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Volumn 13, Issue 1-2, 2008, Pages 14-22

Bright future of optical assays for ion channel drug discovery

Author keywords

[No Author keywords available]

Indexed keywords

AEQUORIN; AMLODIPINE BESYLATE; CALCIUM; CARBAMAZEPINE; CATION CHANNEL; HALORHODOPSIN; ION CHANNEL; LIDOCAINE; MEROCYANINE; PHOTOPROTEIN; POTASSIUM CHANNEL; RHODAMINE; VOLTAGE GATED SODIUM CHANNEL; ZOLPIDEM TARTRATE;

EID: 37649018608     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2007.11.009     Document Type: Review
Times cited : (34)

References (60)
  • 3
    • 1842686090 scopus 로고    scopus 로고
    • Strategies to identify ion channel modulators: current and novel approaches to target neuropathic pain
    • Birch P.J., et al. Strategies to identify ion channel modulators: current and novel approaches to target neuropathic pain. Drug Discov. Today 9 (2004) 410-418
    • (2004) Drug Discov. Today , vol.9 , pp. 410-418
    • Birch, P.J.1
  • 5
    • 0035892592 scopus 로고    scopus 로고
    • Ion-channel assay technologies: quo vadis?
    • Xu J., et al. Ion-channel assay technologies: quo vadis?. Drug Discov. Today 6 (2001) 1278-1287
    • (2001) Drug Discov. Today , vol.6 , pp. 1278-1287
    • Xu, J.1
  • 6
    • 33947512419 scopus 로고    scopus 로고
    • Ion channel pharmacology
    • Camerino D.C., et al. Ion channel pharmacology. Neurotherapeutics 4 (2007) 184-198
    • (2007) Neurotherapeutics , vol.4 , pp. 184-198
    • Camerino, D.C.1
  • 7
    • 0034327493 scopus 로고    scopus 로고
    • Voltage-gated sodium channels as therapeutic targets
    • Clare J.J., et al. Voltage-gated sodium channels as therapeutic targets. Drug Discov. Today 5 (2000) 506-520
    • (2000) Drug Discov. Today , vol.5 , pp. 506-520
    • Clare, J.J.1
  • 8
    • 0019441262 scopus 로고
    • Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
    • Hamill O.P., et al. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391 (1981) 85-100
    • (1981) Pflugers Arch. , vol.391 , pp. 85-100
    • Hamill, O.P.1
  • 9
    • 32444438165 scopus 로고    scopus 로고
    • Comley, J. (2005) Automated Patch Clamping setting a new standard for early hERG. Drug Discovery World Winter 2005/6, 62-79
  • 10
    • 34548250564 scopus 로고    scopus 로고
    • Automated electrophysiology in drug discovery
    • Priest B.T., et al. Automated electrophysiology in drug discovery. Curr. Pharm. Des. 13 (2007) 2325-2337
    • (2007) Curr. Pharm. Des. , vol.13 , pp. 2325-2337
    • Priest, B.T.1
  • 12
    • 33746924487 scopus 로고    scopus 로고
    • Changing dynamics in dispense and imaging assays
    • Comley J. Changing dynamics in dispense and imaging assays. Drug Discov. World Summer (2006) 35-51
    • (2006) Drug Discov. World Summer , pp. 35-51
    • Comley, J.1
  • 13
    • 33644924900 scopus 로고    scopus 로고
    • Exploiting high-throughput ion channel screening technologies in integrated drug discovery
    • Treherne J.M. Exploiting high-throughput ion channel screening technologies in integrated drug discovery. Curr. Pharm. Des. 12 (2006) 397-406
    • (2006) Curr. Pharm. Des. , vol.12 , pp. 397-406
    • Treherne, J.M.1
  • 14
    • 10244264821 scopus 로고    scopus 로고
    • High throughput assay technologies for ion channel drug discovery
    • Zheng W., et al. High throughput assay technologies for ion channel drug discovery. Assay Drug. Dev. Technol. 5 (2004) 543-552
    • (2004) Assay Drug. Dev. Technol. , vol.5 , pp. 543-552
    • Zheng, W.1
  • 15
    • 0346337290 scopus 로고    scopus 로고
    • Comparative study of membrane potential-sensitive fluorescent probes and their use in ion channel screening assays
    • Wolff C., et al. Comparative study of membrane potential-sensitive fluorescent probes and their use in ion channel screening assays. J. Biomol. Screen. 5 (2003) 533-543
    • (2003) J. Biomol. Screen. , vol.5 , pp. 533-543
    • Wolff, C.1
  • 17
    • 0031982875 scopus 로고    scopus 로고
    • Membrane electric properties by combined patch clamp and fluorescence ratio imaging in single neurons
    • Zhang J., et al. Membrane electric properties by combined patch clamp and fluorescence ratio imaging in single neurons. Biophys. J. 74 (1998) 48-53
    • (1998) Biophys. J. , vol.74 , pp. 48-53
    • Zhang, J.1
  • 18
    • 0041488659 scopus 로고    scopus 로고
    • Anellated hemicyanine dyes in a neuron membrane: molecular stark effect and optical voltage recording
    • Kuhn B., and Fromherz P. Anellated hemicyanine dyes in a neuron membrane: molecular stark effect and optical voltage recording. J. Phys. Chem. B 107 (2003) 7903-7913
    • (2003) J. Phys. Chem. B , vol.107 , pp. 7903-7913
    • Kuhn, B.1    Fromherz, P.2
  • 19
    • 37649012675 scopus 로고    scopus 로고
    • ANNINE-6plus, a voltage-sensitive dye with good solubility, strong membrane binding and high sensitivity
    • 17687549
    • Fromherz P., et al. ANNINE-6plus, a voltage-sensitive dye with good solubility, strong membrane binding and high sensitivity. Eur. Biophys. J. (2007) 17687549
    • (2007) Eur. Biophys. J.
    • Fromherz, P.1
  • 20
    • 0034753261 scopus 로고    scopus 로고
    • Validation of FLIPR membrane potential dye for high throughput screening of potassium channel modulators
    • Whiteaker K.L., et al. Validation of FLIPR membrane potential dye for high throughput screening of potassium channel modulators. J. Biomol. Screen. 6 (2001) 305-312
    • (2001) J. Biomol. Screen. , vol.6 , pp. 305-312
    • Whiteaker, K.L.1
  • 21
    • 18344372371 scopus 로고    scopus 로고
    • A novel membrane potential-sensitive fluorescent dye improves cell-based assays for ion channels
    • Baxter D.F., et al. A novel membrane potential-sensitive fluorescent dye improves cell-based assays for ion channels. J. Biomol. Screen. 7 (2002) 79-85
    • (2002) J. Biomol. Screen. , vol.7 , pp. 79-85
    • Baxter, D.F.1
  • 22
    • 0036449329 scopus 로고    scopus 로고
    • Cellular fluorescent indicators and voltage/ion probe reader (VIPR) tools for ion channel and receptor drug discovery
    • González J.E., and Maher M.P. Cellular fluorescent indicators and voltage/ion probe reader (VIPR) tools for ion channel and receptor drug discovery. Recept. Channel. 8 (2002) 283-295
    • (2002) Recept. Channel. , vol.8 , pp. 283-295
    • González, J.E.1    Maher, M.P.2
  • 23
    • 0036452735 scopus 로고    scopus 로고
    • An industrial perspective on utilizing functional ion channel assays for high throughput screening
    • Worley III J.F., and Main M.J. An industrial perspective on utilizing functional ion channel assays for high throughput screening. Recept. Channel. 8 (2002) 269-282
    • (2002) Recept. Channel. , vol.8 , pp. 269-282
    • Worley III, J.F.1    Main, M.J.2
  • 24
    • 0037858858 scopus 로고    scopus 로고
    • High-throughput screening for ion channel modulators
    • Falconer M., et al. High-throughput screening for ion channel modulators. J. Biomol. Screen. 5 (2002) 460-465
    • (2002) J. Biomol. Screen. , vol.5 , pp. 460-465
    • Falconer, M.1
  • 25
    • 33645733252 scopus 로고    scopus 로고
    • Characterization of voltage-gated sodium-channel blockers by electrical stimulation and fluorescence detection of membrane potential
    • Huang C.J., et al. Characterization of voltage-gated sodium-channel blockers by electrical stimulation and fluorescence detection of membrane potential. Nat. Biotechnol. 4 (2006) 439-446
    • (2006) Nat. Biotechnol. , vol.4 , pp. 439-446
    • Huang, C.J.1
  • 27
    • 0038125562 scopus 로고    scopus 로고
    • Looking forward to seeing calcium
    • Rüdiger R., et al. Looking forward to seeing calcium. Nat. Rev. Molec. Cell Biol. 4 (2003) 579-586
    • (2003) Nat. Rev. Molec. Cell Biol. , vol.4 , pp. 579-586
    • Rüdiger, R.1
  • 28
    • 34547812014 scopus 로고    scopus 로고
    • Evaluation of no-wash calcium assay kits: enabling tools for calcium mobilization
    • Xin H., et al. Evaluation of no-wash calcium assay kits: enabling tools for calcium mobilization. J. Biomol. Screen. 12 (2007) 705-714
    • (2007) J. Biomol. Screen. , vol.12 , pp. 705-714
    • Xin, H.1
  • 29
    • 34548576414 scopus 로고
    • Extraction, purification and properties of aequorin, a bioluminescent protein from the luminous hydromedusan
    • Shimomura O., et al. Extraction, purification and properties of aequorin, a bioluminescent protein from the luminous hydromedusan. Aequorea. J. Cell. Comp. Physiol. 59 (1962) 223-239
    • (1962) Aequorea. J. Cell. Comp. Physiol. , vol.59 , pp. 223-239
    • Shimomura, O.1
  • 30
    • 0032404444 scopus 로고    scopus 로고
    • Aequorea victoria bioluminescence moves into an exciting new era
    • Kendall J.M., and Badminton M.N. Aequorea victoria bioluminescence moves into an exciting new era. Trends Biotechnol. 16 (1998) 216-224
    • (1998) Trends Biotechnol. , vol.16 , pp. 216-224
    • Kendall, J.M.1    Badminton, M.N.2
  • 31
    • 34547811380 scopus 로고    scopus 로고
    • ®, and its application to high-throughput screening
    • ®, and its application to high-throughput screening. J. Biomol. Screen. 12 (2007) 694-704
    • (2007) J. Biomol. Screen. , vol.12 , pp. 694-704
    • Bovolenta, S.1
  • 32
    • 34047250307 scopus 로고    scopus 로고
    • 2+ release from endoplasmic reticulum and Golgi
    • 2+ release from endoplasmic reticulum and Golgi. J. Biol. Chem. 282 (2007) 3325-3336
    • (2007) J. Biol. Chem. , vol.282 , pp. 3325-3336
    • Mahieu, F.1
  • 33
    • 34547564432 scopus 로고    scopus 로고
    • Aequorin luminescence-based assay for 5-hydroxytryptamine (serotonin) type 3 receptor characterization
    • Walstab J., et al. Aequorin luminescence-based assay for 5-hydroxytryptamine (serotonin) type 3 receptor characterization. Anal. Biochem. 368 (2007) 185-192
    • (2007) Anal. Biochem. , vol.368 , pp. 185-192
    • Walstab, J.1
  • 35
    • 0033613235 scopus 로고    scopus 로고
    • Circular permutation and receptor insertion within green fluorescent proteins
    • Baird G.S., et al. Circular permutation and receptor insertion within green fluorescent proteins. Proc. Natl. Acad. Sci. U.S.A 96 (1999) 11241-11246
    • (1999) Proc. Natl. Acad. Sci. U.S.A , vol.96 , pp. 11241-11246
    • Baird, G.S.1
  • 37
    • 0033514515 scopus 로고    scopus 로고
    • 2+ measurements using improved cameleons
    • 2+ measurements using improved cameleons. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 2135-2140
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 2135-2140
    • Miyawaki, A.1
  • 38
    • 0036048153 scopus 로고    scopus 로고
    • Green fluorescent protein calcium biosensors. Calcium imaging with GFP cameleons
    • Váradi A., and Rutter G.A. Green fluorescent protein calcium biosensors. Calcium imaging with GFP cameleons. Methods Mol. Biol. 183 (2002) 255-264
    • (2002) Methods Mol. Biol. , vol.183 , pp. 255-264
    • Váradi, A.1    Rutter, G.A.2
  • 39
    • 3242706582 scopus 로고    scopus 로고
    • 2+ by circularly permuted yellow fluorescent proteins
    • 2+ by circularly permuted yellow fluorescent proteins. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 10554-10559
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 10554-10559
    • Nagai, T.1
  • 41
    • 10244237790 scopus 로고    scopus 로고
    • Nonradioactive rubidium ion efflux assay and its applications in drug discovery and development
    • Terstappen G.C. Nonradioactive rubidium ion efflux assay and its applications in drug discovery and development. Assay Drug. Dev. Technol. 5 (2004) 553-559
    • (2004) Assay Drug. Dev. Technol. , vol.5 , pp. 553-559
    • Terstappen, G.C.1
  • 42
    • 16844367241 scopus 로고    scopus 로고
    • A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cells
    • Weaver C.D., et al. A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cells. J. Biomol. Screen. 8 (2004) 671-677
    • (2004) J. Biomol. Screen. , vol.8 , pp. 671-677
    • Weaver, C.D.1
  • 43
    • 0035165533 scopus 로고    scopus 로고
    • Permeant ion-dependent changes in gating of Kir2.1 inward rectifier potassium channels
    • Lu T., et al. Permeant ion-dependent changes in gating of Kir2.1 inward rectifier potassium channels. J. Gen. Physiol. 118 (2001) 509-522
    • (2001) J. Gen. Physiol. , vol.118 , pp. 509-522
    • Lu, T.1
  • 44
    • 33646131414 scopus 로고    scopus 로고
    • Relationship between pore occupancy and gating in BK potassium channels
    • Piskorowski R.A., and Aldrich R.W. Relationship between pore occupancy and gating in BK potassium channels. J. Gen. Physiol. 127 (2006) 557-576
    • (2006) J. Gen. Physiol. , vol.127 , pp. 557-576
    • Piskorowski, R.A.1    Aldrich, R.W.2
  • 45
    • 33645298755 scopus 로고    scopus 로고
    • A cell-sparing electric field stimulation technique for high-throughput screening of voltage-gated ion channels
    • Bugianesi R.M., et al. A cell-sparing electric field stimulation technique for high-throughput screening of voltage-gated ion channels. Assay Drug Dev. Technol. 1 (2006) 21-35
    • (2006) Assay Drug Dev. Technol. , vol.1 , pp. 21-35
    • Bugianesi, R.M.1
  • 46
    • 34547638628 scopus 로고    scopus 로고
    • Caged compounds: photorelease technology for control of cellular chemistry and physiology
    • Ellis-Davies G.C. Caged compounds: photorelease technology for control of cellular chemistry and physiology. Nat. Methods 8 (2007) 619-628
    • (2007) Nat. Methods , vol.8 , pp. 619-628
    • Ellis-Davies, G.C.1
  • 47
    • 0015103977 scopus 로고
    • Photochromic activators of the acetylcholine receptor
    • Bartels E., et al. Photochromic activators of the acetylcholine receptor. Proc. Natl. Acad. Sci. U.S.A. 68 (1971) 1820-1823
    • (1971) Proc. Natl. Acad. Sci. U.S.A. , vol.68 , pp. 1820-1823
    • Bartels, E.1
  • 48
    • 33846246029 scopus 로고    scopus 로고
    • Reversibly caged glutamate: a photochromic agonist of ionotropic glutamate receptors
    • Volgraf M., et al. Reversibly caged glutamate: a photochromic agonist of ionotropic glutamate receptors. J. Am. Chem. Soc. 129 (2007) 260-261
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 260-261
    • Volgraf, M.1
  • 49
    • 33746734322 scopus 로고    scopus 로고
    • Biologically active molecules with a 'light switch'
    • Mayer G., and Heckel A. Biologically active molecules with a 'light switch'. Angew. Chem., Int. Ed. 45 (2006) 4900-4921
    • (2006) Angew. Chem., Int. Ed. , vol.45 , pp. 4900-4921
    • Mayer, G.1    Heckel, A.2
  • 50
    • 0345133280 scopus 로고    scopus 로고
    • Channelrhodopsin-2, a directly light-gated cation-selective membrane channel
    • Nagel G., et al. Channelrhodopsin-2, a directly light-gated cation-selective membrane channel. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 13940-13945
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 13940-13945
    • Nagel, G.1
  • 51
    • 26444621497 scopus 로고    scopus 로고
    • Millisecond-timescale, genetically-targeted optical control of neural activity
    • Boyden E.S., et al. Millisecond-timescale, genetically-targeted optical control of neural activity. Nat. Neurosci. 8 (2005) 1263-1268
    • (2005) Nat. Neurosci. , vol.8 , pp. 1263-1268
    • Boyden, E.S.1
  • 52
    • 0034717007 scopus 로고    scopus 로고
    • Structure of the light-driven chloride pump halorhodopsin at 1.8 Å resolution
    • Kolbe M., et al. Structure of the light-driven chloride pump halorhodopsin at 1.8 Å resolution. Science 288 (2000) 1390-1396
    • (2000) Science , vol.288 , pp. 1390-1396
    • Kolbe, M.1
  • 53
    • 34247222730 scopus 로고    scopus 로고
    • Multimodal fast optical interrogation of neural circuitry
    • Zhang F., et al. Multimodal fast optical interrogation of neural circuitry. Nature 446 (2007) 633-639
    • (2007) Nature , vol.446 , pp. 633-639
    • Zhang, F.1
  • 54
    • 12344309164 scopus 로고    scopus 로고
    • Light-activated ion channels for remote control of neuronal firing
    • Banghart M., et al. Light-activated ion channels for remote control of neuronal firing. Nat. Neurosci. 12 (2004) 1381-1386
    • (2004) Nat. Neurosci. , vol.12 , pp. 1381-1386
    • Banghart, M.1
  • 55
    • 33749076327 scopus 로고    scopus 로고
    • + channel and a molecular photoswitch
    • + channel and a molecular photoswitch. J. Neurophysiol. 96 (2006) 2792-2796
    • (2006) J. Neurophysiol. , vol.96 , pp. 2792-2796
    • Chambers, J.J.1
  • 56
    • 34248548818 scopus 로고    scopus 로고
    • Remote control of neuronal activity with a light-gated glutamate receptor
    • Szobota S., et al. Remote control of neuronal activity with a light-gated glutamate receptor. Neuron 54 (2007) 535-545
    • (2007) Neuron , vol.54 , pp. 535-545
    • Szobota, S.1
  • 57
    • 25844434860 scopus 로고    scopus 로고
    • Semiconductor nanocrystals for biological imaging
    • Fu A., et al. Semiconductor nanocrystals for biological imaging. Curr. Opin. Neurobiol. 15 (2005) 568-575
    • (2005) Curr. Opin. Neurobiol. , vol.15 , pp. 568-575
    • Fu, A.1
  • 58
    • 19944433260 scopus 로고    scopus 로고
    • Quantum dots for live cells, in vivo imaging, and diagnostics
    • Michalet X., et al. Quantum dots for live cells, in vivo imaging, and diagnostics. Science 307 (2005) 538-544
    • (2005) Science , vol.307 , pp. 538-544
    • Michalet, X.1
  • 59
    • 33847729958 scopus 로고    scopus 로고
    • Nanoscale engineering of a cellular interface with semiconductor nanoparticle films for photoelectric stimulation of neurons
    • Pappas T.C., et al. Nanoscale engineering of a cellular interface with semiconductor nanoparticle films for photoelectric stimulation of neurons. Nano. Lett. 7 (2007) 513-519
    • (2007) Nano. Lett. , vol.7 , pp. 513-519
    • Pappas, T.C.1
  • 60
    • 37649014870 scopus 로고    scopus 로고
    • ® nanoparticles. Proc. Soc. Neurosci. Meet., 317.11


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