Anti-progestogenic effect of flutamide on uterine expression of calbindin-D9k mRNA and protein in immature mice

Reproductive Toxicology

Volumn 22, Issue 4, 2006, Pages 694-701

  Ji, Youn Kyu ^a   Lee, Geun Shik ^a   Choi, Kyung Chul ^b   Jeung, Eui Bae ^a  

^a Research Institute of Veterinary Medicine   (South Korea)

^b CHILDREN S AND WOMEN S HEALTH CENTRE OF BRITISH COLUMBIA   (Canada)

Author keywords

Calbindin D9k; Flutamide; Immature mice; Progesterone receptors

Indexed keywords

ANTIGESTAGEN; CALBINDIN; FLUTAMIDE; MIFEPRISTONE; PROGESTERONE;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; IMMATURITY; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; TIME;

ANDROGEN ANTAGONISTS; ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CALCIUM-BINDING PROTEIN, VITAMIN D-DEPENDENT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLUTAMIDE; GENE EXPRESSION; INJECTIONS, SUBCUTANEOUS; MICE; MICE, INBRED ICR; MIFEPRISTONE; MOLECULAR STRUCTURE; PROGESTERONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS; UP-REGULATION; UTERUS;

EID: 33749598321     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2006.04.015     Document Type: Article

References (37)

1. Christakos S., Gabrielides C., and Rhoten W.B. Vitamin D-dependent calcium binding proteins: chemistry, distribution, functional considerations, and molecular biology. Endocrinol Rev 10 (1989) 3-26
2. Kumar R., Wieben E., and Beecher S.J. The molecular cloning of the complementary deoxyribonucleic acid for bovine vitamin D-dependent calcium-binding protein: structure of the full-length protein and evidence for homologies with other calcium-binding proteins of the troponin-C superfamily of proteins. Mol Endocrinol 3 (1989) 427-432
3. Wasserman R.H., Brindak M.E., Meyer S.A., and Fullmer C.S. Evidence for multiple effects of vitamin D3 on calcium absorption: response of rachitic chicks, with or without partial vitamin D3 repletion, to 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci USA 79 (1982) 7939-7943
4. Wasserman R.H., and Fullmer C.S. On the molecular mechanism of intestinal calcium transport. Adv Exp Med Biol 249 (1989) 45-65
5. Christian M., Mak I., White J.O., and Brosens J.J. Mechanisms of decidualization. Reprod Biomed Online 4 Suppl 3 (2002) 24-30
6. Delorme A.C., Danan J.L., Acker M.G., Ripoche M.A., and Mathieu H. In rat uterus 17 beta-estradiol stimulates a calcium-binding protein similar to the duodenal vitamin D-dependent calcium-binding protein. Endocrinology 113 (1983) 1340-1347
7. L'Horset F., Blin C., Brehier A., Thomasset M., and Perret C. Estrogen-induced calbindin-D 9k gene expression in the rat uterus during the estrous cycle: late antagonistic effect of progesterone. Endocrinology 132 (1993) 489-495
8. 9k gene: expression in endometrium, myometrium, and placenta in the absence of a functional estrogen response element in intron A. Biol Reprod 52 (1995) 115-123
9. 9k in the uterus during a luteal phase. Mol Reprod Dev 67 (2004) 251-256
10. Inpanbutr N., Miller E.K., Petroff B.K., and Iacopino A.M. CaBP9K levels during the luteal and follicular phases of the estrous cycle in the bovine uterus. Biol Reprod 50 (1994) 561-571
11. 9k gene expression in the uterus during late pregnancy and lactation. Mol Cell Endocrinol 205 (2003) 79-88
12. Hall K. Histochemical studies of enzymes in the uterus during development and regression of deciduomata in pseudopregnant mice. J Endocrinol 41 (1968) 8-9
13. Tsai M.J., and O'Malley B.W. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Ann Rev Biochem 63 (1994) 451-486
14. Mangelsdorf D.J., Thummel C., Beato M., Herrlich P., Schutz G., Umesono K., et al. The nuclear receptor superfamily: the second decade. Cell 83 (1995) 835-839
15. Mulac-Jericevic B., and Conneely O.M. Reproductive tissue selective actions of progesterone receptors. Reproduction 128 (2004) 139-146
16. Chwalisz K., Perez M.C., Demanno D., Winkel C., Schubert G., and Elger W. Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis. Endocrinol Rev 26 (2005) 423-438
17. 9k by steroid hormones and their receptors in the uterus of immature mice. J Reprod Dev 50 (2004) 445-453
18. Tatsumi K., Higuchi T., Fujiwara H., Nakayama T., Itoh K., Mori T., et al. Expression of calcium binding protein D-9k messenger RNA in the mouse uterine endometrium during implantation. Mol Hum Reprod 5 (1999) 153-161
19. Brenner R.M., Slayden O.D., Nayak N.R., Baird D.T., and Critchley H.O. A role for the androgen receptor in the endometrial antiproliferative effects of progesterone antagonists. Steroids 68 (2003) 1033-1039
20. Schulz M., Schmoldt A., Donn F., and Becker H. The pharmacokinetics of flutamide and its major metabolites after a single oral dose and during chronic treatment. Eur J Clin Pharmacol 34 (1988) 633-636
21. Dukes M., Furr B.J., Hughes L.R., Tucker H., and Woodburn J.R. Nonsteroidal progestins and antiprogestins related to flutamide. Steroids 65 (2000) 725-731
22. Chandrasekhar Y., and Armstrong D.T. Ability of progesterone to reverse anti-androgen (hydroxyflutamide)-induced interference with the preovulatory LH surge and ovulation in PMSG-primed immature rats. J Reprod Fertil 85 (1989) 309-316
23. Chandrasekhar Y., Armstrong D.T., and Kennedy T.G. Implantation delay and anti-deciduogenic activity in the rat by the anti-androgen, hydroxyflutamide. Biol Reprod 42 (1990) 120-125
24. Chandrasekhar Y., and Armstrong D.T. Regulation of uterine progesterone receptors by the nonsteroidal anti-androgen hydroxyflutamide. Biol Reprod 45 (1991) 78-81
25. Chandrasekhar Y. Effects of hydroxyflutamide on female reproductive function. Adv Contracept Deliv Syst 7 (1991) 157-166
26. Choi K., and Jeung E. The biomarker and endocrine disruptors in mammals. J Reprod Dev 49 (2003) 337-345
27. 9k protein as a useful biomarker for environmental estrogenic compounds in the uterus of immature rats. Reprod Toxicol 17 (2003) 311-319
28. 9k messenger RNA and protein by maternal exposure to alkylphenols during late pregnancy in maternal and neonatal uteri of rats. Biol Reprod 71 (2004) 669-675
29. 9k in an immature mouse model. Toxicol Sci 83 (2005) 78-88
30. 9k gene expression during the perinatal period in the rat: correlation to estrogen receptor expression in uterus. Mol Cell Endocrinol 97 (1993) 61-69
31. Darwish H., Krisinger J., Furlow J.D., Smith C., Murdoch F.E., and DeLuca H.F. An estrogen-responsive element mediates the transcriptional regulation of calbindin D-9K gene in rat uterus. J Biol Chem 266 (1991) 551-558
32. Blin C., L'Horset F., Romagnolo B., Colnot S., Lambert M., Thomasset M., et al. Functional and growth properties of a myometrial cell line derived from transgenic mice: effects of estradiol and antiestrogens. Endocrinology 137 (1996) 2246-2253
33. Edwards J., and Bartlett J.M. The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 2. Androgen-receptor cofactors and bypass pathways. BJU Int 95 (2005) 1327-1335
34. 9k in the early pregnant rat uterus: effects of RU 486 and correlation to estrogen receptor mRNA. Mol Cell Endocrinol 102 (1994) 15-22
35. 9k (calbindin-D(9k)) in the mouse uterus during early pregnancy and at the site of embryo implantation. Biol Reprod 62 (2000) 27-36
36. 9k mRNA and protein during pregnancy in rat model. Mol Cell Endocrinol 212 (2003) 63-72
37. Degen G.H. Endocrine disruptors in food. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 47 (2004) 848-856