Apolipoprotein E and cognitive performance: A meta-analysis

Psychology and Aging

Volumn 19, Issue 4, 2004, Pages 592-600

  Small, Brent J ^a   Rosnick, Christopher B ^a   Fratiglioni, Laura ^b   Bäckman, Lars ^b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E;

ARTICLE; COGNITION; COGNITIVE DEFECT; GENOTYPE; HUMAN; MEMORY;

ADULT; AGED; AGED, 80 AND OVER; AGING; ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; COGNITION; FEMALE; GENOTYPE; HETEROZYGOTE DETECTION; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; REACTION TIME;

EID: 10044243556     PISSN: 08827974     EISSN: None     Source Type: Journal    
DOI: 10.1037/0882-7974.19.4.592     Document Type: Article

References (75)

1. Ahles, T. A., Saykin, A. J., Noll, W. W., Furstenberg, C. T., Guerin, S., Cole, B., & Mott, L. A. (2003). The relationship of APOE genotype to neuropsychological performance in long-term cancer survivors treated with standard dose chemotherapy. Psych-oncology, 12, 612-619.
2. Anstey, K., & Christensen, H. (2000). Education, activity, health, blood pressure, and apolipoprotein E as predictors of cognitive change in old age: A review. Gerontology, 46, 163-177.
3. *Berr, C., Dufouil, C., Brousseau, T., Richard, F., Amouyel, P., Marceteau, E. & Alpérovitch, A. (1996). Early effect of ApoE-ε4 allele on cognitive results in a group of highly performing subjects:. The EVA study. Neuroscience Letters, 218, 9-12.
4. *Bondi, M. W., Salmon, D. P., Galasko, D., Thomas, R. G., & Thal, L. J. (1999). Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease. Psychology and Aging, 14, 295-303.
5. Bondi, M. W., Salmon, D. P., Monsch, A. U., Galasko, D., Butters, N., Klauber, M. R., et al. (1995). Episodic memory changes are associated with the APOE-ε4 allele in nondemented older adults. Neurology, 45, 2203-2206.
6. *Bookheimer, S. Y., Strojwas, M. H., Cohen, M. S., Saunders, A. M., Pericak-Vance, M. A., Mazziotta, J. C., & Small, G. W. (2000). Patterns of brain activation in people at risk for Alzheimer's disease. New England Journal of Medicine, 343, 450-456.
7. Breitner, J. C. S., Wyse, B. W., Anthony, J. C., Welsh-Bohmer, K. A., Steffens, D. C., Norton, M. C., et al. (1999). APOE-ε4 count predicts age when prevalence of AD increases, then declines: The Cache County Study. Neurology, 53, 321-331.
8. Bretsky, P., Guralnik, J. M., Launer, L., Albert, M., & Seeman, T. E. (2003). The role of APOE-ε4 in longitudinal cognitive decline: MacArthur studies of successful aging. Neurology, 60, 1077-1081.
9. Caselli, R. J., Graff-Radford, N. R., Reiman, E. M., Weaver, A., Osborne, D., Lucas, J., et al. (1999). Preclinical memory decline in cognitively normal apolipoprotein E-ε4 homozygotes. Neurology, 53, 201-207.
10. Caselli, R. J., Osborne, D., Reiman, E. M., Hentz, J. G., Barbieri, C. J., Saunders, A. M., et al. (2001). Preclinical cognitive decline in late middle-aged asymptomatic apolipoprotein E-ε4/4 homozygotes: A replication study. Journal of Neurological Sciences, 189, 93-98.
11. *Caselli, R. J., Reiman, E. M., Hentz, J. G., Osborne, D., Alexander, G. E., & Boeve, B. F. (2002). A distinctive interaction between memory and chronic daytime somnolence in asymptomatic APOE ε4 homozygotes. Sleep, 25, 447-453.
12. *Chen, J. G., Edwards, C. L., Vidyarthi, S., Pitchumoni, S., Tabrizi, S., Barboriak, D., et al. (2002). Learning and recall in subjects at genetic risk for Alzheimer's disease. Journal of Neuropsychiatry and Clinical Neurosciences, 14, 58-63.
13. Cohen, J. (1988). Statistical power analysis for the behavioral sciences. Hillsdale, NJ: Erlbaum.
14. *Cohen, R. M., Small, C., Lalonde, F., Friz, J., & Sunderland, T. (2001). Effect of apolipoprotein E genotype on hippocampal volume loss in aging healthy women. Neurology, 57, 2223-2228.
15. Corder, E. H., Lannfelt, L., Viitanen, M., Corder, L. S., Manton, K. G., Winblad, B., & Basun, H. (1996). Apolipoprotein E genotype determines survival in the oldest old (85 years or older) who have good cognition. Archives of Neurology, 53, 418-422.
16. Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. A., et al. (1993, August 13). Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science, 261, 921-923.
17. Deary, I. J., Whalley, W. J., St. Clair, D., Breen, G., Leaper, S., Lemmon, H., et al. (2003). The influence of the ε4 allele of the apolipoprotein E gene on childhood IQ, nonverbal reasoning in old age, and lifetime cognitive change. Intelligence, 31, 85-92.
18. *Deary, I. J., Whiteman, M. C., Pattie, A., Starr, J. M., Hayward, C., Wright, A. F., et al. (2002, August 29). Cognitive change and the APOE ε4 allele. Nature, 48, 932.
19. Deary, I. J., Whiteman, M. C., Pattie, A., Starr, J. M., Hayward, C., Wright, A. F., et al. (2004). Apolipoprotein E gene variability and cognitive functions at age 79: A follow-up of the Scottish Mental Survey of 1932. Psychology and Aging, 19, 367-371.
20. *den Heijer, T., Oudkerk, M., Launer, L. J., van Duijn, C. M., Hofman, A., & Breteler, M. M. B. (2002). Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes. Neurology, 59, 746-748.
21. *Dik, M. G., Jonker, C., Bouter, L. M., Geerlings, M. I., van Kamp, G. J., & Deeg, D. J. H. (2000). APOE-ε4 is associated with memory decline in cognitively impaired elderly. Neurology, 54, 1492-1497.
22. Farrer, L. A., Cupples, L. A., Haines, J. L., Hyman, B. T., Kukull, W. A., Mayeux, R., et al. (1997). Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: A meta-analysis. Journal of the American Medical Association, 278, 1349-1356.
23. *Flory, J. D., Manuck, S. B., Ferrell, R. E., Ryan, C. M., & Muldoon, M. F. (2000). Memory performance and the apolipoprotein E polymorphism in a community sample of middle-aged adults. American Journal of Medical Genetics, 96, 707-711.
24. Gerdes, L. U., Jeune, B., Ranberg, K. A., Nybo, H., & Vaupel, J. W. (2000). Estimation of apolipoprotein E genotype-specific relative mortality risks from the distribution of genotypes in centenarians and middle-aged men: Apolipoprotein E gene as a frailty gene, not a longevity gene. Genetics Epidemiology, 19, 202-210.
25. Growdon, J. H., Locascio, J. J., Corkin, S., Gomez-Isla, T., & Hyman, B. T. (1996). Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer' disease. Neurology, 47, 444-448.
26. *Haan, M. N., Shemanski, L., Jagust, W. J., Manolio, T. A., & Kuller, L. (1999). The role of APOE ε4 in modulating effects of other risk factors for cognitive decline in elderly persons. Journal of the American Medical Association, 282, 40-46.
27. Hashimoto, M., Yasuda, M., Tanimukai, S., Matsui, M., Hirono, N., Kazui, H., & Mori, E. (2001). Apolipoprotein E ε4 and the pattern of regional brain atrophy in Alzheimer's disease. Neurology, 57, 1461-1466.
28. Hedges, L. V., & Olkin, I. (1985). Statistical methods for meta-analysis. New York: Academic Press.
29. *Helkala, E-L, Koivisto, K., Hänninen, T., Vanhanen, M., Kervinen, K., Kuusisto, J., et al. (1995). The association of apolipoprotein E polymorphism with memory: A population-based study. Neuroscience Letters, 191, 141-144.
30. Helkala, E-L, Koivisto, K., Hänninen, T., Vahnanen, M., Kervinen, K., Kuusisto, J., et al. (1996). Memory functions in human subjects with different apolipoprotein E phenotypes during a 3-year population-based follow-up study. Neuroscience Letters, 204, 177-180.
31. Helkala, E-L, Lakka, T., Vanhanen, M., Tuomainen, T-P, Ehnholm, C., Kaplan, G. A., & Salonen, J. T. (2001). Associations between apolipoprotein E phenotype, glucose metabolism and cognitive function in men. An explorative study in a population sample. Diabetic Medicine, 18, 991-997.
32. *Hofer, S. M., Christensen, H, Mackinnon, A. J., Korten, A. E., Jorm, A. F., Henderson, A. S., & Easteal, S. (2002). Change in cognitive functioning associated with APOE genotype in a community sample of older adults. Psychology and Aging, 17, 194-208.
33. Horsburgh, K., McCarron, M. O., White, F., & Nicoll, J. A. (2000). The role of apolipoprotein E in Alzheimer's disease, acute brain injury and cerebrovascular disease: Evidence of common mechanisms and utility of animal models. Neurobiology of Aging, 21, 245-255.
34. Jack, C. R., Jr., Petersen, R. C., Xu, Y. C., O'Brien, P. C., Waring, S. C., Tangalos, E. G., et al. (1998). Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease. Annals of Neurology, 43, 303-310.
35. Juottonen, K., Lehtovirta, M., Helisalmi, S., Riekkinen, P. J., Sr., & Soinien, J. (1998). Major decrease in the volume of the entorhinal cortex in patients with Alzheimer's disease carrying the apolipoprotein E epsilon 4 allele. Journal of Neurology, Neurosurgery, and Psychiatry, 65, 322-327.
36. *Juva, K., Verkkoniemi, A., Viramo, P., Polvikoski, T., Kainulainen, K., Kontula, K., & Sulkava, R. (2000). Apolipoprotein E, cognitive function, and dementia in a general population age 85 years and over. International Psychogeriatrics, 12, 379-387.
37. *Kim, K. W., Youn, J. C., Jhoo, J. H., Lee, D. Y., Lee, D. U., Lee, J. H., & Woo, J. I. (2002). Apolipoprotein E ε4 allele is not associated with the cognitive impairment in community-dwelling normal elderly individuals. International Journal of Geriatric Psychiatry, 17, 635-640.
38. *Klages, J. D., Fisk, J. D., & Rockwood, K. (2003). APOE genotype, memory test performance, and the risk of Alzheimer's disease in the Canadian Study of Health and Aging. Dementia and Geriatric Cognitive Disorders, 15, 1-5.
39. Lehtovirta, M., Kuikka, J., Helisalmi, S., Hartikainen, P., Mannermaa, A., Ryynane, M., et al. (1998). Longitudinal SPECT study in Alzheimer's disease: Relation to apolipoprotein E polymorphism. Journal of Neurology, Neurosurgery, and Psychiatry, 64, 742-746.
40. Lehtovirta, M., Laakso, M. P., Soininen, H., Helisalmi, S., Mannermaa, A., Helkala, E-L, et al. (1995). Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes. Neuroscience, 67, 65-72.
41. Lehtovirta, M., Soininen, H., Helisalmi, S., Mannermaa, A., Helkala, E-L, Hartikainen, et al. (1996). Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: Relation to apolipoprotein E polymorphism. Neurology, 46, 413-419.
42. *Levy, J. A., Bergeson, J., Putnam, K., Rosen, V., Cohen, R., Lalonde, F., et al. (2004). Context-specific memory and apolipoprotein E (ApoE) ε4: Cognitive evidence from the NIMH prospective study of risk for Alzheimer's disease. Journal of the International Neuropsychological Society, 10, 362-370.
43. Lezak, M. D. (1995). Neuropsychological assessment (3rd ed.). London: Oxford University Press.
44. Mahley, R. W. (1988, April 29). Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology. Science, 240, 622-630.
45. Menzel, H. J., Kladetzky, R. G., & Assmann, G. (1983). Apolipoprotein E polymorphism and coronary artery disease. Arteriosclerosis, 3, 310-315.
46. *Moffat, S. D., Szekely, C. A., Zonderman, A. B., Kabani, N. J., & Resnick, S. M. (2000). Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype. Neurology, 55, 134-136.
47. *Mortensen, E. L., & Høgh, P. (2001). A gender difference in the association between APOE genotype and age-related cognitive decline. Neurology, 57, 89-95.
48. National Library of Medicine (2004). Medical subject headings. Retrieved May 16, 2004 from http://www.nlm.nih.gov/mesh/meshhome.html
49. *Newman, M. C., Holland, A. L., Caselli, R. J., Gongoll, R., White, K., & Reiman, E. M. (2000). Talkativeness in cognitively normal women at genetic risk for Alzheimer's disease. Aging, Neuropsychology, and Cognition, 7, 217-226.
50. *Nilsson, L. -G., Adolfsson, R., Bäckman, L., Cruts, M., Nyberg, L., Small, B. J., & van Broeckoven, C. (2004). The influence of APOE status on episodic and semantic memory: Data from a population-based study. Manuscript submitted for publication.
51. Nyberg, L., McIntosh, A. R., Houle, S., Nilsson, L-G, & Tulving, E. (1996, April 25). Activation of medial temporal structures during episodic memory retrieval. Nature, 380, 715-717.
52. *O'Hara, R., Yesavage, J. A., Kraemer, H. C., Mauricio, M., Friedman, L. F., & Murphy, G. M. (1998). The apoe epsilon 4 allele is associated with decline on delayed recall performance in community-dwelling older adults. Journal of the American Geriatrics Society, 46, 1493-1498.
53. Parasuraman, R., Greenwood, P. M., & Sunderland, T. (2002). The apolipoprotein E gene, attention, and brain function. Neuropsychology, 16, 254-274.
54. *Pendleton, N., Payton, A., van den Boogerd, E. H., Holland, F., Diggle, P., Rabbitt, P. M. A., et al. (2002). Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults. Neuroscience Letters, 324, 74-76.
55. *Plassman, B. L., Welsh-Bohmer, K. A., Bigler, E. D., Johnson, S. C., Anderson, C. V., Helms, M. J., et al. (1997). Apolipoprotein E ε4 allele and hippocampal volume in twins with normal cognition. Neurology, 48, 985-989.
56. Reitan, R. M., & Wolfson, D. (1993). The Halstead-Reitan Neuropsychological Test Battery: Theory and clinical interpretation. Tucson, AZ: Neuropsychology Press.
57. *Riley, K. P., Snowdon, D. A., Saunders, A. M., Roses, A. D., Mortimer, J. A, & Nanyakkara, N. (2000). Cognitive function and apolipoprotein E in very old adults: Findings from the Nun Study. Journals of Gerontology, Series B: Psychological Sciences and Social Sciences, 55, S69-S75.
58. *Rosen, V. M., Bergeson, K., Putnam, K., Harwell, A., & Sunderland, T. (2002). Working memory and apolipoprotein E: What's the connection? Neuropsychologia, 40, 2226-2233.
59. *Salo, A., Ylikoski, R., Verkkoniemi, A., Polvikoski, T., Juva, K., Rastas, S., et al. (2001). Does apolipoprotein E influence learning and memory in the nondemented oldest old? International Psychogeriatics, 13, 451-459.
60. *Schmidt, H., Schmidt, R., Fazekas, F., Semmler, J., Kapeller, P., Reinhart, B., & Kostner, G. M. (1996). Apolipoprotein E ε4 allele in the normal elderly: Neuropsychologic and brain MRI correlates. Clinical Genetics, 50, 293-299.
61. *Small, B. J., Basun, H., & Bäckman, L. (1998). Three-year changes in cognitive performance as a function of apolipoprotein E genotype: Evidence from very-old adults without dementia. Psychology and Aging, 13, 80-87.
62. *Small, B. J., Graves, A. B., McEvoy, C. L., Crawford, F. C., Mullan, M., & Mortimer, J. A. (2000). Is APOE-ε4 a risk factor for cognitive impairment in normal aging? Neurology, 54, 2082-2088.
63. *Smith, G. E., Bohac, D. L., Waring, S. C., Kokmen, E., Tangalos, E. G., Ivnik, R. J., & Petersen, R. C. (1998). Apolipoprotein E genotype influences cognitive "phenotype" in patients with Alzheimer's disease but not in healthy control subjects. Neurology, 50, 355-362.
64. Smith, J. D. (2002). Apolipoproteins and aging: Emerging mechanisms. Aging Research Reviews, 1, 345-365.
65. Spreen, O., & Strauss, E. (1998). A compendium of neuropsychological tests (2nd ed.). London: Oxford University Press.
66. Squire, L. R. (1986, June 27). Mechanisms of memory. Science, 232, 1612-1619.
67. Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993). Apolipoprotein E: High avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer's disease. Proceedings of the National Academy of Science, 90, 1977-1981.
68. *Tardiff, B. E., Newman, M. F., Saunders, A. M., Strittmatter, W. J., Blumenthal, J. A., White, W. D., et al. (1997). Preliminary report of a genetic basis for cognitive decline after cardiac operations. Annals of Thoracic Surgery, 64, 715-720.
69. *Tohgi, H., Takahashi, S., Kato, E., Homma, A., Niina, R., Sasaki, K., et al. (1997). Reduced size of right hippocampus in 39- to 80-year-old normal subjects carrying the apolipoprotein E ε4 allele. Neuroscience Letters, 236, 21-24.
70. Turic, D., Fisher, P. J., Plomin, R., & Owen, M. J. (2001). No association between apolipoprotein E polymorphisms and general cognitive ability in children. Neuroscience Letters, 299, 97-100.
71. *Wilson, R. S., Bienias, J. L., Berry-Kravis, E., Evans, D. A., & Bennett, D. A. (2002). The apolipoprotein E ε2 allele and decline in episodic memory. Journal of Neurology, Neurosurgery, and Psychiatry, 73, 672-677.
72. *Wilson, R. S., Schneider, J. A., Barnes, L. L., Beckett, L. A., Aggarwal, N. T., Cochran, E. J., et al. (2002). The apolipoprotein E ε4 allele and decline in different cognitive systems during a 6-year period. Archives of Neurology, 59, 1154-1160.
73. *Winnock, M., Letenneur, L., Jacqmin-Gadda, H., Dallongeville, J., Amouyel, P., & Dartigues, J. F. (2002). Longitudinal analysis of the effect of apolipoprotein E ε4 and education on cognitive performance in elderly subjects: The PAQUID study. Journal of Neurology, Neurosurgery, and Psychiatry, 72, 794-797.
74. *Yaffe, K., Cauley, J., Sands, L., & Browner, W. (1997). Apolipoprotein E phenotype and cognitive decline in a prospective study of elderly community women. Archives of Neurology, 54, 1110-1114.
75. *Yip, A. G., Brayne, C., Easton, D., & Rubinsztein, D. C. (2002). Apolipoprotein E4 is only a weak predictor of dementia and cognitive decline in the general population. Journal of Medical Genetics, 39, 639-643.