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Volumn 6, Issue 24, 1996, Pages 3035-3040

Solid-phase synthesis of peptidosulfonamide containing peptides derived from Leu-enkephalin

Author keywords

[No Author keywords available]

Indexed keywords

ENKEPHALIN DERIVATIVE; LEUCINE ENKEPHALIN; LEUCINE ENKEPHALINAMIDE; SULFONAMIDE;

EID: 0030591839     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(96)00565-3     Document Type: Article
Times cited : (45)

References (43)
  • 36
    • 0011353796 scopus 로고    scopus 로고
    • note
    • 15. Although Fmoc β-aminosulfonates can be synthesized from the corresponding zwitterions of 7b and 7c, preparation starting from the HCl salts 7b and 7c is more convenient since tedious ion-exchange steps are avoided. The use of sodium salts of 8b and 8c is preferred since these compounds are solids whereas the corresponding tetrabutyl ammonium salts are oils.
  • 37
    • 0011273392 scopus 로고    scopus 로고
    • note
    • 2, followed by addition of 150 mg triphosgene (0.5 mmol), 100 μL dry DMF and a catalytic amount of tetrabutylammonium chloride. After completion of the reaction (1 h), as was demonstrated by TLC, the reaction mixture was filtrated over a small amount of silica 60 (eluent: EtOAc/hexanes, 1/3, v/v) and the solvent evaporated affording sulfonylchloride 9c in a yield of 94% (198 mg).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.