Kurosawa N, Horiuchi T, Yoshida Y 1996 Sterol 14α-demethylase P450 (P45014DM) is one of the most ancient and conserved P450 species. J Biochem 119:926-933
19. Vanin EF 1985 Processed pseudogenes: characteristics and evolution. Annu Rev Genet 19:253-272
20. Goldstein JL, Brown MS 1990 Regulation of the mevalonate pathway. Nature 343:425-430
21. Byskov AG, Andersen CY, Nordholm L, Thogersen H, Guoliang X, Wassman O, Guddal JVAE, Roed T 1995 Chemical structure of sterols that activte oocyte meiosis. Nature 374:559-562
22. Øyen O, Mykleburst F, Scott JD, Gadd GG, McKnight GS, Hansson V, Jahnsen T 1990 Subunits of cyclic adenosine 3′,5′-monophosphate-dependent protein kinase show differential and distinct expression patterns during germ cell differentiation: alternative polyadenylation in germ cells gives rise to unique smaller sized mRNA species. Biol Reprod 43:46-54
23. Øyen O, Froysa A, Sandberg M, Eskild W, Joseph D, Hansson V, Jahnsen T 1987 Cellular localization and age-dependent changes in mRNA for cyclic adenosine 3′,5′-monophosphate-dependent protein kinases in rat testis. Biol Reprod 37:947-956
24. Strömstedt M, Warner M, Gustafsson J-Å 1994 Cytochrome P450s of the 4A subfamily in the brain. J Neurochem 63:671-676
25. Taskén K, Skȧlhegg BS, Solberg R, Andersson KB, Taylor SS, Lea T, Blomhoff HK, Jahnsen T, Hansson V 1993 Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RIa-RIb heterodimeric complexes. J Biol Chem 268:21276-21283
26. McKenzie TL, Jiang G, Straubhaar JR, Conrad DG, Schechter I 1992 Molecular cloning, expression, and characterization of the cDNA for the rat hepatic squalene synthase. J Biol Chem 267:21368-21374
27. Sambrook J, Fritsch EF, Maniatis T 1989 Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor
28. Keeney DS, Ikeda Y, Waterman MR, Parker KL 1995 Cholesterol side-chain cleavage cytochrome P450 gene expression in the primitive gut of the mouse embryo does not require steroidogenic factor 1. Mol Endocrinol 9:1091-1098
29. Meistrich ML, Bruce WR, Clermont Y 1973 Cellular composition of fractions of mouse testis following velocity sedimentation separation. Exp Cell Res 79:213-227
30. Leblond CP, Clermont Y 1952 Definition of the stages of the cycle of the seminiferous epithelium in the rat. Ann NY Acad Sci 55:548-573
31. Parvinen M, Vanha-Perttula T 1972 Identification and enzyme quantitation of the stages of the seminiferous epithelial wave in the rat. Anat Rev 174:435-450
32. Parvinen M, Ruokonen A 1982 Endogenous steroids in rat seminiferous tubules. Comparison of the stages of the epithelial cycle isolated by transillumination-assisted microdissection. J Androl 3:211-220
33. Huszar G, Vigue L 1993 Incomplete development of human spermatozoa is associated with increased creatine phosphokinase concentration and abnormal head morphology. Mol Reprod Dev 34:292-298
34. Lalwani S, Sayme N, Vigue L, Corrales M, Huzar G 1996 Biochemical markers of early and late spermatogenesis: relationship between the lactate dehydrogenase-X and creatine kinase-M isoform concentrations in human spermatozoa. Mol Reprod Dev 43:495-502
35. Li S-L, O'Brien DA, Hou EW, Versola J, Rockett DL, Eddy EM 1989 Different activity and synthesys of lactate dehydrogenase isozymes A (muscle), and C (testis) in mouse spermatogenic cells. Biol Reprod 40:173-180
36. Porter JA, Zoung KE, Beachy PA 1996 Cholesterol modification of hedgehog signalling proteins in animal development. Science 274:255-259
37. Silve S, Dupuy PH, Labit-Leboutellier C, Kaghad M, Chalon P, Raiher A, Taton M, Lupker J, Shire D, Loison G 1996 Emopamil-binding protein, a mammalian protein that binds a series of structurally diverse neuroprotective agents, exhibits Δ8-Δ7 sterol isomerase activity. J Biol Chem 37:22434-22440
38. Janowski BA, Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ 1996 An oxysterol signallimg pathway mediated by the nuclear receptor LXRα. Nature 383:728-731
39. Braun RE, Peschon JJ, Behringer RR, Brinster RL 1989 Protamine 3′-untranslated sequences regulate temporal translational control and subcellular localization of growth hormone in spermatids of transgenic mice. Genes Dev 3:793-802
40. Kwon YK, Hecht NB 1991 Cytoplasmic protein binding to highly conserved sequences in the 3′-untranslated region of the mouse protamine 2 mRNA, a translationally regulated transcript of male germ cells. Proc Natl Acad Sci USA 88:3584-3588
41. Teruya JH, Kutsunai DHS, Edwards PA, Clarke CF 1990 Testis-specific transcription initiation sites of rat farnesyl pyrophosphate synthetase mRNA. Mo Cell Biol 10:2315-2326
42. Wahle E 1995 3′-end cleavage and polyadenilation of mRNA precursors. Biochim Biophys Acta 1261:183-194
43. Slaughter GR, Means AR 1989 Analysis of expression of multiple genes encoding calmodulin during spermatogenesis. Mol Endocrinol 3:1569-1578
44. Sherbany AA, Parent AS, Brosius J 1987 Rat calmodulin cDNA. DNA 6:267-272
45. Meijer D, Hermans A, Lindern Mv, Agthoven Tv, Klein Ad, Mackenbach P, Grootegoed A, Talarico D, Valle GD, Grosveld G 1987 Molecular characterization of the testis-specific c-abl mRNA in mouse. EMBO J 6:4041-4048
46. Øyen O, Myklebust F, Scott JD, Hansson V, Jahnsen T 1989 Human testis cDNA for the regulatory subunit RIIα of cAMP-dependent protein kinase encodes an alternate aminoterminal region. FEBS Lett 246:57-64
47. Jahnsen T, Hedin L, Kidd VJ, Beattie WG, Lohmann SM, Walther U, Durica J, Schultz TZ, Schiltz E, Browner M, Goldman D, Ratoosh SL, Richards JS 1986 Molecular cloning, cDNA structure and regulation of the regulatory subunit (RII51) of type II cAMP-dependent protein kinase from rat granulosa cells. J Biol Chem 261:12352-12361
48. Foulkes NS, Schlotter F, Pévet P, Sassone-Corsi P 1993 Pituitary hormone FSH directs the CREM functional swithc during spermatogenesis. Nature 362:264-267
49. Shaw G, Kamen R 1986 A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46:659-667
50. Byskov A-G 1978 Regulation of initiation of meiosis in fetal gonads. Int J Androl [Supp] 2:29-37
51. Parvinen M 1982 Is the spermatogenic cycle regulated by MIS and MPS? Ann NY Acad Sci 383:483-484