Runx proteins are involved in regulation of CD122, Ly49 family and IFN-γ expression during NK cell differentiation

International Immunology

Volumn 20, Issue 1, 2008, Pages 71-79

  Ohno, Shin Ichiro ^a   Sato, Takehito ^a   Kohu, Kazuyoshi ^b   Takeda, Kazuyoshi ^c   Okumura, Ko ^c   Satake, Masanobu ^b   Habu, Sonoko ^a  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Differentiation; NK cell; Runx

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2 RECEPTOR BETA; LEUKOSIALIN; LY49 PROTEIN; MAC 1 PROTEIN; PROTEIN DERIVATIVE; TRANSCRIPTION FACTOR RUNX; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR RUNX3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOLYSIS; DEVELOPMENTAL STAGE; HEMATOPOIETIC STEM CELL; LYMPHOCYTE CULTURE; LYMPHOCYTE DIFFERENTIATION; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, LY; CELL DIFFERENTIATION; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 2 SUBUNIT; CORE BINDING FACTOR ALPHA 3 SUBUNIT; GENE EXPRESSION REGULATION; INTERFERON TYPE II; INTERLEUKIN-2 RECEPTOR BETA SUBUNIT; KILLER CELLS, NATURAL; LECTINS, C-TYPE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC;

EID: 37549021100     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxm120     Document Type: Article

References (58)

1. Cerwenka, A. and Lanier, L. L. 2001. Natural killer cells, viruses and cancer. Nat. Rev. Immunol. 1:41.
2. Trinchieri, G. 1989. Biology of natural killer cells. Adv. Immunol. 47:187.
3. Habu, S., Fukui, H., Shimamura, K. et al. 1981. In vivo effects of anti-asialo GM1. J. Immunol. 127:34.
4. + human natural killer cell progenitor that responds to interleukin-15. Blood 92:3647.
5. Williams, N. S., Kubota, A., Bennett, M., Kumar, V. and Takei, F. 2000. Clonal analysis of NK cell development from bone marrow progenitors in vitro: Orderly acquisition of receptor gene expression. Eur. J. Immunol. 30:2074.
6. Rosmaraki, E. E., Douagi, L., Roth, C. et al. 2001. Identification of committed NK cell progenitors in adult murine bone marrow. Eur. J. Immunol. 31:1900.
7. Kennedy, M. K., Glaccum, M., Brown, S. N. et al. 2000. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J. Exp. Med. 191:771.
8. Lodolce, J. P., Boone, D. L., Chai, S. et al. 1998. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9:669.
9. Suzuki, H., Duncan, G. S., Takimoto, H. and Mak, T. W. 1997. Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor β chain. J. Exp. Med. 185:499.
10. Di Santo, J. P., Müller, W., Guy-Grand, D., Fischer, A. and Rajewsky, K. 1995. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor γ chain. Proc. Natl Acad. Sci. USA 92:377.
11. Kim, S., Iizuka, K., Kang, H. P. et al. 2002. In vivo developmental stages in murine natural killer cell maturation. Nat. Immunol. 3:523.
12. Di Santo, J. P. 2006. Natural killer cell developmental pathways: A question of balance. Annu. Rev. Immunol. 24:257.
13. Samson, S. I., Richard, O., Tavian, M. et al. 2003. GATA-3 promotes maturation, IFN-γ production, and liver-specific homing of NK cells. Immunity 19:701.
14. Taki, S., Nakajima, S., Ichikawa, E., Saito, T and Hida, S. 2005. IFN regulatory factor-2 deficiency revealed a novel checkpoint critical for the generation of peripheral NK cells. J. Immunol. 174:6005.
15. Townsend, M. J., Weinmann, A. S., Matsuda, J. L. et al. 2004. T-bet regulates the terminal maturation and homeostasis of NK and Vα14i NKT cells. Immunity 20:477.
16. Saleh, A., Davies, G. E., Pascal, V. et al. 2004. Identification of probabilistic transcriptional switches in the Ly49 gene cluster: A eukaryotic mechanism for selective gene activation. Immunity 21:55.
17. Trompeter, H., Gómez-Lozano, N., Santourlidis, S. et al. 2005. Three structurally and functionally divergent kinds of promoters regulate expression of clonally distributed killer cell Ig-like receptors (KIR), of KIR2DL4, and of KIR3DL3. J. Immunol. 174:4135.
18. Ito, Y. 2004. Oncogenic potential of the Runx gene family: 'overview'. Oncogene 23:4198.
19. Kamachi, Y., Ogawa, E., Asano, M. et al. 1990. Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer. J. Virol. 64:4808.
20. Ogawa, E, Inuzuka, M., Maruyama, M. et al. 1993, Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha. Virology 194:314.
21. Wang, S., Wang, Q., Crute, B. E., Melnikova, I. N., Keller, S. R. and Speck, N. A. 1993. Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor Mol. Cell. Biol. 13:3324.
22. Okuda, T., Deursen, J. V., Hiebert, S. W., Grosveld, G. and Downing, J. R. 1996. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 184:321.
23. Wang, Q., Stacy, T., Binder, M., Marín-Padilla, M., Sharpe, A. H. and Speck, N. A. 1996. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc. Natl Acad. Sci. USA 93:3444.
24. Wang, A, Stacy, T., Miller, J. D. et al. 1996. The CBFβ subunit is essential for CBFα2 (AML1) function in vivo. Cell 87:697.
25. Niki, M., Okada, H., Takano, H. et al. 1997. Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyoma-virus enhancer binding protein 2/core binding factor. Proc. Natl Acad. Sci. USA 94:5697.
26. Ichikawa, M., Asai, T., Saito, T. et al. 2004. AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hernatopoietic stem cells in adult hematopoiesis. Nat. Med. 10:299.
27. Egawa, T., Eberl, G., Taniuchi, I. et al. 2005. Genetic evidence supporting selection of the Vα14i NKT cell lineage from double-positive thymocyte precursors. Immunity 22:705.
28. Taniuchi, I., Osato, M., Egawa, T. et al. 2002. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development, Cell 111:621.
29. Sato, T., Ohno, S., Hayashi, T. et al. 2005. Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes. Immunity 22:317.
30. Kohu, K., Sato, T., Ohno, S. et al. 2005. Overexpression of the Runx3 transcription factor increases the proportion of mature thymocytes of the CD8 single-positive lineage. J. Immunol. 174:2627.
31. Woolf, E., Xiao, C., Fainaru, O. et al. 2003. Runx3 and Runx1 are required for CD8 T cell development during thyrnopoiesis. Proc. Natl Acad. Sci. USA 100:7731.
32. Hayashi, K., Natsume, W., Watanabe, T. et al. 2000. Diminution of the AML1 transcription factor function causes differential effects on the fates of CD4 and CD8 single-positive T cells. J. Immunol. 165:6816.
33. Fukushima-Nakase, Y., Naoe, Y., Taniuchi, I., Sugimoto, T. and Okuda, T. 2005. Shared and distinct roles mediated through C-terminal subdomains of acute myeloid leukemia/Runt-related transcription factor molecules in murine development. Blood 105:4298.
34. Goyama, S, Yamaguchi, Y., Imai, Y. et al. 2004. The transcriptionally active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) region. Blood 104:3558.
35. Spender, L. C., Whiteman, H. J., Karstegl, C. E. and Farrell, P. J. 2005. Transcriptional cross-regulation of RUNX1 by RUNX3 in human B cells. Oncogene 10:1873.
36. Tanaka, Y., Watanabe, T., Chiba, N. et al. 1997. The protooncogene product, PEBP2β/CBFβ is mainly located in the cytoplasm and has an affinity with cytoskeletal structures. Oncogene 15:677.
37. Morita, S., Kojima, T. and Kitamura, T. 2000. Plat-E: An efficient and stable system for transient packaging of retrovinuses. Gene Ther. 7:1063.
38. Williams, N. S., Klem, J., Puzanov, I. J., Sivakumar, P. V., Bennett, M. and Kumar, V. 1999. Differentiation of NK1.1+, Ly49+ NK cells from flt3+ multipotent marrow progenitor cells. J. Immunol. 163: 2648.
39. Djuretic, I. M., Levanon, D., Negreanu, V., Groner, Y., Rao, A. and Ansel, K. M. 2006. Transcription factor T-bet and Runx3 cooperate to activate Ifng and silencing 114 in T helper type 1 cells. Nat. Immunol. 8:145.
40. Pozner, A., Goldenberg, D., Negreanu, V. et al. 2000. Transcription-coupled translation control of AML1/RUNX1 is mediated by cap-and internal ribosome entry site-dependent mechanisms. Mol. Cell. Biol. 20:2297.
41. Telfer, J. C. and Rothenberg, E. V. 2001. Expression and function of a stem cell promoter for the murine CBFα2 gene: Distinct roles and regulation in natural killer and T cell development. Dev. Biol. 229:363.
42. Taghon, T., Yui, M. A., Pant, R., Diamond, R. A. and Rothenberg, E. V. 2006. Developmental and molecular characterization of emerging β- and γδ-selected pre-T cells in the adult mouse thymus. Immunity 24:53.
43. Jamieson, A. M., Diefenbach, A., McMahon, C. W., Xiong, N., Carlyle, J. R. and Raulet, D. H. 2002. The role of the NKG2D immunoreceptor in immune cell activation and natural killing. Immunity 17:19.
44. Ogasawara, K., Hamerman, J. A., Hsin, H. et al. 2003. Impairment of NK cell function by NKG2D modulation in NOD mice. Immunity 18:41.
45. Takeda, K., Cretney, E., Hayakawa, Y. et al. 2005. TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver. Blood 105:2082.
46. Vosshenrich, C. A.J., Ranson, T., Samson, S. I. et al. 2005. Roles for common cytokine receptor γ-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo. J. Immunol. 174:1213.
47. Colucci, F., Caligiuri, M. A. and Di Santo, J. P. 2003. What does it take to make a natural killer? Nat. Rev. Immunol. 3:413.
48. Vosshenrich, C. A.J., García, M. J., Samson, S. I. et al. 2006. A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127. Nat. Immunol. 7: 1217.
49. Brenner, O., Levanon, D., Negreanu, V. et al. 2004. Loss of Runx3 function in leukocyte is associated with spontaneously developed colitis and gastric mucosal hyperplasia. Proc. Natl Acad. Sci. USA 101:16016.
50. Yu, J., Wei, M., Becknell, B. et al. 2006. Pro- and anti-inflammatory cytokine signaling: Reciprocal antagonism regulates interferon-gamma production by human natural killer cells. Immunity 24:575.
51. Laouar, Y., Sutterwala, F. S., Gorelik, L. and Flavell, R. A. 2005. Transforming growth factor-β controls T helper type 1 cell development through regulation of natural killer cell interferon-γ. Nat. Immunol. 6:600.
52. Miyazono, K., Maeda, S. and Imamura, T. 2004. Coordinate regulation of cell growth and differentiation by TGF-β superfamily and Runx proteins. Oncogene 23:4232.
53. Yarmus, M., Woolf, E., Bernstein, Y. et al. 2006. Groucho/ transducin-like enhancer-of-split (TLE)-dependent and -independent transcriptional regulation by Runx3. Proc. Natl Acad. Sol. USA 103:7384.
54. Kitabayashi, I., Yokoyama, A., Shimizu, K. and Ohki, M. 1998. Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation. EMBO J. 17:2994.
55. Wong, J. C., Lee, S. B., Bell, M. D. et al. 2002. Induction of the interleukin-2/15 receptor β-chain by the EWS-WT1 translocation product. Oncogene 21:2009.
56. Lin, J. X. and Leonard, W. J. 1997. The immediate-early gene product Egr-1 regulates the human interleukin-2 receptor β-chain promoter through noncanonical Egr and Sp1 binding sites. Mol. Cell. Biol. 17:3714.
57. Ye, S., Kim, T. J., Won, S. S. et al. 2005. Transcriptional regulation of the mouse interleukin-2 receptor β chain gene by Ets and Egr-1. Biochem. Biophys. Res. Commun. 329:1094.
58. Lin, J. X., Bhat, N. K., John, S., Queale, W. S. and Leonard, W. J. 1993. Characterization of the human interleukin-2 receptor β-chain gene promoter: Regulation of promoter activity by ets gene products. Mol. Cell. Biol. 13:6201.