Partially crystalline systems in lyophilization: II. Withstanding collapse at high primary drying temperatures and impact on protein activity recovery

Journal of Pharmaceutical Sciences

Volumn 94, Issue 4, 2005, Pages 809-820

  Chatterjee, Koustuv ^a,c   Shalaev, Evgenyi Y ^b   Suryanarayanan, Raj ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c AMGEN INC   (United States)

Author keywords

Collapse; Freeze drying; Glycine; Protein activity; Raffinose; Trehalose

Indexed keywords

BUFFER; CARBOHYDRATE; CITRIC ACID; GLYCINE; LACTATE DEHYDROGENASE; PROTEIN; RAFFINOSE; TREHALOSE; WATER;

AQUEOUS SOLUTION; ARTICLE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; ENVIRONMENTAL TEMPERATURE; ENZYME ACTIVITY; FREEZE DRYING; TEMPERATURE DEPENDENCE; X RAY POWDER DIFFRACTION;

EID: 17744375823     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20304     Document Type: Article

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