Low joining efficiency and non-conservative repair of two distant double-strand breaks in mouse embryonic stem cells

DNA Repair

Volumn 7, Issue 2, 2008, Pages 149-161

  Boubakour Azzouz, Imenne ^a   Ricchetti, Miria ^a  

^a CNRS   (France)

Author keywords

DNA junctions; DSB repair; Genome rearrangements; Mouse ES cells; NHEJ

Indexed keywords

DNA; ENDONUCLEASE; PROTEIN I SCEL; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL CELL; ARTICLE; BASE PAIRING; CELL SURVIVAL; CHROMOSOME PAIRING; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA STRUCTURE; DOUBLE STRANDED DNA BREAK; EMBRYONIC STEM CELL; EXPERIMENTAL STUDY; GENOME; HOMOZYGOSITY; MOUSE; NONHOMOLOGOUS END JOINING; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

ANIMALS; BASE SEQUENCE; BLOTTING, SOUTHERN; COMPUTATIONAL BIOLOGY; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA BREAKS, DOUBLE-STRANDED; DNA PRIMERS; DNA REPAIR; EMBRYONIC STEM CELLS; GENOMIC INSTABILITY; MICE; MOLECULAR SEQUENCE DATA; SEQUENCE ANALYSIS, DNA;

EID: 37549041373     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2007.09.005     Document Type: Article

References (44)

1. Mills K.D., Ferguson D.O., and Alt F.W. The role of DNA breaks in genomic instability and tumorigenesis. Immunol. Rev. 194 (2003) 77-95
2. Rowley J.D. Chromosome translocations: dangerous liaisons revisited. Nat. Rev. Cancer 1 (2001) 245-250
3. Haber J.E. Partners and pathways repairing a double-strand break. Trends Genet. 16 (2000) 259-264
4. Pipiras E., Coquelle A., Bieth A., and Debatisse M. Interstitial deletions and intrachromosomal amplification initiated from a double-strand break targeted to a mammalian chromosome. EMBO J. 17 (1998) 325-333
5. Allen C., Miller C.A., and Nickoloff J.A. The mutagenic potential of a single DNA double-strand break in a mammalian chromosome is not influenced by transcription. DNA Repair (Amst) 2 (2003) 1147-1156
6. van Gent D.C., Hoeijmakers J.H., and Kanaar R. Chromosomal stability and the DNA double-stranded break connection. Nat. Rev. Genet. 2 (2001) 196-206
7. Guirouilh-Barbat J., Huck S., Bertrand P., Pirzio L., Desmaze C., Sabatier L., and Lopez B.S. Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells. Mol. Cell 14 (2004) 611-623
8. Richardson C., and Jasin M. Frequent chromosomal translocations induced by DNA double-strand breaks. Nature 405 (2000) 697-700
9. Arnold K., Kim M.K., Frerk K., Edler L., Savelyeva L., Schmezer P., and Wiedemeyer R. Lower level of BRCA2 protein in heterozygous mutation carriers is correlated with an increase in DNA double strand breaks and an impaired DSB repair. Cancer Lett. (2006)
10. Coupier I., Baldeyron C., Rousseau A., Mosseri V., Pages-Berhouet S., Caux-Moncoutier V., Papadopoulo D., and Stoppa-Lyonnet D. Fidelity of DNA double-strand break repair in heterozygous cell lines harbouring BRCA1 missense mutations. Oncogene 23 (2004) 914-919
11. Ham M.F., Takakuwa T., Luo W.J., Liu A., Horii A., and Aozasa K. Impairment of double-strand breaks repair and aberrant splicing of ATM and MRE11 in leukemia-lymphoma cell lines with microsatellite instability. Cancer Sci. 97 (2006) 226-234
12. Nakanishi K., Yang Y.G., Pierce A.J., Taniguchi T., Digweed M., D'Andrea A.D., Wang Z.Q., and Jasin M. Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 1110-1115
13. Fairhead C., and Dujon B. Consequences of unique double-stranded breaks in yeast chromosomes: death or homozygosis. Mol. Gen. Genet. 240 (1993) 170-178
14. Lin Y., Lukacsovich T., and Waldman A.S. Multiple pathways for repair of DNA double-strand breaks in mammalian chromosomes. Mol. Cell. Biol. 19 (1999) 8353-8360
15. Kramer K.M., Brock J.A., Bloom K., Moore J.K., and Haber J.E. Two different types of double-strand breaks in Saccharomyces cerevisiae are repaired by similar RAD52-independent, nonhomologous recombination events. Mol. Cell. Biol. 14 (1994) 1293-1301
16. Ricchetti M., Dujon B., and Fairhead C. Distance from the chromosome end determines the efficiency of double strand break repair in subtelomeres of haploid yeast. J. Mol. Biol. 328 (2003) 847-862
17. Egli D., Hafen E., and Schaffner W. An efficient method to generate chromosomal rearrangements by targeted DNA double-strand breaks in Drosophila melanogaster. Genome Res. 14 (2004) 1382-1393
18. Abeysinghe S.S., Stenson P.D., Krawczak M., and Cooper D.N. Gross rearrangement breakpoint database (GRaBD). Hum. Mutat. 23 (2004) 219-221
19. Greaves M.F., and Wiemels J. Origins of chromosome translocations in childhood leukaemia. Nat. Rev. Cancer 3 (2003) 639-649
20. Ricchetti M., Fairhead C., and Dujon B. Mitochondrial DNA repairs double-strand breaks in yeast chromosomes. Nature 402 (1999) 96-100
21. Weinstock D.M., Elliott B., and Jasin M. A model of oncogenic rearrangements: differences between chromosomal translocation mechanisms and simple double-strand break repair. Blood 107 (2006) 777-780
22. Zarrin A.A., Del Vecchio C., Tseng E., Gleason M., Zarin P., Tian M., and Alt F.W. Antibody class switching mediated by yeast endonuclease-generated DNA breaks. Science 315 (2007) 377-381
23. Kassar-Duchossoy L., Gayraud-Morel B., Gomes D., Rocancourt D., Buckingham M., Shinin V., and Tajbakhsh S. Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice. Nature 431 (2004) 466-471
24. Conner D.A. Current Protocols in Molecular Biology (2006), John Wiley & Sons Inc.
25. Choulika A., Perrin A., Dujon B., and Nicolas J.F. Induction of homologous recombination in mammalian chromosomes by using the I-SceI system of Saccharomyces cerevisiae. Mol. Cell Biol. 15 (1995) 1968-1973
26. Niwa H., Yamamura K., and Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108 (1991) 193-199
27. Tajbakhsh S., Vivarelli E., Cusella-De-Angelis G., Rocancourt D., Buckingham M., and Cossu G. A population of myogenic cells derived from the mouse neural tube. Neuron 13 (1994) 813-821
28. Laird P.W., Zijderveld A., Linders K., Rudnicki M.A., Jaenisch R., and Berns A. Simplified mammalian DNA isolation procedure. Nucleic. Acids Res. 19 (1991) 4293
29. Thierry A., and Dujon B. Nested chromosomal fragmentation in yeast using the meganuclease I-Sce I: a new method for physical mapping of eukaryotic genomes. Nucleic. Acids Res. 20 (1992) 5625-5631
30. Pierce A.J., Hu P., Han M., Ellis N., and Jasin M. Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev. 15 (2001) 3237-3242
31. Subramani S., and Rubnitz J. Recombination events after transient infection and stable integration of DNA into mouse cells. Mol. Cell Biol. 5 (1985) 659-666
32. Bertrand P., Rouillard D., Boulet A., Levalois C., Soussi T., and Lopez B.S. Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein. Oncogene 14 (1997) 1117-1122
33. Nick McElhinny S.A., Havener J.M., Garcia-Diaz M., Juarez R., Bebenek K., Kee B.L., Blanco L., Kunkel T.A., and Ramsden D.A. A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining. Mol. Cell. 19 (2005) 357-366
34. Schratt G., Weinhold B., Lundberg A.S., Schuck S., Berger J., Schwarz H., Weinberg R.A., Ruther U., and Nordheim A. Serum response factor is required for immediate-early gene activation yet is dispensable for proliferation of embryonic stem cells. Mol. Cell. Biol. 21 (2001) 2933-2943
35. Zhang E., Li X., Zhang S., Chen L., and Zheng X. Cell cycle synchronization of embryonic stem cells: effect of serum deprivation on the differentiation of embryonic bodies in vitro. Biochem. Biophys. Res. Commun. 333 (2005) 1171-1177
36. Guo D., Han J., Adam B.L., Colburn N.H., Wang M.H., Dong Z., Eizirik D.L., She J.X., and Wang C.Y. Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. Biochem. Biophys. Res. Commun. 337 (2005) 1308-1318
37. Rouet P., Smih F., and Jasin M. Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease. Mol. Cell Biol. 14 (1994) 8096-8106
38. Elliott B., Richardson C., and Jasin M. Chromosomal translocation mechanisms at intronic alu elements in mammalian cells. Mol. Cell 17 (2005) 885-894
39. Manis J.P., Tian M., and Alt F.W. Mechanism and control of class-switch recombination. Trends Immunol. 23 (2002) 31-39
40. Schlissel M.S. Structure of nonhairpin coding-end DNA breaks in cells undergoing V(D)J recombination. Mol. Cell. Biol. 18 (1998) 2029-2037
41. Brown M.L., and Chang Y. Metabolism of recombination coding ends in scid cells. J. Immunol. 164 (2000) 4135-4142
42. Collis S.J., DeWeese T.L., Jeggo P.A., and Parker A.R. The life and death of DNA-PK. Oncogene 24 (2005) 949-961
43. Pastwa E., and Blasiak J. Non-homologous DNA end joining. Acta Biochim. Pol. 50 (2003) 891-908
44. Ma J.L., Kim E.M., Haber J.E., and Lee S.E. Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences. Mol. Cell. Biol. 23 (2003) 8820-8828