A hierarchy of T cell receptor motifs determines responsiveness to the immunodominant epitope in experimental autoimmune myasthenia gravis

Journal of Neuroimmunology

Volumn 145, Issue 1-2, 2003, Pages 68-76

  Standifer, Nathan E ^a,b   Kraig, Ellen ^a   Infante, Anthony J ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b BENAROYA RESEARCH INSTITUTE   (United States)

Author keywords

Avidity; Myasthenia gravis; T cell receptor; T lymphocytes

Indexed keywords

CD4 ANTIGEN; EPITOPE; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNITY; CELL ISOLATION; CONTROLLED STUDY; FEMALE; GENETIC ANALYSIS; MOLECULAR CLONING; MOLECULAR RECOGNITION; MOUSE; MYASTHENIA GRAVIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; T LYMPHOCYTE SUBPOPULATION;

EID: 0344872721     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2003.09.007     Document Type: Article

References (23)

1. Aime-Sempe C., Cohen-Kaminsky S., Bruand C., Klingel-Schmitt I., Truffault F., Berrih-Anknin S. In vivo preferential usage of TCR Vβ8 in Torpedo acetylcholine receptor immune response in the murine experimental model of myasthenia gravis. J. Neuroimmunol. 58:1995;191-200.
2. Bellone M., Ostlie N., Lei S., Manfredi A., Conti-Tronconi B.M. T helper function of CD4+ cells specific for defined epitopes on the acetylcholine receptor in congenic mouse strains. J. Autoimmun. 5:1992;27-46.
3. Berman P.W., Patrick J. Experimental myasthenia gravis: a murine system. J. Exp. Med. 151:1980;204-223.
4. Christadoss P., Dauphinee M.J. Immunotherapy for myasthenia gravis: a murine model. J. Immunol. 136:1986;2437-2440.
5. Christadoss P., Shenoy M., Oshima M., Atassi M.Z. Suppression of experimental autoimmune myasthenia gravis by epitope-specific neonatal tolerance. Adv. Exp. Med. Biol. 347:1994;65-75.
6. Drachman D.B. Myasthenia gravis. N. Engl. J. Med. 330:1994;1797-1810.
7. Fasso M., Anandasabapathy N., Crawford F., Kappler J., Fathman C.G., Ridgeway W.M. T cell receptor (TCR)-mediated repertoire selection and loss of TCR Vβ diversity during the initiation of a CD4+ T cell response in vivo. J. Exp. Med. 192:2000;1719-1730.
8. Infante A.J., Kraig E. Myasthenia gravis and its animal model: T cell receptor expression in an antibody mediated autoimmune disease. Int. Rev. Immunol. 18:1999;83-109.
9. Infante A.J., Thompson P.A., Krolick K.A., Wall K.A. Determinant selection in murine experimental autoimmune myasthenia gravis. J. Immunol. 146:1991;2977-2982.
10. Infante A.J., Levcovitz H., Gordon V., Wall K.A., Thompson P.A., Krolick K.A. Preferential use of a T cell receptor Vβ gene by acetylcholine receptor reactive T cells from myasthenia gravis susceptible mice. J. Immunol. 148:1992;3385-3390.
11. Kaul R., Shenoy M., Goluszko E., Christadoss P. Major histocompatibility complex class II gene disruption prevents experimental autoimmune myasthenia gravis. J. Immunol. 152:1994;3152-3157.
12. Kraig E., Pierce J.L., Clarkin K.Z., Standifer N.E., Currier P., Wall K.A., Infante A.J. Restricted T cell receptor repertoire for acetylcholine receptor in murine myasthenia gravis. J. Neuroimmunol. 71:1996;887-895.
13. high expression as a marker. J. Immunol. 162:1999;5707-5714.
14. high, proliferating subset. Int. Immunol. 13:2001;799-806.
15. Pierce J.L., Zborowski K.A., Kraig E., Infante A.J. Highly conserved TCR β chain sequences among immunodominant acetylcholine receptor-reactive T cells in murine myasthenia gravis. Int. Immunol. 6:1994;775-783.
16. s) tetramers. J. Immunol. 170:2003;870-877.
17. Ridgeway W., Fasso M., Fathman C.G. Following antigen challenge, T cells up-regulate cell surface expression of CD4 in vitro and in vivo. J. Immunol. 161:1998;714-720.
18. Thompson P.A., McAtee R., Infante A.J., Currier P., Beninati W., Krolick K.A. Vβ-specific immunotoxin selectively kills acetylcholine receptor-reactive T lymphocytes from mice with experimental autoimmune myasthenia gravis. Int. Immunol. 6:1994;1807-1815.
19. b binding, self-nonself discrimination, and TCR antagonism. J. Immunol. 152:1994;4526-4536.
20. b strains. J. Immunol. 154:1995;3603-3610.
21. Wu B., Deng C., Goluszko E., Christadoss P. Tolerance to a dominant T cell epitope in the acetylcholine receptor molecule induces epitope spread and suppresses murine myasthenia gravis. J. Immunol. 159:1997;3016-3023.
22. Yang B., McIntosh K.R., Drachman D.B. How subtle differences in MHC class II affect the severity of experimental myasthenia gravis. Clin. Immunol. Immunopathol. 86:1998;45-58.
23. Yokoi T., Mulac-Jericevic B., Kurisaki J.-I., Atassi M.Z. T lymphocyte recognition of acetylcholine receptor: localization of the full T cell recognition profile on the extracellular part of the α chain of Torpedo californica acetylcholine receptor. Eur. J. Immunol. 17:1987;1697-1702.