SPARC, a matricellular protein: at the crossroads of cell-matrix

Matrix Biology

Volumn 19, Issue 7, 2000, Pages 569-580

  Brekken, Rolf A ^a   Sage, E Helene ^a  

^a HOPE HEART INSTITUTE   (United States)

Author keywords

Cell matrix interaction; Matricellular; SPARC osteonectin BM 40

Indexed keywords

CALCIUM BINDING PROTEIN; COLLAGEN; FIBROBLAST GROWTH FACTOR 2; FOLLISTATIN; GLYCOPROTEIN; GROWTH FACTOR; MATRICELLULAR PROTEIN; OSTEONECTIN; PLATELET DERIVED GROWTH FACTOR; SCLEROPROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; VITRONECTIN;

ANIMAL MODEL; BONE REMODELING; CALCIUM BINDING; CATARACT; CELL ADHESION; CELL CYCLE G1 PHASE; CELL INTERACTION; CELL PROLIFERATION; CRYSTAL STRUCTURE; DEVELOPMENT; EXTRACELLULAR MATRIX; FIBROSIS; GENE DISRUPTION; GENE LOCUS; HUMAN; INTESTINE MUCOSA; KNOCKOUT MOUSE; LENS; MOUSE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STRUCTURE; PROTEIN STRUCTURE, FUNCTION AND VARIABILITY; REGULATORY MECHANISM; REVIEW; TISSUE DISTRIBUTION; TUMOR; WOUND HEALING;

ANIMALIA;

EID: 0033741904     PISSN: 0945053X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0945-053X(00)00105-0     Document Type: Short Survey

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6. Basic fibroblast growth factor destabilizes osteonectin mRNA in osteoblasts
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9. Visceral glomerular epithelial cells can proliferate in vivo and synthesize platelet-derived growth factor B-chain
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12. SPARC/osteonectin induces matrix metalloproteinase 2 activation in human breast cancer cell lines
13. Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens
14. Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC
15. Modulation of endothelial cell adhesion by hevin, an acidic protein associated with high endothelial venules
16. Mapping of the binding of platelet-derived growth factor to distinct domains of the basement membrane proteins BM-40 and perlecan and distinction from the BM-40 collagen-binding epitope
17. SPARC (secreted protein acidic and rich in cysteine) regulates endothelial cell shape and barrier function
18. Increased SPARC expression promotes U87 glioblastoma invasion in vitro
19. Cell cycle-dependent nuclear location of the matricellular protein SPARC: association with the nuclear matrix
20. Transcription of a quail gene expressed in embryonic retinal cells is shut off sharply at hatching
21. SPARC antagonizes the effect of basic fibroblast growth factor on the migration of bovine aortic endothelial cells
22. Structure of a novel extracellular Ca(2+)-binding module in BM-40
23. Crystal structure of a pair of follistatin-like and EF-hand calcium-binding domains in BM-40
24. 2+-binding protein SPARC (osteonectin) revealed by in situ hybridization
25. Expression and structure of human SPARC transcripts: SPARC mRNA is expressed by human cells involved in extracellular matrix production and some of these cells show an unusual expression pattern
26. On global sequence alignment
27. Expression of SPARC during development of the chicken chorioallantoic membrane: evidence for regulated proteolysis in vivo
28. Type I collagen-deficient Mov-13 mice do not retain SPARC in the extracellular matrix: implications for fibroblast function
29. Osteonectin promotes prostate cancer cell migration and invasion: a possible mechanism for metastasis to bone
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33. SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells
34. Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis
35. The biology of SPARC, a protein that modulates cell-matrix interactions
36. SPARC is a source of copper-binding peptides that stimulate angiogenesis
37. The expression of the secreted protein acidic and rich in cysteine (SPARC) is associated with the neoplastic progression of human melanoma
38. Suppression of SPARC expression by antisense RNA abrogates the tumorigenicity of human melanoma cells
39. Developmental and transformation-sensitive expression of the SPARC gene on mouse chromosome 11
40. Osteonectin expression correlates with clinical outcome in thin cutaneous malignant melanomas
41. Remodelling of cardiac extracellular matrix during beta-adrenergic stimulation: upregulation of SPARC in the myocardium of adult rats
42. High-affinity and low-affinity calcium binding and stability of the multidomain extracellular 40-kDa basement membrane glycoprotein (BM-40/SPARC/osteonectin)
43. Structural and functional characterization of the extracellular calcium-binding protein BM-40/secreted protein, acidic, rich in cysteine/osteonectin from the nematode Caenorhabditis elegans
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45. Extracellular matrix-associated protein Sc1 is not essential for mouse development
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47. SPARC and thrombospondin genes are repressed by the c-jun oncogene in rat embryo fibroblasts
48. SPARC, an extracellular matrix protein with tumor-suppressing activity in human ovarian epithelial cells
49. SPARC inhibits endothelial cell adhesion but not proliferation through a tyrosine phosphorylation-dependent pathway
50. Morphological and biochemical studies of a mouse mutant (fro/fro) with bone fragility
51. Enhancement of SPARC (osteonectin) synthesis in arthritic cartilage. Increased levels in synovial fluids from patients with rheumatoid arthritis and regulation by growth factors and cytokines in chondrocyte cultures
52. Heat-shock response in cultured chick embryo chondrocytes. Osteonectin is a secreted heat-shock protein
53. Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization
54. Evidence for positive and negative regulatory elements in the 5'-flanking sequence of the mouse sparc (osteonectin) gene
55. SPARC deficiency leads to early-onset cataractogenesis
56. SPARC is expressed by mesangial cells in experimental mesangial proliferative nephritis and inhibits platelet-derived-growth-factor-medicated mesangial cell proliferation in vitro
57. Distribution of SPARC in normal and neoplastic human tissue
58. Developmental anomalies of Xenopus embryos following microinjection of SPARC antibodies
59. The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors
60. SPARC and the extracellular matrix: implications for cancer and wound repair
61. SPARC: a signal of astrocytic neoplastic transformation and reactive response in human primary and xenograft gliomas
62. SPARC: a potential diagnostic marker of invasive meningiomas
63. Differential modulation of cell adhesion by interaction between adhesive and counter-adhesive proteins: characterization of the binding of vitronectin to osteonectin (BM40, SPARC)
64. Inhibition of endothelial cell proliferation by SPARC is mediated through a Ca(2+)-binding EF-hand sequence
65. Distribution of the calcium-binding protein SPARC in tissues of embryonic and adult mice
66. A physical map of 15 loci on human chromosome 5q23-q33 by two-color fluorescence in situ hybridization
67. Limited cleavage of extracellular matrix protein BM-40 by matrix metalloproteinases increases its affinity for collagens
68. Crystal structure and mapping by site-directed mutagenesis of the collagen-binding epitope of an activated form of BM-40/SPARC/osteonectin
69. Immunochemical and tissue analysis of protease generated neoepitopes of BM-40 (osteonectin, SPARC) which are correlated to a higher affinity binding to collagens
70. Lead inhibits secretion of osteonectin/SPARC without significantly altering collagen or Hsp47 production in osteoblast-like ROS 17/2.8 cells
71. The Caenorhabditis elegans homologue of the extracellular calcium binding protein SPARC/osteonectin affects nematode body morphology and mobility
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73. Effects of basic fibroblast growth factor on proliferation, the expression of osteonectin (SPARC) and alkaline phosphatase, and calcification in cultures of human pulp cells
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75. Cloning from a mouse osteoblastic cell line of a set of transforming-growth-factor-beta 1-regulated genes, one of which seems to encode a follistatin-related polypeptide
76. Cloning and expression of murine SC1, a gene product homologous to SPARC
77. Molecular analysis of the cDNA for human SPARC/osteonectin/BM-40: sequence, expression, and localization of the gene to chromosome 5q31-q33
78. Osteonectin, a bone-specific protein linking mineral to collagen
79. SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway
80. Osteogenesis imperfecta: changes in noncollagenous proteins in bone
81. Regulation of Smad activity
82. Regulation of the expression of a secreted acidic protein rich in cysteine (SPARC) in human fibroblasts by transforming growth factor beta. Comparison of transcriptional and post-transcriptional control with fibronectin and type I collagen
83. SPARC, a matricellular glycoprotein with important biological functions
84. Specific interaction of SPARC with endothelial cells is mediated through a carboxyl-terminal sequence containing a calcium-binding EF hand
85. The counteradhesive protein SPARC regulates an endothelial paracellular pathway through protein tyrosine phosphorylation