BacMam technology and its application to drug discovery

Expert Opinion on Drug Discovery

Volumn 2, Issue 12, 2007, Pages 1669-1681

  Ames, Robert S ^a   Kost, Thomas A ^a   Condreay, J Patrick ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Baculovirus; Biochemical assays; Cell engineering; Cell based assays; High throughput

Indexed keywords

BACULOVIRUS VECTOR; DENDROASPIS NATRIURETIC PEPTIDE; NATRIURETIC FACTOR; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

BACMAM TECHNOLOGY; BACULOVIRUS; BIOENGINEERING; BIOSAFETY; CELL VIABILITY; CLINICAL EFFECTIVENESS; DRUG MECHANISM; DRUG SCREENING; HIGH THROUGHPUT SCREENING; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; REPRODUCIBILITY; REVIEW; VIRAL GENE DELIVERY SYSTEM;

EID: 37349084541     PISSN: 17460441     EISSN: None     Source Type: Journal    
DOI: 10.1517/17460441.2.12.1669     Document Type: Review

References (87)

1. The Baculoviruses. Miller LK (Ed.), Plenum Publishing Corporation, New York, USA (1997).
2. Advances in Virus Research: Insect Viruses: Biotechnological Applications. Elsevier, New York, USA (2006).
3. SMITH GE, SUMMERS MD, FRASER MJ: Production of human β-interferon in insect cells infected with a baculovirus expression vector. Mol. Cell. Biol. (1983) 3:2156-2165.
4. PENNOCK GD, SHOEMAKER C, MILLER LK: Strong and regulated expression of Escherichia coli β-galactosidase in insect cells with a baculovirus vector. Mol. Cell. Biol. (1984) 4:399-406.
5. VOLKMAN LE, GOLDSMITH PA: In vitro survey of Autographa californica nuclear polyhedrosis virus interaction with nontarget vertebrate host cells. Appl. Environ. Microbiol. (1983) 45:1085-1093.
6. GRONER A, GRANADOS RR, BURAND JP: Interaction of Autographa californica nuclear polyhedrosis virus with two nonpermissive cell lines. Intervirology (1984) 21:203-209.
7. CARBONELL LF, KLOWDEN MJ, MILLER LK: Baculovirus-mediated expression of bacterial genes in dipteran and mammalian cells. J. Virol. (1985) 56:153-160.
8. CARBONELL LF, MILLER LK: Baculovirus interaction with nontarget organisms: a virus-borne reporter gene is not expressed in two mammalian cell lines. Appl. Environ. Microbiol. (1987) 53:1412-1417.
9. HOFMANN C, SANDIG V, JENNINGS G et al.: Efficient gene transfer into human hepatocytes by baculovirus vectors. Proc. Natl. Acad. Sci. USA (1995) 92:10099-10103.
10. BOYCE FM, BUCHER NL: Baculovirus-mediated gene transfer into mammalian cells. Proc. Natl. Acad. Sci. USA (1996) 93:2348-2352.
11. SHOJI I, AIZAKI H, TANI H et al.: Efficient gene transfer into various mammalian cells, including non-hepatic cells, by baculovirus vectors. J. Gen. Virol. (1997) 78:2657-2664.
12. CONDREAY JP, WITHERSPOON SM, CLAY WC et al.: Transient and stable gene expression in mammalian cells transduced with a recombinant baculovirus vector. Proc. Natl. Acad. Sci. USA (1999) 96:127-132.
13. HOFMANN C, STRAUSS M: Baculovirus-mediated gene transfer in the presence of human serum or blood facilitated by inhibition of the complement system. Gene Ther. (1998) 5:531-536.
14. KOST TA, CONDREAY JP: Recombinant baculoviruses as mammalian cell gene-delivery vectors. Trends Biotechnol. (2002) 20:173-180.
15. DREWS J: Drug discovery: a historical perspective. Science (2000) 287:1960-1964.
16. HERTZBERG RP, POPE AJ: High-throughput screening: new technology for the 21st century. Curr. Opin. Chem. Biol. (2000) 4:445-451.
17. FORNWALD JA, WANG D, LU Q, WANG D, AMES RS: Gene expression in mammalian cells using BacMam, a modified baculovirus system. In: Methods in Molecular Biology, Baculovirus and Insect Cell Expression Protocols. Murhammer DW (Ed.), Humana Press, Totowa, New Jersey, USA (2007):95-114.
18. TRANSFIGURACION J, JORIO H, MEGHROUS J et al.: High yield purification of functional baculovirus vectors by size exclusion chromatography. J. Virol. Methods (2007) 142:21-28.
19. JARVIS DL, GARCIA Jr: Long-term stability of baculoviruses stored under various conditions. Biotechniques (1994) 16:508-513.
20. AMES R, FORNWALD J, NUTHULAGANTI P et al.: BacMam recombinant baculoviruses in G protein-coupled receptor drug discovery. Receptors Channels (2004) 10:99-107.
21. AMES R, NUTHULAGANTI P, FORNWALD J et al.: Heterologous expression of G protein-coupled receptors in U-2 OS osteosarcoma cells. Receptors Channels (2004) 10:117-124.
22. PFOHL JL, WORLEY JF III, CONDREAY JP et al.: Titration of KATP channel expression in mammalian cells utilizing recombinant baculovirus transduction. Receptors Channels (2002) 8:99-111.
23. CLAY WC, CONDREAY JP, MOORE LB et al.: Recombinant baculoviruses used to study estrogen receptor function in human osteosarcoma cells. Assay Drug Dev. Tech. (2004) 1:801-810.
24. KATSO RM, PARHAM JH, CAIVANO M et al.: Evaluation of cell-based assays for steroid nuclear receptors delivered by recombinant baculoviruses. J. Biomol. Screen. (2005) 10:715-724.
25. HASSAN NJ, POUNTNEY DJ, ELLIS C et al.: BacMam recombinant baculovirus in transporter expression: a study of BCRP and OATPIBI. Protein Expr. Purif. (2006) 47:591-598.
26. RAMOS L, KOPEC LA, SWEITZER SM et al.: Rapid expression of recombinant proteins in modified CHO cells using the baculovirus system. Cytotechnology (2002) 38:37-41.
27. SCOTT MJ, MODHA SS, RHODES AD et al.: Efficient expression of secreted proteases via recombinant BacMam virus. Protein Expr. Purif. (2007) 52:104-116.
28. SU JL, FORNWALD J, RIVERS P et al.: A cell-based time-resolved fluorescence assay for selection of antibody reagents for G protein-coupled receptor immunohistochemistry. J. Immunol. Methods (2004) 291:123-135.
29. MERRIHEW RV, KOST TA, CONDREAY JP: Baculovirus-mediated gene delivery into mammalian cells. Methods Mol. Biol. (2004) 246:355-365.
30. HUSER A, HOFMANN C: Baculovirus vectors: novel mammalian cell gene-delivery vehicles and their applications. Am. J. Pharmacogenomics (2003) 3:53-63.
31. CONDREAY JP, AMES RS, HASSAN NJ et al.: Baculoviruses and mammalian cell-based assays for drug screening. Adv. Virus Res. (2006) 68:255-286.
32. KOST TA, CONDREAY JP, JARVIS DL: Baculovirus as versatile vectors for protein expression in insect and mammalian cells. Nat. Biotechnol. (2005) 23:567-575.
33. KOST TA, CONDREAY JP, AMES RS et al.: Implementation of BacMam virus gene delivery technology in a drug discovery setting. Drug Discov. Today (2007) 12:396-403.
34. BEHM DJ, STANKUS G, DOE CP et al.: The peptidic urotensin-II receptor ligand GSK248451 possesses less intrinsic activity than the low-efficacy partial agonists SB-710411 and urantide in native mammalian tissues and recombinant cell systems. Br. J. Pharmacol. (2006) 148:173-190.
35. KOLLER KJ, GOEDDEL DV: Molecular biology of the natriuretic peptides and their receptors. Circulation (1992) 86:1081-1088.
36. JOHNS DG, AO Z, HEIDRICH BJ et al.: Dendroaspis natriuretic peptide binds to the natriuretic peptide clearance receptor. Biochem. Biophys. Res. Commun. (2007) 358:145-149.
37. SCHROEDER KS, NEAGLE BD: FLIPR: A new instrument for accurate, high-throughput optical screening. J. Biomol. Screen. (1996) 1:75-80.
38. BRISCOE CP, TADAYYON M, ANDREWS JL et al.: The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J. Biol. Chem. (2003) 278:11303-11311.
39. COVINGTON DK, BRISCOE CA, BROWN AJ et al.: The G protein-coupled receptor 40 family (GPR40-GPR43) and its role in nutrient sensing. Biochem. Soc. Trans. (2006) 34:770-773.
40. BROWN AJ, JUPE S, BRISCOE CP: A family of fatty acid binding receptors. DNA Cell Biol. (2005) 24:54-61.
41. BROWN AJ, GOLDSWORTHY SM, BARNES AA et al.: The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic adds. J. Biol. Chem. (2003) 278:11312-11319.
42. BRISCOE CP, PEAT AJ, MCKEOWN SC et al.: Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br. J. Pharmacol. (2006) 148:619-628.
43. 2+ based on green fluorescent proteins and calmodulin. Nature (1997) 388:882-887.
44. NAGAI T, YAMADA S, TOMINAGA T et al.: Expanded dynamic range of fluorescent indicators for Ca(2+) by circularly permuted yellow fluorescent proteins. Proc. Natl. Acad. Sci. USA (2004) 101:10554-10559.
45. ZHANG JH, CHUNG TD, OLDENBURG KR: A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J. Biomol. Screen. (1999) 4:67-73.
46. HANEY SA, LAPAN P, PAN J et al.: High-content screening moves to the front of the line. Drug Discov. Today (2006) 11:889-894.
47. FOX S, FARR-JONES S, SOPCHAK L et al.: High-throughput screening: update on practices and success. J. Biomol. Screen. (2006) 11:864-869.
48. OAKLEY RH, HUDSON CC, CRUICKSHANK RD et al.: The cellular distribution of fluorescently labeled arrestins provides a robust, sensitive, and universal assay for screening G protein-coupled receptors. Assay Drug Dev. Technol. (2002) 1:21-30.
49. HUDSON CC, OAKLEY RH, SJAASTAD MD et al.: High-content screening of known G protein-coupled receptors by arrestin translocation. Methods Enzymol. (2006) 414:63-78.
50. OAKLEY RH, HUDSON CC, SJAASTAD MD et al.: The ligand-independent translocation assay: an enabling technology for screening orphan G protein-coupled receptors by arrestin recruitment. Methods Enzymol. (2006) 414:50-63.
51. PONTEN J, SAKSELA E: Two established in vitro cell lines from human mesenchymal tumors, Int. J. Cancer (1967) 2:434 447.
52. SONG SU, SHIN SH, KIM SK et al.: Effective transduction of osteogenic sarcoma cells by a baculovirus vector. J. Gen. Virol. (2003) 84:697-703.
53. GARIPPA RJ, HOFFMAN AF, GRADL G et al.: High-throughput confocal microscopy for β-arrestin-green fluorescent protein translocation G protein-coupled receptor assays using the Evotec Opera. Methods Enzymol. (2006) 414:99-120.
54. HOFFMAN AF, GARIPPA RJ: A pharmaceutical company user's perspective on the potential of high content screening in drug discovery. Methods Mol. Biol. (2007) 356:19-31.
55. HORROCKS C, HALSE R, SUZUKI R et al.: Human cell systems for drug discovery. Curr. Opin. Drug Discov. Dev. (2003) 6:570-575.
56. ANDERSSON M, WAROLEN M, NILSSON J et al.: Baculovirus-mediated gene transfer and recombinant protein expression do not interfere with insulin dependent phosphorylation of PKB/Akt in human SHSY-5Y and C3A cells. BMC Cell Biol. (2007) 8:6.
57. SUNG LY, LO WH, CHIU HY et al.: Modulation of chondrocyte phenotype via baculovirus-mediated growth factor expression. Biomaterials (2007) 28:3437-3447.
58. ZENG J, DU J, ZHAO Y et al.: Baculoviral vector-mediated transient and stable transgene expression in human embryonic stem cells. Stem Cells (2007) 25:1055-1061.
59. TANI H, NISHIJIMA M, USHIJIMA H et al.: Characterization of cell-surface determinants important for baculovirus infection. Virology (2001) 279:343-353.
60. DUISIT G, SALEUN S, DOUTHE S et al.: Baculovirus vector requires electrostatic interactions including heparan sulfate for efficient gene transfer in mammalian cells. J. Gene Med. (1999) 1:93-102.
61. MATILAINEN H, RINNE J, GILBERT L et al.: Baculovirus entry into human hepatoma cells. J. Virol. (2005) 79:15452-15459.
62. GE J, HUANG Y, HU X et al.: A surface-modified baculovirus vector with improved gene delivery to B-lymphocytic cells. J. Biotechnol. (2007) 129:367-372.
63. PHILIPPS B, FORSTNER M, MAYR LM: A baculovirus expression vector system for simultaneous protein expression in insect and mammalian cells. Biotechnol. Prog. (2005) 21:708-711.
64. KOST TA, CONDREAY JP: Baculovirus vectors as gene transfer vectors for mammalian cells: biosafety considerations. Appl. Biosaf. (2002) 7:167-169.
65. KOST TA, CONDREAY JP, MICKELSON CA: Biosafety and viral gene transfer vectors. In: Biological Safety, Principles and Practices (4th Edition), Fleming DOHDL (Ed.), American Society for Microbiology Press (2006):509-530.
66. SUZUKI H, KANEKO H, TAMAI N et al.: Suppression of HCV RNA replication by baculovirus-mediated shRNA expression. Nucleic Acids Symp. Ser. (Oxf.) (2005) 339-340.
67. NICHOLSON LJ, PHILIPPE M, PAINE AJ et al.: RNA interference mediated in human primary cells via recombinant baculoviral vectors. Mol. Ther. (2005) 11:638-644.
68. LU L, HO Y, KWANG J: Suppression of porcine arterivirus replication by baculovirus-delivered shRNA targeting nucleoprotein. Biochem. Biophys. Res. Commun. (2006) 340: 1178-1183.
69. CHUANG CK, SUNG LY, HWANG SM et al.: Baculovirus as a new gene delivery vector for stem cell engineering and bone tissue engineering. Gene Ther. (2007).
70. ISOM HC, ABDELHAMED AM, BILELLO JP et al.: Baculovirus-mediated gene transfer for the study of hepatitis B virus. Methods Mol. Med. (2004) 96:219-237.
71. MCCORMICK CJ, CHALLINOR L,. MACDONALD A et al.: Introduction of replication-competent hepatitis C virus transcripts using a tetracycline-regulable baculovirus delivery system. J. Gen. Virol. (2004) 85:429-439.
72. MATSUO E, TANI H, LIM C et al.: Characterization of HCV-like particles produced in a human hepatoma cell line by a recombinant baculovirus. Biochem. Biophys. Res. Commun. (2006) 340:200-208.
73. KUKKONEN SP, AIRENNE KJ, MARJOMAKI V et al.: Baculovirus capsid display: a novel tool for transduction imaging. Mol. Ther. (2003) 8:853-862.
74. LONG G, PAN X, KORMELINK R et al.: Functional entry of baculovirus into insect and mammalian cells is dependent on clathrin-mediated endocytosis. J. Virol. (2006) 80:8830-8833.
75. OKER-BLOM C, AIRENNE KJ, GRABHERR R: Baculovirus display strategies: emerging tools for eukaryotic libraries and gene delivery. Brief Funct. Genomic Proteomic (2003) 2:244-253.
76. MAKELA AR, OKER-BLOM C: Baculovirus display: a multifunctional technology for gene delivery and eukaryotic library development. Adv. Virus Res. (2006) 68:91-112.
77. SPENGER A, ERNST W, CONDREAY JP et al.: Influence of promoter choice and trichostatin A treatment on expression of baculovirus delivered genes in mammalian cells. Protein Expr. Purif. (2004) 38:17-23.
78. CHIANG YW, WU JC, WANG KC et al.: Efficient expression of histidine-tagged large hepatitis δ antigen in baculovirus-transduced baby hamster kidney cells, World J. Gastroenterol. (2006) 12:1551-1557.
79. HU YC, TSAI CT, CHANG YJ et al.: Enhancement and prolongation of baculovirus-mediated expression in mammalian cells: focuses on strategic infection and feeding. Biotechnol Prog. (2003) 19:373-379.
80. WANG KC, WU JC, CHUNG YC et al.: Baculovirus as a highly efficient gene delivery vector for the expression of hepatitis δ virus antigens in mammalian cells.Biotechnol. Bioeng. (2005) 89:464-473.
81. SHEN HC, LEE HP, LO WH et al.: Baculovirus-mediated gene transfer is attenuated by sodium bicarbonate. J. Gene Med. (2007) 9:470-478.
82. WU C, SOH KY, WANG S: Ion-exchange membrane chromatography method for rapid and efficient purification of recombinant baculovirus and baculovirus gp64 protein. Hum. Gene Ther. (2007) 18:665-672.
83. TSAI CT, CHAN ZR, LU JT et al.: Factors influencing the production and storage of baculovirus for gene delivery: an alternative perspective from the transducing titer assay. Enzyme Microbial Tech. (2007) 40:1345-1351.
84. GHOSH S, PARVEZ MK, BANERJEE K et al.: Baculovirus as mammalian cell expression vector for gene therapy: an emerging strategy. Mol. Ther. (2002) 6:5-11.
85. HU YC: Baculovirus vectors for gene therapy. Adv. Virus Res. (2006) 68:287-320.
86. KIM CH, YOON JS, SOHN HJ et al.: Direct vaccination with pseudotype baculovirus expressing murine telomerase induces antitumor immunity comparable with RNA-electroporated dendritic cells in a murine glioma model. Cancer Lett. (2007) 250:276-283.
87. STRAUSS R, HUSER A, NI S et al.: Baculovirus-based vaccination vectors allow for efficient induction of immune responses against Plasmodium falciparum circumsporozoite protein. Mol. Ther. (2007) 15:193-202.