Infection of a canine macrophage cell line with Leishmania infantum: Determination of nitric oxide production and anti-leishmanial activity

Veterinary Parasitology

Volumn 92, Issue 3, 2000, Pages 181-189

  Pinelli, Elena ^a   Gebhard, Douglas ^b   Mommaas, A Mieke ^c   Van Hoeij, Maggy ^a   Langermans, Jan A M ^d   Ruitenberg, E Joost ^a,e   Rutten, Victor P M G ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

^e CENTRAL LABORATORY   (Netherlands)

Author keywords

Dog; Leishmania infantum; Macrophage cell line; NO

Indexed keywords

CYTOKINE; INTERLEUKIN 2; NITRIC OXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL LINE; CONTROLLED STUDY; DOG; HOST PARASITE INTERACTION; IN VITRO STUDY; LEISHMANIA INFANTUM; MACROPHAGE; NONHUMAN; PARASITE CULTIVATION; PROMASTIGOTE; T LYMPHOCYTE;

ANIMALS; ARGININE; CELL LINE; DOG DISEASES; DOGS; ENZYME INHIBITORS; INTERFERON TYPE II; INTERLEUKIN-2; LEISHMANIA INFANTUM; LEISHMANIASIS, VISCERAL; MACROPHAGE ACTIVATION; MACROPHAGES; MICROSCOPY, ELECTRON; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; TUMOR NECROSIS FACTOR-ALPHA;

CANIS FAMILIARIS; LEISHMANIA INFANTUM; PROTOZOA;

EID: 0034308233     PISSN: 03044017     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4017(00)00312-5     Document Type: Article

References (24)

1. Adams L.B., Hibbs J.B. Jr., Taintor R.R., Krahenbuhl J.L. Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine. J. Immunol. 144:1990;2725-2729.
2. Alexander J., Russell D.G. The interaction of Leishmania species with macrophages. Adv. Parasitol. 31:1992;175-254.
3. Crocker P.R., Blackwell J.M., Bradley D.J. Transfer of innate resistance and susceptibility to Leishmania donovani infection in mouse radiation bone marrow chimeras. Immunology. 52:1984;417-422.
4. Gebhard, D.H. Levy, M.G., Ley d. Bucci, J.G., Gager, R., 1995. Isolation and characterization of functionally and phenotypically distinct continuous monocytoid cell lines from a canine malignant histiocytosis. In: Gershwin, L., Lunney, J., Shore, C. (Eds.), Fourth International Veterinary Immunology Symposium. Davis, California, USA, 312 pp.
5. 15N] nitrate in biological fluids. Anal. Biochem. 126:1982;131-138.
6. Green S.J., Crawford R.M., Hockmeyer J.T., Meltzer M.S., Nacy C.A. Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-gamma-stimulated macrophages by induction of tumor necrosis factor-alpha. J. Immunol. 145:1990;4290-4297.
7. Hughes H.P.A. Oxidative killing of intracellular parasites mediated by macrophages. Parasitol. Today. 4:1988;340.
8. James S.L., Glaven J. Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates. J. Immunol. 143:1989;4208-4212.
9. Langermans J.A., Van der Hulst M.E., Nibbering P.H., Hiemstra P.S., Fransen L., Van Furth R. IFN-gamma-induced L-arginine-dependent toxoplasmastatic activity in murine peritoneal macrophages is mediated by endogenous tumor necrosis factor-alpha. J. Immunol. 148:1992;568-574.
10. Liew F.Y., Xu D.M., Chan W.L. Immune effector mechanism in parasitic infections. Immunol. Let. 65:1999;101-104.
11. Mallinson D.J., Coombs G.H. Interaction of leishmania metacyclics with macrophages. Int. J. Parasitol. 19:1989;647-656.
12. Mauel J., Ransijn A., Buchmuller Rouiller Y. Killing of Leishmania parasites in activated murine macrophages is based on an L-arginine-dependent process that produces nitrogen derivatives. J. Leukoc. Biol. 49:1991;73-82.
13. Munoz Fernandez M.A., Fernandez M.A., Fresno M. Synergism between tumor necrosis factor-alpha and interferon-gamma on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxide-dependent mechanism. Eur. J. Immunol. 22:1992;301-307.
14. Nacy C.A., Fortier A.H., Pappas M.G., Henry R.R. Susceptibility of inbred mice to Leishmania tropica infection, correlation of susceptibility with in vitro defective macrophage microbicidal activities. Cell Immunol. 77:1983;298-307.
15. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6:1992;3051-3064.
16. Panaro M.A., Fasanella A., Lisi S., Mitolo V., Andriola A., Brandonisio O. Evaluation of nitric oxide production by Leishmania infantum-infected dog macrophages. Immunopharmacol. Immunotoxicol. 20:1998;147-158.
17. Pearson R.D., Harcus J.L., Roberts D., Donowitz G.R. Differential survival of Leishmania donovani amastigotes in human monocytes. J. Immunol. 131:1983;1994-1999.
18. Pinelli E., Killick Kendrick R., Wagenaar J., Bernadina W., del Real G., Ruitenberg J. Cellular and humoral immune responses in dogs experimentally and naturally infected with Leishmania infantum. Infect. Immun. 62:1994;229-235.
19. Pinelli E., Boog C.J., Rutten V.P., van Dijk B., Bernadina W.E., Ruitenberg E.J. A Canine CD8+ cytotoxic T-cell line specific for Leishmania infantum-infected macrophages. Tissue Antigens. 43:1994;189-192.
20. Pinelli E., Gonzalo R.M., Boog C.J., Rutten V.P., Gebhard D., del Real G., Ruitenberg E.J. Leishmania infantum-specific T cell lines derived from asymptomatic dogs that lyse infected macrophages in a major histocompatibility complex-restricted manner. Eur. J. Immunol. 25:1995;1594-1600.
21. Rockett K.A., Awburn M.M., Cowden W.B., Clark I.A. Killing of Plasmodium falciparum in vitro by nitric oxide derivatives. Infect. Immun. 59:1991;3280-3283.
22. Scott P., James S., Sher A. The respiratory burst is not required for killing of intracellular and extracellular parasites by a lymphokine-activated macrophage cell line. Eur. J. Immunol. 15:1985;553-558.
23. Stuehr D.J., Marletta M.A. Mammalian nitrate biosynthesis, mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide. Proc. Natl. Acad. Sci. USA. 82:1985;7738-7742.
24. Vouldoukis I., Drapier J.C., Nussler A.K., Tselentis Y., da Silva O.A., Gentilini M., Mossalayi D.M., Monjour L., Dugas B. Canine visceral leishmaniasis, successful chemotherapy induces macrophage antileishmanial activity via the L-arginine nitric oxide pathway. Antimicrob. Agents Chemother. 40:1996;253-256.