Leishmania infantum: Mixed T-helper-1/T-helper-2 immune response in experimentally infected BALB/c mice

Experimental Parasitology

Volumn 115, Issue 3, 2007, Pages 270-276

  Rolão, Nuno ^a   Cortes, Sofia ^a   Gomes Pereira, Sandra ^a   Campino, Lenea ^a  

^a INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

Author keywords

deoxyribonucleic acid; DNA; ELISA; enzyme linked immunosorbent assay; IFN; IgG; IL; Immune response; immunoglobulin G; interferon; interleukin; Leishmania infantum; Liver; Mice; min; minutes; Parasite load; PCR; pi; polymerase chain reaction; post inoculation; s; seconds; Spleen; T helper; TGF; Th; transforming growth factor

Indexed keywords

CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 4; PROTOZOAL DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNE RESPONSE; KINETICS; LEISHMANIA INFANTUM; LIVER; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITISM; PRIORITY JOURNAL; PROTOZOAL INFECTION; REAL TIME POLYMERASE CHAIN REACTION; SPLEEN; TH1 CELL; TH2 CELL;

ANIMALS; ANTIBODIES, PROTOZOAN; CYTOKINES; DNA, PROTOZOAN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOGLOBULIN G; KINETICS; LEISHMANIA INFANTUM; LEISHMANIASIS, VISCERAL; LIVER; MICE; MICE, INBRED BALB C; POLYMERASE CHAIN REACTION; SPLEEN; TH1 CELLS; TH2 CELLS;

LEISHMANIA INFANTUM;

EID: 34548171717     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2006.09.013     Document Type: Article

References (47)

1. Abbas A.K., Murphy K.M., and Sher A. Functional diversity of helper T lymphocytes. Nature 383 (1996) 787-793
2. Barral A., Barral-Netto M., Yong E.C., Brownell C.E., Twardzik D.R., and Reed S.G. Transforming growth factor beta as a virulence mechanism for Leishmania braziliensis. Proceedings of the National Academy of Sciences of the United States of America 90 (1993) 3442-3446
3. Belkaid Y. The role of CD4(+)CD25(+) regulatory T cells in Leishmania infection. Expert Opinion on Biological Therapy 3 (2003) 875-885
4. Belkaid Y., Piccirillo C.A., Mendez S., Shevach E.M., and Sacks D.L. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 420 (2002) 502-507
5. Bogdan C., and Nathan C. Modulation of macrophage function by transforming growth factor beta, interleukin-4, and interleukin-10. Annals of the New York Academy of Sciences 685 (1993) 713-739
6. Bogdan C., Moll H., Solbach W., and Rollinghoff M. Tumor necrosis factor-alpha in combination with interferon-gamma, but not with interleukin 4 activates murine macrophages for elimination of Leishmania major amastigotes. European Journal of Immunology 20 (1990) 1131-1135
7. Campino L., Cortes S., Pires R., Oskam L., and Abranches P. Detection ofLeishmania in immunocompromised patients using peripheral blood spots on filter paper and the polymerase chain reaction. European Journal of Clinical Microbiology and Infectious Diseases 19 (2000) 396-398
8. Compton H.L., and Farrell J.P. CD28 costimulation and parasite dose combine to influence the susceptibility of BALB/c mice to infection with Leishmania major. Journal of Immunology 168 (2002) 1302-1308
9. Engwerda C.R., Murphy M.L., Cotterell S.E., Smelt S.C., and Kaye P.M. Neutralization of IL-12 demonstrates the existence of discrete organ-specific phases in the control of Leishmania donovani. European Journal of Immunology 28 (1998) 669-680
10. Farrell J.P. The immunology of cutaneous leishmaniasis: experimental infections and human disease. In: Farrell J.P. (Ed). World Class Parasites: Leishmania (2002), Kluwer, Boston/Dordrecht/London 151-168
11. Fitzpatrick D.R., and Bielefeldt-Ohmann H. Transforming growth factor beta in infectious disease: always there for the host and the pathogen. Trends in Microbiology 7 (1999) 232-236
12. Gantt K.R., Schultz-Cherry S., Rodriguez N., Jeronimo S.M., Nascimento E.T., Goldman T.L., Recker T.J., Miller M.A., and Wilson M.E. Activation of TGF-beta by Leishmania chagasi: importance for parasite survival in macrophages. Journal of Immunology 170 (2003) 2613-2620
13. Garin Y.J., Sulahian A., Pratlong F., Meneceur P., Gangneux J.P., Prina E., Dedet J.P., and Derouin F. Virulence of Leishmania infantum is expressed as a clonal and dominant phenotype in experimental infections. Infection and Immunity 69 (2001) 7365-7373
14. Gomes-Pereira S., Rodrigues O.R., Rolao N., Almeida P.D., and Santos-Gomes G.M. Hepatic cellular immune responses in mice with cure" and "non-cure" phenotype to Leishmania infantum infection: importance of CD8+ T cells and TGF-beta production. FEMS Immunology and Medical Microbiology 41 (2004) 59-68
15. Goossens P.L., Jouin H., Marchal G., and Milon G. Isolation and flow cytometric analysis of the free lymphomyeloid cells present in murine liver. Journal of Immunological Methods 132 (1990) 137-144
16. Gorelik L., Constant S., and Flavell R.A. Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation. The Journal of Experimental Medicine 195 (2002) 1499-1505
17. Gumy A., Louis J.A., and Launois P. The murine model of infection with Leishmania major and its importance for the deciphering of mechanisms underlying differences in Th cell differentiation in mice from different genetic backgrounds. International Journal for Parasitology 34 (2004) 433-444
18. Heinzel F.P., Sadick M.D., Holaday B.J., Coffman R.L., and Locksley R.M. Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. The Journal of Experimental Medicine 169 (1989) 59-72
19. Honore S., Garin Y.J., Sulahian A., Gangneux J.P., and Derouin F. Influence of the host and parasite strain in a mouse model of visceral Leishmania infantum infection. FEMS Immunology and Medical Microbiology 21 (1998) 231-239
20. Karp C.L., el-Safi S.H., Wynn T.A., Satti M.M., Kordofani A.M., Hashim F.A., Hag-Ali M., Neva F.A., Nutman T.B., and Sacks D.L. In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma. The Journal of Clinical Investigation 91 (1993) 1644-1648
21. Kaye P.M., Curry A.J., and Blackwell J.M. Differential production of Th1- and Th2-derived cytokines does not determine the genetically controlled or vaccine-induced rate of cure in murine visceral leishmaniasis. Journal of Immunology 146 (1991) 2763-2770
22. Kemp K., Kemp M., Kharazmi A., Ismail A., Kurtzhals J.A., Hviid L., and Theander T.G. Leishmania-specific T cells expressing interferon-gamma (IFN-gamma) and IL-10 upon activation are expanded in individuals cured of visceral leishmaniasis. Clinical and Experimental Immunology 116 (1999) 500-504
23. Kenney R.T., Sacks D.L., Gam A.A., Murray H.W., and Sundar S. Splenic cytokine responses in Indian kala-azar before and after treatment. The Journal of Infectious Diseases 177 (1998) 815-818
24. Lehmann J., Enssle K.H., Lehmann I., Emmendorfer A., and Lohmann-Matthes M.L. The capacity to produce IFN-gamma rather than the presence of interleukin-4 determines the resistance and the degree of susceptibility to Leishmania donovani infection in mice. Journal of Interferon and Cytokine Research 20 (2000) 63-77
25. Liew F.Y., and O'Donnell C.A. Immunology of leishmaniasis. Advances in Parasitology 32 (1993) 161-259
26. Locksley R.M., Heinzel F.P., Sadick M.D., Holaday B.J., and Gardner Jr. K.D. Murine cutaneous leishmaniasis: susceptibility correlates with differential expansion of helper T-cell subsets. Annales de l'Institut Pasteur. Immunologie 138 (1987) 744-749
27. Maluish A.E., and Strong D.M. Lymphocyte proliferation. In: Rose N.R., Friedman H., and Fahey J.L. (Eds). Manual of Clinical Laboratory Immunology (1986), American Society for Microbiology, Washinton DC 241-281
28. Marques C.S., Rolão N., Centeno-Lima S., Lousada H., Maia C., Campino L., do Rosário V.E., and Silveira H. Studies in a co-infection murine model of Plasmodium chabaudi chabaudi and Leishmania infantum: interferon-gamma and interleukin-4 mRNA expression. Memórias do Instituto Oswaldo Cruz 100 (2005) 889-892
29. Melby P.C., Yang Y.Z., Cheng J., and Zhao W. Regional differences in the cellular immune response to experimental cutaneous or visceral infection with Leishmania donovani. Infection and Immunity 66 (1998) 18-27
30. Melby P.C., Chandrasekar B., Zhao W., and Coe J.E. The hamster as a model of human visceral leishmaniasis: progressive disease and impaired generation of nitric oxide in the face of a prominent Th1-like cytokine response. Journal of Immunology 166 (2001) 1912-1920
31. Mendez S., Fernandez-Perez F.J., Santin M., De La Fuente C., Cuquerella M., Gomez-Munoz M.T., and Alunda J.M. Correlation between in vitro and in vivo infectivity of Leishmania infantum clones. The Journal of Eukaryotic Microbiology 48 (2001) 616-621
32. Miralles G.D., Stoeckle M.Y., McDermott D.F., Finkelman F.D., and Murray H.W. Th1 and Th2 cell-associated cytokines in experimental visceral leishmaniasis. Infection and Immunity 62 (1994) 1058-1063
33. Moll H. Experimental cutaneous leishmaniasis: langerhans cells internalize Leishmania major and induce an antigen-specific T-cell response. Advances in Experimental Medicine and Biology 329 (1993) 587-592
34. Omer F.M., Kurtzhals J.A., and Riley E.M. Maintaining the immunological balance in parasitic infections: a role for TGF-beta?. Parasitology Today 16 (2000) 18-23
35. Requena J.M., Soto M., Doria M.D., and Alonso C. Immune and clinical parameters associated with Leishmania infantum infection in the golden hamster model. Veterinary Immunology and Immunopathology 76 (2000) 269-281
36. Rodrigues Roos, O., Marques, C., Ferronha, M.H., Moura, R., Santos-Gomes, G.M., 2005. CD25+ and CD25- CD4+ T cell populations in murine visceral leishmaniaisis, in: Third World Congress on Leishmaniosis, Palermo-Terrasini, Sicily, Italy, 10-15 April, pp. 273.
37. Rogers K.A., DeKrey G.K., Mbow M.L., Gillespie R.D., Brodskyn C.I., and Titus R.G. Type 1 and type 2 responses to Leishmania major. FEMS Microbiology Letters 209 (2002) 1-7
38. Rolão N., Cortes S., Rodrigues O.R., and Campino L. Quantification of Leishmania infantum parasites in tissue biopsies by real-time polymerase chain reaction and polymerase chain reaction-enzyme-linked immunosorbent assay. The Journal of Parasitology 90 (2004) 1150-1154
39. Rousseau D., Demartino S., Anjuere F., Ferrua B., Fragaki K., Le Fichoux Y., and Kubar J. Sustained parasite burden in the spleen of Leishmania infantum-infected BALB/c mice is accompanied by expression of MCP-1 transcripts and lack of protection against challenge. European Cytokine Network 12 (2001) 340-347
40. Sacks D., and Noben-Trauth N. The immunology of susceptibility and resistance to Leishmania major in mice. Nature Reviews. Immunology 2 (2002) 845-858
41. Saha B., Basak S.K., and Roy S. Immunobiological studies on experimental visceral leishmaniasis. III. Cytokine-mediated regulation of parasite replication. Scandinavian Journal of Immunology 37 (1993) 155-158
42. Sakaguchi S. Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annual Review of Immunology 22 (2004) 531-562
43. Scott P. Differentiation, regulation, and death of T helper cell subsets during infection with Leishmania major. Immunologic Research 17 (1998) 229-238
44. Scott P., Pearce E., Cheever A.W., Coffman R.L., and Sher A. Role of cytokines and CD4+ T-cell subsets in the regulation of parasite immunity and disease. Immunological Reviews 112 (1989) 161-182
45. Stenger S., Thuring H., Rollinghoff M., and Bogdan C. Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major. The Journal of Experimental Medicine 180 (1994) 783-793
46. Vodovotz Y., Bogdan C., Paik J., Xie Q.W., and Nathan C. Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta. The Journal of Experimental Medicine 178 (1993) 605-613
47. Wilson M.E., Young B.M., Davidson B.L., Mente K.A., and McGowan S.E. The importance of TGF-beta in murine visceral leishmaniasis. Journal of Immunology 161 (1998) 6148-6155