Reduced activation of protein kinase B, Rac, and F-actin polymerization contributes to an impairment of stromal cell-derived factor-1-induced migration of CD34+ cells from patients with myelodysplasia

Blood

Volumn 111, Issue 1, 2008, Pages 359-368

  Fuhler, Gwenny M ^a,b   Drayer, A Lyndsay ^c   Olthof, Sandra G M ^a   Schuringa, Jan Jacob ^a,b   Coffer, Paul J ^d   Vellenga, Edo ^a,e  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c Sanquin Bloedbank Regio Nordoost Groningen   (Netherlands)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^e NONE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIBODY; CHEMOATTRACTANT; F ACTIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAC PROTEIN; STROMAL CELL DERIVED FACTOR 1;

ADULT; AGED; ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CELL FUNCTION; CELL LINE; CELL MIGRATION; CELL MOTILITY; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INACTIVATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LENTIVIRINAE; MYELODYSPLASIA; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN POLYMERIZATION; SIGNAL TRANSDUCTION;

EID: 38049144636     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-11-060632     Document Type: Article

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