Methoxychlor induces proliferation of the mouse ovarian surface epithelium

Toxicological Sciences

Volumn 83, Issue 2, 2005, Pages 355-362

  Symonds, Daniel A ^a   Tomic, Dragana ^a   Miller, Kimberly P ^a   Flaws, Jodi A ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Cell cycle; Estrogen receptor; Methoxychlor; Ovarian surface epithelium; Proliferation

Indexed keywords

1,1,1 TRICHLOROETHANE; CYCLIN D2; CYCLINE; ESTROGEN RECEPTOR; FULVESTRANT; METHOXYCHLOR; PESTICIDE; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CULTURE; CELL CYCLE; CELL DENSITY; CELL GROWTH; CELL ISOLATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CULTURAL ANTHROPOLOGY; CULTURE MEDIUM; ENZYME DEGRADATION; EPITHELIUM CELL; FEMALE; GROWTH INHIBITION; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; OVARY CELL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REPRODUCTIVE TOXICITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL COUNT; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASES; CYCLINS; EPITHELIUM; ESTRADIOL; ESTROGEN ANTAGONISTS; ESTROGEN RECEPTOR ALPHA; FEMALE; INSECTICIDES; METHOXYCHLOR; MICE; MICE, INBRED STRAINS; OVARY; PHENOLS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 13644266459     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfi024     Document Type: Article

References (26)

1. Auersperg, N., Wong, A. S., Choi, K. C., Kang, S. K., and Leung, P. C. (2001). Ovarian surface epithelium: Biology, endocrinology, and pathology. Endocr. Rev. 22, 255-288.
2. Bai, W., Oliveros-Saunders, B., Wang, Q., Acevedo-Duncan, M. E., and Nicosia, S. V. (2000). Estrogen stimulation of ovarian surface epithelial cell proliferation. In Vitro Cell. Dev. Biol. Anim. 36, 657-666.
3. Borgeest, C., Symonds, D., Mayer, L. P., Hoyer, P. B., and Flaws, J. A. (2002). Methoxychlor may cause ovarian follicular atresia and proliferation of the ovarian epithelium in the mouse. Toxicol. Sci. 68, 473-478.
4. Borgeest, C., Miller, K. P., Gupta, R., Greenfeld, C., Hruska, K. S., Hoyer, P., and Flaws, J. A. (2004). Methoxychlor-induced atresia in the mouse involves Bcl-2 family members, but not gonadotropins or estradiol. Biol. Reprod. 70, 1828-1835.
5. Chedrese, P. J., and Feyles, F. (2001). The diverse mechanism of action of dichlorodiphenyldichloroethylene (DDE) and methoxychlor in ovarian cells in vitro. Reprod. Toxicol. 15, 693-698.
6. Choi, K. C., Kang, S. K., Tai, C. J., Auersperg, N., and Leung, P. C. (2001). Estradiol up-regulates antiapoptotic Bcl-2 messenger ribonucleic acid and protein in tumorigenic ovarian surface epithelium cells. Endocrinology 142, 2351-2360.
7. Cummings, A. M. (1997). Methoxychlor as a model for environmental estrogens. Crit. Rev. Toxicol. 27, 367-379.
8. Dunfield, L. D., Shepherd, T. G., and Nachtigal, M. W. (2002). Primary culture and mRNA analysis of human ovarian cells. Biol. Proc. Online 4, 55-61.
9. Ghosh, D., Taylor, J. A., Green, J. A., and Lubahn, D. B. (1999). Methoxychlor stimulates estrogen-responsive messenger ribonucleic acids in mouse uterus through a non-estrogen receptor (non-ER) alpha and non-ER beta mechanism. Endocrinology 140, 3526-3533.
10. Harrington, W. R., Sheng, S., Barnett, D. H., Petz, L. N., Katzenellenbogen, J. A., and Katzenellenbogen, B. S. (2003). Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression. Mol. Cell. Endocrinol. 206, 13-22.
11. Hodges, L. C., Bergerson, J. S., Hunter, D. S., and Walker, C. L. (2000). Estrogenic effects of organochlorine pesticides on uterine leiomyoma cells in vitro. Toxicol. Sci. 54, 355-364.
12. Gaido, K. W., Leonard, L. S., Maness, S. C., Hall, J. M., McDonnel, D. P., Saville, B., and Safe, S. (1999). Differential interaction of the methoxychlor metabolite 2,2-bis-(p hydroxyphenyl)-1,1,1,-trichloroethane with estrogen receptors α and β. Endocrinology 140, 5746-5753.
13. Jiang, F., Saunders, B. O., Haller, E., Livingston, S., Nicosia, S. V., and Bai, W. (2003). Conditionally immortal ovarian cell lines for investigating the influence of ovarian stroma on the estrogen sensitivity and tumorigenicity of ovarian surface epithelial cells. In Vitro Cell Dev. Biol. Anim. 39, 304-312.
14. Jones, L. J., Gray, M., Yue, S. T., Haugland, R. P., and Singer, V. L. (2001). Sensitive determination of cell number using the CyQUANT cell proliferation assay. J. Immunol. Methods 254, 85-98.
15. Kido, M., and Shibuya, M. (1998). Isolation and characterization of mouse ovarian surface epithelial cell lines. Pathol. Res. Pract. 194, 725-730.
16. Nicosia, S. V., Johnson, J. H., and Streibel, E. J. (1984). Isolation and ultrastructure of rabbit ovarian mesothelium (surface epithelium). Int. J. Gynecol. Pathol. 3, 348-360.
17. Pelletier, G., Labrie, C., and Labrie, F. (2000). Localization of oestrogen receptor alpha, oestrogen receptor beta and androgen receptors in the rat reproductive organs. J. Endocrinol. 165, 359-370.
18. Perez de Castro, I. P., Malumbres, M., Santos, J., Pellicer, A., and Fernandez-Piqueras, J. (1999). Comparative alterations on Rb pathway regulators in mouse primary T cell lymphomas. Carcinogenesis 20, 1675-1682.
19. Piatelli, M. J., Doughty, C., and Chiles, T. C., (2002). Requirement for a hsp90 chaperone-deperident MEK 1/2-ERK pathway for B cell antigen receptor-induced cyclin D2 expression in mature B lymphocytes. J. Biol. Chem. 277, 12144-12150.
20. Robker, R. L., and Richards, J. S. (1998). Hormonal control of the cell cycle in ovarian cells: Proliferation versus differentiation. Biol. Reprod. 59, 476-482.
21. Rodriguez, G. C., Walmer, D. K., Cline, M., Krigman, H., Lessey, B. A., Whitaker, R. S., Dodge, R., and Hughes, C. L. (1998). Effect of progestin on the ovarian epithelium of macaques: Cancer prevention through apoptosis? J. Soc. Gynecol. Investig. 5, 271-276.
22. Somai, S., Chaouat, M., Jacob, D., Perrot, J. Y., Rostene, W., Forgez, P., and Gompel, A. (2003). Antiestrogens are pro-apoptotic in normal human breast epithelial cells. Int. J. Cancer 105, 607-612.
23. Stewart, S. L., Querec, T. D., Gruver, B. N., O'Hare, B., Babb, J. S., and Patriotis, C. (2004). Gonadotropin and steroid hormones stimulate proliferation of the rat ovarian surface epithelium. J. Cell Physiol. 198, 119-124.
24. Turusov, V., Rakitsky, V., and Tomatis, L. (2002). Dichlorodiphenyltrichlorethane (DDT): Ubiquity, persistence, and risks. Environ. Health Perspect. 110, 125-128.
25. Weihua, Z., Saji, S., Makinen, S., Cheng, G., Jensen, E. V., Warner, M., and Gustafsson,J.A. (2000). Estrogen receptor (ER) beta, a modulator of ER alpha in the uterus. Proc. Natl. Acad. Sci. U.S.A. 97, 5936-5941.
26. Wyllie, A. H. (1997). Apoptosis and carcinogenesis. Eur. J Cell Biol. 73, 189-197.