Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens

EMBO Journal

Volumn 17, Issue 7, 1998, Pages 1860-1870

  Gilmour, Darren T ^f   Lyon, Gholson J ^g   Carlton, Mark B L ^a   Sanes, Joshua R ^d   Cunningham, Jeanette M ^d   Anderson, Janice R ^b   Hogan, Brigid L M ^e   Evans, Martin J ^a   Colledge, William H ^c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^f MAX PLANCK INSTITUTE FOR DEVELOPMENTAL BIOLOGY   (Germany)

^g Cornell/R/M S K T I MD/PhD P ^*  (United States)

Author keywords

BM40; Cataract; Gene targeting; Osteonectin; SPARC

Indexed keywords

GLYCOPROTEIN; OSTEONECTIN; SECRETORY PROTEIN;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATARACTOGENESIS; CELL VACUOLE; CONTROLLED STUDY; EMBRYO; EPITHELIUM CELL; GENE DISRUPTION; LENS; LENS CAPSULE; LENS DISEASE; LENS FIBER; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL;

AGE OF ONSET; ANIMALS; BONE AND BONES; CATARACT; EMBRYONIC AND FETAL DEVELOPMENT; EPITHELIAL CELLS; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; LENS CAPSULE, CRYSTALLINE; LENS, CRYSTALLINE; MALE; MICE; MICE, KNOCKOUT; OSTEONECTIN; RNA, MESSENGER; TESTIS;

ANIMALIA; MURINAE;

EID: 0032055746     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.7.1860     Document Type: Article

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