Homocysteine and cognitive performance: Modification by the ApoE genotype

Neuroscience Letters

Volumn 430, Issue 1, 2008, Pages 64-69

  Elias, Merrill F ^a   Robbins, Michael A ^a   Budge, Marc M ^b   Elias, Penelope K ^a   Dore, Gregory A ^a   Brennan, Suzanne L ^a   Johnston, Carole ^c   Nagy, Zsuzsanna ^d  

^a University of Maine   (United States)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

ApoE; Cardiovascular risk factors; Cognitive performance; Homocysteine; Vitamins

Indexed keywords

APOLIPOPROTEIN E; HOMOCYSTEINE;

ADULT; ARTICLE; CARDIOVASCULAR DISEASE; COGNITION; COHORT ANALYSIS; CONTROLLED STUDY; DEMENTIA; EDUCATION; ETHNICITY; FEMALE; GENOTYPE; GROUPS BY AGE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REGRESSION ANALYSIS; RISK FACTOR; SEX DIFFERENCE; STROKE; TASK PERFORMANCE;

ADULT; AGED; AGED, 80 AND OVER; APOLIPOPROTEIN E4; CARDIOVASCULAR DISEASES; COGNITION; CROSS-SECTIONAL STUDIES; FEMALE; GENOTYPE; HOMOCYSTEINE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; RISK FACTORS; VITAMIN B COMPLEX;

EID: 37549044622     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2007.10.021     Document Type: Article

References (47)

1. Bretsky P., Guralnik J.M., Launer L., Albert M., and Seeman T.E. The role of APOE-epsilon4 in longitudinal cognitive decline: MacArthur studies of successful aging. Neurology 60 (2003) 1077-1081
2. Budge M.M., de Jager C., Hogervorst E., and Smith A.D. Total plasma homocysteine, age, systolic blood pressure, and cognitive performance in older people. J. Am. Geriatr. Soc. 50 (2002) 2014-2018
3. Bunce D., Kivipelto M., Wahlin A., and Apolipoprotein E. B vitamins, and cognitive function in older adults. J. Gerontol. B Psychol. Sci. Soc. Sci. 60 (2005) P41-P48
4. Bunce D., Kivipelto M., and Wahlin A. Utilization of cognitive support in episodic free recall as a function of apolipoprotein E and vitamin B12 or folate among adults aged 75 years and older. Neuropsychology 18 (2004) 362-370
5. Clarke R., Smith A.D., Jobst K.A., Refsum H., Sutton L., and Ueland P.M. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch. Neurol. 55 (1998) 1449-1455
6. Cockcroft D.W., and Gault M.H. Prediction of creatinine clearance from serum creatinine. Nephron 16 (1976) 31-41
7. Dufouil C., Alperovitch A., Ducros V., and Tzourio C. Homocysteine, white matter hyperintensities, and cognition in healthy elderly people. Ann. Neurol. 53 (2003) 214-221
8. Elias M.F., Beiser A., Wolf P.A., Au R., White R.F., and D'Agostino R.B. The preclinical phase of Alzheimer disease: a 22-year prospective study of the Framingham Cohort. Arch. Neurol. 57 (2000) 808-813
9. Elias P.K., Elias M.F., D'Agostino R.B., Sullivan L.M., and Wolf P.A. Serum cholesterol and cognitive performance in the Framingham Heart Study. Psychosom. Med. 67 (2005) 24-30
10. Elias M.F., Elias P.K., Robbins M.A., Wolf P.A., and D'Agostino R.B. Cardiovascular risk factors and cognitive functioning: an epidemiological perspective. In: Waldstein S., and Elias M.F. (Eds). Neuropsychology of Cardiovascular Disease (2001), Lawrence Erlbaum Associates, Inc., Hillsdale, NJ 83-105
11. Elias M.F., Robbins M.A., Budge M.M., Elias P.K., Brennan S.L., Johnston C., Nagy Z., and Bates C.J. Homocysteine, folate, and vitamins B6 and B12 blood levels in relation to cognitive performance: the Maine-Syracuse study. Psychosom. Med. 68 (2006) 547-554
12. Elias M.F., Sullivan L.M., D'Agostino R.B., Elias P.K., Jacques P.F., Selhub J., Seshadri S., Au R., Beiser A., and Wolf P.A. Homocysteine and cognitive performance in the Framingham offspring study: age is important. Am. J. Epidemiol. 162 (2005) 644-653
13. Farrer L.A., Cupples L.A., Haines J.L., Hyman B., Kukull W.A., Mayeux R., Myers R.H., Pericak-Vance M.A., Risch N., and van Duijn C.M. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. J. Am. Med. Assoc. 278 (1997) 1349-1356
14. Fykse E.M., Iversen E.G., and Fonnum F. Inhibition of l-glutamate uptake into synaptic vesicles. Neurosci. Lett. 135 (1992) 125-128
15. Haan M.N., Shemanski L., Jagust W.J., Manolio T.A., and Kuller L. The role of APOE epsilon4 in modulating effects of other risk factors for cognitive decline in elderly persons. J. Am. Med. Assoc. 282 (1999) 40-46
16. Hankey G.J., and Eikelboom J.W. Homocysteine and vascular disease. Lancet 354 (1999) 407-413
17. Hixson J.E., and Vernier D.T. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J. Lipid. Res. 31 (1990) 545-548
18. Horsburgh K., McCarron M.O., White F., and Nicoll J.A. The role of apolipoprotein E in Alzheimer's disease, acute brain injury and cerebrovascular disease: evidence of common mechanisms and utility of animal models. Neurobiol. Aging 21 (2000) 245-255
19. Kado D.M., Karlamangla A.S., Huang M.H., Troen A., Rowe J.W., Selhub J., and Seeman T.E. Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur studies of successful aging. Am. J. Med. 118 (2005) 161-167
20. Kruman II, Culmsee C., Chan S.L., Kruman Y., Guo Z., Penix L., and Mattson M.P. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J. Neurosci. 20 (2000) 6920-6926
21. Lentz S.R. Mechanisms of homocysteine-induced atherothrombosis. J. Thromb. Haemost. 3 (2005) 1646-1654
22. Leoncini G., Viazzi F., Parodi D., Vettoretti S., Ratto E., Ravera M., Tomolillo C., Del Sette M., Bezante G.P., Deferrari G., and Pontremoli R. Mild renal dysfunction and subclinical cardiovascular damage in primary hypertension. Hypertension 42 (2003) 14-18
23. Lezak M.D., Howieson D.B., and Loring D.W. Neuropsychological Assessment (2004), Oxford University Press, New York xiv, 1016 pp.
24. Lipton S.A., Kim W.K., Choi Y.B., Kumar S., D'Emilia D.M., Rayudu P.V., Arnelle D.R., and Stamler J.S. Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 5923-5928
25. McCaddon A., Davies G., Hudson P., Tandy S., and Cattell H. Total serum homocysteine in senile dementia of Alzheimer type. Int. J. Geriatr. Psychiatry 13 (1998) 235-239
26. McCaddon A., Hudson P., Davies G., Hughes A., Williams J.H., and Wilkinson C. Homocysteine and cognitive decline in healthy elderly. Dement. Geriatr. Cogn. Disord 12 (2001) 309-313
27. McKhann G., Drachman D., Folstein M., Katzman R., Price D., and Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34 (1984) 939-944
28. Miller J.W., Green R., Ramos M.I., Allen L.H., Mungas D.M., Jagust W.J., and Haan M.N. Homocysteine and cognitive function in the Sacramento Area Latino Study on aging. Am. J. Clin. Nutr. 78 (2003) 441-447
29. Nagy Z. Cell cycle-related protein expression in Alzheimer's disease and vascular disease. Int. Psychogeriatr. 15 Suppl. 1 (2003) 77-79
30. Nathan B.P., Bellosta S., Sanan D.A., Weisgraber K.H., Mahley R.W., and Pitas R.E. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science 264 (1994) 850-852
31. Parasuraman R., Greenwood P.M., and Sunderland T. The apolipoprotein E gene, attention, and brain function. Neuropsychology 16 (2002) 254-274
32. Parsons R.B., Waring R.H., Ramsden D.B., and Williams A.C. In vitro effect of the cysteine metabolites homocysteic acid, homocysteine and cysteic acid upon human neuronal cell lines. Neurotoxicology 19 (1998) 599-603
33. Prins N.D., Den Heijer T., Hofman A., Koudstaal P.J., Jolles J., Clarke R., and Breteler M.M. Homocysteine and cognitive function in the elderly: the Rotterdam Scan Study. Neurology 59 (2002) 1375-1380
34. Radloff L.S. The CES-D scale: a self-report depression scale for research in the general population. Appl. Psychol. Meas. 1 (1977) 385-401
35. Refsum H., Ueland P.M., Nygard O., and Vollset S.E. Homocysteine and cardiovascular disease. Annu. Rev. Med. 49 (1998) 31-62
36. Regland B., Blennow K., Germgard T., Koch-Schmidt A.C., and Gottfries C.G. The role of the polymorphic genes apolipoprotein E and methylene-tetrahydrofolate reductase in the development of dementia of the Alzheimer type. Dement. Geriatr. Cogn. Disord 10 (1999) 245-251
37. Riggs K.M., Spiro III A., Tucker K., and Rush D. Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study. Am. J. Clin. Nutr. 63 (1996) 306-314
38. Schafer J.H., Glass T.A., Bolla K.I., Mintz M., Jedlicka A.E., and Schwartz B.S. Homocysteine and cognitive function in a population-based study of older adults. J. Am. Geriatr. Soc. 53 (2005) 381-388
39. Selhub J., Bagley L.C., Miller J., and Rosenberg I.H. B vitamins, homocysteine, and neurocognitive function in the elderly. Am. J. Clin. Nutr. 71 (2000) 614S-620S
40. Seshadri S., Beiser A., Selhub J., Jacques P.F., Rosenberg I.H., D'Agostino R.B., Wilson P.W., and Wolf P.A. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N. Engl. J. Med. 346 (2002) 476-483
41. Shipchandler M.T., and Moore E.G. Rapid, fully automated measurement of plasma homocyst(e)ine with the Abbott IMx analyzer. Clin. Chem. 41 (1995) 991-994
42. Small B.J., Graves A.B., McEvoy C.L., Crawford F.C., Mullan M., and Mortimer J.A. Is APOE-epsilon4 a risk factor for cognitive impairment in normal aging?. Neurology 54 (2000) 2082-2088
43. Small B.J., Rosnick C.B., Fratiglioni L., and Backman L. Apolipoprotein E and cognitive performance: a meta-analysis. Psychol. Aging 19 (2004) 592-600
44. Smith J.D. Apolipoproteins and aging: emerging mechanisms. Ageing Res. Rev. 1 (2002) 345-365
45. Teunissen C.E., Blom A.H., Van Boxtel M.P., Bosma H., de Bruijn C., Jolles J., Wauters B.A., Steinbusch H.W., and de Vente J. Homocysteine: a marker for cognitive performance? A longitudinal follow-up study. J. Nutr. Health Aging 7 (2003) 153-159
46. Tucker K.L., Qiao N., Scott T., Rosenberg I., and Spiro III A. High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study. Am. J. Clin. Nutr. 82 (2005) 627-635
47. Zhou J., Werstuck G.H., Lhotak S., de Koning A.B., Sood S.K., Hossain G.S., Moller J., Ritskes-Hoitinga M., Falk E., Dayal S., Lentz S.R., and Austin R.C. Association of multiple cellular stress pathways with accelerated atherosclerosis in hyperhomocysteinemic apolipoprotein E-deficient mice. Circulation 110 (2004) 207-213