Topical Analgesics

Anesthesiology Clinics

Volumn 25, Issue 4, 2007, Pages 825-839

  McCleane, Gary ^a  

^a Rampark Pain Centre   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE RECEPTOR; AMITRIPTYLINE; CANNABINOID; CAPSAICIN; CLOMIPRAMINE; DESIPRAMINE; DOXEPIN; FORMALDEHYDE; GLUTAMATE RECEPTOR ANTAGONIST; GLYCERYL TRINITRATE; IMIPRAMINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; NITRIC ACID DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PLACEBO; SODIUM CHANNEL; TRICYCLIC ANTIDEPRESSANT AGENT;

ANALGESIA; ANTIINFLAMMATORY ACTIVITY; ARTHRALGIA; CHRONIC PAIN; CLINICAL TRIAL; DRUG APPROVAL; DRUG EFFECT; DRUG FORMULATION; DRUG HYPERSENSITIVITY; DRUG SAFETY; DRUG TOLERABILITY; HUMAN; MYALGIA; NEUROPATHIC PAIN; NONHUMAN; PATIENT COMPLIANCE; POSTOPERATIVE PAIN; REVIEW; SEDATION; SIDE EFFECT; URINE RETENTION; VISCERAL PAIN; WEIGHT GAIN; XEROSTOMIA;

ADMINISTRATION, TOPICAL; ANALGESICS; ANIMALS; HUMANS; PAIN; PERIPHERAL NERVOUS SYSTEM; RATS;

EID: 36549083749     PISSN: 19322275     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.anclin.2007.07.004     Document Type: Review

References (120)

1. Vane J.R., Bakhle Y.S., and Botting J. Cyclo-oxygenase 1 and 2. Annu Rev Pharmacol Toxicol 38 (1998) 97-120
2. Yaksh T.L., Dirig D.M., and Malmberg A.B. Mechanisms of action of nonsteroidal anti-inflammatory drugs. Cancer Investig 16 (1998) 509-527
3. Chandrasekharan N.V., Dai H., Roos K.L., et al. Cox-3, a cyclo-oxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs. Cloning, structure and expression. Proc Natl Acad Sci U S A 99 (2002) 13926-13931
4. Heyneman C.A., Lawless-Liday C., and Wall G.C. Oral versus topical NSAIDs in rheumatic diseases. A comparison. Drugs 60 (2000) 555-574
5. Kress M., and Reeh P.W. Chemical excitation and sensitization in nociceptors. In: Cavero F., and Belmonte C. (Eds). Neurobiology and nociceptors (1996), Oxford University Press, Oxford (UK) 258-297
6. Steen K.H., Reeh P.W., and Kreysel H.W. Topical acetylsalicylic, salicylic acid and indomethacin suppresses pain from experimental tissue acidosis in human skin. Pain 62 (1995) 339-347
7. Steen K.H., Reeh P.W., and Kreysel H.W. Dose-dependent competitive block by topical acetylsalicylic acid and salicylic acid of low pH-induced cutaneous pain. Pain 64 (2001) 71-82
8. Schmelz M., and Kress M. Topical acetylsalicylate attenuates capsaicin induced pain, flare and allodynia but not thermal hyperalgesia. Neurosci Lett 214 (1996) 72-74
9. Steen K.H., Wegner H., and Meller S.T. Analgesic profile of peroral and topical ketoprofen upon low pH-induced muscle pain. Pain 93 (2001) 23-33
10. Vaile J.H., and Davis P. Topical NSAIDs for musculoskeletal conditions. A review of the literature. Drugs 56 (1998) 783-799
11. Moore R.A., Tramer M.R., Carrol D., et al. Quantitative systematic review of topically applied non-steroidal anti-inflammatory drugs. BMJ 316 (1998) 333-338
12. Feelisch M., and Noack E.A. Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase. Eur J Pharmacol 139 (1987) 19-30
13. Knowles R.G., Palacios M., Palmer R.M., et al. Formation of nitric oxide from l-arginine in the central nervous system: a transduction mechanism for stimulation of soluble guanylate cyclase. Proc Natl Acad Sci U S A 86 (1989) 5159-5162
14. Duarte I.D., Lorenzetti B.B., and Ferreira S.H. Acetylcholine induces peripheral analgesia by the release of nitric oxide. In: Moncada S., and Higgs A. (Eds). Nitric oxide from l-arginine. A bioregulatory system (1990), Elsevier, Amsterdam 165-170
15. Soares A., Leite R., Patsuo M., et al. Activation of ATP sensitive K channels: mechanisms of peripheral antinociceptive action of the nitric oxide donor, sodium nitroprusside. Eur J Pharmacol 14 (2000) 67-71
16. Okuda K., Sakurada C., Takahashi M., et al. Characterization of nociceptive responses and spinal release of nitric oxide metabolites and glutamate evoked by different concentrations of formalin in rats. Pain 92 (2001) 107-115
17. McCleane G.J. The addition of piroxicam to topically applied glyceryl trinitrate enhances its analgesic effect in musculoskeletal pain: a randomised, double-blind, placebo-controlled study. Pain Clin 12 (2000) 113-116
18. Berrazueta J.R., Losada A., Poveda J., et al. Successful treatment of shoulder pain syndrome due to supraspinatus tendonitis with transdermal nitroglycerin. A double blind study. Pain 66 (1996) 63-67
19. Berrazeuta J.R., Poveda J.J., Ochoteco J.A., et al. The anti-inflammatory and analgesic action of transdermal glyceryl trinitrate in the treatment of infusion related thrombophlebitis. Postgrad Med J 69 (1993) 37-40
20. Berrazueta J.R., Fleitas M., Salas E., et al. Local transdermal glyceryl trinitrate has an anti-inflammatory action on thrombophlebitis induced by sclerosis of leg varicose veins. Angiology 45 (1994) 347-351
21. Walsh K.E., Berman J.R., Berman L.A., et al. Safety and efficacy of topical nitroglycerin for treatment of vulvar pain in women with vulvodynia: a pilot study. J Gend Specif Med 5 (2002) 21-27
22. Lauretti G.R., de Oliveira R., Reis M.P., et al. Transdermal nitroglycerine enhances spinal sufentanil postoperative analgesia following orthopaedic surgery. Anesthesiology 90 (1999) 734-739
23. Lauretti G.R., Lima I.C., and Reis M.P. Oral ketamine and transdermal nitroglycerin as analgesic adjuvants to oral morphine therapy for cancer pain management. Anesthesiology 90 (1999) 1528-1533
24. Lauretti G.R., Perez M.V., Reis M.P., et al. Double-blind evaluation of transdermal nitroglycerine as an adjuvant to oral morphine for cancer pain management. J Clin Anesth 14 (2002) 83-86
25. Galer B.S. Topical medications. In: Loeser J.D. (Ed). Bonica's management of pain (2001), Lippincott-Williams & Wilkins, Philadelphia 1736-1741
26. ®) cream on spontaneous and evoked pain in post-herpetic neuralgia. Pain 81 (1999) 203-209
27. ® cream in the treatment of post-herpetic neuralgia. J Clin Anesth 8 (1996) 54-57
28. ® cream for the treatment of pain caused by post-herpetic neuralgia: a double-blind, placebo controlled study. Proceedings of the Annual Meeting of the American Pain Society. Glenview (IL): American Pain Society; 1996. A111 (abstract).
29. Rowbotham M.C., Davies P.S., Verkempinck C., et al. Lidocaine patch: double-blind controlled study of a new treatment method for post-herpetic neuralgia. Pain 65 (1996) 39-44
30. Galer B.S., Rowbotham M.C., Perander J., et al. Topical lidocaine patch relieves post-herpetic neuralgia more effectively than vehicle patch: results of an enriched enrolment study. Pain 80 (1999) 533-538
31. Katz N.P., Davis M.W., and Dworkin R.H. Topical lidocaine patch produces a significant improvement in mean pain scores and pain relief in treated PHN patients: results of a multicenter open-label trial. J Pain 2 (2001) 9-18
32. Meier T., Wasner G., Faust M., et al. Efficacy of lidocaine 5% patch in treatment of focal peripheral neuropathic pain syndromes: a randomized, double-blind, placebo-controlled study. Pain 106 (2003) 151-158
33. Devers A., and Galer B.S. Topical lidocaine patch relieves a variety of neuropathic pain conditions: an open-label study. Clin J Pain 16 (2000) 205-208
34. Capsaicin Study Group. Treatment of painful diabetic neuropathy with topical capsaicin. Arch Intern Med 151 (1991) 2225-2229
35. Tandan R., Lewis G.A., Krusinski P.B., et al. Topical capsaicin in painful diabetic neuropathy. Diabetes Care 15 (1992) 8-13
36. Capsaicin Study Group. Effect of treatment with capsaicin on daily activities of patients with painful diabetic neuropathy. Diabetes Care 15 (1992) 159-165
37. Chad D.A., Aronin N., Lundstorm R., et al. Does capsaicin relieve the pain of diabetic neuropathy?. Pain 42 (1990) 387-388
38. Bernstein J.E., Korman N.J., Bickers D.R., et al. Topical capsaicin treatment of chronic postherpetic neuralgia. J Am Acad Dermatol 21 (1989) 265-270
39. Watson C.P., Tyler K.L., Bickers D.R., et al. A randomized vehicle controlled trial of topical capsaicin in the treatment of postherpetic neuralgia. Clin Ther 15 (1993) 510-526
40. Watson C.P., Evans R., and Watt V.R. Post herpetic neuralgia and topical capsaicin. Pain 33 (1988) 333-340
41. Low P.A., Opfer-Gehrking T.L., Dyck P.J., et al. Double blind, placebo controlled study of the application of capsaicin cream in chronic distal painful polyneuropathy. Pain 45 (1995) 163-168
42. Epstein J.B., and Marcoe J.H. Topical application of capsaicin for treatment of oral neuropathic pain and trigeminal neuralgia. Oral Surg Oral Med Oral Pathol 77 (1994) 135-140
43. Ellison N., Loprinzi C.L., Kugler J., et al. Phase III placebo controlled trial of capsaicin cream in the management of surgical neuropathic pain in cancer patients. J Clin Oncol 15 (1997) 2974-2980
44. Morgenlander J.C., Hurwitz B.J., and Massey E.W. Capsaicin for the treatment of pain in Guillain-Barré syndrome. Ann Neurol 12 (1990) 199
45. Turnbull A. Tincture of capsicum as a remedy for chilblains and toothache (1850), Dublin Medical Press, Dublin (Ireland) p. 95-6
46. Altman R.D., Aven A., Holmburg C.E., et al. Capsaicin cream 0.025% as monotherapy for osteoarthritis: a double blind study. Sem Arth Rheum 23S (1994) 25-33
47. Deal C.L. The use of topical capsaicin in managing arthritis pain: a clinician's perspective. Sem Arth Rheum 23S (1994) 48-52
48. Deal C.L., Schnitzer T.J., Lipstein E., et al. Treatment of arthritis with topical capsaicin: a double blind trial. Clin Ther 13 (1991) 383-395
49. McCarthy G.M., and McCarty D.J. Effect of topical capsaicin in the therapy of painful osteoarthritis of the hands. J Rheumatol 19 (1992) 604-607
50. McCleane G.J. The analgesic efficacy of topical capsaicin in enhanced by glyceryl trinitrate in painful osteoarthritis: a randomized, double-blind, placebo controlled study. Eur J Pain 4 (2000) 355-360
51. Schnitzer T., Morton C., and Coker S. Topical capsaicin therapy for osteoarthritis pain: achieving a maintenance regimen. Sem Arth Rheum 23S (1994) 34-40
52. Mathias B.J., Dillingham T.R., Zeigler D.N., et al. Topical capsaicin for chronic neck pain. Am J Phys Med Rehabil 74 (1995) 39-44
53. Fitzgerald M. Capsaicin and sensory neurones. Pain 15 (1983) 109-130
54. Rains C., and Bryson H.M. Topical capsaicin. A review of its pharmacological properties and therapeutic potential in post herpetic neuralgia, diabetic neuropathy and osteoarthritis. Drugs Aging 7 (1995) 317-328
55. Nolano M., Simone D.A., Wendelschafer-Crabb G., et al. Topical capsaicin in humans: parallel loss of epidermal nerve fibers and pain sensation. Pain 81 (1999) 135-141
56. Walker R.A., and McCleane G.J. The addition of glyceryl trinitrate to capsaicin cream reduces the thermal allodynia associated with the use of capsaicin in humans. Neurosci Lett 323 (2002) 78-80
57. McCleane G.J., and McLaughlin M. The addition of GTN to capsaicin cream reduces the discomfort associated with application of capsaicin alone. A volunteer study. Pain 78 (1998) 149-151
58. Yosipovitch G., Mailback H.I., and Rowbotham M.C. Effect of EMLA pre-treatment on capsaicin-induced burning and hyperalgesia. Acta Derm Venereol 79 (1999) 118-121
59. Sawynok J. Adenosine receptor activation and nociception. Eur J Pharmacol 317 (1998) 1-11
60. Esser M.J., and Sawynok M.J. Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain. Eur J Pharmacol 399 (2000) 131-139
61. Sudoh Y., Cahoon E.E., Gerner P., et al. Tricyclic antidepressant as long acting local anesthetics. Pain 103 (2003) 49-55
62. Haderer A., Gerner P., Kao G., et al. Cutaneous analgesia after transdermal application of amitriptyline versus lidocaine in rats. Anesth Analg 96 (2003) 1707-1710
63. Esser M.J., and Sawynok J. Acute amitriptyline in a rat model of neuropathic pain: differential symptom and route effects. Pain 80 (1999) 643-653
64. Esser M.J., Chase T., Allen G.V., et al. Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions. Eur J Pharmacol 430 (2001) 211-218
65. Sawynok J., Esser M.J., and Reid A.R. Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. Pain 82 (1999) 149-158
66. Sawynok J., Reid A.R., and Esser M.J. Peripheral antinociceptive action of amitriptyline in the rat formalin test: involvement of adenosine. Pain 80 (1999) 45-55
67. Sawynok J., and Reid A. Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviours and paw edema in rats. Pain 102 (2003) 179-186
68. Heughan C.E., Allen G.V., Chase T.D., et al. Peripheral amitriptyline suppresses formalin-induced Fos expression in the rat spinal cord. Anesth Analg 94 (2002) 427-431
69. Su X., and Gebhart G.F. Effects of tricyclic antidepressants on mechanosensitive pelvic nerve afferent fibers innervating the rat colon. Pain 76 (1998) 105-114
70. Oatway M., Reid A., and Sawynok J. Peripheral antihyperalgesic and analgesic actions of ketamine and amitriptyline in a model of mild thermal injury in the rat. Anesth Analg 97 (2003) 168-173
71. McCleane G.J. Topical doxepin hydrochloride reduces neuropathic pain: a randomized, double-blind, placebo controlled study. Pain Clin 12 (1999) 47-50
72. McCleane G.J. Topical application of doxepin hydrochloride, capsaicin and a combination of both produces analgesia in chronic human neuropathic pain: a randomized, double-blind, placebo-controlled study. Br J Clin Pharmacol 49 (2000) 574-579
73. Lynch M.E., Clarke A.J., and Sawynok J. A pilot study examining topical amitriptyline, ketamine, and a combination of both in the treatment of neuropathic pain. Clin J Pain 19 (2003) 323-328
74. McCleane G.J. Topical application of doxepin hydrochloride can reduce the symptoms of complex regional pain syndrome: a case report. Injury 33 (2002) 88-89
75. Epstein J.B., Truelove E.L., Oien H., et al. Oral topical doxepin rinse: analgesic effect in patients with oral mucosal pain due to cancer or cancer therapy. Oral Oncol 37 (2001) 632-637
76. Zhou S., Komak S., Du J., et al. Metabotropic glutamate 1α receptors on peripheral primary afferent fibers: their role in nociception. Brain Res 913 (2001) 18-26
77. Carlton S.M., Hargett G.L., and Coggeshall R.E. Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin. Neurosci Lett 197 (1995) 25-28
78. Carlton S.M., and Coggeshall R.E. Inflammation-induced changes in peripheral glutamate receptor populations. Brain Res 820 (1999) 63-70
79. Zhou S., Bonasera L., and Carlton S.M. Peripheral administration of NMDA, AMPA or KA results in pain behaviour in rats. Neuroreport 7 (1996) 895-900
80. Jackson D.L., Graff C.B., and Richardson J.D. Glutamate participates in the peripheral modulation of thermal hyperalgesia in rats. Eur J Pharmacol 284 (1995) 321-325
81. Lawland N.B., Willis W.D., and Westlund K.N. Excitatory amino acid receptor involvement in peripheral nociceptive transmission in rats. Eur J Pharmacol 324 (1997) 169-177
82. Walker K., Reeve A., Bowes M., et al. mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia. Neuropharmacology 40 (2001) 10-19
83. Tverskoy M., Oren M., Vaskovich M., et al. Ketamine enhances local anesthetic and analgesic effects of bupivicaine by a peripheral mechanism: a study in postoperative patients. Neurosci Lett 215 (1996) 5-8
84. Warncke T., JØrum E., and Stubhaug A. Local treatment with the N-methyl-d-aspartate receptor antagonist ketamine, inhibits development of secondary hyperalgesia in man by a peripheral action. Neurosci Lett 227 (1997) 1-4
85. Pedersen J.L., Galle T.S., and Kehlet H. Peripheral analgesic effects of ketamine in acute inflammatory pain. Anesthesiology 89 (1998) 58-66
86. Hirota K., and Lambert D.G. Ketamine: its mechanism(s) of action and unusual clinical uses. Br J Anaesth 77 (1996) 441-444
87. Meller S.T. Ketamine: relief from chronic pain through actions at the NMDA receptor?. Pain 68 (1996) 435-436
88. Sawynok J., and Reid A.R. Modulation of formalin-induced behaviours and edema by local and systemic administration of dextromethorphan, memantine and ketamine. Eur J Pharmacol 450 (2002) 115-121
89. Crowley K.L., Flores J.A., Hughes C.N., et al. Clinical application of ketamine ointment in the treatment of sympathetically maintained pain. Int J Pharmaceutical Compounding 2 (1998) 122-127
90. Wood R.M. Ketamine for pain in hospice patients. Int J Pharmaceutical Compounding 4 (2000) 253-254
91. Davis C.L., Treede R.D., Raja S.N., et al. Topical application of clonidine relieves hyperalgesia in patients with sympathetically maintained pain. Pain 47 (1991) 309-317
92. Epstein J.B., Grushka M., and Le N. Topical clonidine for orofacial pain: a pilot study. J Orofac Pain 11 (1997) 346-352
93. Torebjörk E., Wahren L., Wallin G., et al. Noradrenaline-evoked pain in neuralgia. Pain 63 (1995) 11-20
94. Ali Z., Raja S.N., Wesselmann U., et al. Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain. Pain 88 (2000) 161-168
95. Chabal C., Jacobson L., Mariano A., et al. The use of oral mexiletine for the treatment of pain after peripheral nerve injury. Anesthesiology 76 (1992) 513-517
96. Choi B., and Rowbotham M.C. Effect of adrenergic receptor activation on post-herpetic neuralgia pain and sensory disturbances. Pain 69 (1997) 55-63
97. Gentili M., Houssel P., Osman H., et al. Intra-articular morphine and clonidine produce comparable analgesia but the combination is not more effective. Br J Anaesth 79 (1997) 660-661
98. Gentili M., Juhel A., and Bonnet F. Peripheral analgesic effect of intra-articular clonidine. Pain 64 (1996) 593-596
99. Reuben S.S., and Connelly N.R. Postoperative analgesia for outpatient arthroscopic knee surgery with intraarticular clonidine. Anesth Analg 88 (1999) 729-733
100. Joshi M., Reuben S.S., Kilaru P.R., et al. Postoperative analgesia for outpatient arthroscopic knee surgery with intraarticular clonidine and/or morphine. Anesth Analg 90 (2000) 1102-1106
101. Buerkle H., Huge V., Wolfgart M., et al. Intra-articular clonidine analgesia after knee arthroscopy. Eur J Anaesthesiol 17 (2000) 295-299
102. Calignano A., La Ranna G., Giuffrida A., et al. Control of pain initiation by endogenous cannabinoids. Nature 394 (1998) 277-281
103. Richardson J.D., Kilo S., and Hargreaves K.M. Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors. Pain 75 (1998) 111-119
104. 1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain. Pain 92 (2001) 91-100
105. Rice A.S., Farquhar-Smith W.P., and Nagy I. Endocannabinoids and pain: spinal and peripheral analgesia in inflammation and neuropathy. Prostaglandins Leukot Essent Fatty Acids 66 (2002) 243-256
106. Zhou L., Zhang Q., Stein C., et al. Contribution of opioid receptors on primary afferent versus sympathetic neurons to peripheral opioid analgesia. J Pharmacol Exp Ther 286 (1998) 1000-1006
107. Stein C., Schafer H., and Hassan A.H. Peripheral opioid receptors. Ann Med 27 (1995) 219-221
108. Coggeshall R.E., Zhou S., and Carlton S.M. Opioid receptors on peripheral sensory axons. Brain Res 764 (1997) 126-132
109. Hassan A.H., Ableitner A., Stein C., et al. Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue. Neuroscience 55 (1993) 185-195
110. Cerchietti L.C., Navigante A.H., Bonomi M.R., et al. Effect of topical morphine for mucositis-associated pain following concomitant chemoradiotherapy for head and neck carcinoma. Cancer 95 (2002) 2230-2236
111. Cerchietti L.C., Navigante A.H., Körte M.W., et al. Potential utility of the peripheral analgesic properties of morphine in stomatitis-related pain: a pilot study. Pain 105 (2003) 265-273
112. Krajnik M., Zylicz Z., Finlay I., et al. Potential uses of topical opioids in palliative care-report of 6 cases. Pain 80 (1999) 121-125
113. Twillman R.K., Long T.D., Cathers T.A., et al. Treatment of painful skin ulcers with topical opioids. J Pain Symptom Manage 17 (1999) 288-292
114. Likar R., Sittl R., Gragger K., et al. Peripheral morphine analgesia in dental surgery. Pain 76 (1998) 145-150
115. Likar R., Koppert W., Blatnig H., et al. Efficacy of peripheral morphine analgesia in inflamed, non-inflamed perineural tissue of dental surgery patients. J Pain Symptom Manage 21 (2001) 330-337
116. Moore R.J., Seymour R.A., Gilro J., et al. The efficacy of locally applied morphine in post-operative pain after bilateral third molar surgery. Br J Clin Pharmacol 37 (1994) 227-230
117. Duckett J.W., Cangiano T., Cubina M., et al. Intravesical morphine analgesia after bladder surgery. J Urol 157 (1997) 1407-1409
118. McCoubrie R., and Jeffrey D. Intravesical diamorphine for bladder spasm. J Pain Symptom Manage 25 (2003) 1-2
119. Picard P.R., Tramer M.R., McQuay H.J., et al. Analgesic efficacy of peripheral opioids (all except intra-articular): a qualitative systematic review of randomised controlled trials. Pain 72 (1997) 309-318
120. Gupta A., Bodin L., Holmstrom B., et al. A systematic review of the peripheral analgesic effects of intraarticular morphine. Anesth Analg 93 (2001) 761-770