Cat's claw inhibits TNFα production and scavenges free radicals: Role in cytoprotection

Free Radical Biology and Medicine

Volumn 29, Issue 1, 2000, Pages 71-78

  Sandoval, Manuel ^a   Charbonnet, Randi M ^a   Okuhama, Nataly N ^a   Roberts, Jarod ^a   Krenova, Zdenka ^a   Trentacosti, Ann Marie ^b   Miller, Mark J S ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

^b Rainforest Phytoceuticals   (United States)

Author keywords

Cytoprotection; Free radicals; Inflammation; NF B; Oxidant; TNF ; Uncaria tomentosa; UV irradiation

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; FREE RADICAL; HERBACEOUS AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; HERBAL MEDICINE; IMMUNOMODULATION; INFLAMMATORY DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ULTRAVIOLET RADIATION;

ANIMALS; ANTIOXIDANTS; BEPRIDIL; CAT'S CLAW; CELL DEATH; CELL LINE; CELL SURVIVAL; FREE RADICAL SCAVENGERS; FREE RADICALS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; PICRATES; PLANT EXTRACTS; PLANT STEMS; PLANTS, MEDICINAL; TUMOR NECROSIS FACTOR-ALPHA; ULTRAVIOLET RAYS;

ANIMALIA; FELIS CATUS; MURINAE; UNCARIA TOMENTOSA;

EID: 0034233223     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(00)00327-0     Document Type: Article

References (37)

1. De Smet P.A.G.M. The role of plant-derived drugs. and herbal medicines in healthcare. Drugs. 54:1997;801-840.
2. Gray A.M., Flatt P.R. Antihyperglycemic actions of eucalyptus globulus (Eucalyptus) are associated with pancreatic and extra-pancreatic effects in mice. J. Nutr. 128:1998;2319-2323.
3. Duke J.A., Vasquez R. Amazonian ethnobotanical dictionary. 1994;CRC Press, Boca Raton, FL.
4. Obregon L.E. Cat's claw, Uncaria genus. Botanical, chemical and pharmacological studies of Uncaria tomentosa (Willd.) D.C. (Rubiaceae) and Uncaria guianensis (Aubl.) Gmel. 1995;Instituto de Fitoterapia Americano, Lima, Peru.
5. Cerri R., Aquino R., De Simone F., Pizza C. New Quinovic acid glycosides from Uncaria tomentosa. J. Nat. Prod. 51:1988;257-261.
6. Aquino R., De Simone F., Vincieri F.F., Pizza C. New polyhydroxylated triterpenes from Uncaria tomentosa. J. Nat. Prod. 53:1990;559-564.
7. Yepez A.M., Lock de Ugaz O., Alvarez A., De Feo V., Aquino R., De Simone F., Pizza C. Quinovic acid glycosides from Uncaria guianensis. Phytochemistry. 30:1991;1635-1637.
8. Senatore A., Cataldo A., Iaccarino F.P., Elberti M.G. Ricerche fitochimiche e biologiche sull' Uncaria tomentosa. Boll. Soc. Ital. Biol. Sper. 65:1989;517-520.
9. Keplinger, K.; Wagner, H.; Kreutzkamp, B. Oxindole alkaloids having properties stimulating the immunologic system and preparation containing the same. United States Patent No. 4,844,901 July; 1989.
10. Keplinger, K.; Keplinger, D. Oxindole alkaloids having properties stimulating the immunologic system and preparation containing the same. United States Patent No. 5,302,611 April 12; 1994.
11. Stuppner H., Sturm S. Capillary electrophoretic analysis of oxindole alkaloids from Uncaria tomentosa. J. Chromatogr. 609:1992;375-380.
12. Laus G., Keplinger D. Separation of stereoisomeric oxindole alkaloids from Uncaria tomentosa by high performance liquid chromatography. J. Chromatogr. A. 662:1994;243-249.
13. Stuppner H., Sturm S., Konwalinka G. HPLC analysis of the main oxindole alkaloids from Uncaria tomentosa. Chromatography. 34:1992;597-600.
14. Laus G., Brossner D., Keplinger K. Alkaloids of Peruvian Uncaria tomentosa. Phytochemistry. 45:1997;855-860.
15. Aquino R., De Feo V., De Simone F., Pizza C., Cirino G. Plant metabolites. New compounds and anti-inflammatory activity of. Uncaria tomentosa. J. Nat. Prod. 54:1991;453-459.
16. Keplinger K., Laus G., Wurm M., Dierich M.P., Teppner H. Uncaria tomentosa (Willd.) DC.- Ethomedical use and new pharmacological, toxicological and botanical results. J. Ethnopharmacol. 64:1999;23-34.
17. Sandoval-Chacón M., Thompson J.H., Zhang X.-J., Liu X., Mannick E.E., Sadowska-Krowicka H., Charbonnet R.M., Clark D.A., Miller M.J. Antiinflammatory actions of cat's claw the role of NF-κB . Aliment. Pharmacol. Ther. 12:1998;1279-1289.
18. Aubert V., Schneeberger D., Sauty A., Winter J., Sperisen P., Aubert J.D., Spertini F. Induction of tumor necrosis factor alpha and interleukin-8 gene expression in bronchial epithelial cells by toxic shock syndrome toxin 1. Infect. Immun. 68:2000;120-124.
19. Present D.H., Rutgeerts P., Targan S., Hanauer S.B., Mayer L., van Hogezand R.A., Podolsky D.K., Sands B.E., Braakman T., DeWoody K.L., Schaible T.F., van Deventer S.J. Infliximab for the treatment of fistulas in patients with Crohn's disease. N. Engl. J. Med. 340:1999;1398-1405.
20. Charles P., Elliot M.J., Davis D., Potter A., Kalden J.R., Antoni C., Breedveld F.C., Smolen J.S., Eberl G., DeWoody K., Feldmann M., Maini R.N. Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNFα therapy in rheumatoid arthritis. J. Immunol. 163:1999;1521-1528.
21. Ohshima S., Saeki Y., Mima T., Sasai M., Nishioka K., Ishida H., Shimizu M., Suemura M., McCloskey R., Kishimoto T. Long term follow-up of the changes in circulating cytokines, soluble receptors, and white blood cell subset counts in patients with rheumatoid arthritis (RA) after monoclonal anti-TNFα antibody therapy. J. Clin. Immunol. 19:1999;305-313.
22. Feldman M., Taylor P., Paleolog E., Brennan F.M., Maini R.N. Anti-TNFα therapy is useful in rheumatoid arthritis and Crohn's disease analysis of the mechanism of action predicts utility in other diseases . Transplant Proc. 30:1998;4126-4127.
23. von Gadow A., Joubert E., Hansmann C.F. Comparison of the antioxidant activity of rooibos tea (Aspalathus linearis) with green, oolong and black tea. Food Chemistry. 60:1997;73-77.
24. Sandoval M., Liu X., Mannick E.E., Clark D.A., Miller M.J.S. Peroxynitrite-induced apoptosis in human intestinal epithelial cells is attenuated by mesalamine. Gastroenterology. 113:1997;1480-1488.
25. Desmarchelier C., Mongelli E., Coussio J., Ciccia G. Evaluation of the in vitro antioxidant activity in extracts of Uncaria tomentosa (Willd.) DC. Phytother. Res. 11:1997;254-256.
26. McNaughton W.K., Aurora A.R., Bhamra J., Sharkey K.A., Miller M.J.S. Expression, activity, and cellular localization of inducible nitric oxide synthase in rat ileum and colon post-irradiation. Int. J. Radiat. Biol. 74:1998;255-262.
27. Lee B.M., Lee S.K., Kim H.S. Inhibition of oxidative DNA damage, 8-OhdG, and carbonyl contents in smokers treated with antioxidants (vitamin E, vitamin C, β-carotene and red ginseng). Cancer Lett. 132:1998;219-227.
28. Fuchs J., Kern H. Modulation of UV-light-induced skin inflammation by D-alpha-tocopherol and L-ascorbic acid a clinical study using solar simulated radiation . Free Radic. Biol. Med. 25:1998;1006-1012.
29. Obermuller-Jevic U.C., Francz P.I., Frank J., Flaccus A., Biesalski H.K. Enhancement of the UVA induction of haem oxygenase-1 expression by β-carotene in human skin fibroblasts. FEBS Lett. 460:1999;212-216.
30. Rizzi R., Re F., Bianchi A., De Feo V., de Simone F., Bianchi L., Stivala L.A. Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts. J. Ethnopharmacol. 38:1993;63-77.
31. Urban M.B., Schreck R., Bauerle P.A. NF-κB contacts DNA by a heterodimer of p50 and p65 subunit. EMBO J. 10:1991;1817-1825.
32. Tsai S.-H., Lin-Shiau S.-Y., Lin J.-K. Suppression of nitric oxide synthase and the down regulation of the activation of NF-κB in macrophages by resveratrol. Br. J. Pharmacol. 126:1999;673-680.
33. Beauparlant P., Hiscott J. Biological and biochemical inhibitors of the NF-κB/Rel proteins and cytokine synthesis. Cytokine Growth Factor Rev. 7:1996;175-190.
34. Sheng Y., Pero R.W., Amiri A., Bryngelsson C. Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa. Anticancer Res. 18:1998;3363-3368.
35. Mannick E.E., Mishra J., Marque J., Clavell M., Miller M.J.S., Oliver P.D. Inhibitors of nuclear factor kappa B cause apoptosis in cultured macrophages. Mediators Inflamm. 6:1997;225-232.
36. Beg A.A., Baltimore D. An essential role of NF-κB in preventing TNF-α induced cell death. Science. 274:1996;782-784.
37. Lemaire L., Assinewe V., Cano P., Awang D.V.C., Arnason J.T. Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa (Uña de Gato). J. Ethnopharmacol. 64:1999;109-115.