Induction of insulin secretion in engineered liver cells by nitric oxide

BMC Physiology

Volumn 7, Issue , 2007, Pages

  Muniappan, Latha ^a   Özcan, Sabire ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; INSULIN; NITRIC OXIDE; TRANSCRIPTION FACTOR PDX 1; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; HOMEODOMAIN PROTEIN; INSULIN PROMOTER FACTOR 1; MAFA PROTEIN, HUMAN; NEUROD1 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR MAF; UNCLASSIFIED DRUG;

ARTICLE; DIABETES MELLITUS; GENE TRANSFER; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; INSULIN RELEASE; LIVER CELL; PANCREAS ISLET BETA CELL; ADENOVIRUS; ANIMAL; BIOMEDICAL ENGINEERING; CELL CULTURE; CELL LINE; DRUG EFFECT; GENE VECTOR; GENETICS; METABOLISM; METHODOLOGY; RAT; SECRETION;

ADENOVIRIDAE; ANIMALS; ARGININE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BIOMEDICAL ENGINEERING; CELL LINE; CELLS, CULTURED; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEPATOCYTES; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; MAF TRANSCRIPTION FACTORS, LARGE; NITRIC OXIDE; RATS; TRANS-ACTIVATORS;

EID: 36849094977     PISSN: None     EISSN: 14726793     Source Type: Journal    
DOI: 10.1186/1472-6793-7-11     Document Type: Article

References (35)

1. Gene therapy for type 1 diabetes: a proposal to move to the next level. N Giannoukakis M Trucco, Curr Opin Mol Ther 2005 7 5 467 475 16248282
2. Cytoprotection of beta cells: rational gene transfer strategies. C McCabe A Samali T O'Brien, Diabetes Metab Res Rev 2006 22 3 241 252 10.1002/dmrr.615 16397906
3. Gene therapy for diabetes: reinventing the islet. SL Samson L Chan, Trends Endocrinol Metab 2006 17 3 92 100 10.1016/j.tem.2006.02.002 16504534
4. Auto-regulated hepatic insulin gene expression in type 1 diabetic rats. R Chen ML Meseck SL Woo, Mol Ther 2001 3 4 584 590 10.1006/mthe.2001.0299 11319921
5. Hepatic insulin expression improves glycemic control in type 1 diabetic rats. H Dong N Morral R McEvoy M Meseck SN Thung SL Woo, Diabetes Res Clin Pract 2001 52 3 153 163 10.1016/S0168-8227(01)00220-0 11323084
6. Hepatic insulin production for type 1 diabetes. H Dong SL Woo, Trends Endocrinol Metab 2001 12 10 441 446 10.1016/S1043-2760(01)00491-X 11701342
7. Hepatic insulin gene therapy in insulin-dependent diabetes mellitus. PC Nett HW Sollinger T Alam, Am J Transplant 2003 3 10 1197 1203 10.1046/j.1600-6143.2003.00221.x 14510692
8. Glucose sensing by the hepatoportal sensor is GLUT2-dependent: in vivo analysis in GLUT2-null mice. R Burcelin W Dolci B Thorens, Diabetes 2000 49 10 1643 1648 10.2337/diabetes.49.10.1643 11016447
9. Nonviral gene therapy. S Li Z Ma, Curr Gene Ther 2001 1 2 201 226 10.2174/1566523013348814 12108955
10. The basic science of gene therapy. RC Mulligan, Science (New York, NY 1993 260 5110 926 932
11. Viral vectors for gene-directed enzyme prodrug therapy. S Schepelmann CJ Springer, Curr Gene Ther 2006 6 6 647 670 10.2174/156652306779010679 17168697
12. Constitutive and regulated expression of processed insulin following in vivo hepatic gene transfer. A Auricchio GP Gao QC Yu S Raper VM Rivera T Clackson JM Wilson, Gene Ther 2002 9 14 963 971 10.1038/sj.gt.3301746 12085245
13. Reprogramming liver-stem WB cells into functional insulin-producing cells by persistent expression of Pdx1- and Pdx1-VP16 mediated by lentiviral vectors. DQ Tang S Lu YP Sun E Rodrigues W Chou C Yang LZ Cao LJ Chang LJ Yang, Lab Invest 2006 86 1 83 93 10.1038/labinvest.3700368 16294197
14. Regulated hepatic insulin gene therapy of STZ-diabetic rats. PM Thule JM Liu, Gene Ther 2000 7 20 1744 1752 10.1038/sj.gt.3301297 11083496
15. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. S Ferber A Halkin H Cohen I Ber Y Einav I Goldberg I Barshack R Seijffers J Kopolovic N Kaiser A Karasik, Nat Med 2000 6 5 568 572 10.1038/75050 10802714
16. PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance. H Kaneto Y Nakatani T Miyatsuka TA Matsuoka M Matsuhisa M Hori Y Yamasaki, Diabetes 2005 54 4 1009 1022 10.2337/diabetes.54.4.1009 15793239
17. Adenovirus transduction is required for the correction of diabetes using Pdx-1 or Neurogenin-3 in the liver. AY Wang A Ehrhardt H Xu MA Kay, Mol Ther 2007 15 2 255 263 10.1038/sj.mt.6300032 17235302
18. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. H Kojima M Fujimiya K Matsumura P Younan H Imaeda M Maeda L Chan, Nat Med 2003 9 5 596 603 10.1038/nm867 12704384
19. Regulation of the insulin gene by glucose and fatty acids. V Poitout D Hagman R Stein I Artner RP Robertson JS Harmon, J Nutr 2006 136 4 873 876 16549443
20. Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function. CM McKinnon K Docherty, Diabetologia 2001 44 10 1203 1214 10.1007/s001250100628 11692168
21. Regulation of insulin gene transcription. D Melloul S Marshak E Cerasi, Diabetologia 2002 45 3 309 326 10.1007/s00125-001-0728-y 11914736
22. Regulation of insulin secretion: insights from engineered beta-cell lines. S Efrat, Ann N Y Acad Sci 2004 1014 88 96 10.1196/annals.1294.009 15153423
23. Formation of the insulin-containing secretory granule core occurs within immature beta-granules. XF Huang P Arvan, J Biol Chem 1994 269 33 20838 20844 8063699
24. Function of a genetically modified human liver cell line that stores, processes and secretes insulin. BE Tuch B Szymanska M Yao MT Tabiin DJ Gross S Holman MA Swan RK Humphrey GM Marshall AM Simpson, Gene Ther 2003 10 6 490 503 10.1038/sj.gt.3301911 12621453
25. Dual mechanism of the potentiation by glucose of insulin secretion induced by arginine and tolbutamide in mouse islets. N Ishiyama MA Ravier JC Henquin, Am J Physiol Endocrinol Metab 2006 290 3 E540 9 10.1152/ajpendo.00032. 2005 16249257
26. Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides. HH Schmidt TD Warner K Ishii H Sheng F Murad, Science (New York, NY 1992 255 5045 721 723
27. L-arginine stimulation of glucose-induced insulin secretion through membrane depolarization and independent of nitric oxide. P Thams K Capito, Eur J Endocrinol 1999 140 1 87 93 10.1530/eje.0.1400087 10037257
28. SNAP-25/syntaxin 1A complex functionally modulates neurotransmitter gamma-aminobutyric acid reuptake. HP Fan FJ Fan L Bao G Pei, J Biol Chem 2006 281 38 28174 28184 10.1074/jbc.M601382200 16861228
29. Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor. K Matsushita CN Morrell B Cambien SX Yang M Yamakuchi C Bao MR Hara RA Quick W Cao B O'Rourke JM Lowenstein J Pevsner DD Wagner CJ Lowenstein, Cell 2003 115 2 139 150 10.1016/S0092-8674(03)00803-1 14567912
30. Nitric oxide modulates synaptic vesicle docking fusion reactions. MK Meffert NC Calakos RH Scheller H Schulman, Neuron 1996 16 6 1229 1236 10.1016/S0896-6273(00)80149-X 8663999
31. Sequence of the human insulin gene. GI Bell RL Pictet WJ Rutter B Cordell E Tischer HM Goodman, Nature 1980 284 5751 26 32 10.1038/284026a0 6243748
32. A simplified system for generating recombinant adenoviruses. TC He S Zhou LT da Costa J Yu KW Kinzler B Vogelstein, Proc Natl Acad Sci U S A 1998 95 5 2509 2514 9482916 10.1073/pnas.95.5.2509
33. Adenoviral gene transfer into beta-cell lines. AL Mosley S Ozcan, Methods Mol Med 2003 83 73 79 12619717
34. Regulation of cytochrome P450 2C11 (CYP2C11) gene expression by interleukin-1, sphingomyelin hydrolysis, and ceramides in rat hepatocytes. J Chen M Nikolova-Karakashian AH Merrill Jr. ET Morgan, J Biol Chem 1995 270 42 25233 25238 10.1074/jbc.270.42.25233 7559661
35. Expression of liver phenotypes in cultured mouse hepatoma cells. GJ Darlington HP Bernhard RA Miller FH Ruddle, J Natl Cancer Inst 1980 64 4 809 819 6102619