Delayed fibril formation of amylin(20-29) by incorporation of alkene dipeptidosulfonamide isosteres obtained by solid phase olefin cross metathesis

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 1, 2008, Pages 78-84

  Brouwer, Arwin J ^a   Elgersma, Ronald C ^a   Jagodzinska, Monika ^a   Rijkers, Dirk T S ^a   Liskamp, Rob M J ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Alkenedipeptide isosteres; Alkenedipeptidosulfonamide isosteres; Amyloid; Peptidomimetics; Solid phase cross metathesis

Indexed keywords

ALKENE; AMYLIN; DIPEPTIDE; DIPEPTIDOSULFONAMIDE; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CIRCULAR DICHROISM; ELECTROSPRAY MASS SPECTROMETRY; ENZYMATIC DEGRADATION; FIBER; PEPTIDE SYNTHESIS; SOLID PHASE SYNTHESIS; TRANSMISSION ELECTRON MICROSCOPY; WITTIG REACTION;

ALKENES; AMYLOID; DIPEPTIDES; PEPTIDE FRAGMENTS; SULFONAMIDES;

EID: 37549050928     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.11.009     Document Type: Article

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