Cyclic adenosine 3',5'- Monophosphate(cAMP)/cAMP-responsive element modulator (CREM)-dependent regulation of cholesterogenic lanosterol 14α-demethylase (CYP51) in spermatids

Molecular Endocrinology

Volumn 13, Issue 11, 1999, Pages 1951-1962

  Rozman, Damjana ^a   Fink, Martina ^a   Fimia, Gian Maria ^b   Sassone Corsi, Paolo ^b   Waterman, Michael R ^c  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b CNRS   (France)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; COMPLEMENTARY DNA; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT MODULATOR; CYTOCHROME P450 ISOENZYME; MESSENGER RNA; REGULATOR PROTEIN; SQUALENE SYNTHASE; STEROL; STEROL 14ALPHA DEMETHYLASE; STEROL REGULATORY ELEMENT BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENZYME REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SOMATIC CELL; SPERMATID; TESTIS;

EID: 0033304572     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.13.11.0377     Document Type: Article

References (45)

1. Regulation of the mevalonate pathway
2. Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51). II. Evolutionary analysis of protein and gene structures
3. The ubiquitously expressed human CYP51 encodes lanosterol 14α-demethylase, a cytochrome P450 whose expression is regulated by oxysterols
4. Molecular cloning and mapping of a human cDNA (SC5DL) encoding a protein homologous to fungal sterol-C5-desaturase
5. Purification and characterization of the human SR 31747A-binding protein
6. Molecular cloning and expression of the human delta7-sterol reductase
7. Chemical structure of sterols that activate oocyte meiosis
8. Meiosis-activating sterol promotes resumption of meiosis in mouse oocytes cultured in vitro in contrast to related oxysterols
9. Meiosis-activating sterols: Background, discovery and possible use
10. Elevated expression of lanosterol 14α-demethylase (CYP51) and the synthesis of oocyte meiosis-activating sterols in postmeiotic germ cells of male rats
11. Structural and evolutionary studies on sterol 14α-demethylase P450 (CYP51), the most conserved monooxygenase. I. Structural analyses of the gene and multiple sizes of mRNA
12. Structure and mapping of the human lanosterol 14α-demethylase gene (CYP51) encoding the cytochrome P450 involved in cholesterol biosynthesis; comparison of exon/intron organization with other mammalian and fungal CYP genes
13. Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice
14. Induction of CREM activator proteins in spermatids: Downstream targets and implications for haploid germ cell differentiation
15. Molecular cloning and functional analysis of the promoter of the human squalene synthase gene
16. cAMP-Response element modulator tau is a positive regulator of testis angiotensin converting enzyme transcription
17. Developmental switch of CREM function during spermatogenesis: From antagonist to activator
18. Regulating the balance betwen differentiation and apoptosis
19. Molecular aspects in feedback regulation of gene expression by cholesterol in mammalian cells
20. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-la
21. Specificity in cholesterol regulation of gene expression by coevolution of sterol regulatory DNA element and its binding protein
22. Hormanal control of gene expression: Multiplicity and versatility of cyclic adenosine 3',5'-monophosphate-responsive nuclear regulators
23. More is better: Activators and repressors from the same gene
24. Alternative exon splicing controls translational switch from activator to repressor isoforms of transcription factor CREB during spermatogenesis
25. A role for cAMP-response element motifs in transcriptional regulation of postmeiotic male germ cell-specific genes
26. Transcriptional checkpoints determining the fate of mate germ cells
27. Severe impairment of spermatogenesis in mice lacking the CREM gene
28. Regulation of 'haploid expressed genes' in male germ cells
29. Deoxyribonucleic acid-protein interactions and expression of the human testis-specific lactate dehydrogenase promoter: Transcription factor Sp1 plays a major role
30. Occurrence of a P450 showing high homology to yeast lanosterol 14-demethylase (P45014DM) in the rat liver
31. Preimplantation mouse blastocysts fail to express CYP genes required for estrogene biosynthesis
32. Cellular composition of fractions of mouse testis following velocity sedimentation separation
33. The NCl-H295 cell-line - A pluripotent model for human adrenocortical studies
34. Regulation of type-1 angiotensin-II receptor messenger-ribonucleic-acid expression in human adrenocortical carcinoma H295 cells
35. A one-hour minipreparation technique for extraction of DNA-binding proteins from animal tissues
36. Cooperation by sterol regulatory element-binding protein and Sp1 in sterol regulation of low density lipoprotein receptor gene
37. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells
38. Isoform 1c of sterol regulatory element binding protein is less active that isoform 1a in livers of transgenic mice and culture cells
39. Autoregulation of pit-1 gene expression mediated by two cis-active promoter elements
40. A rapid, sensitive, and inexpensive assay for chloramphenicol acetyltransferase
41. Sterol 14-demethylase P450 activity expressed in rat gonads: Contribution to the formation of mammalian meiosis-activating sterol