A cell-spring electric field stimulation technique for high-throughput screening of voltage-gated ion channels

Assay and Drug Development Technologies

Volumn 4, Issue 1, 2006, Pages 21-35

  Bugianesi, Randal M ^a   Augustine, Paul R ^a   Azer, Karim ^a   Dufresne, Claude ^a   Herrington, James ^a   Kath, Gary S ^a   McManus, Owen B ^a   Napolitano, Christopher S ^a   Rush, Alison ^a   Sachs, Jeff ^a   Simpson, Neal ^a   Wismer, Michael K ^a   Kaczorowski, Gregory J ^a   Slaughter, Robert S ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; FLUNARIZINE; ISRADIPINE; MEXILETINE; MIBEFRADIL; NICARDIPINE; NIFEDIPINE; NITRENDIPINE; OMEGA CONOTOXIN GVIA; PHENYTOIN; QUINIDINE; TETRACAINE; TETRODOTOXIN; VERAPAMIL; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL; MUSCLE PROTEIN; SCN5A PROTEIN, HUMAN; SODIUM CHANNEL;

ARTICLE; BLEACHING; CELL FUNCTION; CELL MEMBRANE POTENTIAL; CELL STRAIN HEK293; COMPUTER SIMULATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG POTENCY; DRUG TARGETING; ELECTRODE; ELECTROPHYSIOLOGY; ELECTROSTIMULATION; EXPERIMENTAL DESIGN; FLUORESCENCE RESONANCE ENERGY TRANSFER; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MATHEMATICAL MODEL; METHODOLOGY; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; CELL LINE; CHANNEL GATING; DRUG EFFECT; INSTRUMENTATION; KINETICS; PHYSIOLOGY;

CALCIUM CHANNEL BLOCKERS; CELL LINE; COMPUTER SIMULATION; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; HUMANS; ION CHANNEL GATING; KINETICS; MEMBRANE POTENTIALS; MUSCLE PROTEINS; OMEGA-CONOTOXIN GVIA; SODIUM CHANNELS; TETRODOTOXIN;

EID: 33645298755     PISSN: 1540658X     EISSN: None     Source Type: Journal    
DOI: 10.1089/adt.2006.4.21     Document Type: Article

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