Partial blockage of sterol biosynthesis with a squalene synthase inhibitor in early postnatal Niemann-Pick type C npcnih null mice brains reduces neuronal cholesterol accumulation, abrogates astrogliosis, but may inhibit myelin maturation

Journal of Neuroscience Methods

Volumn 168, Issue 1, 2008, Pages 15-25

  Reid, Patrick C ^a   Lin, Song ^a   Vanier, Marie T ^b   Ohno Iwashita, Yoshiko ^c   Harwood Jr , H James ^d   Hickey, William F ^a   Chang, Catherine C Y ^a   Chang, Ta Yuan ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b INSERM   (France)

^c TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^d PFIZER INC   (United States)

Author keywords

Late endosomes lysosomes; Lipid trafficking; Neurodegenerative disease; Squalene synthase inhibitor; Sterol synthesis in brain

Indexed keywords

CHOLESTEROL; CP 340868; GANGLIOSIDE GM3; MEVINOLIN; MYELIN; SQUALENE SYNTHASE; SQUALENE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DRUG MECHANISM; GENE; GENE MUTATION; LIPID METABOLISM; MOUSE; MYELINATION; NEUROPATHOLOGY; NIEMANN PICK DISEASE; NONHUMAN; NPC1 GENE; NPC2 GENE; PERINATAL PERIOD; PRIORITY JOURNAL;

ACETATES; ANIMALS; ANIMALS, NEWBORN; BRAIN; CHOLESTEROL; ENZYME INHIBITORS; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; FATTY ACIDS; GANGLIOSIDES; LIVER; LOVASTATIN; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; NEURONS; PROTEINS; STEROLS; TIME FACTORS; TRITIUM;

EID: 38049049792     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2007.09.002     Document Type: Article

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