The methoxychlor metabolite, HPTE, directly inhibits the catalytic activity of cholesterol side-chain cleavage (P450scc) in cultured rat ovarian cells

Reproductive Toxicology

Volumn 25, Issue 1, 2008, Pages 67-75

  Akgul, Yucel ^a   Derk, Raymond C ^b   Meighan, Terence ^b   Rao, K Murali Krishna ^b   Murono, Eisuke P ^a,b  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Cholesterol side chain cleavage; Granulosa cells; HPTE; Methoxychlor; Ovarian steroidogenesis; P450scc; Theca cells

Indexed keywords

1,1,1 TRICHLORO 2,2 BIS(4 HYDROXYPHENYL)ETHANE; 4 TERT OCTYLPHENOL; 4,4' ISOPROPYLIDENEDIPHENOL; ANDROGEN RECEPTOR; CHOLESTEROL; CYTOCHROME P450; ESTROGEN RECEPTOR; METHOXYCHLOR; PESTICIDE; PROGESTERONE; TRICHLOROETHANE; UNCLASSIFIED DRUG;

ANDROGEN SYNTHESIS; ANIMAL EXPERIMENT; ARTICLE; CATALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; FEMALE FERTILITY; GRANULOSA CELL; HORMONE SYNTHESIS; LEYDIG CELL; NONHUMAN; OVARY CELL CULTURE; RAT; SIGNAL TRANSDUCTION;

ANDROGEN ANTAGONISTS; ANIMALS; CATALYTIC DOMAIN; CELLS, CULTURED; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ESTRADIOL; ESTROGEN ANTAGONISTS; ESTROGENS; FEMALE; FLUTAMIDE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GONADOTROPINS, EQUINE; METHOXYCHLOR; OVARY; OXAZOLES; PHENOLS; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANDROGEN; RECEPTORS, ESTROGEN; RNA, MESSENGER;

ANIMALIA; RATTUS; RODENTIA;

EID: 37449008357     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2007.10.007     Document Type: Article

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