메뉴 건너뛰기




Volumn 26, Issue 5, 2008, Pages 677-685

Immunization with the cysteine proteinase Ldccys1 gene from Leishmania (Leishmania) chagasi and the recombinant Ldccys1 protein elicits protective immune responses in a murine model of visceral leishmaniasis

Author keywords

Cysteine proteinase; Leishmania (Leishmania) chagasi; Visceral leishmaniasis

Indexed keywords

BCG VACCINE; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE LDCCYS1; GAMMA INTERFERON; LEISHMANIA VACCINE; NITRIC OXIDE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

EID: 37849026965     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2007.11.044     Document Type: Article
Times cited : (30)

References (66)
  • 2
    • 37849035065 scopus 로고    scopus 로고
    • World Health Organization. Leishmaniasis. Fourteenth Program Report. UNDP/World Bank/Special Program for Research and Training in Tropical Diseases (TDR). Tropical Disease Research Progress 1997-1998. Geneva: World Health Organization; 1999, p. 1-6.
  • 3
    • 0030114502 scopus 로고    scopus 로고
    • The reemergence of visceral leishmaniasis in Brazil
    • Arias J.R., Monteiro P.S., and Zicker F. The reemergence of visceral leishmaniasis in Brazil. Emerg Infect Dis 2 (1996) 145-146
    • (1996) Emerg Infect Dis , vol.2 , pp. 145-146
    • Arias, J.R.1    Monteiro, P.S.2    Zicker, F.3
  • 5
    • 0026585442 scopus 로고
    • Immunologic markers of clinical evolution in children recently infected with Leishmania donovani chagasi
    • Carvalho E.M., Barral A., Pedral-Sampaio D., Barral-Netto M., Badaró R., Rocha H., et al. Immunologic markers of clinical evolution in children recently infected with Leishmania donovani chagasi. J Infect Dis 165 (1992) 535-540
    • (1992) J Infect Dis , vol.165 , pp. 535-540
    • Carvalho, E.M.1    Barral, A.2    Pedral-Sampaio, D.3    Barral-Netto, M.4    Badaró, R.5    Rocha, H.6
  • 6
    • 0025752328 scopus 로고
    • Differential production of Th1- and Th2-derived cytokines does not determine the genetically controlled or vaccine-induced rate of cure in murine visceral leishmaniasis
    • Kaye P.M., Curry A.J., and Blackwell J.M. Differential production of Th1- and Th2-derived cytokines does not determine the genetically controlled or vaccine-induced rate of cure in murine visceral leishmaniasis. J Immunol 146 (1991) 2763-2770
    • (1991) J Immunol , vol.146 , pp. 2763-2770
    • Kaye, P.M.1    Curry, A.J.2    Blackwell, J.M.3
  • 7
    • 0025266647 scopus 로고
    • Effect of continuous administration of interferon-γ in experimental visceral leishmaniasis
    • Murray H.W. Effect of continuous administration of interferon-γ in experimental visceral leishmaniasis. J Infect Dis 161 (1990) 992-994
    • (1990) J Infect Dis , vol.161 , pp. 992-994
    • Murray, H.W.1
  • 8
    • 0023145125 scopus 로고
    • Experimental visceral leishmaniasis: production of interleukin 2 and interferon-γ, tissue immune reaction, and response to treatment with interleukin 2 and interferon-γ
    • Murray H.W., Stern J.J., Welte K., Rubin B.Y., Carriero S.M., and Nathan C.F. Experimental visceral leishmaniasis: production of interleukin 2 and interferon-γ, tissue immune reaction, and response to treatment with interleukin 2 and interferon-γ. J Immunol 138 (1987) 2290-2297
    • (1987) J Immunol , vol.138 , pp. 2290-2297
    • Murray, H.W.1    Stern, J.J.2    Welte, K.3    Rubin, B.Y.4    Carriero, S.M.5    Nathan, C.F.6
  • 9
    • 0024805717 scopus 로고
    • Experimental visceral leishmaniasis: role of endogenous IFN-γ in host defense and tissue granulomatous response
    • Squires K.E., Schreiber R.D., McElraith M.J., Rubin B.Y., Anderson S.L., and Murray H.W. Experimental visceral leishmaniasis: role of endogenous IFN-γ in host defense and tissue granulomatous response. J Immunol 143 (1989) 4244-4249
    • (1989) J Immunol , vol.143 , pp. 4244-4249
    • Squires, K.E.1    Schreiber, R.D.2    McElraith, M.J.3    Rubin, B.Y.4    Anderson, S.L.5    Murray, H.W.6
  • 10
    • 0028952707 scopus 로고
    • A recombinant Leishmania chagasi antigen that stimulates cellular immune responses in infected mice
    • Wilson M.E., Young B.M., Andersen K.P., Weinstock J.V., Metwali A., Ali K.M., et al. A recombinant Leishmania chagasi antigen that stimulates cellular immune responses in infected mice. Infect Immun 63 (1995) 2062-2069
    • (1995) Infect Immun , vol.63 , pp. 2062-2069
    • Wilson, M.E.1    Young, B.M.2    Andersen, K.P.3    Weinstock, J.V.4    Metwali, A.5    Ali, K.M.6
  • 11
    • 0034668153 scopus 로고    scopus 로고
    • Immunization with recombinant LD1 antigens protects against experimental leishmaniasis
    • Dole V.S., Raj V.S., Ghosh A., Madhubala R., Myler P.J., and Stuart K.D. Immunization with recombinant LD1 antigens protects against experimental leishmaniasis. Vaccine 19 (2001) 423-430
    • (2001) Vaccine , vol.19 , pp. 423-430
    • Dole, V.S.1    Raj, V.S.2    Ghosh, A.3    Madhubala, R.4    Myler, P.J.5    Stuart, K.D.6
  • 12
    • 0025008836 scopus 로고
    • Characterization of two proteins from Leishmania donovani and their use for vaccination against visceral leishmaniasis
    • Jaffe C.L., Rachamim N., and Sarfstein R. Characterization of two proteins from Leishmania donovani and their use for vaccination against visceral leishmaniasis. J Immunol 144 (1990) 699-706
    • (1990) J Immunol , vol.144 , pp. 699-706
    • Jaffe, C.L.1    Rachamim, N.2    Sarfstein, R.3
  • 13
    • 0025721114 scopus 로고
    • The Leishmania donovani lipophosphoglycan T lymphocyte-reactive component is a tightly associated protein complex
    • Jardim A., Tolson D.L., Turco S.J., Pearson T.W., and Olafson R.W. The Leishmania donovani lipophosphoglycan T lymphocyte-reactive component is a tightly associated protein complex. J Immunol 147 (1991) 3538-3544
    • (1991) J Immunol , vol.147 , pp. 3538-3544
    • Jardim, A.1    Tolson, D.L.2    Turco, S.J.3    Pearson, T.W.4    Olafson, R.W.5
  • 14
    • 0028380624 scopus 로고
    • Experimental murine Leishmania donovani infection: immunoprotection by the fucose-mannose ligand (FML)
    • Palatnik-de-Sousa C.B., Paraguai-de-Souza E., Gomes E.M., and Borojevic R. Experimental murine Leishmania donovani infection: immunoprotection by the fucose-mannose ligand (FML). Braz J Med Biol Res 27 (1994) 547-551
    • (1994) Braz J Med Biol Res , vol.27 , pp. 547-551
    • Palatnik-de-Sousa, C.B.1    Paraguai-de-Souza, E.2    Gomes, E.M.3    Borojevic, R.4
  • 15
    • 0035971970 scopus 로고    scopus 로고
    • Vaccination of BALB/c mice against experimental visceral leishmaniasis with the GP36 glycoprotein antigen of Leishmania donovani
    • Paraguai de Souza E., Bernardo R.R., Palatnik M., and Palatnik de Sousa C.B. Vaccination of BALB/c mice against experimental visceral leishmaniasis with the GP36 glycoprotein antigen of Leishmania donovani. Vaccine 19 (2001) 3104-3115
    • (2001) Vaccine , vol.19 , pp. 3104-3115
    • Paraguai de Souza, E.1    Bernardo, R.R.2    Palatnik, M.3    Palatnik de Sousa, C.B.4
  • 17
    • 0032403592 scopus 로고    scopus 로고
    • LeIF: a recombinant Leishmania protein that induces an IL-12-mediated Th1 cytokine profile
    • Skeiky Y.A.W., Kennedy M., Kaufman D., Borges M.M., Guderian J.A., Scholler J.K., et al. LeIF: a recombinant Leishmania protein that induces an IL-12-mediated Th1 cytokine profile. J Immunol 161 (1998) 6171-6179
    • (1998) J Immunol , vol.161 , pp. 6171-6179
    • Skeiky, Y.A.W.1    Kennedy, M.2    Kaufman, D.3    Borges, M.M.4    Guderian, J.A.5    Scholler, J.K.6
  • 18
    • 0034671822 scopus 로고    scopus 로고
    • Immunization with a recombinant stage-regulated surface protein from Leishmania donovani induces protection against visceral leishmaniasis
    • Stäger S., Smith D.F., and Kaye P.M. Immunization with a recombinant stage-regulated surface protein from Leishmania donovani induces protection against visceral leishmaniasis. J Immunol 165 (2000) 7064-7071
    • (2000) J Immunol , vol.165 , pp. 7064-7071
    • Stäger, S.1    Smith, D.F.2    Kaye, P.M.3
  • 19
    • 0033959560 scopus 로고    scopus 로고
    • BCG expressing LCR1 of Leishmania chagasi induces protective immunity in susceptible mice
    • Streit J.A., Recker T.J., Donelson J.E., and Wilson M.E. BCG expressing LCR1 of Leishmania chagasi induces protective immunity in susceptible mice. Exp Parasitol 94 (2000) 33-41
    • (2000) Exp Parasitol , vol.94 , pp. 33-41
    • Streit, J.A.1    Recker, T.J.2    Donelson, J.E.3    Wilson, M.E.4
  • 20
    • 0031757985 scopus 로고    scopus 로고
    • Vaccine requirements for sustained cellular immunity to an intracellular parasitic infection
    • Gurunathan S., Prussin C., Sacks D.L., and Seder R.A. Vaccine requirements for sustained cellular immunity to an intracellular parasitic infection. Nat Med 4 (1998) 1409-1415
    • (1998) Nat Med , vol.4 , pp. 1409-1415
    • Gurunathan, S.1    Prussin, C.2    Sacks, D.L.3    Seder, R.A.4
  • 21
    • 0030822043 scopus 로고    scopus 로고
    • Vaccination with DNA encoding the immunodominat LACK parasite antigen confers protective immunity to mice infected with Leishmania major
    • Gurunathan S., Sacks D.L., Brown D.R., Reiner S.L., Charest H., Glaichenhaus N., et al. Vaccination with DNA encoding the immunodominat LACK parasite antigen confers protective immunity to mice infected with Leishmania major. J Exp Med 186 (1997) 1137-1147
    • (1997) J Exp Med , vol.186 , pp. 1137-1147
    • Gurunathan, S.1    Sacks, D.L.2    Brown, D.R.3    Reiner, S.L.4    Charest, H.5    Glaichenhaus, N.6
  • 22
    • 0032388140 scopus 로고    scopus 로고
    • Vaccination with recombinant parasitic surface antigen 2 from Leishmania major induces a Th1 type of immune response but does not protect against infection
    • Sjolander A., Baldwin T.M., Curtis J.M., Bengtsson K.L., and Handman E. Vaccination with recombinant parasitic surface antigen 2 from Leishmania major induces a Th1 type of immune response but does not protect against infection. Vaccine 16 (1998) 2077-2084
    • (1998) Vaccine , vol.16 , pp. 2077-2084
    • Sjolander, A.1    Baldwin, T.M.2    Curtis, J.M.3    Bengtsson, K.L.4    Handman, E.5
  • 23
    • 0032171035 scopus 로고    scopus 로고
    • Genetic immunization with glycoprotein 63 cDNA results in a helper T cell type 1 immune response and protection in a murine model of leishmaniasis
    • Walker P.S., Scharton-Kersten T., Rowton E.D., Hengge U., Bouloc A., Udey M.C., et al. Genetic immunization with glycoprotein 63 cDNA results in a helper T cell type 1 immune response and protection in a murine model of leishmaniasis. Hum Gene Ther 9 (1998) 1899-1907
    • (1998) Hum Gene Ther , vol.9 , pp. 1899-1907
    • Walker, P.S.1    Scharton-Kersten, T.2    Rowton, E.D.3    Hengge, U.4    Bouloc, A.5    Udey, M.C.6
  • 24
    • 0028957929 scopus 로고
    • Protection against leishmaniasis by injection of DNA encoding a major surface glycoprotein, gp63, of L. major
    • Xu D., and Liew F.Y. Protection against leishmaniasis by injection of DNA encoding a major surface glycoprotein, gp63, of L. major. Immunology 84 (1995) 173-176
    • (1995) Immunology , vol.84 , pp. 173-176
    • Xu, D.1    Liew, F.Y.2
  • 25
    • 0037081386 scopus 로고    scopus 로고
    • A heterologous prime-boost regime using DNA and recombinant vaccinia virus expressing the Leishmania infantum P36/LACK antigen protects BALB/c mice from cutaneous leishmaniasis
    • Gonzalo R.M., Real G., Rodríguez J.R., Rodríguez D., Heljasvaara R., Lucas P., et al. A heterologous prime-boost regime using DNA and recombinant vaccinia virus expressing the Leishmania infantum P36/LACK antigen protects BALB/c mice from cutaneous leishmaniasis. Vaccine 20 (2002) 1226-1231
    • (2002) Vaccine , vol.20 , pp. 1226-1231
    • Gonzalo, R.M.1    Real, G.2    Rodríguez, J.R.3    Rodríguez, D.4    Heljasvaara, R.5    Lucas, P.6
  • 26
    • 3342965738 scopus 로고    scopus 로고
    • DNA-Salmonella enterica serovar Typhimurium primer-booster vaccination biases towards T helper 1 responses and enhances protection against Leishmania major infection in mice
    • Lange U.G., Mastroeni P., Blackwell J.M., and Stober C.B. DNA-Salmonella enterica serovar Typhimurium primer-booster vaccination biases towards T helper 1 responses and enhances protection against Leishmania major infection in mice. Infect Immun 72 (2004) 4924-4928
    • (2004) Infect Immun , vol.72 , pp. 4924-4928
    • Lange, U.G.1    Mastroeni, P.2    Blackwell, J.M.3    Stober, C.B.4
  • 27
    • 20444402610 scopus 로고    scopus 로고
    • A heterologous prime-boost vaccination regimen using ORFF DNA and recombinant ORFF protein confers protective immunity against experimental visceral leishmaniasis
    • Tewary P., Jain M., Sahani M.H., Saxena S., and Madhubala R. A heterologous prime-boost vaccination regimen using ORFF DNA and recombinant ORFF protein confers protective immunity against experimental visceral leishmaniasis. J Infect Dis 191 (2005) 2130-2137
    • (2005) J Infect Dis , vol.191 , pp. 2130-2137
    • Tewary, P.1    Jain, M.2    Sahani, M.H.3    Saxena, S.4    Madhubala, R.5
  • 28
    • 0030915007 scopus 로고    scopus 로고
    • Characterization of an antigen from Leishmania amazonensis amastigotes able to elicit protective responses in a murine model
    • Beyrodt C.G.P., Pinto A.R., Freymüller E., and Barbiéri C.L. Characterization of an antigen from Leishmania amazonensis amastigotes able to elicit protective responses in a murine model. Infect Immun 65 (1997) 2052-2059
    • (1997) Infect Immun , vol.65 , pp. 2052-2059
    • Beyrodt, C.G.P.1    Pinto, A.R.2    Freymüller, E.3    Barbiéri, C.L.4
  • 29
    • 0034655633 scopus 로고    scopus 로고
    • Identification of a 30 kDa antigen from Leishmania (L.) chagasi amastigotes implicated in protective cellular responses in a murine model
    • Pinto A.R., Beyrodt C.G.P., Lopes R.A., and Barbiéri C.L. Identification of a 30 kDa antigen from Leishmania (L.) chagasi amastigotes implicated in protective cellular responses in a murine model. Int J Parasitol 30 (2000) 599-607
    • (2000) Int J Parasitol , vol.30 , pp. 599-607
    • Pinto, A.R.1    Beyrodt, C.G.P.2    Lopes, R.A.3    Barbiéri, C.L.4
  • 30
    • 0035858106 scopus 로고    scopus 로고
    • A protective cocktail vaccine against murine cutaneous leishmaniasis with DNA encoding cysteine proteinases of Leishmania major
    • Rafati S., Salmanian A.H., Taheri T., Vafa M., and Fasel N. A protective cocktail vaccine against murine cutaneous leishmaniasis with DNA encoding cysteine proteinases of Leishmania major. Vaccine 19 (2001) 3369-3375
    • (2001) Vaccine , vol.19 , pp. 3369-3375
    • Rafati, S.1    Salmanian, A.H.2    Taheri, T.3    Vafa, M.4    Fasel, N.5
  • 31
    • 32844459122 scopus 로고    scopus 로고
    • Prime-boost vaccination using cysteine proteinases type I and II of Leishmania infantum confers protective immunity in murine visceral leishmaniasis
    • Rafati S., Zahedifard F., and Nazgouee F. Prime-boost vaccination using cysteine proteinases type I and II of Leishmania infantum confers protective immunity in murine visceral leishmaniasis. Vaccine 24 (2006) 2169-2175
    • (2006) Vaccine , vol.24 , pp. 2169-2175
    • Rafati, S.1    Zahedifard, F.2    Nazgouee, F.3
  • 32
    • 21044441505 scopus 로고    scopus 로고
    • Protective vaccination against experimental canine visceral leishmaniasis using a combination of DNA and protein immunization with cysteine proteinase type I and II of L. infantum
    • Rafati S., Nakhaee A., Taheri T., Taslimi Y., Darabi H., Eravani D., et al. Protective vaccination against experimental canine visceral leishmaniasis using a combination of DNA and protein immunization with cysteine proteinase type I and II of L. infantum. Vaccine 23 (2005) 3716-3725
    • (2005) Vaccine , vol.23 , pp. 3716-3725
    • Rafati, S.1    Nakhaee, A.2    Taheri, T.3    Taslimi, Y.4    Darabi, H.5    Eravani, D.6
  • 33
    • 19744368943 scopus 로고    scopus 로고
    • Recombinant cysteine proteinase from Leishmania (Leishmania) chagasi implicated in human and dog T-cell responses
    • Pinheiro P.H.C., Dias S.S., Eulálio K.D., Mendonça I.L., Katz S., and Barbieri C.L. Recombinant cysteine proteinase from Leishmania (Leishmania) chagasi implicated in human and dog T-cell responses. Infect Immun 73 (2005) 3787-3789
    • (2005) Infect Immun , vol.73 , pp. 3787-3789
    • Pinheiro, P.H.C.1    Dias, S.S.2    Eulálio, K.D.3    Mendonça, I.L.4    Katz, S.5    Barbieri, C.L.6
  • 34
    • 15844425097 scopus 로고    scopus 로고
    • A recombinant cysteine proteinase from Leishmania (Leishmania) chagasi suitable for serodiagnosis of American visceral leishmaniasis
    • Dias S.S., Pinheiro P.H.C., Katz S., Santos M.R.M., and Barbieri C.L. A recombinant cysteine proteinase from Leishmania (Leishmania) chagasi suitable for serodiagnosis of American visceral leishmaniasis. Am J Trop Med Hyg 72 (2005) 126-132
    • (2005) Am J Trop Med Hyg , vol.72 , pp. 126-132
    • Dias, S.S.1    Pinheiro, P.H.C.2    Katz, S.3    Santos, M.R.M.4    Barbieri, C.L.5
  • 35
    • 0025003070 scopus 로고
    • Lysosomal depletion in macrophages from spleen and foot lesions of Leishmania-infected hamster
    • Barbiéri C.L., Doine A.I., and Freymüller E. Lysosomal depletion in macrophages from spleen and foot lesions of Leishmania-infected hamster. Exp Parasitol 71 (1990) 218-228
    • (1990) Exp Parasitol , vol.71 , pp. 218-228
    • Barbiéri, C.L.1    Doine, A.I.2    Freymüller, E.3
  • 37
    • 0029149252 scopus 로고
    • Culture microtitration: a sensitive method for quantifying Leishmania infantum in tissues of infected mice
    • Buffet P.A., Sulahian A., Garin Y.J., Nassar N., and Derouin F. Culture microtitration: a sensitive method for quantifying Leishmania infantum in tissues of infected mice. Antimicrob Agents Chemother 39 (1995) 2167-2168
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 2167-2168
    • Buffet, P.A.1    Sulahian, A.2    Garin, Y.J.3    Nassar, N.4    Derouin, F.5
  • 38
    • 0035850989 scopus 로고    scopus 로고
    • Immunization with A2 protein results in a mixed Th1/Th2 and a humoral response which protects mice against Leishmania donovani infections
    • Ghosh A., Zhang W.W., and Matlashewski G. Immunization with A2 protein results in a mixed Th1/Th2 and a humoral response which protects mice against Leishmania donovani infections. Vaccine 20 (2001) 59-66
    • (2001) Vaccine , vol.20 , pp. 59-66
    • Ghosh, A.1    Zhang, W.W.2    Matlashewski, G.3
  • 39
    • 0037456693 scopus 로고    scopus 로고
    • A Leishmania infantum multi-component antigenic protein mixed with live BCG confers protection to dogs experimentally infected with L. infantum
    • Molano I., Alonso M.G., Mirón C., Redondo E., Requena J.M., Soto M., et al. A Leishmania infantum multi-component antigenic protein mixed with live BCG confers protection to dogs experimentally infected with L. infantum. Vet Immunol Immunopathol 92 (2003) 1-13
    • (2003) Vet Immunol Immunopathol , vol.92 , pp. 1-13
    • Molano, I.1    Alonso, M.G.2    Mirón, C.3    Redondo, E.4    Requena, J.M.5    Soto, M.6
  • 42
    • 0027535694 scopus 로고
    • Immunobiological studies on experimental visceral leishmaniasis. III. Cytokine-mediated regulation of parasite replication
    • Saha B., Basak S.K., and Roy S. Immunobiological studies on experimental visceral leishmaniasis. III. Cytokine-mediated regulation of parasite replication. Scand J Immunol 37 (1993) 155-158
    • (1993) Scand J Immunol , vol.37 , pp. 155-158
    • Saha, B.1    Basak, S.K.2    Roy, S.3
  • 43
    • 34548171717 scopus 로고    scopus 로고
    • Leishmania infantum: mixed T-helper-1/T-helper-2 immune response in experimentally infected BALB/c mice
    • Rolão N., Cortes S., Gomes-Pereira S., and Campino L. Leishmania infantum: mixed T-helper-1/T-helper-2 immune response in experimentally infected BALB/c mice. Exp Parasitol 115 (2007) 270-276
    • (2007) Exp Parasitol , vol.115 , pp. 270-276
    • Rolão, N.1    Cortes, S.2    Gomes-Pereira, S.3    Campino, L.4
  • 44
    • 0029670174 scopus 로고    scopus 로고
    • Local suppression of IFN-gamma in hepatic granulomas correlates with tissue-specific replication of Leishmania chagasi
    • Wilson M.E., Sandor M., Blum A.M., Young B.M., Metwali A., Elliott D., et al. Local suppression of IFN-gamma in hepatic granulomas correlates with tissue-specific replication of Leishmania chagasi. J Immunol 156 (1996) 2231-2239
    • (1996) J Immunol , vol.156 , pp. 2231-2239
    • Wilson, M.E.1    Sandor, M.2    Blum, A.M.3    Young, B.M.4    Metwali, A.5    Elliott, D.6
  • 46
    • 0027159096 scopus 로고
    • In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma
    • Karp C.L., el-Safi S.H., Wynn T.A., Satti M.M., Kordofani A.M., Hashim F.A., et al. In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma. J Clin Invest 91 (1993) 1644-1648
    • (1993) J Clin Invest , vol.91 , pp. 1644-1648
    • Karp, C.L.1    el-Safi, S.H.2    Wynn, T.A.3    Satti, M.M.4    Kordofani, A.M.5    Hashim, F.A.6
  • 47
    • 0031985666 scopus 로고    scopus 로고
    • Regional differences in the cellular immune response to experimental cutaneous or visceral infection with Leishmania donovani
    • Melby P.C., Yang Y.Z., Cheng J., and Zhao W. Regional differences in the cellular immune response to experimental cutaneous or visceral infection with Leishmania donovani. Infect Immun 66 (1998) 18-27
    • (1998) Infect Immun , vol.66 , pp. 18-27
    • Melby, P.C.1    Yang, Y.Z.2    Cheng, J.3    Zhao, W.4
  • 49
    • 0041656392 scopus 로고    scopus 로고
    • Determinants of response to interleukin-10 receptor blockade immunotherapy in experimental visceral leishmaniasis
    • Murray H.W., Moreira A.L., Lu C.M., DeVecchio J.L., Matsuhashi M., Ma X., et al. Determinants of response to interleukin-10 receptor blockade immunotherapy in experimental visceral leishmaniasis. J Infect Dis 188 (2003) 458-464
    • (2003) J Infect Dis , vol.188 , pp. 458-464
    • Murray, H.W.1    Moreira, A.L.2    Lu, C.M.3    DeVecchio, J.L.4    Matsuhashi, M.5    Ma, X.6
  • 50
    • 0036839677 scopus 로고    scopus 로고
    • Interleukin-10 (IL-10) in experimental visceral leishmaniasis and IL-10 receptor blockade as immunotherapy
    • Murray H.W., Lu C.M., Mauze S., Freeman S., Moreira A.L., Kaplan G., et al. Interleukin-10 (IL-10) in experimental visceral leishmaniasis and IL-10 receptor blockade as immunotherapy. Infect Immun 70 (2002) 6284-6293
    • (2002) Infect Immun , vol.70 , pp. 6284-6293
    • Murray, H.W.1    Lu, C.M.2    Mauze, S.3    Freeman, S.4    Moreira, A.L.5    Kaplan, G.6
  • 51
    • 27944452329 scopus 로고    scopus 로고
    • Intramuscular immunization with p36(LACK) DNA vaccine induces IFN-γ production but does not protect BALB/c mice against Leishmania chagasi intravenous challenge
    • Marques-da-Silva E.A., Coelho E.A.F., Gomes D.C.O., Vilela M.C., Masioli C.Z., Tavares C.A.P., et al. Intramuscular immunization with p36(LACK) DNA vaccine induces IFN-γ production but does not protect BALB/c mice against Leishmania chagasi intravenous challenge. Parasitol Res 98 (2005) 67-74
    • (2005) Parasitol Res , vol.98 , pp. 67-74
    • Marques-da-Silva, E.A.1    Coelho, E.A.F.2    Gomes, D.C.O.3    Vilela, M.C.4    Masioli, C.Z.5    Tavares, C.A.P.6
  • 52
    • 0034308233 scopus 로고    scopus 로고
    • Infection of a canine macrophage cell line with Leishmania infantum: determination of nitric oxide production and anti-leishmanial activity
    • Pinelli E., Gebhard D., Mommaas A.M., van Hoeij M., Langermans J.A.M., Ruitenberg E.J., et al. Infection of a canine macrophage cell line with Leishmania infantum: determination of nitric oxide production and anti-leishmanial activity. Vet Parasitol 2 (2000) 181-189
    • (2000) Vet Parasitol , vol.2 , pp. 181-189
    • Pinelli, E.1    Gebhard, D.2    Mommaas, A.M.3    van Hoeij, M.4    Langermans, J.A.M.5    Ruitenberg, E.J.6
  • 54
    • 0032762414 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase and nitric oxide production in Leishmania infantum-infected human macrophages stimulated with interferon-gamma and bacterial lipopolysaccharide
    • Panaro M.A., Acquafredda A., Lisi S., Lofrumento D.D., Trotta T., Satalino R., et al. Inducible nitric oxide synthase and nitric oxide production in Leishmania infantum-infected human macrophages stimulated with interferon-gamma and bacterial lipopolysaccharide. Int J Clin Lab Res 29 (1999) 122-127
    • (1999) Int J Clin Lab Res , vol.29 , pp. 122-127
    • Panaro, M.A.1    Acquafredda, A.2    Lisi, S.3    Lofrumento, D.D.4    Trotta, T.5    Satalino, R.6
  • 55
  • 56
    • 0031026083 scopus 로고    scopus 로고
    • Characterization of humoral immune responses induced by an influenza hemagglutinin DNA vaccine
    • Deck R.R., DeWitt C.M., Donnelly J.J., Liu M.A., and Ulmer J.B. Characterization of humoral immune responses induced by an influenza hemagglutinin DNA vaccine. Vaccine 15 (1997) 71-78
    • (1997) Vaccine , vol.15 , pp. 71-78
    • Deck, R.R.1    DeWitt, C.M.2    Donnelly, J.J.3    Liu, M.A.4    Ulmer, J.B.5
  • 57
    • 0030750733 scopus 로고    scopus 로고
    • DNA immunization for influenza virus: studies using hemagglutinin- and nucleoprotein-expressing DNAs
    • Robinson H.L., Boyle C.A., Feltquate D.M., Morin M.J., Santoro J.C., and Webster R.G. DNA immunization for influenza virus: studies using hemagglutinin- and nucleoprotein-expressing DNAs. J Infect Dis 176 Suppl. 1 (1997) S50-S55
    • (1997) J Infect Dis , vol.176 , Issue.SUPPL. 1
    • Robinson, H.L.1    Boyle, C.A.2    Feltquate, D.M.3    Morin, M.J.4    Santoro, J.C.5    Webster, R.G.6
  • 58
    • 23344439229 scopus 로고    scopus 로고
    • Heterologous prime-boost vaccination with the LACK antigen protects against murine visceral leishmaniasis
    • Dondji B., Perez-Gimenez E., Goldsmith-Pestana K., Esteban M., and McMahon-Pratt D. Heterologous prime-boost vaccination with the LACK antigen protects against murine visceral leishmaniasis. Infect Immun 73 (2005) 5286-5289
    • (2005) Infect Immun , vol.73 , pp. 5286-5289
    • Dondji, B.1    Perez-Gimenez, E.2    Goldsmith-Pestana, K.3    Esteban, M.4    McMahon-Pratt, D.5
  • 59
    • 0029956512 scopus 로고    scopus 로고
    • Gene vaccination with naked plasmid DNA: mechanism of CTL priming
    • Corr M., Lee D.J., Carson D.A., and Tighe H. Gene vaccination with naked plasmid DNA: mechanism of CTL priming. J Exp Med 184 (1996) 1555-1560
    • (1996) J Exp Med , vol.184 , pp. 1555-1560
    • Corr, M.1    Lee, D.J.2    Carson, D.A.3    Tighe, H.4
  • 61
    • 1842586922 scopus 로고    scopus 로고
    • CD8 (+) T cells with parasite-specific cytotoxic activity and a Tc1 profile of cytokine and chemokine secretion develop in experimental visceral leishmaniasis
    • Tsagozis P., Karagouni E., and Dotsika E. CD8 (+) T cells with parasite-specific cytotoxic activity and a Tc1 profile of cytokine and chemokine secretion develop in experimental visceral leishmaniasis. Parasite Immunol 25 (2003) 569-579
    • (2003) Parasite Immunol , vol.25 , pp. 569-579
    • Tsagozis, P.1    Karagouni, E.2    Dotsika, E.3
  • 62
    • 18144388288 scopus 로고    scopus 로고
    • + T lymphocytes in a self-curing mouse model of visceral leishmaniasis
    • + T lymphocytes in a self-curing mouse model of visceral leishmaniasis. Parasitol Int 54 (2005) 139-146
    • (2005) Parasitol Int , vol.54 , pp. 139-146
    • Tsagozis, P.1    Karagouni, E.2    Dotsika, E.3
  • 63
    • 0037726800 scopus 로고    scopus 로고
    • Protection in dogs against visceral leishmaniasis caused by Leishmania infantum is achieved by immunization with a heterologous prime-boost regime using DNA and vaccinia recombinant vectors expressing LACK
    • Ramiro M.J., Zárate J.J., Hanke T., Rodriguez D., Rodriguez J.R., Esteban M., et al. Protection in dogs against visceral leishmaniasis caused by Leishmania infantum is achieved by immunization with a heterologous prime-boost regime using DNA and vaccinia recombinant vectors expressing LACK. Vaccine 21 (2003) 2474-2484
    • (2003) Vaccine , vol.21 , pp. 2474-2484
    • Ramiro, M.J.1    Zárate, J.J.2    Hanke, T.3    Rodriguez, D.4    Rodriguez, J.R.5    Esteban, M.6
  • 64
    • 0037124332 scopus 로고    scopus 로고
    • + T cell responses and protection against Leishmania major infection
    • + T cell responses and protection against Leishmania major infection. J Exp Med 195 (2002) 1565-1573
    • (2002) J Exp Med , vol.195 , pp. 1565-1573
    • Rhee, E.G.1    Mendez, S.2    Shah, J.A.3
  • 65
    • 2442583468 scopus 로고    scopus 로고
    • Immunity and immunosupression in experimental visceral leishmaniasis
    • Goto H., and Lindoso J.A.L. Immunity and immunosupression in experimental visceral leishmaniasis. Braz J Med Biol Res 37 (2004) 615-623
    • (2004) Braz J Med Biol Res , vol.37 , pp. 615-623
    • Goto, H.1    Lindoso, J.A.L.2
  • 66
    • 15744396294 scopus 로고    scopus 로고
    • Immunopathogenesis of infection with the visceralizing Leishmania species
    • Wilson M.E., Jeronimo S.M.B., and Pearson R.D. Immunopathogenesis of infection with the visceralizing Leishmania species. Microb Pathog 38 (2005) 147-160
    • (2005) Microb Pathog , vol.38 , pp. 147-160
    • Wilson, M.E.1    Jeronimo, S.M.B.2    Pearson, R.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.