Osteopenia in Sparc (osteonectin)-deficient mice: Characterization of phenotypic determinants of femoral strength and changes in gene expression

Physiological Genomics

Volumn 32, Issue 1, 2007, Pages 64-73

  Mansergh, Fiona C ^a,d   Wells, Timothy ^a   Elford, Carole ^b   Evans, Samuel L ^b   Perry, Mark J ^c   Evans, Martin J ^a   Evans, Bronwen A J ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Adiposity; Knockout mice; Microarray; Osteoporosis

Indexed keywords

LEPTIN; OSTEONECTIN;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BONE DENSITY; BONE FRAGILITY; BONE MARROW; BONE MINERAL; BONE STRENGTH; CONTROLLED STUDY; CORTICAL BONE; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMUR; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENE MUTATION; KNOCKOUT MOUSE; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOPENIA; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION;

ADIPOCYTES; ANIMALS; BONE DISEASES, METABOLIC; BONE MARROW CELLS; COMPRESSIVE STRENGTH; DISEASE MODELS, ANIMAL; EXONS; FEMUR; GENE EXPRESSION REGULATION; LEPTIN; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; OSTEONECTIN; PHENOTYPE;

MUS;

EID: 37449026264     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00151.2007     Document Type: Article

References (38)

1. Baldock PA, Eisman JA. Genetic determinants of bone mass. Curr Opin Rheumatol 16: 450-445, 2004.
2. Bassuk JA, Birkebak T, Rothmier JD, Clark JM, Bradshaw A, Muchowski PJ, Howe CC, Clark JI, Sage EH. Disruption of the Sparc locus in mice alters the differentiation of lenticular epithelial cells, and leads to cataract formation. Exp Eye Res 68: 321-331, 1999.
3. Beamer WG, Donahue LR, Rosen CJ, Baylink DJ. Genetic variability in adult bone density among inbred strains of mice. Bone 18: 397-403, 1996.
4. Beamer WG, Shultz KL, Donahue LR, Churchill GA, Sen S, Wergedal JR, Baylink DJ, Rosen CJ. Quantitative trait loci for femoral, and lumbar vertebral bone mineral density in C.57BL/6J and C3H/HeJ inbred strains of mice. J Bone Miner Res 16: 1195-1206, 2001.
5. Boskey AL, Moore DJ, Amling M, Canalis E, Delany AM. Infrared analysis of the mineral, and matrix in bones of osteonectin-null mice and their wildtype controls. J Bone Miner Res 18: 1005-1011, 2003.
6. Bradshaw AD, Sage EH. SPARC, a matricellular protein that functions in cellular differentiation, and tissue response to injury. J Clin Invest 107: 1049-1054, 2001.
7. Bradshaw AD, Graves DC, Motamed K, Sage EH. SPARCnull mice exhibit increased adiposity without significant differences in overall body weight. Proc Natl Acad Sci USA 100: 6045-6050, 2003.
8. Brazma A, Hingamp P, Quackenbush J, Sherlock G, Spellman P, Stoeckert C, Aach J, Ansorge W, Ball CA, Causton HC, Gaasterland T, Glenisson P, Holstege FC, Kim IF, Markowitz V, Matese JC, Parkinson H, Robinson A, Sarkans U, Schulze-Kremer S, Stewart J, Taylor R, Vilo J, Vingron M. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat Genet 29: 365-371, 2001.
9. Brekken RA, Sage EH. SPARC, a matricellular protein: at the crossroads of cell-matrix. Matrix Biol 19: 569-580, 2001.
10. Caslini C, Spinelli O, Cazzaniga G, Golay J, De Gioia L, Pedretti A, Breviario F, Amaru R, Barbui T, Biondi A, Introna M, Rambaldi A. Identification of two novel isoforms of the ZNF162 gene: a growing family of signal transduction and activator of RNA proteins. Genomics 42: 268-277, 1997.
11. Chavey C, Boucher J, Monthouel-Kartmann MN, Sage EH, Castan-Laurell I, Valet P, Tartare-Deckert S, Van Obberghen E. Regulation of secreted protein acidic and rich in cysteine during adipose conversion and adipose tissue hyperplasia. Obesity 14: 1890-1897, 2006.
12. Chen XD, Bian X, Teslovich TM, Stephan DA, Young MF. Dissection of the sets of genes that control the behavior of biglycan-deficient pre-osteoblasts using oligonucleotide microarrays. Bone 37: 192-203, 2005.
13. Crusio WE. Flanking gene and genetic background problems in genetically manipulated mice. Biol Psychiatry 56: 381-385, 2004.
14. DeJong DS, Vaes BL, Dechering KJ, Feijen A, Hendriks JM, Wehrens R, Mummery CL, van Zoelen EJ, Olijve W, Steegenga WT. Identification of novel regulators associated with early-phase osteoblast differentiation. J Bone Miner Res 19: 947-958, 2004.
15. Delany AM, Amling M, Priemel M, Howe C, Baron R, Canalis E. Osteopenia and decreased bone formation in osteonectin-deficient mice. J Clin Invest 105: 1325, 2000.
16. Delany AM, Kalajzic I, Bradshaw AD, Sage EH, Canalis E. Osteonectin-null mutation compromises osteoblast formation, maturation, and survival. Endocrinology1 44: 2588-2596. 2003.
17. Ferrari SL, Rizzoli R. Gene variants for osteoporosis and their pleiotropic effects in aging. Mol Aspects Med 26: 145-167, 2005.
18. Gevers EF, Loveridge N, Robinson IC. Bone marrow adipocytes: a neglected target tissue for growth hormone. Endocrinology 143: 4065-4073, 2002.
19. Gilmour DT, Lyon GJ, Carlton MB, Sanes JR, Cunningham JM, Anderson JR, Hogan BL, Evans MJ, Colledge WH. Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. EMBO J 17: 1860-1870, 1998.
20. Gregoire FM, Smas CM, Sul HS. Understanding adipocyte differentiation. Physiol Rev 78: 783-809, 1998.
21. Huang QY, Kung AWC. Genetics of osteoporosis. Mol Genet Metab 88: 295-306, 2006.
22. Humbert PO, Rogers C, Ganiatsas S, Landsberg RL, Trimarchi JM, Dandapani S, Brugnara C, Erdman S, Schrenzel M, Bronson RT, Lees JA. E2F4 is essential for normal erythrocyte maturation and neonatal viability. Mol Cell 6: 281-291, 2000.
23. International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature 409: 860-921, 2001.
24. Ishimori N, Li R, Walsh KA, Korstanje R, Rollins JA, Petkov P, Pletcher MT, Wiltshire T, Donahue LR, Rosen CJ, Beamer WG, Churchill GA, Paigen B. Quantitative Trait Loci That Determine BMD in C57BL/6J and 129S1/SvImJ Inbred Mice. J Bone Miner Res 21: 105-112, 2006.
25. Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, RIKEN Genome Exploration Research Group. Phase II Team and the FANTOM Consortium Functional annotation of a full-length mouse cDNA collection. Nature 409: 685-90, 2001.
26. Leclerc N, Luppen CA, Ho VV, Nagpal S, Hacia JG, Smith E, Frenkel B. Gene expression profiling of glucocorticoid-inhibited osteoblasts. J Mol Endocrinol 33: 175-193, 2004.
27. Long MW. Osteogenesis and bone-marrow-derived cells. Blood Cells Mol Dis 27: 677-690, 2001.
28. Mansergh FC, Wride MA, Walker VE, Adams S, Hunter SM, Evans MJ. Gene expression changes during cataract progression in Sparc null mice: differential regulation of mouse globins in the lens. Mol Vis 10: 490-511, 2004.
29. Mason IJ, Murphy D, Munke M, Francke U, Elliott RW, Hogan BLM. Development and transformation sensitive expression of the Sparc gene on mouse chromosome 11. EMBO J 5: 1465-1472, 1986.
30. McLean W, Olsen BR. Mouse models of abnormal skeletal development and homeostasis. Trends Genet 17: S38-S43, 2001.
31. Norose K, Clark JI, Syed NA, Basu A, Heber-Katz E, Sage EH, Howe CC. SPARC deficiency leads to early-onset cataractogenesis. Invest Ophthalmol Vis Sci 39: 2674-2680, 1998.
32. Ralston SH, deCrombrugghe B. Genetic regulation of bone mass and susceptibility to osteoporosis. Genes Dev 20: 2492-2506, 2006.
33. Ruotolo R, Grassi F, Percudani R, Rivetti C, Martorana D, Maraini G, Ottonello S. Gene expression profiling in human age-related nuclear cataract. Mol Vis 9: 538-548, 2003.
34. Samuels A, Perry MJ, Gibson RL, Colley S, Tobias JH. Role of endothelial nitric oxide synthase in estrogen-induced osteogenesis. Bone 29: 24-29, 2001.
35. Takeshita S, Namba N, Zhao JJ, Jiang Y, Genant HK, Silva MJ, Brodt MD, Helgason CD, Kalesnikoff J, Rauh MJ, Humphries RK, Krystal G, Teitelbaum SL, Ross FP. SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts. Nat Med 8: 943-949, 2002.
36. Tartare-Deckert S, Chavey C, Monthouel MN, Gautier N, Van Obberghen E. The matricellular protein SPARC/osteonectin as a newly identified factor up-regulated in obesity. J Biol Chem 276: 22231-22237, 2001.
37. Teitelbaum SL. Bone resorption by osteoclasts. Science 289: 1504-1508, 2000.
38. Watanabe K, Hishiya A. Mouse models of senile osteoporosis. Mol Aspects Med 26: 221-231, 2005.