Spatio-temporal localization of HIF-1α and COX-2 during irradiation-induced oral mucositis in a rat model system

International Journal of Radiation Biology

Volumn 84, Issue 1, 2008, Pages 35-45

  Feng, Chong Jin ^a   Guo, Jun Bing ^a   Jiang, Hong Wei ^a   Zhu, Shuang Xi ^a   Li, Chun Yang ^a   Cheng, Bin ^a   Chen, Yong ^a   Wang, Han Yu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Cyclooxygenase 2; Head neck malignant tumor; Hypoxia inducible factor 1 ; Irradiation induced oral mucositis; Radiotherapy

Indexed keywords

BIOTIN; CYCLOOXYGENASE 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; STREPTAVIDIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEEK MUCOSA; CONTROLLED STUDY; FEMALE; FRACTIONATION; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IRRADIATION; MALE; METHODOLOGY; MUCOSA INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPATIAL DISCRIMINATION; SPRAGUE DAWLEY RAT;

ANIMALS; CYCLOOXYGENASE 2; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MOUTH MUCOSA; RADIATION INJURIES, EXPERIMENTAL; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STOMATITIS;

RATTUS;

EID: 36749049792     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.1080/09553000701616080     Document Type: Article

References (33)

1. Albina JE, Mastrofrancesco B, Vessella JA, Louis CA, Henry WL, Reichner JS. 2001. HIF-1 expression in healing wounds: HIF-1alpha induction in primary inflammatory cells by TNF-alpha. American Journal of Physiology and Cellular Physiology 281:C1971-C1977.
2. Beasley NJP, Leek R, Alam M, Turley H, Cox GJ, Gatter K, Millard P, Fuggle S, Harris AL. 2002. Hypoxia-inducible factors HIF-1α and HIF-2α in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients. Cancer Research 62:2493-2497.
3. Bloomer WD, Hellman S. 1975. Normal tissue responses to radiation therapy.New England Journal of Medicine 293:80-83.
4. Brennan PA, Mackenzie N, Quintero M. 2005. Hypoxia-inducible factor 1a in oral cancer. Journal of Oral Pathology and Medicine 34:385-389.
5. Carey MA, Bradbury JA, Seubert JM, Langenbach R, Zeldin DC, Germolec DR. 2005. Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection. Journal of Immunology 175:6878-6884.
6. Chan CML, Ma BBY, Hui EP, Wong SCC, Mo FKF, Leung SF, Kam MKM, Chan AT. 2007. Cyclooxygenase-2 expression in advanced nasopharyngeal carcinoma - a prognostic evaluation and correlation with hypoxia inducible factor 1 alpha and vascular endothelial growth factor. Oral Oncology 43:373-378.
7. Fillies T, Werkmeister R, van Diest PJ, Brandt B, Joos U, Buerger H. 2005. HIF-1α overexpression indicates a good prognosis in early stage squamous cell carcinomas of the oral floor. BMC Cancer 5:84-93.
8. Giatromanolaki A, Harris AL. 2001. Tumour hypoxia, hypoxia signaling pathways and hypoxia inducible factor expression in human cancer. Anticancer Research 21:4317-4324.
9. Griffith EA, Pritchard SA, Welch IM, Price PM, West CM. 2005. Is the hypoxia-inducible factor pathway important in gastric cancer? European Journal of Cancer 41:2792-2805.
10. Haddad JJ, Land SC. 2001. A non-hypoxic, ROS-sensitive pathway mediates TNF-alpha-dependent regulation of HIF-1alpha. FEBS Letters 505:269-274.
11. Hellwig-Burgel T, Stiehl DP, Wagner AE, Metzen E, Jelkmann W. 2005. Hypoxia-inducible factor-1 (HIF-1): a novel transcription factor in immune reactions. Journal of Interferon and Cytokine Research 25:297-310.
12. Isa AY, Ward TH, West CML, Slevin NJ, Homer JJ. 2006. Hypoxia in head and neck cancer. British Journal of Radiology 79:791-798.
13. Jeong HJ, Chung HS, Lee BR, Kim SJ, Yoo SJ, Hong SH, Kim HM. 2003. Expression of proinflammatory cytokines via HIF-1alpha and NF-kappaB activation on desferrioxamine-stimulated HMC-1 cells. Biochemical Biophysical Research Communications 306:805-811.
14. Jung YJ, Isaacs JS, Lee S, Trepel J, Neckers L. 2003. IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB Journal 17:2115-2117.
15. Koga H, Sakisaka S, Ohishi M, Kawaguchi T, Taniguchi E, Sasatomi K, Harada M, Kusaba T, Tanaka M, Kimura R, Nakashima Y, Nakashima O, Kojiro M, Kurohiji T, Sata M. 1999. Expression of cyclooxygenase-2 in human hepatocellular carcinoma: relevance to tumor dedifferentiation. Hepatology 29:688-696.
16. Kurumbail RG, Stevens AM, Gierse JK, McDonald JJ, Stegeman RA, Pak JY, Gildehaus D, Miyashiro JM, Penning TD, Seibert K, Isakson PC, Stallings WC. 1996. Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature 384:644-648.
17. Logan RM, Gibson RJ, Sonis ST, Keefe DMK. 2007. Nuclear factor-κB (NF-κB) and cyclooxygenase-2 (COX-2) expression in the oral mucosa following cancer chemotherapy. Oral Oncology 43(4):395-401.
18. Lukiw WJ, Ottlecz A, Lambrou G, Grueninger M, Finley J, Thompson HW, Bazan NG. 2003. Coordinate activation of HIF-1 and NF-kappaB DNA binding and COX-2 and VEGF expression in retinal cells by hypoxia. Investigative Ophthalmology and Visual Sciences 44:4163-4170.
19. McNeill LA, Hewitson KS, Gleadle JM, Horsfall LE, Oldham NJ, Maxwell PH, Pugh CW, Ratcliffe PJ, Schofield CJ. 2002. The use of dioxygen by HIF prolyl hydroxylase (PHD1). Bioorganic and Medicinal Chemistry Letters 12:1547-1550.
20. Metzen E, Zhou J, Jelkmann W, Fandrey J, Brune B. 2003. Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases. Molecular Biology of the Cell 14:3470-3481.
21. Quintero M, Mackenzie N, Brennan PA. 2004. Hypoxia-inducible factor 1 (HIF-1) in cancer. EJSO 30:465-468.
22. Semenza GL. 2001. Hypoxia-inducible factor 1: control of oxygen homeostasis in health and disease. Pediatrics Research 49:614-617.
23. Sonis ST. 2002. The biologic role for nuclear factor-kappaB in disease and its potential involvement in mucosal injury associated with anti-neoplastic therapy. Critical Reviews in Oral Biological Medicine 13:380-389.
24. Sonis ST. 2004. The pathobiology of mucositis. Nature Reviews in Cancer 4:277-284.
25. Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M, Bekele BN, Raber-Durlacher J, Donnelly JP, Rubenstein EB. 2004a. Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 100:1995-2025.
26. Sonis ST, O'Donnell KE, Popat R, Bragdon C, PHelan S, Cocks D, Epstein JB. 2004b. The relationship between mucosal cyclooxygenase-2 (COX-2) expression and experimental radiation-induced mucositis. Oral Oncology 40:170-176.
27. Sonis ST, Peterson RL, Edwards LJ, Lucey CA, Wang L, Mason L, Login G, Ymamkawa M, Moses G, Bouchard P, Hayes LL, Bedrosian C, Dorner AJ. 2000. Defining mechanisms of action of interleukin-11 on the progression of radiation-induced oral mucositis in hamsters. Oral Oncology 36:373-381.
28. Thornton RD, Lane P, Borghaei RC, Pease EA, Caro J, Mochan E. 2000. Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts. Biochemical Journal 350:307-312.
29. Trotti A, Bellm LA, Epstein JB, Frame D, Fuchs HJ, Gwede CK, Komaroff E, Nalysnyk L, Zilberberg MD. 2003. Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review. Radiotherapy and Oncology 66:253-262.
30. Xia R-H, Ao T-L, Yu J-Z, Jin X-R. 2000. HIF-1 and erythropoietin 3′-enhancer regulation the transcription of endothelial cyclooxygenase and TXS. Chinese Journal of Applied Physiology 16:48-51.
31. Yeoh ASJ, Bowen JM, Gibson RJ, Keefe DMK. 2005. Nuclear factor κB (NFκB) and cyclooxygenase-2 (Cox-2) expression in the irradiated colorectum is associated with subsequent histopathological changes. International Journal of Radiation, Oncology, and Biological Physics 63:1295-1303.
32. Yeoh A, Gibson R, Yeoh E, Bowen J, Stringer A, Giam K, Logan R, Keefe D. 2006. Radiation therapy-induced mucositis: relationships between fractionated radiation, NF-κB, COX-1, and COX-2. Cancer Treatment Reviews 32:645-651.
33. Zhang Q, Zhang Z-F, Rao JY, Sato JD, Brown J, Messadi DV, Le AD. 2004. Treatment with siRNA and antisense oligonucleotides targeted to HIF-1α induced apoptosis in human tongue squamous cell carcinomas. International Journal of Cancer 111:849-857.