Aberrancies in signal transduction and cell cycle related events in Alzheimer's disease

Journal of Neural Transmission, Supplement

Volumn , Issue 54, 1998, Pages 147-158

  Arendt, T ^a   Holzer, M ^a   Gartner U ^a   Bruckner M K ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; CYTOSKELETON PROTEIN; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; NEUROTRANSMITTER; ONCOPROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE; PROTEIN P16; PROTEIN P21; PROTEIN TYROSINE KINASE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; PROTEIN KINASE (CALCIUM,CALMODULIN);

AGING; ALZHEIMER DISEASE; CELL CYCLE; CELL LOSS; CELL REGENERATION; HUMAN; NERVE CELL GROWTH; NERVE FIBER GROWTH; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; SYNAPTOGENESIS; ADULT; ANIMAL; DEGENERATIVE DISEASE; GENETICS; METABOLISM; NEURITE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADULT; ALZHEIMER DISEASE; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL CYCLE; HUMANS; NERVE GROWTH FACTORS; NEURITES; NEURODEGENERATIVE DISEASES; NEUROTRANSMITTER AGENTS; SIGNAL TRANSDUCTION;

EID: 0031593598     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-7508-8_14     Document Type: Review

References (82)

1. Ahn NG (1993) The MAP kinase cascade. Discovery of a new signal transduction pathway. Mol Cell Biochem 127/128: 210-209
2. Allen SJ, MacGowan SH, Treanor JJS, Feeney R, Wilcock GK, Dawbarn D (1991) Normal β-NGF content in Alzheimer's disease cerebral cortex and hippocampus. Neurosci Lett 131: 135-139
3. Alvarez J, Moreno RD, Llanos O, Inestrosa NC, Brandan E, Colby C, Esch FS (1992) Axonal sprouting induced in the sciatic nerve by the amyloid precursor protein (APP) and other antiproteases. Neurosci Lett 144: 130-134
4. Arendt Th (1993a) Neuronal dedifferentiation and degeneration in Alzheimer's disease. Biol Chem Hoppe Seyler 374: 911-912
5. Arendt Th (1993b) The cholinergic deafferentation of the cerebral cortex induced by chronic consumption of alcohol - post-mortem and experimental studies. In: Hunt WA, Nixen SJ (eds) Alcohol-induced brain damage. National Institute on Alcohol Abuse and Alcoholism Research Monographs, NIH Publication No. 93-3549, Washington New York, pp 431-460
6. Arendt Th, Brückner MK (1992) Perisomatic sprouts immunoreactive for nerve growth factor receptor and neurofibrillary degeneration affect different neuronal populations in the basal nucleus in patients with Alzheimer's disease. Neurosci Lett 148: 63-66
7. Arendt Th, Zvegintseva HG, Leontovich TA (1986) Dendritic changes in the basal nucleus of Meynert and in the diagonal band nucleus in Alzheimer's disease - a quantitative Golgi investigation. Neuroscience 19: 1265-1278
8. Arendt Th, Brückner MK, Lange M, Bigl V (1992a) Changes in acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease resemble embryonic development - a study of molecular forms. Neurochem Int 21: 381-396
9. Arendt Th, Brückner MK, Pagliusi S (1992b) Reexpression of developmentally regulated proteins in Alzheimer's disease. Eur J Neurosci [Suppl] 5: 18
10. Arendt Th, Brückner MK, Pagliusi S, Krell T (1995) Degeneration of rat cholinergic basal forebrain neurons and reactive changes in NGF expression after chronic neurotoxic injury. I. Degeneration and plastic response of basal forebrain neurons. Neuroscience 65: 633-645
11. Arendt Th, Brückner MK, Krell T, Pagliusi S, Kruska L, Heumann L (1995) Degeneration of rat cholinergic basal forebrain neurons and reactive changes in NGF expression after chronic neurotoxic injury. II. Reactive expression of the NGF gene in astocytes. Neuroscience 65: 647-659
12. Arendt Th, Holzer M, Großmann A, Zedlick D, Brückner MK (1995c) Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease. Neuroscience 68: 5-18
13. Arendt Th, Rödel L, Gärtner U, Holzer M (1996) Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease. NeuroReport 7: 3047-3049
14. Arendt Th, Schindler C, Brückner MK, Eschrich K, Bigl V, Zedlick D, Marcova L (1997) Plastic neuronal remodeling is impaired in patients with Alzheimer's disease carrying apolipoprotein epsilon 4 allele. J Neurosci 17: 516-529
15. Birecree E, Whetsell WO, Stoscheck C, King LE, Nanney LL (1988) Immunoreactive epidermal growth factors in neuritic plaques from patients with Alzheimer's disease. J Neuropathol Exp Neurol 47: 549-560
16. Boulton TG, Yancopoulos GD, Gregory JS, Slaughter C, Moomaw C, Hsu J, Cobb MN (1990) An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control. Science 249: 64-66
17. Boulton TG, Nye SH, Robbins DJ, Ip NY, Radziejewska E, Morgenbesser SD, DePinho RA, Panayotatos N, Cobb MH, Yancopoulos GD (1991) ERKs: a family of protein-serin/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 65: 663-675
18. Bramblett GT, Goedert M, Jakes R, Merrick SE, Trojanowski JQ, Lee VM-Y (1993) Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron 10: 1089-1099
19. Buell SJ, Coleman PD (1979) Dendritic growth in the aged human brain and failure of growth in senile dementia. Science 206: 854-856
20. Buell SJ, Coleman PD (1980) Individual differences in dendritic growth in human aging and senile dementia. In: Stein D (ed) The psychobiology of aging: problems and pespectives. Elsevier, Amsterdam, pp 283-296
21. Buell SJ, Coleman PD (1981) Quantitative evidence for selective dendritic growth in normal human aging but not in senile dementia. Brain Res 214: 23-41
22. Buxbaum JD, Koo EH, Greengard P (1993) Protein phosphorylation inhibits production of Alzheimer amyloid β/A4 peptide. Proc Natl Acad Sci USA 90: 9195-9198
23. Caldas C, Hahn SA, da Costa LT, Redston MS, Schutte M, Seymour AB, Weinstein CL, Hruban RH, Yeo CJ, Kern SE (1994) Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nature Genet 8: 27-32
24. Caporaso GL, Gandy SE, Buxbaum JD, Ramabhadran TV, Greengard P (1992) Protein phosphorylation regulates secretion of Alzheimer β/A4 amyloid precursor protein. Proc Natl Acad Sci USA 89: 3055-3059
25. Chiou J-Y, Westhead EW (1992) Okadaic acid, a protein phosphorylation inhibitor, inhibits nerve growth factor-directed neurite outgrowth in PC12 cells. J Neurochem 59: 1963-1966
26. Chung J, Pelech SL, Blenis J (1991) Mitogen-activated swiss mouse 3T3 RSK kinases I and II are related to p44mpk from sea star oocytes and participate in the regulation of pp90rsk activity. Proc Natl Acad Sci USA 88: 4981-4985
27. Connor JR, Diamond MC, Johnson RE (1980) Occipital cortical morphology of the rat: alterations with age and environment. Exp Neurol 68: 158-170
28. Connor JR, Beban SE, Hopper PA, Hansen B, Diamond MC (1982) A Golgi study of the superficial pyramidal cells of the somatosensory cortex of socially reared old adult rats. Exp Neurol 76: 35-45
29. Cordon-Cardo C (1995) Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am J Pathol 147: 545-560
30. Crutcher KA, Scott SA, Liang S, Everson WV, Weingartner J (1993) Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease. J Neurosci 13: 2540-2550
31. Cupp CJ, Uemura E (1980) Age-related changes in prefrontal cortex of Macaca mulatta: quantitative analysis of dendritic branching patterns. Exp Neurol 69: 143-163
32. Davis RJ (1993) The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 268: 14553-14556
33. Drewes G, Lichtenberg-Kraag B, Döring F, Mandelkow E-M, Biernat J, Goris J, Dorée M, Mandelkow E (1992) Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state. EMBO J 11: 2131-2138
34. Ernfors P, Lindefors N, Chan-Palay V, Persson H (1990) Cholinergic neurons of the nucleus basalis express elevated levels of nerve growth factor receptor mRNA in senile dementia of the Alzheimer type. Dementia 1: 138-145
35. Ferrer I, Guionnet N, Cruz-Sanchez F, Tunon T (1990) Neuronal alterations in patients with dementia: a Golgi study on biopsy samples. Neurosci Lett 114: 11-16
36. Flood DG, Buell SJ, Horwitz GJ, Coleman PD (1987a) Dendritic extent in human dentate gyrus granule cells in normal aging and senile dementia. Brain Res 402: 205-216
37. Fritschy JM, Grzanna R (1992) Restoration of ascending noradrenergic projections by residual locus coeruleus neurons - compensatory response to neurotoxin induced cell death in the adult rat brain. J Comp Neurol 321: 421-441
38. Gärtner U, Holzer M, Heumann R, Arendt Th (1995) Induction of p21ras in Alzheimer pathology. NeuroReport 6: 1313-1316
39. Gärtner U, Holzer M, Arendt Th (1996) Neurofibrillary lesions in Alzheimer's disease are associated with 14-3-3 protein. Biol Chem 377 [Spec Suppl]: S180
40. Geddes JW, Wong J, Choi BH, Kim RC, Cotman CW, Miller FD (1990) Increased expression of the embryonic form of a developmentally-regulated mRNA in Alzheimer's disease. Neurosci Lett 109: 54-61
41. Goedert M, Cohen ES, Jakes R, Cohen Ph (1992) p42 map kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimers disease. FEBS Lett 312: 95-99
42. Goedert M, Jakes R, Crowther RA, Six J, Lübke U, Vandermeeren M, Cras P, Trojanowski JQ, Lee VM-Y (1993) The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development. Proc Natl Acad Sci USA 90: 5066-5070
43. Gomez-Pinilla F, Cummings BJ, Cotman CW (1990) Induction of basic fibroblast growth factor in Alzheimer's disease pathology. NeuroReport 1: 211-214
44. Hall GF, Kosik KS (193) Axotomy-induced neurofilament phosphorylation is inhibited in situ by microinjection of PKA and PKC inhibitors into identified lamprey neurons. Neuron 10: 613-625
45. Harris KA, Oyler GA, Doolittle GM, Vincent I, Lehman RAW, Kincaid RL, Billingsley ML (1993) Okadaic acid induces hyperphosphorylated forms of tau protein in human brain slices. Ann Neurol 33: 77-87
46. Heintz N (1993) Cell-death and the cell-cycle - a relationship between transformation and neurodegeneration. Trends Biochem Sci 18: 157-159
47. Hellweg R, Fischer W, Hock C, Gage FH, Björklund A, Thoenen H (1990) Nerve growth factor levels and choline acetyltransferase activity in the brain of aged rats with spatial memory impairments. Brain Res 537: 123-130
48. Heumann R (1994) Neurotrophin signalling. Curr Opin Neurobiol 4: 668-679
49. Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian SV, Stockert E, Day RS-3rd, Johnson BE, Skolnick MH (1994) A cell cycle regulator potentially involved in genesis of many tumor types. Science 264: 436-440
50. Kanemaru K, Takio K, Miura R, Titani K, Ihara Y (1992) Fetal-type phosphorylation of the tau in paired helical filaments. J Neurochem 58: 1667-1675
51. Kato T, Sasaki H, Katagiri T, Sasaki H, Koiwai K, Youki H, Totsuka S, Ishii T (1991) The binding of fibroblast growth factor to Alzheimer's neurofibrillary tangles and senile plaques. Neurosci Lett 122: 33-36
52. Kobayashi S, Ishiguro K, Omori A, Takamatsu M, Arioka M, Imahori K, Uchida T (1993) A cdc2-related kinase PSSALRE/cdk5 is homologous with the 30kDa subunit of tau protein kinase II, a proline-directed protein kinase associated with microtubule. FEBS Lett 335: 171-175
53. Kranenburg O, Vandereb A, Zantema A (1996) Cyclin D1 is an essential mediator of apoptotic neuronal cell death. EMBO J 15: 46-54
54. Lapchak PA, Jenden DJ, Hefti F (1991) Compensatory elevation of acetylcholine synthesis in vivo by cholinergic neurons surviving partial lesions of the septohippocampal pathway. J Neurosci 11: 2821-2828
55. Ledesma MD, Correas I, Avila J, Diaznido J (1992) Implication of brain Cdc2 and Map2 kinases in the phosphorylation of tau protein in Alzheimers disease. FEBS Lett 308: 218-224
56. Lin L-L, Wartmann M, Lin A, Knopf JL, Seth A, Davis RJ (1993) cPLA2 is phosphorylated and activated by MAP kinase. Cell 72: 269-278
57. Lippa CF, Hamos JE, Pulaskisalo D, Degennaro LJ, Drachmann DA (1992) Alzheimer's disease and aging - effects of perforant pathway perikarya and synapse. Neurobiol Aging 13: 405-411
58. McKee AC, Kowall NW, Kosik KS (1989) Microtubular reorganization and dendritic growth response in Alzheimer's disease. Ann Neurol 26: 652-659
59. Meakin SO, Shooter EM (1992) The nerve growth factor family of receptors. Trends Neurosci 15: 323-331
60. Milward EA, Papadopoulos R, Fuller SJ, Moir RD, Small D, Beyreuther K, Masters CL (1992) The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron 9: 129-137
61. Morishima-Kawashima M, Arai T, Ogawara M, Takio K, Titani K, Saitoh T, Kosik KS, Ihara Y (1991) A possible fetal antigen of MR-70,000 in neurofibrillary tangles. Brain Res 554: 316-320
62. Morrison D (1994) 14-3-3: modulators of signaling proteins? Science 266: 56-57
63. Mufson EJ, Kordower JH (1992) Cortical neurons express nerve growth factor receptors in advanced age and Alzheimer's disease. Proc Natl Acad Sci USA 89: 569-573
64. Nishida E, Gotoh Y (1993) The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem Sci 18: 128-131
65. Pelech SL, Sanghera JS (1992) MAP kinases: charting the regulatory pathways. Science 257: 1355-1356
66. Perry VH, Linden R (1982) Evidence for dendritic competition in the developing retina. Nature 297: 683-685
67. Phillips LL, Belardo ET (1994) Increase of c-fos and ras oncoproteins in the denervated neuropil of the rat dentate gyrus. Neuroscience 58: 503-514
68. Pulverer B, Kyriakis J, Avruch J, Nikolakaki E, Woodgett J (1991) Phosphorylation of c-jun mediated by MAP kinases. Nature 353: 670-674
69. Ramirez V, Ulfhake B (1992) Anatomy of dendrites in motoneurons supplying the intrinsic muscles of the foot sole in the aged cat - evidence for dendritic growth and neo-synaptogenesis. J Comp Neurol 316: 1-16
70. Scheff SW, DeKosky ST, Price DA (1990) Quantitative assessment of cortical synaptic density in Alzheimer's disease. Neurobiol Aging 11: 29-37
71. Schubert D, Cole G, Saitoh T, Oltersdorf T (1989a) Amyloid beta protein precursor is a mitogen. Biochem Biophys Res Commun 162: 83-88
72. Serrano M, Hannon GJ, Beach-D (1993) A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366: 704-707
73. Shimizu K, Birnbaum D, Ruley MA, Fasano O, Suard Y, Edlund L, Taparowsky E, Goldfarb M, Wigler M (1983) Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1. Nature 304: 497-500
74. Standler NA, Bernstein JJ (1982) Degeneration and regeneration of motoneuron dendrites after ventral root crush: computer reconstruction of dendritic fields. Exp Neurol 75: 600-615
75. Stokoe D, MacDonald SG, Cadwallader K, Symons M, Hancock JF (1994) Activation of Raf as a result of recruitment to the plasma membrane. Science 264: 1463-1467
76. Stopa EG, Gonzalez AM, Chorsky R, Corona RJ, Alvarez J, Bird ED, Baird A (1990) Basic fibroblast growth factor in Alzheimer's disease. Biochem Biophys Res Commun 171: 690-696
77. Styren SD, Mufson EJ, Styren GC, Civin WH, Rogers J (1990) Epidermal growth factor receptor expression in demented and aged human brain. Brain Res 512: 347-352
78. Sumner BEH, Watson, WE (1971) Retraction and expansion of the dendritic tree of motor neurones of adult rats induced in vivo. Nature 233: 273-275
79. Suzuki T, Oishi M, Marshak DR, Czernik AJ, Nairn AC, Greengard P (1994) Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein. EMBO J 13: 1114-1122
80. Uemura E (1985) Age-related changes in the subiculum of Macaca mulatta: dendritic branching pattern. Exp Neurol 87: 412-427
81. Vandermeeren M, Lübke U, Six J, Cras P (1993) The phosphatase inhibitor okadaic acid induces a phosphorylated paired helical filament tau epitope in human LA-N-5 neuroblastoma cells. Neurosci Lett 153: 57-60
82. Wolozin B, Scicutella A, Davies P (1988) Reexpression of a developmentally regulated antigen in Down syndrom and Alzheimer disease. Proc Natl Acad Sci 85: 6202-6206