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Volumn 192, Issue 1-2, 2007, Pages 57-67

High cell surface expression of CD4 allows distinction of CD4+CD25+ antigen-specific effector T cells from CD4+CD25+ regulatory T cells in murine experimental autoimmune encephalomyelitis

Author keywords

CD25; CD4; Cellular proliferation; Experimental autoimmune encephalomyelitis; FACS; T cells; Treg

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; MEMBRANE ANTIGEN; TRANSCRIPTION FACTOR FOXP3;

EID: 36749005547     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2007.09.004     Document Type: Article
Times cited : (10)

References (53)
  • 1
    • 0027256807 scopus 로고
    • Identification of a major encephalitogenic epitope of proteolipid protein (residues 56-70) for the induction of experimental allergic encephalomyelitis in Biozzi AB/H and nonobese diabetic mice
    • Amor S., Baker D., Groome N., and Turk J.L. Identification of a major encephalitogenic epitope of proteolipid protein (residues 56-70) for the induction of experimental allergic encephalomyelitis in Biozzi AB/H and nonobese diabetic mice. J. Immunol. 150 12 (1993) 5666-5672
    • (1993) J. Immunol. , vol.150 , Issue.12 , pp. 5666-5672
    • Amor, S.1    Baker, D.2    Groome, N.3    Turk, J.L.4
  • 2
    • 0028006884 scopus 로고
    • Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB/H mice
    • Amor S., Groome N., Linington C., Morris M.M., Dornmair K., Gardinier M.V., Matthieu J.M., and Baker D. Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB/H mice. J. Immunol. 153 10 (1994) 4349-4356
    • (1994) J. Immunol. , vol.153 , Issue.10 , pp. 4349-4356
    • Amor, S.1    Groome, N.2    Linington, C.3    Morris, M.M.4    Dornmair, K.5    Gardinier, M.V.6    Matthieu, J.M.7    Baker, D.8
  • 3
    • 0024368359 scopus 로고
    • Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype
    • Ando D.G., Clayton J., Kono D., Urban J.L., and Sercarz E.E. Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. Cell. Immunol. 124 1 (1989) 132-143
    • (1989) Cell. Immunol. , vol.124 , Issue.1 , pp. 132-143
    • Ando, D.G.1    Clayton, J.2    Kono, D.3    Urban, J.L.4    Sercarz, E.E.5
  • 4
    • 0029788211 scopus 로고    scopus 로고
    • Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
    • Asano M., Toda M., Sakaguchi N., and Sakaguchi S. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184 2 (1996) 387-396
    • (1996) J. Exp. Med. , vol.184 , Issue.2 , pp. 387-396
    • Asano, M.1    Toda, M.2    Sakaguchi, N.3    Sakaguchi, S.4
  • 5
    • 0017167922 scopus 로고
    • Experimental autoimmune encephalomyelitis in mice: genetic control of susceptibility
    • Bernard C.C. Experimental autoimmune encephalomyelitis in mice: genetic control of susceptibility. J. Immunogenet. 3 4 (1976) 263-274
    • (1976) J. Immunogenet. , vol.3 , Issue.4 , pp. 263-274
    • Bernard, C.C.1
  • 8
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot J.D., Gavin M.A., and Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4 4 (2003) 330-336
    • (2003) Nat. Immunol. , vol.4 , Issue.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 9
    • 0020561726 scopus 로고
    • Precursor frequency of antigen-specific T cells: effects of sensitization in vivo and in vitro
    • Ford D., and Burger D. Precursor frequency of antigen-specific T cells: effects of sensitization in vivo and in vitro. Cell. Immunol. 79 2 (1983) 334-344
    • (1983) Cell. Immunol. , vol.79 , Issue.2 , pp. 334-344
    • Ford, D.1    Burger, D.2
  • 10
    • 0020660565 scopus 로고
    • In vitro immunization to KLH. II. Limiting dilution analysis of antigen-reactive cells in primary and secondary culture
    • Gebel H.M., Scott J.R., Parvin C.A., and Rodey G.E. In vitro immunization to KLH. II. Limiting dilution analysis of antigen-reactive cells in primary and secondary culture. J. Immunol. 130 1 (1983) 29-32
    • (1983) J. Immunol. , vol.130 , Issue.1 , pp. 29-32
    • Gebel, H.M.1    Scott, J.R.2    Parvin, C.A.3    Rodey, G.E.4
  • 11
    • 0036196305 scopus 로고    scopus 로고
    • Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals
    • Green E.A., Choi Y., and Flavell R.A. Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. Immunity 16 2 (2002) 183-191
    • (2002) Immunity , vol.16 , Issue.2 , pp. 183-191
    • Green, E.A.1    Choi, Y.2    Flavell, R.A.3
  • 12
    • 0030704726 scopus 로고    scopus 로고
    • A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • Groux H., O'Garra A., Bigler M., Rouleau M., Antonenko S., de Vries J.E., and Roncarolo M.G. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389 6652 (1997) 737-742
    • (1997) Nature , vol.389 , Issue.6652 , pp. 737-742
    • Groux, H.1    O'Garra, A.2    Bigler, M.3    Rouleau, M.4    Antonenko, S.5    de Vries, J.E.6    Roncarolo, M.G.7
  • 13
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington L.E., Hatton R.D., Mangan P.R., Turner H., Murphy T.L., Murphy K.M., and Weaver C.T. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6 11 (2005) 1123-1132
    • (2005) Nat. Immunol. , vol.6 , Issue.11 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6    Weaver, C.T.7
  • 15
    • 0029058504 scopus 로고
    • Myelin oligodendrocyte glycoprotein induces a demyelinating encephalomyelitis resembling multiple sclerosis
    • Johns T.G., Kerlero de R.N., Menon K.K., Abo S., Gonzales M.F., and Bernard C.C. Myelin oligodendrocyte glycoprotein induces a demyelinating encephalomyelitis resembling multiple sclerosis. J. Immunol. 154 10 (1995) 5536-5541
    • (1995) J. Immunol. , vol.154 , Issue.10 , pp. 5536-5541
    • Johns, T.G.1    Kerlero de, R.N.2    Menon, K.K.3    Abo, S.4    Gonzales, M.F.5    Bernard, C.C.6
  • 16
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25+ T regulatory cells
    • Khattri R., Cox T., Yasayko S.A., and Ramsdell F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 4 4 (2003) 337-342
    • (2003) Nat. Immunol. , vol.4 , Issue.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 17
    • 0036838536 scopus 로고    scopus 로고
    • Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis
    • Kohm A.P., Carpentier P.A., Anger H.A., and Miller S.D. Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J. Immunol. 169 9 (2002) 4712-4716
    • (2002) J. Immunol. , vol.169 , Issue.9 , pp. 4712-4716
    • Kohm, A.P.1    Carpentier, P.A.2    Anger, H.A.3    Miller, S.D.4
  • 18
    • 0023948026 scopus 로고
    • Limiting dilution comparison of the repertoires of high and low responder MHC-restricted T cells
    • Kojima M., Cease K.B., Buckenmeyer G.K., and Berzofsky J.A. Limiting dilution comparison of the repertoires of high and low responder MHC-restricted T cells. J. Exp. Med. 167 3 (1988) 1100-1113
    • (1988) J. Exp. Med. , vol.167 , Issue.3 , pp. 1100-1113
    • Kojima, M.1    Cease, K.B.2    Buckenmeyer, G.K.3    Berzofsky, J.A.4
  • 19
    • 33745321276 scopus 로고    scopus 로고
    • IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
    • Komiyama Y., Nakae S., Matsuki T., Nambu A., Ishigame H., Kakuta S., Sudo K., and Iwakura Y. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J. Immunol. 177 1 (2006) 566-573
    • (2006) J. Immunol. , vol.177 , Issue.1 , pp. 566-573
    • Komiyama, Y.1    Nakae, S.2    Matsuki, T.3    Nambu, A.4    Ishigame, H.5    Kakuta, S.6    Sudo, K.7    Iwakura, Y.8
  • 21
    • 0033853625 scopus 로고    scopus 로고
    • Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation
    • Kuniyasu Y., Takahashi T., Itoh M., Shimizu J., Toda G., and Sakaguchi S. Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation. Int. Immunol. 12 8 (2000) 1145-1155
    • (2000) Int. Immunol. , vol.12 , Issue.8 , pp. 1145-1155
    • Kuniyasu, Y.1    Takahashi, T.2    Itoh, M.3    Shimizu, J.4    Toda, G.5    Sakaguchi, S.6
  • 24
    • 0033571458 scopus 로고    scopus 로고
    • Isolation of self antigen-reactive cells from inflamed islets of nonobese diabetic mice using CD4high expression as a marker
    • Lejon K., and Fathman C.G. Isolation of self antigen-reactive cells from inflamed islets of nonobese diabetic mice using CD4high expression as a marker. J. Immunol. 163 10 (1999) 5708-5714
    • (1999) J. Immunol. , vol.163 , Issue.10 , pp. 5708-5714
    • Lejon, K.1    Fathman, C.G.2
  • 25
    • 0037005165 scopus 로고    scopus 로고
    • Identification of the encephalitogenic epitopes of CNS proteolipid protein in BALB/c mice
    • Lyons J.A., Ramsbottom M.J., Trotter J.L., and Cross A.H. Identification of the encephalitogenic epitopes of CNS proteolipid protein in BALB/c mice. J. Autoimmun. 19 4 (2002) 195-201
    • (2002) J. Autoimmun. , vol.19 , Issue.4 , pp. 195-201
    • Lyons, J.A.1    Ramsbottom, M.J.2    Trotter, J.L.3    Cross, A.H.4
  • 26
    • 0036195161 scopus 로고    scopus 로고
    • CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
    • McHugh R.S., Whitters M.J., Piccirillo C.A., Young D.A., Shevach E.M., Collins M., and Byrne M.C. CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16 2 (2002) 311-323
    • (2002) Immunity , vol.16 , Issue.2 , pp. 311-323
    • McHugh, R.S.1    Whitters, M.J.2    Piccirillo, C.A.3    Young, D.A.4    Shevach, E.M.5    Collins, M.6    Byrne, M.C.7
  • 27
    • 1542711246 scopus 로고    scopus 로고
    • A novel protective model against experimental allergic encephalomyelitis in mice expressing a transgenic TCR-specific for myelin oligodendrocyte glycoprotein
    • Mendel I., Natarajan K., Ben Nun A., and Shevach E.M. A novel protective model against experimental allergic encephalomyelitis in mice expressing a transgenic TCR-specific for myelin oligodendrocyte glycoprotein. J. Neuroimmunol. 149 1-2 (2004) 10-21
    • (2004) J. Neuroimmunol. , vol.149 , Issue.1-2 , pp. 10-21
    • Mendel, I.1    Natarajan, K.2    Ben Nun, A.3    Shevach, E.M.4
  • 28
    • 0021328623 scopus 로고
    • Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice
    • Mokhtarian F., McFarlin D.E., and Raine C.S. Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice. Nature 309 5966 (1984) 356-358
    • (1984) Nature , vol.309 , Issue.5966 , pp. 356-358
    • Mokhtarian, F.1    McFarlin, D.E.2    Raine, C.S.3
  • 29
    • 0021328623 scopus 로고
    • Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice
    • Mokhtarian F., McFarlin D.E., and Raine C.S. Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice. Nature 309 5966 (1984) 356-358
    • (1984) Nature , vol.309 , Issue.5966 , pp. 356-358
    • Mokhtarian, F.1    McFarlin, D.E.2    Raine, C.S.3
  • 30
    • 20444380391 scopus 로고    scopus 로고
    • IL-4 modulation of CD4+CD25+ T regulatory cell-mediated suppression
    • Pace L., Pioli C., and Doria G. IL-4 modulation of CD4+CD25+ T regulatory cell-mediated suppression. J. Immunol. 174 12 (2005) 7645-7653
    • (2005) J. Immunol. , vol.174 , Issue.12 , pp. 7645-7653
    • Pace, L.1    Pioli, C.2    Doria, G.3
  • 31
    • 2942538291 scopus 로고    scopus 로고
    • Sensitivity and reproducibility of standardized-competitive RT-PCR for transcript quantification and its comparison with real time RT-PCR
    • Pagliarulo V., George B., Beil S.J., Groshen S., Laird P.W., Cai J., Willey J., Cote R.J., and Datar R.H. Sensitivity and reproducibility of standardized-competitive RT-PCR for transcript quantification and its comparison with real time RT-PCR. Mol. Cancer 3 (2004) 5
    • (2004) Mol. Cancer , vol.3 , pp. 5
    • Pagliarulo, V.1    George, B.2    Beil, S.J.3    Groshen, S.4    Laird, P.W.5    Cai, J.6    Willey, J.7    Cote, R.J.8    Datar, R.H.9
  • 32
    • 0019465748 scopus 로고
    • Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt 1 + 2-T lymphocytes
    • Pettinelli C.B., and McFarlin D.E. Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt 1 + 2-T lymphocytes. J. Immunol. 127 4 (1981) 1420-1423
    • (1981) J. Immunol. , vol.127 , Issue.4 , pp. 1420-1423
    • Pettinelli, C.B.1    McFarlin, D.E.2
  • 33
    • 0025313253 scopus 로고
    • Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity
    • Powell M.B., Mitchell D., Lederman J., Buckmeier J., Zamvil S.S., Graham M., Ruddle N.H., and Steinman L. Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity. Int. Immunol. 2 6 (1990) 539-544
    • (1990) Int. Immunol. , vol.2 , Issue.6 , pp. 539-544
    • Powell, M.B.1    Mitchell, D.2    Lederman, J.3    Buckmeier, J.4    Zamvil, S.S.5    Graham, M.6    Ruddle, N.H.7    Steinman, L.8
  • 35
    • 0032528417 scopus 로고    scopus 로고
    • Following antigen challenge, T cells up-regulate cell surface expression of CD4 in vitro and in vivo
    • Ridgway W., Fasso M., and Fathman C.G. Following antigen challenge, T cells up-regulate cell surface expression of CD4 in vitro and in vivo. J. Immunol. 161 2 (1998) 714-720
    • (1998) J. Immunol. , vol.161 , Issue.2 , pp. 714-720
    • Ridgway, W.1    Fasso, M.2    Fathman, C.G.3
  • 36
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S., Sakaguchi N., Asano M., Itoh M., and Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155 3 (1995) 1151-1164
    • (1995) J. Immunol. , vol.155 , Issue.3 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 38
    • 0023752774 scopus 로고
    • Characterization of a major encephalitogenic T cell epitope in SJL/J mice with synthetic oligopeptides of myelin basic protein
    • Sakai K., Zamvil S.S., Mitchell D.J., Lim M., Rothbard J.B., and Steinman L. Characterization of a major encephalitogenic T cell epitope in SJL/J mice with synthetic oligopeptides of myelin basic protein. J. Neuroimmunol. 19 1-2 (1988) 21-32
    • (1988) J. Neuroimmunol. , vol.19 , Issue.1-2 , pp. 21-32
    • Sakai, K.1    Zamvil, S.S.2    Mitchell, D.J.3    Lim, M.4    Rothbard, J.B.5    Steinman, L.6
  • 39
    • 0032536447 scopus 로고    scopus 로고
    • An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease
    • Segal B.M., Dwyer B.K., and Shevach E.M. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J. Exp. Med. 187 4 (1998) 537-546
    • (1998) J. Exp. Med. , vol.187 , Issue.4 , pp. 537-546
    • Segal, B.M.1    Dwyer, B.K.2    Shevach, E.M.3
  • 40
    • 0026753610 scopus 로고
    • A combination of adoptive transfer and antigenic challenge induces consistent murine experimental autoimmune encephalomyelitis in C57BL/6 mice and other reputed resistant strains
    • Shaw M.K., Kim C., Ho K.L., Lisak R.P., and Tse H.Y. A combination of adoptive transfer and antigenic challenge induces consistent murine experimental autoimmune encephalomyelitis in C57BL/6 mice and other reputed resistant strains. J. Neuroimmunol. 39 1-2 (1992) 139-149
    • (1992) J. Neuroimmunol. , vol.39 , Issue.1-2 , pp. 139-149
    • Shaw, M.K.1    Kim, C.2    Ho, K.L.3    Lisak, R.P.4    Tse, H.Y.5
  • 41
    • 0029785818 scopus 로고    scopus 로고
    • Induction of myelin basic protein-specific experimental autoimmune encephalomyelitis in C57BL/6 mice: mapping of T cell epitopes and T cell receptor V beta gene segment usage
    • Shaw M.K., Kim C., Hao H.W., Chen F., and Tse H.Y. Induction of myelin basic protein-specific experimental autoimmune encephalomyelitis in C57BL/6 mice: mapping of T cell epitopes and T cell receptor V beta gene segment usage. J. Neurosci. Res. 45 6 (1996) 690-699
    • (1996) J. Neurosci. Res. , vol.45 , Issue.6 , pp. 690-699
    • Shaw, M.K.1    Kim, C.2    Hao, H.W.3    Chen, F.4    Tse, H.Y.5
  • 42
    • 36749011914 scopus 로고    scopus 로고
    • Induction of myelin basic protein-specific adoptive experimental autoimmune encephalomyelitis in C57BL/6 mice: longevity of donor T cells and lack of disease relapses
    • Broglio P. (Ed), Nova Science Publishers, Inc.
    • Shaw M.K., Li J., Ho P., Hoa H., Lisak R.P., and Tse H.Y. Induction of myelin basic protein-specific adoptive experimental autoimmune encephalomyelitis in C57BL/6 mice: longevity of donor T cells and lack of disease relapses. In: Broglio P. (Ed). Neuroimmunology Research Focus (2007), Nova Science Publishers, Inc.
    • (2007) Neuroimmunology Research Focus
    • Shaw, M.K.1    Li, J.2    Ho, P.3    Hoa, H.4    Lisak, R.P.5    Tse, H.Y.6
  • 43
    • 0036170938 scopus 로고    scopus 로고
    • Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    • Shimizu J., Yamazaki S., Takahashi T., Ishida Y., and Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 3 2 (2002) 135-142
    • (2002) Nat. Immunol. , vol.3 , Issue.2 , pp. 135-142
    • Shimizu, J.1    Yamazaki, S.2    Takahashi, T.3    Ishida, Y.4    Sakaguchi, S.5
  • 44
    • 0344872721 scopus 로고    scopus 로고
    • A hierarchy of T cell receptor motifs determines responsiveness to the immunodominant epitope in experimental autoimmune myasthenia gravis
    • Standifer N.E., Kraig E., and Infante A.J. A hierarchy of T cell receptor motifs determines responsiveness to the immunodominant epitope in experimental autoimmune myasthenia gravis. J. Neuroimmunol. 145 1-2 (2003) 68-76
    • (2003) J. Neuroimmunol. , vol.145 , Issue.1-2 , pp. 68-76
    • Standifer, N.E.1    Kraig, E.2    Infante, A.J.3
  • 45
    • 33745873727 scopus 로고    scopus 로고
    • A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
    • Sutton C., Brereton C., Keogh B., Mills K.H., and Lavelle E.C. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 203 7 (2006) 1685-1691
    • (2006) J. Exp. Med. , vol.203 , Issue.7 , pp. 1685-1691
    • Sutton, C.1    Brereton, C.2    Keogh, B.3    Mills, K.H.4    Lavelle, E.C.5
  • 46
    • 0028840828 scopus 로고
    • Experimental autoimmune encephalomyelitis in rodents as a model for human demyelinating disease
    • Swanborg R.H. Experimental autoimmune encephalomyelitis in rodents as a model for human demyelinating disease. Clin Immunol. Immunopathol. 77 1 (1995) 4-13
    • (1995) Clin Immunol. Immunopathol. , vol.77 , Issue.1 , pp. 4-13
    • Swanborg, R.H.1
  • 47
    • 0037090253 scopus 로고    scopus 로고
    • De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis
    • Tompkins S.M., Padilla J., Dal Canto M.C., Ting J.P., Van K.L., and Miller S.D. De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis. J. Immunol. 168 8 (2002) 4173-4183
    • (2002) J. Immunol. , vol.168 , Issue.8 , pp. 4173-4183
    • Tompkins, S.M.1    Padilla, J.2    Dal Canto, M.C.3    Ting, J.P.4    Van, K.L.5    Miller, S.D.6
  • 48
    • 0021963715 scopus 로고
    • Acute experimental allergic encephalomyelitis in the mouse: immunopathology of the developing lesion
    • Traugott U., Raine C.S., and McFarlin D.E. Acute experimental allergic encephalomyelitis in the mouse: immunopathology of the developing lesion. Cell. Immunol. 91 1 (1985) 240-254
    • (1985) Cell. Immunol. , vol.91 , Issue.1 , pp. 240-254
    • Traugott, U.1    Raine, C.S.2    McFarlin, D.E.3
  • 49
    • 0022598180 scopus 로고
    • Immunopathology of the lesion in chronic relapsing experimental autoimmune encephalomyelitis in the mouse
    • Traugott U., McFarlin D.E., and Raine C.S. Immunopathology of the lesion in chronic relapsing experimental autoimmune encephalomyelitis in the mouse. Cell. Immunol. 99 2 (1986) 395-410
    • (1986) Cell. Immunol. , vol.99 , Issue.2 , pp. 395-410
    • Traugott, U.1    McFarlin, D.E.2    Raine, C.S.3
  • 51
    • 0024504033 scopus 로고
    • Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice
    • Tuohy V.K., Lu Z., Sobel R.A., Laursen R.A., and Lees M.B. Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J. Immunol. 142 5 (1989) 1523-1527
    • (1989) J. Immunol. , vol.142 , Issue.5 , pp. 1523-1527
    • Tuohy, V.K.1    Lu, Z.2    Sobel, R.A.3    Laursen, R.A.4    Lees, M.B.5
  • 52
    • 0021966856 scopus 로고
    • T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination
    • Zamvil S., Nelson P., Trotter J., Mitchell D., Knobler R., Fritz R., and Steinman L. T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination. Nature 317 6035 (1985) 355-358
    • (1985) Nature , vol.317 , Issue.6035 , pp. 355-358
    • Zamvil, S.1    Nelson, P.2    Trotter, J.3    Mitchell, D.4    Knobler, R.5    Fritz, R.6    Steinman, L.7
  • 53
    • 0022974996 scopus 로고
    • T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis
    • Zamvil S.S., Mitchell D.J., Moore A.C., Kitamura K., Steinman L., and Rothbard J.B. T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis. Nature 324 6094 (1986) 258-260
    • (1986) Nature , vol.324 , Issue.6094 , pp. 258-260
    • Zamvil, S.S.1    Mitchell, D.J.2    Moore, A.C.3    Kitamura, K.4    Steinman, L.5    Rothbard, J.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.