Distance from the chromosome end determines the efficiency of double strand break repair in subtelomeres of haploid yeast

Journal of Molecular Biology

Volumn 328, Issue 4, 2003, Pages 847-862

  Ricchetti, Miria ^a,b   Dujon, Bernard ^a   Fairhead, Cécile ^a  

^a SORBONNE UNIVERSITÉ   (France)

^b INSTITUT PASTEUR   (France)

Author keywords

Chromosomal rearrangement; Double strand breaks; Non homologous end joining; RAD52; Subtelomeres

Indexed keywords

DOUBLE STRANDED DNA;

ARTICLE; CHROMOSOME REARRANGEMENT; CHROMOSOME REPLICATION; DNA REPAIR; DNA STRAND BREAKAGE; EVOLUTION; GENE CONVERSION; GENE SEQUENCE; HAPLOIDY; NONHUMAN; PLASMID; PRIORITY JOURNAL; TELOMERE; YEAST ARTIFICIAL CHROMOSOME;

EID: 0037427471     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(03)00315-2     Document Type: Article

References (45)

1. Weiffenbach B., Haber J.E. Homothallic switching of Saccharomyces cerevisiae mating type genes by using a donor containing a large internal deletion. Mol. Cell. Biol. 5:1985;2154-2158.
2. Fairhead C., Llorente B., Denis F., Soler M., Dujon B. New vectors for combinatorial deletions in yeast chromosomes and for gap-repair cloning using 'split-marker' recombination. Yeast. 12:1996;1439-1457.
3. Clikeman J.A., Khalsa G.J., Barton S.L., Nickoloff J.A. Homologous recombinational repair of double-strand breaks in yeast is enhanced by MAT heterozygosity through yKU-dependent and -independent mechanisms. Genetics. 157:2001;579-589.
4. Sandell L.L., Zakian V.A. Loss of a yeast telomere: arrest, recovery, and chromosome loss. Cell. 75:1993;729-739.
5. Malkova A., Ivanov E.L., Haber J.E. Double-strand break repair in the absence of RAD51 in yeast: a possible role for break-induced DNA replication. Proc. Natl Acad. Sci. USA. 93:1996;7131-7136.
6. Morrow D.M., Connelly C., Hieter P. "Break copy" duplication: a model for chromosome fragment formation in Saccharomyces cerevisiae. Genetics. 147:1997;371-382.
7. Bosco G., Haber J.E. Chromosome break-induced DNA replication leads to nonreciprocal translocations and telomere capture. Genetics. 150:1998;1037-1047.
8. Haber J.E. Recombination: a frank view of exchanges and vice versa. Curr. Opin. Cell. Biol. 12:2000;286-292.
9. Louis E.J. The chromosome ends of Saccharomyces cerevisiae. Yeast. 11:1995;1553-1573.
10. Su Y., Barton A.B., Kaback D.B. Decreased meiotic reciprocal recombination in subtelomeric regions in Saccharomyces cerevisiae. Chromosoma. 109:2000;467-475.
11. Fairhead C., Thierry A., Denis F., Eck M., Dujon B. 'Mass-murder' of ORFs from three regions of chromosome XI from Saccharomyces cerevisiae. Gene. 223:1998;33-46.
12. Gotta M., Laroche T., Formenton A., Maillet L., Scherthan H., Gasser S.M. The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae. J. Cell. Biol. 134:1996;1349-1363.
13. Galy V., Olivo-Marin J.C., Scherthan H., Doye V., Rascalou N., Nehrbass U. Nuclear pore complexes in the organization of silent telomeric chromatin. Nature. 403:2000;108-112.
14. Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P., Banrevi A., Bolle P.A., Bolotin-Fukuhara M., Bossier P., et al. Complete DNA sequence of yeast chromosome XI. Nature. 369:1994;371-378.
15. Ricchetti M., Fairhead C., Dujon B. Mitochondrial DNA repairs double-strand breaks in yeast chromosomes. Nature. 402:1999;96-100.
16. Kramer K.M., Brock J.A., Bloom K., Moore J.K., Haber J.E. Two different types of double-strand breaks in Saccharomyces cerevisiae are repaired by similar RAD52-independent, nonhomologous recombination events. Mol. Cell. Biol. 14:1994;1293-1301.
17. Orr-Weaver T.L., Szostak J.W., Rothstein R.J. Yeast transformation: a model system for the study of recombination. Proc. Natl Acad. Sci. USA. 78:1981;6354-6358.
18. Malkova A., Signon L., Schaefer C.B., Naylor M.L., Theis J.F., Newlon C.S., Haber J.E. RAD51-independent break-induced replication to repair a broken chromosome depends on a distant enhancer site. Genes Dev. 15:2001;1055-1060.
19. Paques F., Haber J.E. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 63:1999;349-404.
20. Kramer K.M., Haber J.E. New telomeres in yeast are initiated with a highly selected subset of TG1-3 repeats. Genes Dev. 7:1993;2345-2356.
21. Kimura A., Umehara T., Horikoshi M. Chromosomal gradient of histone acetylation established by Sas2p and Sir2p functions as a shield against gene silencing. Nature Genet. 32:2002;370-377.
22. Martin S.G., Laroche T., Suka N., Grunstein M., Gasser S.M. Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell. 97:1999;621-633.
23. Mills K.D., Sinclair D.A., Guarente L. MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell. 97:1999;609-620.
24. Mezard C., Nicolas A. Homologous, homeologous, and illegitimate repair of double-strand breaks during transformation of a wild-type strain and a rad52 mutant strain of Saccharomyces cerevisiae. Mol. Cell. Biol. 14:1994;1278-1292.
25. Jinks-Robertson S., Michelitch M., Ramcharan S. Substrate length requirements for efficient mitotic recombination in Saccharomyces cerevisiae. Mol. Cell. Biol. 13:1993;3937-3950.
26. Chen C., Umezu K., Kolodner R.D. Chromosomal rearrangements occur in S. cerevisiae rfa1 mutator mutants due to mutagenic lesions processed by double-strand-break repair. Mol. Cell. 2:1998;9-22.
27. Chen C., Kolodner R.D. Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants. Nature Genet. 23:1999;81-85.
28. Tennyson R.B., Ebran N., Herrera A.E., Lindsley J.E. A novel selection system for chromosome translocations in Saccharomyces cerevisiae. Genetics. 160:2002;1363-1373.
29. Fischer G., James S.A., Roberts I.N., Oliver S.G., Louis E.J. Chromosomal evolution in Saccharomyces. Nature. 405:2000;451-454.
30. Rabbitts T.H. Chromosomal translocations in human cancer. Nature. 372:1994;143-149.
31. Pierce A.J., Hu P., Han M., Ellis N., Jasin M. Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev. 15:2001;3237-3242.
32. Richardson C., Jasin M. Coupled homologous and nonhomologous repair of a double-strand break preserves genomic integrity in mammalian cells. Mol. Cell. Biol. 20:2000;9068-9075.
33. Moore J.K., Haber J.E. Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae. Mol. Cell. Biol. 16:1996;2164-2173.
34. Hegde V., Klein H. Requirement for the SRS2 DNA helicase gene in non-homologous end joining in yeast. Nucl. Acids Res. 28:2000;2779-2783.
35. Tsukamoto Y., Kato J., Ikeda H. Effects of mutations of RAD50, RAD51, RAD52, and related genes on illegitimate recombination in Saccharomyces cerevisiae. Genetics. 142:1996;383-391.
36. Lee S.E., Moore J.K., Holmes A., Umezu K., Kolodner R.D., Haber J.E., et al. Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage. Cell. 94:1998;399-409.
37. Inbar O., Kupiec M. Recombination between divergent sequences leads to cell death in a mismatch-repair-independent manner. Curr. Genet. 38:2000;23-32.
38. Bennett C.B., Lewis A.L., Baldwin K.K., Resnick M.A. Lethality induced by a single site-specific double-strand break in a dispensable yeast plasmid. Proc. Natl Acad. Sci. USA. 90:1993;5613-5617.
39. Vandenbol M., Fairhead C. Mass-murder deletion of 19 ORFs from Saccharomyces cerevisiae chromosome XI. Gene. 247:2000;45-52.
40. Baudin A., Ozier-Kalogeropoulos O., Denouel A., Lacroute F., Cullin C. A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae. Nucl. Acids Res. 21:1993;3329-3330.
41. Fairhead C., Dujon B. Consequences of unique double-stranded breaks in yeast chromosomes: death or homozygosis. Mol. Gen. Genet. 240:1993;170-178.
42. Thierry A., Gaillon L., Galibert F., Dujon B. Construction of a complete genomic library of Saccharomyces cerevisiae and physical mapping of chromosome XI at 3.7 kb resolution. Yeast. 11:1995;121-135.
43. Poustka A., Pohl T.M., Barlow D.P., Frischauf A.M., Lehrach H. Construction and use of human chromosome jumping libraries from NotI-digested DNA. Nature. 325:1987;353-355.
44. Costanzo M.C., et al. YPD PombePD and WormPD: model organism volumes of the BioKnowledge library, an integrated resource for protein information. Nucl. Acids Res. 29:2001;75-79.
45. Marck C. 'DNA Strider': a 'C' program for the fast analysis of DNA and protein sequences on the Apple Macintosh family of computers. Nucl. Acids Res. 16:1988;1829-1836.