Local suppression of IFN-γ in hepatic granulomas correlates with tissue-specific replication of Leishmania chagasi

Journal of Immunology

Volumn 156, Issue 6, 1996, Pages 2231-2239

  Wilson, Mary E ^a   Sandor, Matyas ^a   Blum, Arthur M ^a   Young, Betty M ^a   Metwali, Ahmed ^a   Elliott, David ^a   Lynch, Richard G ^a   Weinstock, Joel V ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; THY 1 ANTIGEN;

AMASTIGOTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; LEISHMANIA; LEISHMANIASIS; LIVER GRANULOMA; MOUSE; NONHUMAN; PARASITE SURVIVAL; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE;

ANIMALS; CELL SEPARATION; CELLS, CULTURED; CYTOKINES; DOWN-REGULATION; GRANULOMA; IMMUNITY, NATURAL; INTERFERON TYPE II; LEISHMANIA INFANTUM; LEISHMANIASIS, VISCERAL; LIVER DISEASES, PARASITIC; MICE; MICE, INBRED BALB C; ORGAN SPECIFICITY; SPLEEN;

EID: 0029670174     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (66)

1. Pearson, R. D., and M E. Wilson. 1989 Host defenses against prototypical intracellular protozoans, the Leishmania In Parasitic Infections in the Compromised Host. P. D. Walzer and R. M Genta, eds. Marcel Dekker, New York, p. 31
2. Gorczynski, R. M. 1982. Nature of resistance to leishmaniasis in experimental rodents. Dev. Comp. Immunol. 6:199
3. Mock, B. A., A. H Fortier, M. Potter, and C. A. Nacy. 1985. Genetic control of systemic Leishmania major infections: dissociation of intrahepatic amastigote replication from control by the Lsh gene Infect. Immun 50 588.
4. Bradley, D J , B A Taylor, J Blackwell, E P. Evans, and J Freeman 1979. Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse. Clin Exp. Immunol. 37:7.
5. Scott, P., P. Natovitz, R. L. Coffman, E. Pearce, and A. Sher 1988 Immunoregulation of cutaneous leishmaniasis: T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond in distinct parasite antigens. J. Exp. Med. 168 1675.
6. - lymphocytes in vivo during healing and progressive murine leishmaniasis Proc Natl Acad Sci USA 88:7011
7. Holaday, B. J , M D. Sadick, Z. Wang, S. L. Reiner, F. P Heinzel, T G Parslow, and R M Locksley 1991. Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines. J Immunol. 147:1653
8. + T cells in leishmaniasis Immunol Today 40 40
9. Scott, P. 1991. IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis. J. Immunol 147.3149
10. + T cells during initiation of infection. J. Exp. Med. 179.447.
11. Heinzel, F P., D. S. Schoenhaut, R. M Rerko, L. E. Rosser, and M. K. Gately. 1993. Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp Med. 177:1505.
12. + T cell subsets and induces early resistance to Leishmania major in mice J. Exp Med. 178:567.
13. + T-cell subset responses during murine leishmaniasis. Parasitol. Today 10:190.
14. Kaye, P. M., A. J Curry, and J. M. Blackwell. 1991. Differential production of Th1- and Th2-derived cytokines does not determine the genetically controlled or vaccine-induced rate of cure in murine visceral leishmaniasis J Immunol. 146:2763
15. Manson-Bahr, P. E. C. 1959. East African kala-azar with special reference to the pathology, prophylaxis and treatment Trans. Roy. Soc. Trop. Med. Hyg. 53:123.
16. McElrath, M. J., H. W. Murray, and Z. A Cohn 1988 The dynamics of granuloma formation in experimental visceral leishmaniasis. J. Exp. Med. 167:1927.
17. Warren, K. S. 1976. A functional classification of granulomatous inflammation. Ann. N. Y. Acad. Sci. 278.7.
18. Dannenberg, A. M., Jr. 1991. Delayed-type hypersensitivity and cell-mediated immunity in the pathogenesis of tuberculosis. Immunol. Today 12:228
19. Cook, G. A., A. Metwali, A. Blum, R. Mathew, and J. V. Weinstock. 1993. Lymphokine expression in granulomas of Schistosoma mansoni infected mice Cell. Immunol. 152:49.
20. Metwali, A., D. Elliott, A. M Blum, and J. V. Weinstock. 1993. Granuloma eosinophils enhance EL-5 production by lymphocytes from mice infected with Schistosoma mansoni. J Immunol. 151:7048.
21. Weinstock, J. V. 1994. Function and regulation of granulomatous responses (experimental granulomatosis). In Sarcoidosis and Other Granulomatous Disorders. D. G James, ed. Marcel Dekker, New York, p 99.
22. Pearson, R. D , and R T. Steigbigel. 1980. Mechanism of lethal effect of human serum upon Leishmania donovani. J. Immunol. 125.2195.
23. Wilson, M. E., and R. D. Pearson 1984. Stage-specific variations in lectin binding to Leishmania donovani Infect. Immun 46:128.
24. Wilson, M E., K. K. Hardin, and J. E. Donelson 1989. Expression of the major surface glycoprotein of Leishmania donovani chagasi in virulent and attenuated promastigotes. J. Immunol. 143:678.
25. Stauber, L A. 1958. Host resistance to the Khartoum strain of Leishmania donovani. Rice Inst. Pamphlets 45.80.
26. Blum, A. M , A. Metwali, G. Cook, R. C. Mathew, D. Elliott, and J. V. Weinstock 1993 Substance P modulates antigen-induced, IFN-gamma production in murine Schistosomiasis mansoni. J. Immunol. 151:225
27. Coligan, J. E., A. M. Kruisbeek, D. H Margulies, E. M Shevach, and W. Strober 1991. Current Protocols in Immunology, John Wiley and Sons, New York.
28. Kager, P. A., and P. H. Rees. 1993. Haematological investigations in visceral leishmaniasis. Trop. Geogr. Med. 38:371.
29. Xu. Y., J Macedonia, A. Sher, E. Pearce, and A. W. Cheever. 1991. Dynamic analysis of splenic Th1 and Th2 lymphocyte functions in mice infected with Schistosoma japonicum. Infect. Immun 59:2934
30. Mosman, T. R., J. H. Schumacher, D. F. Fiorentino, J. Leverah, K. W. Moore, and M W. Bond. 1990 Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (DL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay J. Immunol. 145:2938.
31. Belosevic, M., D. S. Finbloom, P. H. Van der Meide, M. V. Slayter, and C. A. Nacy. 1989. Administration of monoclonal anti-IFN-γ antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major. J. Immunol. 143:266.
32. Murray, H. W., G. L. Spitalny, and C. F. Nathan 1985. Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-γ. J. Immunol. 134. 1619.
33. Murray, H W., B Y. Rubin, and C. D Rothermel 1983. Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes. J. Clin Invest 72:1506
34. Liew, F Y. 1991. Role of cytokines in killing of intracellular pathogens. Immunol. Lett. 30:193.
35. Bogdan, C., H. Moll, W. Solbach, and M. Rollinghoff. 1990. Tumor necrosis factor-α in combination with interferon-γ, but not with interleukin 4 activates murine macrophages for elimination of Leishmania major amastigotes. Eur. J. Immunol. 20.1131.
36. Chang, K.-P 1983. Cellular and molecular mechanisms of intracellular symbiosis in leishmaniasis. Int. Rev. Cytol. 14:267
37. Florentino, D. F., M. W. Bond, and T. R. Mosmann 1989. Two types of mouse T helper cell clones IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med. 170:2081
38. Cervia, J. S., H. Rosen, and H. W. Murray. 1993. Effector role of blood monocytes in experimental visceral leishmaniasis. Infect. Immun. 61.1330.
39. Wilson, M. E., D. J. Innes, A de Q Sousa, and R. D. Pearson. 1987. Early histopathology of experimental infection with Leishmania donovani in hamsters J. Parasitol. 73.55
40. + cells in experimental visceral leishmaniasis. J. Immunol. 140.3971
41. Testi, R., D. D'Ambrosio, R. De Maria, and A. Santoni. 1994. The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells. Immunol. Today 15:479.
42. + T cells during experimental infection of mice with Leishmania major. J. Immunol. 150: 550.
43. Russo, D. M., R. J. Armitage, M Barral-Netto, A. Barral, K H. Grabstein, and S. G. Reed. 1993. Antigen-reactive γδ T cells in human leishmaniasis. J. Immunol. 151. 3712.
44. Alaibac, M., G. Harms, K. Zwingenberger, J. Morris, R Yu, and A C. Chu. 1993 γδ T lymphocytes in oriental cutaneous leishmaniasis. occurrence and variable δ gene expression. Br. J. Dermatol. 128:388.
45. Murray, H. W., S. J. Stern, K. Welte, B. Y. Rubin, S. M. Carriero, and C. F. Nathan. 1987. Experimental visceral leishmaniasis: production of interleukin 2 and interferon-γ, tissue immune reaction, and response to treatment with interieukin 2 and interferon-γ. J. Immunol. 138:2290.
46. Squires, K. E., R. D Schreiber, M. J. McElraith, B. Y. Rubin, S. L. Anderson, and H. W. Murray. 1989. Experimental visceral leishmaniasis: role of endogenous IFN-γ in host defense and tissue granulomatous response. J. Immunol. 143.4244.
47. Curry, A. J., and P. M. Kaye. 1992. Recombinant interleukin-1 a augments granuloma formation and cytokine production but not parasite clearance in mice infected with Leishmania donovani. Infect. Immun. 60:4422.
48. Miralles, G. D., M. Y. Stoeckle, D. F. McDermoll, F. D. Finkelman, and H. W. Murray. 1994. Th1 and Th2 cell-associated cytokines in experimental visceral leishmaniasis Infect. Immun. 62:1058.
49. Reiner, N. E. 1994. Altered cell signaling and mononuclear phagocyte deactivation during intracellular infection Immunol Today 15:374.
50. Tumang, M. C. T., C. Keogh, L. L. Moldawer, D. C. Helfgott, R. Teitelbaum, J. Hariprashad, and H. W Murray. 1994. Role and effect of TNF-α in experimental visceral leishmaniasis. J. Immunol 153:768
51. Titus, R G., B. Sherry, and A Cerami. 1989 Tumor necrosis factor plays a protective role in experimental murine cutaneous leishmaniasis. J. Exp. Med. 170:2097.
52. Murray, H. W , G Diego Miralles, M. Y. Stoeckle, and D. F. McDermott. 1993. Role and effect of IL-2 in experimental visceral leishmaniasis. J. Immunol. 151: 929.
53. Green, S. J., R. M. Crawford, J. T. Hockmeyer, M S. Meltzer, and C. A. Nacy. 1990. Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-γ stimulated macrophages by induction of tumor necrosis factor-a1. J. Immunol. 145:4290.
54. Liew, F. Y., Y. Li, and S. Millott 1990. Tumor necrosis factor-α synergizes with IFN-γ in mediating killing of Leishmania major through the induction of nitric oxide. J Immunol. 145:4306
55. Bogdan, C., and C Nathan 1993. Modulation of macrophage function by transforming growth factor β, interleukin-4, and interleukin-10. Ann. N.Y. Acad. Sci. 685.713.
56. Holaday, B. J., M. M de L. Pompeu, S. M. B. Jeronimo, M. J. Texeira, A. de Q. Sousa, A. W. Vasconcelos, R D. Pearson, J. S. Abrams, and R. M. Locksley. 1993 Potential role for interleukin-10 in the immunosuppression associated with kala azar J. Clin Invest. 92:2626.
57. Carvalho, E. M , O. Bacellar, C. Brownell, T. Regis, R. L. Coffman, and S. G. Reed. 1994 Restoration of IFN-γ production and lymphocyte proliferation in visceral leishmaniasis. J. Immunol. 152:5949.
58. Hatzigeorgiou, D E., S He, J. Sobel, K. H. Grabstein, A. Hafner, and J. L. Ho, 1993. IL-6 down-modulates the cytokine-enhanced antileishmanial activity in human macrophages J. Immunol 151 3682.
59. Barral-Netto, M , A Barral, C. E. Brownell, Y. A. W. Skeiky, L R. Ellingsworth, D. R Twardzik, and S. G. Reed. 1992. Transforming growth factor-β in leishmanial infection a parasite escape mechanism. Science 257.545.
60. Barral, A., M Barral-Netto, E C Yong, C E. Brownell, D. R. Twardzik, and S G. Reed. 1993. Transforming growth factor β as a virulence mechanism for Leishmania braziliensis Proc Natl. Acad Sci. USA 90:3442.
61. Gillessen, S., D. Carvajal, P. Ling, F. J. Podlaski, D. L Stremlo, P. C. Familletti, U Gubler, D H. Presky, A S. Stern, and M K. Gately. 1995. Mouse interleukin-12 (IL-12) p40 homodimers a potent IL-12 antagonist. Eur. J Immunol. 25:200.
62. Ghalib, H. W., M R. Piuvezam, Y A. W Skeiky, M. Siddig, F. A. Hashim, A. M. El-Hassan, D M. Russo, and S. G. Reed. 1993 Interleukin 10 production correlates with pathology in human Leishmania donovani infections. J Clin. Invest 92:324.
63. Karp, C L , S. H. El-Safi, T A. Wynn, M M. H. Satti, A. M. Kordofani, F A. Hashim, M Hag-Ali, F A. Neva, T. B. Nutman, and D. L Sacks. 1993. In vivo cytokine profiles in patients with kala-azar marked elevation of both interleukin-10 and interferon-gamma. J. Clin. Invest. 91:1644.
64. Nelson, B J., D. Danielpour, J. L. Rossio, J Turpin, and C. A. Nacy. 1994 Interleukin-2 suppresses activated macrophage intracellular killing activity by inducing macrophages to secrete TGF-β J Leukocyte Biol. 55:81.
65. Crocker, P. R., J M. Blackwell, and D J. Bradley 1984. Expression of the natural resistance gene Lsh in resident liver macrophages. Infect. Immun. 43: 1033.
66. 2-terminal sequence of macrophage-expressed natural resistance-associated macrophage protein (Nramp) encodes a proline-serine-rich putative Src homology 3-binding domain. J. Exp. Med. 179:1683