Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content

Phytomedicine

Volumn 9, Issue 4, 2002, Pages 325-337

  Sandoval, M ^a   Okuhama, N N ^a   Zhang, X J ^a   Condezo, L A ^b   Lao, J ^b   Angeles, F M ^a   Musah, R A ^c   Bobrowski, P ^d   Miller, M J S ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

^b UNIVERSIDAD NACIONAL AGRARIA DE LA SELVA   (Peru)

^c STATE UNIVERSITY OF NEW YORK   (United States)

^d Rainforest Phytoceuticals   (United States)

Author keywords

Antioxidant; Cat's claw; Free radical; Gastritis; Inflammation; NSAID; TNF

Indexed keywords

1,1 DIPHENYL 2 PICRILHYDRAZYL; ALKALOID; FREE RADICAL; HYDROXYL RADICAL; INDOMETACIN; NITRITE; NONSTEROID ANTIINFLAMMATORY AGENT; OXINDOLE; PENTACYCLIC ALKALOID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIOXIDANT; DIAGNOSTIC AGENT; LIPOPOLYSACCHARIDE; MESSENGER RNA; PLANT EXTRACT; PRIMER DNA; SCAVENGER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GASTRITIS; HERBAL MEDICINE; INFLAMMATION; LIPID PEROXIDATION; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STOMACH EPITHELIUM; TRADITIONAL MEDICINE; UNCARIA GUIANENSIS; UNCARIA TOMENTOSA; ANIMAL; BARK; CELL CULTURE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG EFFECT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IC 50; MALE; MOUSE; NICK END LABELING; PATHOLOGY; PHYTOTHERAPY; SPRAGUE DAWLEY RAT;

ANIMALIA; FELIS CATUS; UNCARIA GUIANENSIS; UNCARIA TOMENTOSA;

ALKALOIDS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; APOPTOSIS; CAT'S CLAW; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FREE RADICAL SCAVENGERS; GASTRITIS; HUMANS; HYDROXYL RADICAL; IN SITU NICK-END LABELING; INDOMETHACIN; INHIBITORY CONCENTRATION 50; LIPID PEROXIDATION; LIPOPOLYSACCHARIDES; MALE; MICE; PHYTOTHERAPY; PLANT BARK; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035986384     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1078/0944-7113-00117     Document Type: Article

References (45)

1. Plant metabolites. New compounds and anti-inflammatory activity of Uncaria tomentosa
2. Plant metabolites. Structure and in vitro antiviral activity of quinovic acid glycosides from Uncaria tomentosa and Guettarda platypoda
3. New polyhydroxylated triterpenes from Uncaria tomentosa
4. Nuclear factor-kB - A pivotal transcription factor in chronic inflammatory diseases
5. An essential role for NF-κB in preventing TNFα-induced cell death
6. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures
7. New quinovic acid glycosides from Uncaria tomentosa
8. Role of oxidants in NF-κB activation and TNFα gene transcription induced by hypoxia and endotoxin
9. Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNFα therapy in rheumatoid arthritis
10. Evaluation of the in vitro antioxidant activity in extracts of Uncaria tomentosa (Willd.) DC
11. TNFα-processing enzyme inhibitors prevent aspirin-induced TNFα release and protect against mucosal injury in rats
12. Nitric oxide (NO)-releasing NSAIDs inhibit interleukin-1 β converting enzyme (ICE)-like cysteine proteases and protect endothelial cells from apoptosis induced by TNFα
13. Oxidative stress induced in pathologies: The role of antioxidants
14. The deoxyribose method: A simple "test tube" assay for the determination of rate constants for reactions of hydroxyl radicals
15. Reactive oxygen species, cell signaling, and cell injury
16. Oxidant regulation of gene expression in the chronically inflamed intestine
17. Uncaria tomentosa (Willd.) DC.- Ethnomedical use and new pharmacological, toxicological and botanical results
18. Antioxidant and antitumor promoting activities of the methanol extract of heat processed ginseng
19. A new gluco indole alkaloid, 3, 4-dehydro-5-carboxystrictosidine, from Peruvian uña de gato (Uncaria tomentosa)
20. A threshold concept for cancer therapy
21. Alkaloids of Peruvian Uncaria tomentosa
22. By how much does fruit and vegetable consumption reduce the risk of ischaemic heart disease?
23. Bioactive indole alkaloids from the bark of Uncaria guianensis
24. Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa (Uña de Gato)
25. Inhibitors of nuclear factor Kappa B cause apoptosis in cultured macrophages
26. Bastions of tradition adapt to alternative medicine
27. Mitogen-activated protein kinase and nuclear factor B together regulate interleukin-17-induced nitric oxide production in human osteoarthritic chondrocytes. Possible role of transactivating factor mitogen-activated protein kinase-activated protein kinase (MAP-KAPK)
28. NF-κB activation provides the potential link between inflammation and hyperplasia in the arthritic joint
29. Treatment of gastric ulcers and diarrhea with the Amazonian herbal medicine sangre de grado
30. Antioxidant activity and biologic properties of a procyanadin-rich extract from pine (Pinus maritima) bark, pycnogenol
31. Treatment of osteoarthritis with freeze-dried cat's claw: Mechanisms of action of the specie Uncaria guianensis
32. Uncaria tomentosa (Willd) D.C.: Cat's claw, Uña de Gato, or Savéntaro
33. Cat's claw inhibits TNFα production and scavenges free radicals: Role in cytoprotection
34. Antiinflammatory actions of cat's claw: The role of NF-κB
35. Ricerche fitochimiche e biologiche sull' Uncaria tomentosa
36. Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa
37. Nuclear factor B: An oxidative stress-response transcription factor of eukaryotic cells
38. HPLC analysis of the main Oxindole alkaloids from Uncaria tomentosa
39. Tyrosine as important contributor to the antioxidant capacity of seminal plasma
40. Die alkaloid von Uncaria tomentosa und ihre phagozytose-steigernde wirkung
41. Role of prostanoids in the protective actions of BW 755C on the gastric mucosa
42. Pentacyclic oxindole alkaloids from Uncaria tomentosa induce human endothelial cells to release a lymphocyte-proliferation-regulating factor
43. Quinovic acid glycosides from Uncaria guianensis
44. Localization of inducible nitric oxide synthase mRNA in inflamed gastrointestinal mucosa by in situ reverse transcriptase-polymerase chain reaction