Aβ42-peptide assembly on lipid bilayers

Journal of Molecular Biology

Volumn 318, Issue 1, 2002, Pages 97-107

  Yip, Christopher M ^a   Darabie, Audrey A ^b   McLaurin, JoAnne ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Ab peptides; Alzheimer's disease; Electron microscopy and atomic force microscopy; Fluorescence anisotropy; Membrane

Indexed keywords

AMYLOID BETA PROTEIN; PEPTIDE; BETA CYCLODEXTRIN DERIVATIVE; CHOLESTEROL; CYCLODEXTRIN; METHYL BETA CYCLODEXTRIN; METHYL-BETA-CYCLODEXTRIN; PEPTIDE FRAGMENT;

ALZHEIMER DISEASE; ARTICLE; ATOMIC FORCE MICROSCOPY; CELL MEMBRANE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FLUOROMETRY; HUMAN; HYPOTHESIS; LIPID BILAYER; LIPID BRAIN LEVEL; PATHOLOGY; PRIORITY JOURNAL; PROTEIN INTERACTION; SENILE PLAQUE; SPECTROFLUOROMETRY; BIOSYNTHESIS; BRAIN LEVEL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; ELECTRON MICROSCOPY; FIBER; FLUORESCENCE POLARIZATION; ISOLATION AND PURIFICATION; MEMBRANE FLUIDITY; METABOLISM; SCANNING PROBE MICROSCOPY; SOLUBILITY; TIME; ULTRASTRUCTURE;

AMYLOID BETA-PROTEIN; BETA-CYCLODEXTRINS; BRAIN CHEMISTRY; CHOLESTEROL; CYCLODEXTRINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENCE POLARIZATION; LIPID BILAYERS; MEMBRANE FLUIDITY; MICROFIBRILS; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, ELECTRON; MICROSCOPY, SCANNING PROBE; PEPTIDE FRAGMENTS; SOLUBILITY; SPECTROMETRY, FLUORESCENCE; TIME FACTORS;

EID: 0036019210     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)00028-1     Document Type: Article

References (54)

1. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants
2. Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation
3. Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease
4. Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43)
5. Amyloid beta protein (Abeta) deposition: Abeta 42(43) precedes Abeta 40 in Down syndrome
6. Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome
7. Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: Predominance of Abeta 42(43)
8. The length of amyloid-beta in hereditary cerebral hemorrhage with amyloidosis, Dutch type. Implications for the role of amyloid-beta 1-42 in Alzheimer's disease
9. Enhancement of amyloid β42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease
10. Diffusible, nonfibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins
11. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
12. Delayed behavioral effects following intrahippo-campal injection of aggregated Aβ1-42
13. Protective effects of idebenone and α-tocopherol on β-amyloid (1-42) induced learning and memory deficits in rats: Implication of oxidative stress in β-amyloid-induced neurotoxicity in vivo
14. Amyloid β protein (Aβ) starts to deposit as plasma membrane-bound form in diffuse plaques of brains from hereditary cerebral hemorrhage with amyloidosis-Dutch type, Alzheimer disease and nondemented aged subjects
15. β-Amyloid (Aβ)42(43), Aβ42, Aβ40 and apoE immunostaining of plaques in fatal head injury
16. Cholesterol-dependent generation of a seeding amyloid β-protein in cell culture
17. Cholesterol modulates the membrane-disordering effects of beta-amyloid peptides in the hippocampus: Specific changes in Alzheimer's disease
18. Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Aβ1-42 pathogenesis
19. Trifluoroacetic acid pre-treatment reproducibly disaggregates the amyloid beta-peptide
20. Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, Aβ1-42, in differentiated PC12 cells
21. Membrane disruption by Alzheimer beta-amyloid peptides mediated through specific binding to either phospholipids or gangliosides. Implications for neuro-toxicity
22. Structural transitions associated with the interaction of Alzheimer beta-amyloid peptides with gangliosides
23. Solution structures of beta peptide and its constituent fragments: Relation to amyloid deposition
24. Imaging material properties by resonant tapping-force microscopy: A model investigation
25. Allogenic stimulation of cytotoxic T cells by supported planar membranes
26. From liposomes to supported, planar bilayer structures on hydrophilic and hydrophobic surfaces: An atomic force microscopy study
27. Architecture and function of membrane proteins in planar supported bilayers: A study with photosynthetic reaction centres
28. Physical properties of single phospholipid bilayers adsorbed to micro glass beads. A new vesicular model system studied by 2H-nuclear magnetic resonance
29. In situ atomic force microscopy study of Alzheimer's beta-amyloid peptide on different substrates: New insights into mechanism of beta-sheet formation
30. Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease
31. An ultrastructural study of amyloid intermediates in Aβ42 fibrillogenesis
32. Amyloid and lipids in the pathology of Alzheimer disease
33. Induction of Alzheimer-like β-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol
34. Cholesterol as a modulator of receptor function
35. Cellular cholesterol efflux mediated by cyclodextrins
36. An animal virus-derived peptide switches membrane morphology: Possible relevance to nodaviral transfection processes
37. Gramicidin A aggregation in supported gel state phosphatidylcholine bilayers
38. 2H NMR and ESR study using designed trans-membrane α-helical peptides and gramicidin A
39. Physical state of bulk and protein-associated lipid in nicotinic acetlycholine receptor-rich membrane studied by Laurdan generalized polarization and fluorescence energy transfer
40. Quantitation of lipid phases in phospholipid vesicles by the generalized polarization of Laurdan fluorescence
41. Assembly of Aβ amyloid protofibrils: An in vitro model for a possible early event in Alzheimer's disease
42. Accelerated accumulation of amyloid-β proteins on oxidatively damaged lipid membranes
43. Amyloid β-protein (Aβ) 1-40 but not Aβ1-42 contributes to the experimental formation of Alzheimer disease amyloid fibrils in rat brain
44. Ultrastructural evidence of early non-fibrillar Aβ42 in the capillary basement membrane of patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type
45. Amyloid β protein 1-42/43 (Aβ1-42/43) in cerebellar diffuse plaques: Enzyme linked immunosorbent assay and immunocytochemical study
46. Amyloid β protein deposition in normal aging has the same characteristics as that in Alzheimer's disease
47. Molecular modeling of the Aβ1-42 peptide from Alzheimer's disease
48. Modulation of secreted β-amyloid precursor protein and amyloid β-peptide in brain by cholesterol
49. Visualization of highly ordered striated domains induced by transmembrane peptides in supported phosphatidylcholine bilayers
50. Alcohol induction of interdigitation in distearoylphosphatidyl-choline: Fluorescence studies of alcohol chain length requirements
51. Induction of nonbilayer structures in diacylphosphatidylcholine model membranes by transmembrane α-helical peptides: Importance of hydrophobic mismatch and proposed role of tryptophans
52. Amyloid-β peptide assembly: A critical step in fibrillogenesis and membrane disruption
53. Lipid structural order parameters (reciprocal of fluidity) in biomembranes derived from steady-state fluorescence polarization measurements
54. Correlation of α-amyloid aggregate size and hydrophobicity with decreased bilayer fluidity of model membranes