Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: A randomized controlled trial [ISRCTN25438351]

BMC Complementary and Alternative Medicine

Volumn 7, Issue , 2007, Pages

  Mehta, Komal ^a   Gala, Jayesh ^b   Bhasale, Surendra ^c   Naik, Sattayasheel ^d   Modak, Millind ^e   Thakur, Harshad ^f   Deo, Nivedita ^a   Miller, Mark J S ^g  

^a Vedic Lifesciences   (India)

^b Diamond Hospital ^*  (India)

^c Diamond Hospital   (India)

^d Naik Hospital   (India)

^e Yogesh Hospital   (India)

^f TATA INSTITUTE OF SOCIAL SCIENCES   (India)

^g ALBANY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSAMINE SULFATE; LEPIDIUM MEYENII EXTRACT; PARACETAMOL; PLANT EXTRACT; REPARAGEN; SOMATOMEDIN C; UNCARIA GUIANENSIS EXTRACT; UNCLASSIFIED DRUG; GLUCOSAMINE;

ABSENCE OF SIDE EFFECTS; ADULT; AGE; ALTERNATIVE MEDICINE; ANALGESIA; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE ACTIVITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; FEMALE; HERBAL MEDICINE; HUMAN; INDIA; JOINT FUNCTION; JOINT STIFFNESS; KNEE OSTEOARTHRITIS; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PAIN ASSESSMENT; PATIENT COMPLIANCE; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; SOUTH AMERICA; TREATMENT DURATION; TREATMENT OUTCOME; VISUAL ANALOG SCALE; VITAL SIGN; BLOOD; COMPARATIVE STUDY; METABOLISM; MIDDLE AGED; PAIN;

ACETAMINOPHEN; DOUBLE-BLIND METHOD; FEMALE; GLUCOSAMINE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PAIN; PAIN MEASUREMENT; PLANT EXTRACTS; TREATMENT OUTCOME;

EID: 37249031369     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-7-34     Document Type: Article

References (65)

1. Murray CJL Lopez AD The Global Burden of Disease Boston: Harvard University Press 1996
2. Felson DT Zhang Y An update on the epidemiology of knee and hip osteoarthritis with a view to prevention Arthritis Rheum 1998, 41:1343-1355 10.1002/1529-0131(199808)41:8<1343::AID- ART3>3.0.CO;2-9 9704632
3. Grainger R Cicuttini FM Medical management of osteoarthritis of the knee and hip joints Med J Aust 2004, 180(5):232-236 14984344
4. Hogenmiller MS Lozada CJ An update on osteoarthritis therapeutics Curr Opin Rheumatol 2006, 18:256-260 10.1097/01.bor.0000218945.96988.0a 16582688
5. Ameye LG Chee WSS Osteoarthritis and nutrition. From nutraceuticals to functional foods: A systemic review of the scientific evidence Arthritis Res Therap 2006, 8:R127 10.1186/ar2016
6. Kraan PM Berg WM Anabolic and destructive mediators in osteoarthritis Curr Opin Nur Metab Care 2000, 3:205-211 10.1097/00075197-200005000-00007
7. Altman RD Hochberg MC Moskowitz RW Schnitzer TJ Recommendations for the medical management of osteoarthritis of the hip and knee Arthritis Rheum 2000, 43:1905-1915 10.1002/ 1529-0131(200009)43:9<1905::AID-ANR1>3.0.CO;2-P 11014340
8. Reginster JY Deroisy R Rovati LC Lee RL Lejeune E Bruyere O Giacovelli G Henrotin Y Dacre JE Gossett C Long-term effects of glucosamine sulphate on osteoarthritis progression: A randomised, placebo-controlled clinical trial Lancet 2001, 357:251-256 10.1016/S0140-6736(00)03610-2 11214126
9. Pavelka K Gatterova J Olejarova M Machacek S Giacovelli C Rovarti LC Glucosamine sulphate use and delay of progression of knee osteoarthritis: A 3-year, randomized, placebo-controlled, double-blind study Arch Intern Med 2002, 162:2113-2123 10.1001/archinte.162.18.2113 12374520
10. McAlindon TE LaValley MP Gulin JP Felson DT Glucosamine and chondroitin for treatment of osteoarthritis. A systematic quality assessment and meta-analysis JAMA 2000, 283:1469-1475 10.1001/jama.283.11.1469 10732937
11. Clegg DO Reda DJ Harris CL Klein MA O'Dell JR Hooper MM Bradley JD Bingham CO 3rd Weisman MH Jackson CG Lane NE Cush JJ Moreland LW Schumacher HR Jr Oddis CV Wolfe F Molitor JA Yocum DE Schnitzer TJ Furst DE Sawitzke AD Shi H Brandt KD Moskowitz RW Williams HJ Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis New Engl J Med 2006, 354:795-808 10.1056/NEJMoa052771 16495392
12. Herrero-Beaumont G Ivorra JAR Trabado MC Blanco FJ Benito P Martin-Mola E Paulino J Marenco JL Porto A Laffon A Araujo D Figueroa M Branco J Glucosamine sulfate in the treatment of knee osteoarthritis symptoms. A randomized double-blind, placebo-controlled study using acetominophen as a side comparator Arthritis Rheum 2007, 56:555-567 10.1002/art.22371 17265490
13. Houpt JB McMillan R Wein C Paget-Dellio SD Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee J Rheumatol 1999, 26:2423-2430 10555905
14. Towheed TE Maxwell L Anastassiades TP Shea B Houpt J Robinson V Hochberg MC Wells G Glucosamine therapy for treating osteoarthritis Cochrane Database Syst Rev [serial online] 2005, 2:CD002946 http://www.thecochranelibrary.com
15. Vlad SC LaValley MP McAlindon TE Felson DT Glucosamine for pain in osteoarthritis: Why do trial results differ? Arthritis Rheum 2007, 56:2267-2277 10.1002/art.22728 17599746
16. Muniyappa R Karne RJ Hall G Crandon SK Bronstein JA Ver MR Hortin GL Quon MJ Oral glucosamine for 6 weeks at standard doses does not cause or worsen insulin resistance or endothelial dysfunction in lean or obese subjects Diabetes 2006, 55:3142-3150 10.2337/db06-0714 17065354
17. Biggee BA Blinn CH Nuite M Silbert JE McAlindon TE Effects of oral glucosamine sulfate on serum glucose and insulin during an oral glucose tolerance test of subjects with osteoarthritis Ann Rheum Dis 2007, 66:260-262 10.1136/ard.2006.058222 16818461
18. Pham T Cornea A Blick KE Jenkins A Scofield RH Oral glucosamine in doses used to treat osteoarthritis worsens insulin resistance Am J Med Sci 2007, 333:333-339 10.1097/MAJ.0b013e318065bdbe 17570985
19. Werstruck GH Khan MI Fernia G Kim AJ Tedesco V Trigatti B Shi Y Glucosamine-induced endoplasmic reticulum dysfunction is associated with accelerated atherosclerosis in a hyperglycemic mouse model Diabetes 2006, 55:93-101 10.2337/diabetes.55.01.06.db05-0633 16380481
20. Miller MJS Ahmed S Bobrowski PJ Haqqi TM The chondroprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1β BMC Complement Altern Med 2006, 6:13 1456997 16603065 10.1186/1472-6882-6-13
21. Sandoval-Chacon M Thompson JH Liu X Mannick EE Sadowska-Krowicka H Charbonnet R Clark DA Miller MJS Anti-inflammatory actions of cat's claw: The role of NF-κB Alimentary Pharmacol Ther 1998, 12:1279-1289 10.1046/j.1365-2036.1998.00424.x
22. Sandoval M Charbonnet RM Okuhama N Roberts J Krenova Z Trentacosti AM Miller MJS Cat's claw inhibits TNFα production and scavenges free radicals: Role in cytoprotection Free Radical Biol Med 2000, 29:71-78 10.1016/S0891-5849(00)00327-0
23. Sandoval M Okuhama NN Zhang X-J Condezo LA Lao J Angeles FM Bobrowski P Miller MJS Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content Phytomedicine 2002, 9:325-337 10.1078/0944-7113-00117 12120814
24. Miller MJS Angeles FM Reuter BK Bobrowski P Sandoval M Dietary antioxidants protect gut epithelial cells from oxidant induced apoptosis BMC Compl Altern Med 2001, 1:11 10.1186/1472-6882-1-11
25. Piscoya J Rodriuez Z Bustamante SA Okuhama NN Miller MJS Sandoval M Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: Mechanisms of action of the species Uncaria guianensis Inflamm Res 2001, 50:442-448 10.1007/PL00000268 11603848
26. De Ceuninck F Claiez A Dassencourt L Anract P Renard P Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes Arthritis Res Ther 2004, 6:R393-R403 546277 15380039 10.1186/ar1201
27. Haupt JL Frisbie DD McIlwraith CM Robbins PD Ghivizzani S Evans CH Nixon A Dual transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model J Orthopaedic Res 2005, 23:118-126 10.1016/ j.orthres.2004.06.020
28. Hui W Rowan AD Cawston TE Insulin-like growth factor 1 blocks collagen release and down regulates matrix metalloproteinase-1, -3, -8, and -13 mRNA expression in bovine nasal cartilage stimulated with oncostatin M in combination with interleukin1α Ann Rheum Dis 2001, 60:254-261 1753584 11171688 10.1136/ard.60.3.254
29. Verschure PJ Van Noorden CJ Van Marle J Van de Berg WB Articular cartilage destruction in experimental inflammatory arthritis: insulin-like growth factor-1 regulation of proteoglycan metabolism in chondrocytes Histochem J, 1996, 28(12):835-857 10.1007/BF02331388 9015706
30. Madry H Kaul G Cucchiarini M Stein U Zurakowski D Remberger K Menger MD Kohnn D Trippel SB Enhanced repair of articular cartilage defects in vivo by transplanted chondrocytes overexpressing insulin-like growth factor I (IGF-1) Gene Ther 2005, 12:1171-1179 10.1038/sj.gt.3302515 15815701
31. Fernandez-Celemin L Pasko N Blomart V Thiessen J-P Inhibition of muscle insulin-like growth factor 1 expression by tumor necrosis factor-alpha Am J Physiol Endocrinol Metab 2002, 283:E1279-E1290 12388149
32. Barbieri M Ferrucci L Ragno E Corsi A Bandinelli S Bonafe M Oliveri F Giovagneti S Franscheschi C Guralnik JM Paolisso G Chronic inflammation and the effects of IGF-1 on muscle strength and power in older persons Am J Physiol Endocrinol Metab 2003, 284:E481-E487 12419777
33. Cappola AR Xue QL Ferrucci L Guralnik JM Volpato S Fried LP Insulin-like growth factor and interleukin-6 contribute synergistically to disability and mortality in older women J Clin Endocrinol Metab 2003, 88:2019-2025 10.1210/jc.2002-021694 12727948
34. Schulze PC Gielen S Adams V Linke A Mobius-Winkler S Erbs S Kratzsch J Hambrecht R Schuler G Muscular levels of insulin-like growth factor-1 in chronic heart failure Basic Res Cardiol 2003, 98:267-274 12835956
35. Strle K Broussard SR McCusker RH Shen W-H Johnson RW Freund GG Dantzer RH Kelley KW Proinflammatory cytokine impairment of insulin-like growth factor I-induced protein synthesis in skeletal myoblasts requires ceramide Endocrinology 2004, 145:4592-4602 10.1210/en.2003-1749 15256490
36. Higashi Y Peng T Du J Sukhanov S Li Y Itabe H Parthasarathy S Delafontaine P A redox-sensitive pathway mediates oxidized LDL-induced downregulation of insulin-like growth factor-1 receptor J Lipid Res 2005, 46:1266-77 10.1194/jlr.M400478-JLR200 15805544
37. Uitterlinden EJ Jahr H Koevoet JLM Jenniskens YM Bierma-Zeinstra SMA DeGroot J Verhaar JAN Weinans H van Osch GJVM Glucosamine decreases expression of anabolic and catabolic genes in human osteoarthritic cartilage explants Osteoarthritis Cartilage 2006, 14:250-257 10.1016/ j.joca.2005.10.001 16300972
38. Gouze J-N Gouze E Popp MP Bush ML Dacanay EA Kay JD Levings PP Patel KR Saran J-PS Watson RS Ghivizzani SC Exogenous glucosamine globally protects chondrocytes from the arthritic effects of IL-1β Arthritis Res Ther 2006, 8:R173 1794517 17109745 10.1186/ar2082
39. Usha PR Naidu MU Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylurea and their combination in osteoarthritis Clin Drug Invest 2004, 24:353-363 10.2165/ 00044011-200424060-00005
40. Thie NM Prasad NG Major PW Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint arthritis: A randomized double-blind controlled 3 month clinical trial J Rheumatol 2001, 28:1347-1355 11409130
41. Qiu GX Gao SN Giacovelli G Rovarti L Setnikar I Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis Arzneimittelforschung 1998, 48:469-474 9638313
42. Muller-Fassbender H Bach GL Haase W Rovati LC Setnikar I Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee Osteoarthritis Cartilage 1994, 2:61-69 10.1016/S1063-4584(05)80007-X 11548225
43. Duke J Vasquez R Amazonian Ethnobotanical Dictionary CRC Press, Boca Raton, FL 1994
44. Gonzales GF Cordova A Gonzales C Chung A Vega K Villena A Lepidium meyenii (Maca) improved semen parameters in adult men Asian J Androl 2001, 3:301-303 11753476
45. Gonzales GF Cordova A Vega K Chung A Villena A Gonez C Castillo S Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men Andrologia 2002, 34:367-372 10.1046/j.1439-0272.2002.00519.x 12472620
46. Miller MJS Mehta K Kunte S Raut V Gala J Dhumale R Shukla A Tupalli H Parikh H Bobrowski P Chaudhary J Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: A randomized controlled trial [ISRCTN38432711] J Inflammation 2005, 2:11 10.1186/1476-9255-2-11
47. Borgeois P Chales G Dehais J Delcambre B Kuntz JL Rozenberg S Efficacy and tolerability of chondroitin sulfate 1200 mg/day vs. chondroitin sulfate 3 × 400 mg/day vs. placebo Osteoarthritis Cartilage 1998, 6(Suppl A):25-30 10.1016/S1063-4584(98)80008-3 9743816
48. Jackson JK Higo T Hunter WL Burt HM The antioxidants curcumin and quercetin inhibit inflammatory processes associated with arthritis Inflamm Res 2006, 55:168-175 10.1007/s00011-006-0067-z 16807698
49. Funk JL Oyyarzo JN Frye JB Lantz RC Jolad SD Solyom AM Timmermann BN Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis J Nat Prod 2006, 69:351-355 10.1021/np050327j 16562833
50. Shakibaei M Schulze-Tanzil G John T Mobasheri A Curcumin protects chondrocytes from IL-1beta induced inhibition of collagen type II and beta 1-integrin expression and activation of caspase-3: An immunomorphological study Ann Anat 2005, 187:487-497 16320828
51. Liacini A Sylvester J Li WQ Zafarullah M Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-κB) transcription factors down-regulates matrix metalloproteinase gene expression in articular cartilage Matrix Biology 2002, 21:251-262 10.1016/S0945-053X(02)00007-0 12009331
52. Liacini A Sylvester J Li WQ Huang W Dehnade F Ahmad M Zafarullah M Induction of matrix metalloproteinase-13 gene expression by TNF-α is mediated by MAP kinases, AP-1, and NF-κB transcription factors in articular chondrocytes Exp Cell Res 2003, 288:208-217 10.1016/ S0014-4827(03)00180-0 12878172
53. Christgau S Henrotin Y Tanko LB Rovati LC Collette J Bruyere O Deroisy R Reginster JY Osteoarthritis patients with high cartilage turnover show increased responsiveness to the cartilage protecting effects of glucosamine sulfate Clin Exp Rheumatol 2004, 22:36-42 15005002
54. Persiani S Rotini R Trisolino G Rovati LC Locatelli M Paganini D Antonioli D Roda A Synovial and plasma glucosamine concentrations in osteoarthritic patients following oral crystalline glucosamine sulphate at therapeutic dose Osteoarthritis Cartilage 2007, 15(7):764-772 10.1016/ j.joca.2007.01.019 17353133
55. Persiani S Roda E Rovati LC Locatelli M Giacovelli G Roda A Glucosamine oral bioavailability after increasing doses of crystalline glucosamine sulfate in man Osteoarthritis Cartilage 2005, 13:1041-1049 10.1016/ j.joca.2005.07.009 16168682
56. Biggee BA Blinn CM McAlindon TE Nuite M Silbert JE Low levels of human serum glucosamine sulfate after ingestion of glucosamine sulfate relative to capability of peripheral effectiveness Ann Rheum Dis 2006, 65:222-226 10.1136/ard.2005.036368 16079170
57. Hambrecht R Schulze PC Gielen S Linke A Mobius-Winkler S Yu J Kratzsch J Baldauf G Busse MW Schubert A Adams V Schuler G Reduction of insulin-like growth factor-1 expression in the skeletal muscle of noncachetic patients with heart failure J Amer Coll Cardiol 2002, 39:1175-1181 10.1016/S0735-1097(02)01736-9
58. Laughlin GA Barrett-Connor E Criqui MH Kritz-Silverstein D The prospective association of serum insulin-like growth factor I (IGF-1) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: The Rancho Bernardo Study J Clin Endocrinol Metab 2004, 89:114-120 10.1210/jc.2003-030967 14715837
59. Denti L Annoni V Cattadori E Salvagnini MA Visioli S Merli MF Corradi F Ceresini G Valenti G Hoffman AR Ceda GP Insulin-like growth factor 1 as a predictor of ischemic stroke outcome in the elderly Am J Med 2004, 117:312-317 10.1016/j.amjmed.2004.02.049 15336580
60. Vasan RS Sullivan LM D'Agostino RB Roubenoff R Harris T Sawyer DB Levy D Wilson PWF Serum insulin-like growth factor I and risk for heart failure in elderly individuals without a previous myocardial infarction: The Framingham Heart Study Ann Intern Med 2003, 139:642-648 14568852
61. Lee S-D Chen L-M Kuo W-W Shu W-T Kuo W-H Huang E-J Tsai C-C Liu J-Y Chen T-H Huang C-Y Serum insulin-like growth factor-axis and matrix metalloproteinases in patients with rheumatic arthritis and rheumatic heart disease Clin Chim Acta 2006, 367:62-68 10.1016/j.cca.2005.11.015 16406300
62. Vuppalanchi R Liangpunsakul S Chalasani N Etiology of new-onset jaundice: How often is it caused by idiosyncratic drug-induced liver injury in the United States? Amer J Gastroenterol 2006, 101:1-5 10.1111/ j.1572-0241.2006.00460.x
63. Kimmel SE Berlin JA Reilly M Jaskowiak J Kishel L Chittams J Strom BL Patients exposed to rofecoxib and celecoxib have different odds of nonfatal myocardial infarction Ann Intern Med 2005, 142:157-64 15684203
64. Graham DJ Campen D Hui R Spence M Cheetham C Levy G Shoor S Ray WA Risk of acute myocardial infarction and sudden cardiac death in patients treated with cyclo-oxygenase 2 selective and non-selective non-steroidal anti-inflammatory drugs: Nested case-control study Lancet 2005, 365:475-81 15705456
65. Rahme E Nedjar H Risks and benefits of COX-2 inhibitors vs non-selective NSAIDs: Does their cardiovascular risk exceed their gastrointestinal benefit? A restrospective study Rheumatology 2007, 46:435-438 10.1093/ rheumatology/kel428 17255138