Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice

Toxicology

Volumn 243, Issue 3, 2008, Pages 249-260

  Randle, Laura E ^a   Goldring, Chris E P ^a   Benson, Craig A ^a   Metcalfe, Peter N ^a   Kitteringham, Neil R ^a   Park, B Kevin ^a   Williams, Dominic P ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Bromobenzene; Carbon tetrachloride; CD 1 mice; Furosemide; Glutathione; Hepatotoxicity; Nrf2; Paracetamol

Indexed keywords

ALANINE AMINOTRANSFERASE; BROMOBENZENE; CARBON TETRACHLORIDE; CELL PROTEIN; FUROSEMIDE; GLUTATHIONE; HEME OXYGENASE 1; MESSENGER RNA; PARACETAMOL; PROTEIN KEAP1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLUTATHIONE METABOLISM; HISTOPATHOLOGY; LIVER METABOLISM; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INDUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TOXICOKINETICS; WESTERN BLOTTING;

ACETAMINOPHEN; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALANINE TRANSAMINASE; ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; BROMOBENZENES; CARBON TETRACHLORIDE; CELL NUCLEUS; CYTOSKELETAL PROTEINS; FUROSEMIDE; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HEME OXYGENASE-1; INJECTIONS, INTRAPERITONEAL; LIVER; MALE; MICE; MOLECULAR STRUCTURE; NF-E2-RELATED FACTOR 2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; XENOBIOTICS;

MAMMALIA; MURINAE; MUS;

EID: 37149039327     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2007.10.011     Document Type: Article

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